ABOUT THIS PODCAST 🔗
What does the science really say about living longer and staying healthier as we age?
On Longevity Science, Matt Kaeberlein—professor, entrepreneur, and longtime leader in the field— explores the biology underlying human and animal healthspan and the interventions that might actually make a difference.
From rapamycin and peptides to lifestyle, diagnostics, and emerging therapies like epigenetic reprogramming, this podcast separates signal from noise in a space often dominated by hype.
No shortcuts. No miracle cures. Just thoughtful conversations grounded in real science.
On Longevity Science, Matt Kaeberlein—professor, entrepreneur, and longtime leader in the field— explores the biology underlying human and animal healthspan and the interventions that might actually make a difference.
From rapamycin and peptides to lifestyle, diagnostics, and emerging therapies like epigenetic reprogramming, this podcast separates signal from noise in a space often dominated by hype.
No shortcuts. No miracle cures. Just thoughtful conversations grounded in real science.
Hosts:
Update frequency:
weekly
Average audio length:
42 minutes
Guest interviews
English
United States
34 episodes
since May 19, 2026
episodic
IN THIS PODCAST 🔗
LATEST EPISODE 🔗
Can we slow aging in dogs and help them live longer, healthier lives? More than a decade ago, that question inspired the creation of the Dog Aging Project, which has grown from an ambitious idea into one of the largest studies of aging ever conducted in companion animals, with more than 55,000 dogs…
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Search past episodes of Longevity Science with Matt Kaeberlein.
PREVIOUS EPISODES 🔗
Can rapamycin reverse skin aging?In this episode of Longevity Science, I sit down with Dr. Chris Sell and Dr. Christina Chung, co-founders of Hayflick Therapeutics, to explore the science behind using rapamycin to target aging in the skin.Chris has spent decades studying cellular senescence, IGF si…
What can we learn from the first 10,000 experiments in the search for interventions that extend healthy lifespan?In this episode of Longevity Science, I sit down with Dr. Ben Blue, CEO of Ora Biomedical, and Dr. Blair Zhao, CSO, for an update on Ora’s effort to systematically screen interventions f…
In this episode of Longevity Roundtable for September 2026, I’m joined by Brian Kennedy and Marcus Ranney to dig into some of the biggest recent stories in longevity science and medicine.We start with Marcus fresh off a high-altitude marathon and discuss intermittent hypoxia, hyperoxia, and hyperba…
What can we actually do to protect our brains as we age, and how much of cognitive decline may be preventable or even reversible?In this episode of Longevity Science, I sit down with neuroscientist and physician Dr. Tommy Wood, author of The Stimulated Mind, for a wide-ranging conversation about th…
What if the effects of psilocybin extend far beyond the brain and into the biology of aging itself?In this episode of Longevity Science, I sit down with Dr. Louise Hecker and Dr. Kosuke Kato, whose unexpected research on psilocybin has opened up a fascinating new question: Could psilocybin actually…
Bryan Johnson recently announced that he has been diagnosed with autoimmune gastritis, an autoimmune condition that, in his words, means his “stomach is eating itself.”So what does this have to do with rapamycin?Bryan took rapamycin for about four years before stopping it, attributing changes in hi…
Subscribe to our channel: https://www.youtube.com/@mkaeberleinWhat can dogs teach us about human aging?Quite a lot, it turns out.Dogs share our homes, our environments, and many of the same age-related diseases, but they experience aging over a much shorter timescale. That makes companion dogs a un…
Every now and then, a claim in longevity gets so far ahead of the evidence that it deserves a little pushback.This time, the catalyst was a recent video from Longevity Science News that claimed a newly published Nature Communications paper had essentially reversed skin aging and even suggested it p…
What are the biggest developments in longevity medicine right now?In this Longevity Science Update, Dr. Marcus Ranney and I discuss the most important stories shaping the field—from changes to FDA policy on experimental peptides to the tragic death following an NAD infusion, the approval of the fir…
Disclaimer: The podcast and artwork embedded on this page are from Matt Kaeberlein, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.
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