このポッドキャストについて 🔗
Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.
最新エピソード 🔗
In this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared before they become toxic.
As these systems degrade with age, misfolded proteins accumulate, cellular signaling falters, and…
以前のエピソード 🔗
Over the past year, we covered a wide range of ground—from clinicians working directly with patients to top scientists studying the underlying biology of aging. This episode is a chance to look back at some of the more interesting conversations we had on Longevity Roadmap in 2025.
Looking ahead, t…
Aging is usually linked to size, metabolism, and inevitable decline—but bats defy all three.
In this episode, Dr. Buck Joffrey speaks with Dr. Emma Teeling about why bats are rewriting the rules of longevity science.
The discussion explores how bats live far longer than expected for their size wh…
Longevity medicine is moving beyond symptom management—and regenerative therapies are forcing a deeper look at how healing actually works.
In this episode, Dr. Buck Joffrey speaks with the team at BioXcellerator about what separates rigorous regenerative medicine from hype-driven shortcuts.
The c…
Aging begins when cellular quality-control systems lose their precision.
In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective lysosomal degradation pathway essential for proteostasis—progressively declines with age, triggering downstream failures …
In this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging.
He explains how systemic factors, particularly proteins in the blood, influence cognitive function and the aging process.
The discussion covers the role of proteomics, machi…
In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline.
He begins by outlining how reductions in cytochrome oxidase activity, disruptions in oxidative phosphorylation, and the accumulation of mitochondrial m…
We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world.
From frictionless habit design and daily self-monitoring to movement, sleep, and the muscle-preserving realities …
In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine.
She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the …
Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging.
She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that …
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