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Update frequency:
every 12 days
Average audio length:
59 minutes
Guest interviews
English
United States
24 episodes
since May 4, 2026
episodic

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Software today orbits the companies that make it, and it should orbit people, says Alex Komoroske, CEO and cofounder of Common Fabric and coauthor of the Resonant Computing Manifesto. Alex spent more than a decade at Google working on Chrome, Maps, and Earth, then ran corporate strategy at Stripe. …

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As the former chief maintainer of Perl 5 and project manager for Perl 6, as well as a longtime programming team leader, Jesse Vincent learned early that getting good work from smart, capable people often depends less on giving orders than on providing context, clear goals, and useful feedback. That…
Anthropic's interpretability team studies Claude's internals the way neuroscientists study a brain, but the science is younger, messier, and far less mapped. Emmanuel Ameisen has been part of that effort for the last two years, and at O'Reilly's recent Foo Camp, he shared some of what’s happening i…
Drew Breunig has spent years watching how AI teams grow their LLM applications, and he's identified a problem most teams don't notice until it's already slowing them down. As CEO of CMPND, a maintainer of the DSPy open source framework, and author of the forthcoming O'Reilly publication Context Eng…
Trail of Bits is a software security research and development firm that helps clients like Facebook and DARPA solve their hardest security challenges. In 2024 cofounder and CEO Dan Guido decided the company would go fully AI native. Most of the firm's roughly 130 employees didn't buy in right away,…
Long-running Claude Fable 5 agents had become the backbone of Gene Kim's personal knowledge system, one built from thousands of screenshots, videos, and half-finished side projects, spanning 50 code repositories and tens of thousands of changes. He’d been warned that Fable might be pulled from his …
Harper Reed has spent his career building software people actually love working on, from cofounding Threadless to leading engineering for the Obama 2012 campaign. He joined Tim for a conversation about what happens once software becomes less a product and more a medium for expressing values, and wh…
Harper Carroll is a computer scientist who built machine learning systems at Meta but she also describes herself as "born an actress from Manhattan." She’s combined those disparate parts of her background into a unique role as an AI educator, where she uses her magic superpower of making …
DJ Patil co-coined the term "data scientist," served as America's first chief data scientist under President Obama, was chief scientist at LinkedIn, and has spent the past decade on the founding team at Devoted Health, where he's built the kind of data infrastructure that most organizatio…
Ryan Carson has spent 25 years building developer communities, conferences, and Treehouse, which taught over a million people to code. His latest company, Untangle, is an AI-powered divorce assistant—and he’s building it entirely alone. Just $2 million in seed funding, his guidance, and a team of a…
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