ABOUT THIS EPISODE
What if your bloodwork could do more than tell you whether you're "normal" or "abnormal"? What if it could help identify the biggest drivers of your future disease and mortality risk—and show you where to focus first?Recorded at the Life Summit in Berlin, I sit down with my good friend and internationally renowned longevity researcher Brian Kennedy and his business partner, entrepreneur Julie Ying Baron, to discuss Beyond Clock, an effort to democratize access to the next-generation LinAge2 biological age algorithm designed to move beyond simple age prediction and toward actionable health insights.We explore how LinAge2 differs from traditional DNA methylation clocks, why its developers believe it can help prioritize interventions based on individual risk, and how it may uncover hidden disease risk even when standard clinical biomarkers appear normal. We also discuss the commercialization of the platform through Beyond Clock and the challenges of validating longevity interventions in real-world settings.The conversation then turns to one of the hottest debates in aging biology: NAD. We discuss recent studies suggesting that NAD levels may not decline with age in human blood, what that means for the long-standing NAD decline hypothesis, and whether this changes how we should think about NAD precursors as longevity interventions.Finally, we dive into spermidine, autophagy, biological age testing, cardiovascular risk assessment, personalized prevention, and the future of evidence-based longevity medicine.In this episode:Why most biological age clocks aren't clinically actionableHow Lineage uses routine blood biomarkers to estimate mortality riskThe case study that uncovered hidden cardiovascular diseaseWhy clinicians need better tools for prioritizing interventionsNew evidence challenging the idea that NAD declines with ageWhat NAD measurements may (and may not) tell usSpermidine, autophagy, and emerging longevity interventionsThe future of personalized longevity medicineDemocratizing access to longevity technologiesGuestsBrian Kennedy – Director of the Centre for Healthy Longevity at the National University of Singapore, former CEO of the Buck Institute, and internationally recognized expert on the biology of aging.Julie Ying Baron – Entrepreneur and co-founder of Beyond Clock, working to translate advanced longevity analytics into clinical and consumer applications.For more information on Beyond Clock, check out their website here: www.beyondclock.com
