Dr nathan bryan

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Good morning everyone.
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This is Michelle Hughes from Ageless and Timeless. I have
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a guest today that I've been talking to for over
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a year now, and I have to tell you a
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little backstory about doctor Nathan Bryan because he's such a
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special man and this will indicate what I'm more validate
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what I'm talking about.
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So I was at the Radfest festival.
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And Anaheim about a year or so ago, and I
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walked over to the booth called N one oh one
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and Nitric outside. If anyone has heard of the Nightrik Outside,
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you know that that's a big hot topic these days.
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So I was really interested because of my podcast to
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meet doctor Brian.
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And anyway, it turned out by just good fortune.
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Susan, his partner, was there and then doctor Brian came
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by and so we started chatting, and I mean, I
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was just so engaged in all that he's done. So
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today we're going to hear his backstory on how he
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got to where he is today, and we're going to
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hear all about deep dive into nitrigauxide. But the story
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I was going to tell you is that so I
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needed a ride to Los Angeles and I happened to
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mention to doctor Brian that I was going up to
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LA after the and right away he offered me a
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ride with flying back to the air or going back
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to the airport to fly back to home.
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So I was just so impressive.
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Here was a complete stranger and here he was so
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generous to offer. That turned out my schedule change and
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we didn't do it, And I actually regret that because
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I think I would have learned an awful lot in
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that one hour, just having him one on one that
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outside of a conference. But anyway, it just shows you
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the generosity of Brian. And actually I like him so
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much that I have him in October, well September, but
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it won't come out until October.
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First. He'll be the feature column in.
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My Top Doctor magazine, so I do a monthly column there.
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So if you are listening to this podcast or watching
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it today, please check out Topdoctor dot com and you'll
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see another piece on doctor Brian.
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So, good morning, Nathan. How are you well great?
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It's great to see you. I'm doing fantastic.
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How were you I'm doing great. Are you in Austin today?
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I am.
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I'm home for the next couple of days. I live
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about an hour outside of Austin. But I just flew
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in from Miami yesterday and headed to New York next week.
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Yeah, you're on an airplane a lot.
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So Nathan, you know, Night to Go Outside has become
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one of the darlings of the longevity movement, and a
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lot of people, however, I'm shocked, haven't really understood or
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even know about it. So why don't we start first
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with how did you get so engaged in an area
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that is still emerging and evolving as a longevity I
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don't even want to say a biohap because it really
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is a scientific breakthrough that people haven't really understood.
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So it's kind of like inflammation was for many years.
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If you remember when they first started talking about inflammation,
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everybody compooted in the medical world, and then suddenly it
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became this, you know, very important part of the three
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leged stool of health. Right, So I think Nikagatxa might
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be the fourth leg. So let's start in the beginning.
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So what is it that brought you to this awareness
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of something that's so important and so young at such
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a young age.
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Well that takes me back almost thirty years, I know,
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and you're not that old.
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So Okay, so thirty years.
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Means early nineteen Yeah, the late nineties, yeah, late nineties.
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Early ties. I'm sorry.
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Yeah. So I was a student at LSU School of Medicine.
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I was working on a PhD in molecular study of physiology,
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and a Nobel Prize had just been awarded for discovery
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of nitric oxide. And honestly, you know, I had a
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degree in biol chemistry from the University of Texas at Austin,
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so I was familiar with nitrogen based chemistry. Is obviously
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nitrocoxide part of the gentrification unification cycle, but it was
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a new molecule in science or medicine. But obviously it
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was important because the Nobel Prize had just been awarded
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for the discovery of nitric oxide as a signaling molecule
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in the cardiovascer system. And during my PhD work, I
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was working under a pharmacologist who became my mentor, Martin Feelish,
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who had worked in the nitrocoxide field for you know,
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since the early eighties and when it was just first
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starting to be discovered, and so had I had a
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chance to meet lou Ignaro, who had just won the
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Nobel Prize, and you know piqued my interest. It was
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an exciting time. And you know, nitrocoxide's this gas that's
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one it's produced, it's gone in less than a second.
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So we didn't have a lot of analytical tools to
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measure nitrocoxide production in animals in humans. So part of
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my PhD was developing these analytical methods where it could
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detect nitrocoxide and when nitrocoxide is produced, where does it
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go and what does it become? And how does it signal?
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Because once it's produced, it's gone in less than a second,
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So you know, we started trying to figure this out
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through these nitrocoxide analytical methods that we developed, and we
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understood the metabolism of nitrocoxide, how it's produced, when it's produced,
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where does it go, what is it becoming, how does
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it signal? And then how do we detect nitrocoxide deficiencies
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in many different diseases from diabetes to hard disease to
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transplantation surgery. So then we were armed. Our group was
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armed with really a lot of tools that no one
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else in the world had. I finished my PhD in
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less than two years. I think I published two or
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three first author papers during that time, and then went
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to Boston Medical Center and was training in the cardiovascu
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as a a postdoctoral fellow. And then Fredmiradded, the other
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guy who won the Nobel Rise, recruited me to join
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faculty of ut Medical School in Houston. And I believe
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it was two thousand and five, so twenty years ago
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where I started my own independent research career and you know,
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again continued our journey of discovery and innovations and you know,
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started filing patents, patents became issued, and then started making
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products and starting companies and well, you.
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Know later, you know, I did watch Blue on.
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On a tiv on an internet show.
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I don't know if there's a podcast, But anyway, is
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he still with you today?
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I mean, do you collaborate with him?
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Now?
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Low is a close friend and colleague, and he's you know,
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the only remaining surviving member of the Nobel Nobel Aureates.
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But yeah, no, Look, I'm hosting the Nitric Oxide Society
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meeting in Austin in April of next year and lose
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our keynote, lose part of the organizing committee. So you know,
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he's still active. You know, he's still very active in
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the nitric oxide community. He's such a wonderful, caring, humble
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man and really supportive his new investigators and just he
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has been achieving.
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I was just about to say to you he was
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so humble that he didn't even when he was asked
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about his background, he didn't even mention the Nobel Prize,
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and the interviewer had to say, well, you're you're omitting
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one very very important piece of information. So yeah, he
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had to pull it out of him. I mean, that's
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that just shows you his humility. So what has happened
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from then to now in terms of your the scientific
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awareness of the importance of nitrogoxide.
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That's you know, it's thirty years. So what what has transpired?
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Well, today we understand how the human body makes nitrocoxide,
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we understand what leads to a loss of its production,
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We understand the symptoms that develop as a loss of
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nitrocoux as a result of the loss of microcoxid production,
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and most importantly, we know how to overcome and fix
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and repair and recapitulate nitrocoxide production and signaling. So, you know,
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I like to say, those guys has discovered that nitrocoxide
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is a signaling molecule in the cardiovascar system. But it
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was really the work of me and my research group.
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We discovered how to deliver nitrocoxide gas. So we make
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a solid dose form of nitrocoxide gas. We can deliver
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this in an outpatient setting. We do this through consumer
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products and supplements and nutritionals and skincare products. We're developing
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drug therapy, which was my original kind of goal when
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I started in academia and medicine was to understand the
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mechanism disease to the extent that you could start to
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develop rational therapies. And that's what we're doing. We've got
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drugs in development for heart disease, got drugs in development
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for Alzheimer's and dementia. Make a topical drug for diabetic
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ulcers and non healing wounds. And that's just the start,
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you know, because now what we know, it's not what
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we think. It's what we know that there's not a
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single condition or disease indication where nitrocoxide at the right
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dose at the right time and the right patient would
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not be beneficial. And so the future of medicine, health wellness,
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human optimization is absolutely dependent upon adequate production of mitrocoxae,
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and we know how to do it better than anybody
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in the world. And that's what we're doing. When you
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say we, what do you mean we mean collectively? You know,
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I never say I know many of the patents. I'm
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on the sole in vendor on these patents, but you know,
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it's a team I had, you know, when I was
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in academia, had you know, research fellows, I had postdocs,
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I had faculty and staff that work with me in collaboration.
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So I never take credit for this solely. And then
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when I say we, now, you know, I have several
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companies and executives within the companies, there's collaborators, there's you know,
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clinical trial sites that run our clinical trials. So I
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never say I because it's just not part of my fabric.
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That's also showing your humility. Well, so, Nathan, why is
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it that it took so long for this to become
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something that people are now much more aware of? What
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do you think has been the reason that has been
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slowed down even with a Nobel prize back in the
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late nineties.
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Well, I think there's several reason. Number One, on average,
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it takes about seventeen years for new discoveries to become
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so called standard of care or mainstream correct. Nitrocoxide is
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only about a fifty year old. Molecule was first described
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in nineteen seventy seven fred Mirad's paper showing that organic
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nitrates like nitroc listenm and metabolized into nitrocoxide and then
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that leads to vasodilation. That's how these drugs work for angeline.
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And then in nineteen eighty it was discovered by Bob
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Firtscott that the cells along our bud vessels produce this
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nitrocoxide molecule. So that was the initial lag. It just
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takes time. It has to stand the test of time
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and for these experiments to be reproducible by other groups.
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And then the other big I think lag and acceptance
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is there's been no major developments or innovations in nitrocoxide
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drug therapy. When I started in the field in the
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late nineties, every big pharmaceutical company and biotech company had
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a nitrocoxide pipeline of drugs. The reason they failed was
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they were using the wrong target, they were using the
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wrong strategy, and they were putting nitrocoxide linker molecules or
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nitrocoxide active drugs on parent molecules like COX two inhibitors
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or aspirin or insets, and you know you have to
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you have to cleave that nitroester bond, and there's consequences
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to that. So these weren't These drugs weren't safe. And
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then you know, in the nineteen eighties, late eighties, early nineties,
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it was starting to develop nitrocoxide therapy for innoltive therapy
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for premature babies born with pullman or hypertension. So now
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clinically that's been used for more than you know, thirty
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or forty years and save millions of babies' lives that
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are born premature. But then that's where the clinical innovation
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really stopped. Because nitrocoxide is a gas. How do we
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create a solid dose form of nitrocoxide that we can
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deliver in an outpatient setting. That's really the riddle that
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I saw, because my patents are on the method of
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making a solid dose form of nitrocoxide gas. So we
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make we deliver nitricoxide either topically through our orals or
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through an organ disintegrating tablet or other technology. And the
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whole basis of what I do is if your body
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can't make nitrocoxide, then we got to give it for you. Right,
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it's a hormone. It's like estrogen and testosterone. So if
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men or women can't make testosterone or estrogen perspectively, we
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give them testosterone. We give them the actual molecule. And
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so what we do is we give nitrocoxide gas. Where
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all of the companies out there can't do this, they
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don't do it and so their products don't work.
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Because we're never deficient in argentine or cicillin, and we're
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not deficient in a dead beat powder. So taking these
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products is not going to help in nitrocoxide production.
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I think that's very important what you just said, because
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a lot of.
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People I know take L rgenine and they forget to
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take the L siculine with it. But even what you're
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just saying is if you're taking both of those, you know,
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doing it the combo, it's still not going to produce
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the nitrogoxide.
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That you can be used.
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Well, that's because they don't understand the biochemistry, and that's
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why companies are really doing their customers of disservice and
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they're killing an industry. They're killing the nitrocoxide field because
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don't work and then the consumer or the patient goes
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Nitrocoxide must not be that important because these products didn't
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help me. But look, the enzyme that converts argentines to
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nitrol coxide is broken. And furthermore, el citylene is a
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byproduct of nitrocoxide production. It is not a precursor. Right,
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So for me, it's it's an easy litmus test. If
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you're looking for products in your supplement store and that
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product has il argentine or el CityLine in it. Then
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just dismiss it because these the people who are selling
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you that product do not understand the basic biochemistry the
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enzymology of how nitrocoxide is produced. So that's an easy
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litmus test. So save your money, put the product back
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on the shelf.
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And then what sorry the interpret what about it if
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you added glute tocione, if you get a transderal glute
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to scion, because I know glue tocion is very difficult
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to absorb otherwise, uh maybe through ivs, but it's only
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a short lived. So let's just say you're doing a
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you know, an absorbable glutathion, which is a very rare
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thing to find. Does that help the old argentine and
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L siculine and with glutathione added to produce more of
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a nitrogoxide result?
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Not necessarily? Now, not necessarily because here's the problem. The
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nitrocoxide synthase enzyme is what we call a homeo dimer,
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So it's two twins that come together. Okay, these these
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these enzymes have to undergo a conformational change to transfer
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the electrons from rgenine to make nitrocoxide, and then it spits
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out citrilline as a byproduct greate limiting step in the
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uncoupling of that enzyme oxidation of tetrahydroboptria. So more glue
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de thione, more antioxidant antioxidant capacity, But just by increasing
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glue to thion doesn't prevent oxidation of tetrahydroboptrin. There's a
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different redox potential for glue de thione than a scorbic acid,
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than alphalopoic acid, than tetrahydroboptrin, to all other antioxidants, whether
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00:15:44.799 --> 00:15:50.440
fat soluble, water soluble, enzymatic antioxidants, there's a redox potential
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that's required to prevent the extraction of electron from all
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those molecules. So the simple answer is maybe, but not
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necessarily right.
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So basically what you're saying, Nathan, is if you have
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an l arginine and even if you've added the l
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ciculine and you're doing that combo, forget about it.
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It's not going to do. It's not going to do
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what they're the manufacturers are.
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Look look, because there's very defined biochemistry. Right, there's what
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we call the Michalis constant. And this may get too
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technical for young but I think it's very important concept.
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There's a certain concentration of a molecule that's required to
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theoretically saturate fifty percent of the binding sites to activate
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that somatic reaction. The Machaus concept rail argentine is five micromolar.
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Even the sickest of sickest people, we've got one hundred
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00:16:39.279 --> 00:16:41.480
to two hundred micromolar. What does that mean? We have
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00:16:41.600 --> 00:16:45.559
twenty to forty times excess l argen. Then what's needed
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00:16:45.600 --> 00:16:48.679
to bind to the enzyme to make nitrocoxet. We're never
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deficient in largen. It's a semi essential amino acid. We
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get it from the breakdown of protein, whether it's animal
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or plant protein, and we make it through the U recycle.
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The partially recycle is present in every cell in the
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human body, and we're easily making margining. We're constantly making situation.
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We're never deficient in these inzie and these amino acids,
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So it makes no sense to supplement. Why supplement something
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that you're not deficient.
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That you already have.
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So Nathan, go back for a moment and just give
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everybody a very good, short and easy to understand definition
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00:17:25.799 --> 00:17:30.200
beyond it being a molecular gas. But take us a
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little bit deeper to what is nitricoxide.
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00:17:33.680 --> 00:17:36.680
Well, it's a signaling molecular It's first discovered to be
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a vasodilator. So when it's produced in the lining and
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the blood vessel, that relaxes the smooth muscle around the
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blood vessels and it leads to vasodilation. So now we
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were getting increased oxygen nutrient delivery to downstream blood vessels.
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It's the signal that tells our own stem cells to mobilize.
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00:17:52.799 --> 00:17:55.160
So if you have adequate nitrocoxide, you have more stem
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00:17:55.160 --> 00:17:59.400
cells in circulation on you know, autologous our own stem cells.
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It activates an enzyme in our nucleus called telomerase, which
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prevents our telomeres from shortening, so shorter telomere, shorter life span,
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longer telomere's line, longer life span. And then the other
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important thing about longevity is it induces mitochondria biogenesis and
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it improves the efficiency of oxygen utilization to make sailor
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energy or ATP. So if you think about that, if
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you don't if you can't make nitroc oxide, you lose
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the regulation of blood flowing, develop eed high blood pressure.
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Insulin resistance, you have mitochondrial dysfunction, you have shorter telomeres,
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and you don't repair and replace dysfunctional cells because you
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don't have any stem cells in circulation. Do you want to?
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You want to? You want to lead to human optimization
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and biohacking and longer, healthier life free of disease. I
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mean you have to start at nitrocoxide. That is the foundation.
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There are other things you have to address, but without
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added oxide production, nothing else is going to optimize you.
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And this is so compelling.
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00:18:54.640 --> 00:18:56.920
And then that means that you know, adding all the
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other you know, the five legged stool of you know
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of a diet and I mean nutrition and sleep and
351
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stress and all the things that go into a go
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into a healthy lifestyle that you actually without nitrogoxide, all
353
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of those things are not going to be nearly as effective. Right.
354
00:19:17.119 --> 00:19:20.119
You need the nitrogoxa kind of like the foundation, like
355
00:19:20.200 --> 00:19:21.000
building a house.
356
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That's your foundation.
357
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And yes, nitrocoxide is not going to replace sleep, It's
358
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not going to replace you know, a good diet. I
359
00:19:28.680 --> 00:19:31.480
mean it's a two way street. If you have addiput
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00:19:31.519 --> 00:19:34.640
nitrocoxide production, you have good rest. You can improve microoxide
361
00:19:35.000 --> 00:19:38.000
production improves them sol mobilization. So you're gonna rest and repair,
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00:19:38.480 --> 00:19:42.519
right if you need it. More diet, You're gonna high sugar,
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00:19:42.559 --> 00:19:45.200
carbohydrates and you know all that. It's it's going to
364
00:19:45.240 --> 00:19:48.480
continue to deplete, deplete your body availability to make nitrocoxide.
365
00:19:48.680 --> 00:19:52.279
Taking oxide products isn't going to help you. I mean
366
00:19:52.319 --> 00:19:54.680
it will help you, but it's not gonna You still
367
00:19:54.720 --> 00:19:57.000
have to change your diet and do the things that
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you know lead to better natural production nitrocoxide.
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00:20:00.119 --> 00:20:02.559
Right, So this is a collaboration, but it is something
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that is important to look at.
371
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So how do you get a baseline?
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How do you know what your nitrogoxide level is if
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you're starting out on a nitric oxide journey.
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Well, you know, unfortunately there's no biomarkers like blood labs
375
00:20:16.440 --> 00:20:18.119
and we can draw and give you a number of
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00:20:18.119 --> 00:20:21.759
your nitrocoxide because again, once it's produced, it's metabolized in
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different metabolites. We've done this for you know, twenty five
378
00:20:24.359 --> 00:20:26.880
thirty years in the research lab, but unfortunately it's not
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done clinically. So what we do is we rely on symptoms.
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00:20:30.839 --> 00:20:33.880
So the first sign and symptom to develop if your
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00:20:33.880 --> 00:20:37.519
body becomes compromising stabilities to use. Nyitrocoxide is a rectile dysfunction.
382
00:20:37.960 --> 00:20:40.279
And this is just in mail. It's a female and
383
00:20:40.319 --> 00:20:42.880
if you think about it, to get an erection, either
384
00:20:42.880 --> 00:20:45.519
a penile or clinical label erection, we have to increase
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00:20:46.440 --> 00:20:49.720
blood flood flood, not ngorgement, So you have to dilate
386
00:20:49.720 --> 00:20:52.480
the blood vessels. Nitrocoxide dilates the blood vessels. If you
387
00:20:52.480 --> 00:20:56.039
can't make nitrocoxide, we don't get vasodilation, we don't get engorgement.
388
00:20:56.400 --> 00:20:59.160
And that is a rectile dysfunction. It's called the canary
389
00:20:59.160 --> 00:21:01.160
and the coal mine, but because it it is the
390
00:21:01.240 --> 00:21:03.599
canary in the coal mine, because if you have in
391
00:21:03.680 --> 00:21:06.319
the field of dysfunction in the vascular bed of your
392
00:21:06.319 --> 00:21:09.559
sex organs, that same dysfunctions occurring in your heart, in
393
00:21:09.559 --> 00:21:11.720
your brain, in your lungs, in your liver. It's a
394
00:21:11.759 --> 00:21:15.880
systemic disease that manifests first when we're trying to dilate
395
00:21:15.920 --> 00:21:18.559
the blood vessels on demand. And then number two, your
396
00:21:18.559 --> 00:21:22.359
blood pressure starts to go up because without adequate nitrocoxide,
397
00:21:22.359 --> 00:21:24.200
now we've got the same volume of blood going through
398
00:21:24.200 --> 00:21:27.880
smaller blood vessels and pressure does out. Number three you
399
00:21:27.880 --> 00:21:31.440
start to get insulin resistance in metabolic disease. Nine out
400
00:21:31.480 --> 00:21:35.039
of ten Americans are metabolically unhealthy. Number four, you can't
401
00:21:35.160 --> 00:21:37.440
maintain an exercise regimen because if you can't dilate the
402
00:21:37.480 --> 00:21:39.759
blood vessels to the heart or the skelele to muscle
403
00:21:40.119 --> 00:21:43.759
when you're exercising, you tire, You get lactic acid build up,
404
00:21:44.119 --> 00:21:46.759
and you can no longer maintain that exercise regional. And
405
00:21:46.799 --> 00:21:49.279
then number five, you start to get brain foged, mold,
406
00:21:49.400 --> 00:21:53.319
cognitive impairment, dementia, and eventually Alzheimer's. So those are the
407
00:21:53.359 --> 00:21:56.480
things that you should pay attention on. And you know,
408
00:21:56.680 --> 00:22:00.240
the analogy I use is that you're, you know, our smartphone.
409
00:22:00.559 --> 00:22:02.319
When we look at our smartphone and we see the
410
00:22:02.319 --> 00:22:04.680
red light come on here that our batteries low, people
411
00:22:04.720 --> 00:22:06.119
pay and they go, oh shit, I got to charge
412
00:22:06.119 --> 00:22:09.920
my battery. Ed is your red light coming on? Senior batteries?
413
00:22:10.599 --> 00:22:15.799
High blood pressure, insular resistance, exercise intolerance, cognitive brain full
414
00:22:16.200 --> 00:22:19.640
that's your body telling you, hey, I need some nitrococide.
415
00:22:19.640 --> 00:22:22.039
I'm getting low, and so pay attention. Your body's always
416
00:22:22.039 --> 00:22:23.960
talking to you. He's going to pay attention.
417
00:22:25.000 --> 00:22:28.480
But yet, Nathan, if you're going to a even a
418
00:22:28.480 --> 00:22:33.200
functional medicine doctor, how often if they have these symptoms,
419
00:22:33.200 --> 00:22:35.759
are they going to tell someone to go get nitrogoxide?
420
00:22:36.480 --> 00:22:39.039
You know, talk to me doctor Brian and go to
421
00:22:39.160 --> 00:22:42.400
N one oh one your company and you know, start
422
00:22:42.559 --> 00:22:45.640
using the product. So you know in your experience, are
423
00:22:45.680 --> 00:22:49.440
people that are in your world, in your wheelhouse are
424
00:22:49.440 --> 00:22:53.599
they are they advocating that as a solution for those
425
00:22:53.680 --> 00:22:54.640
kinds of symptoms.
426
00:22:55.680 --> 00:22:58.119
You know, we're making some progress, but here's the problem.
427
00:22:58.960 --> 00:23:01.839
I mean, as this market is expanding and the awareness
428
00:23:01.880 --> 00:23:06.319
around nitrocoxide is growing, more companies are coming in trying
429
00:23:06.359 --> 00:23:10.279
to sell a nitrocoxide product. Yes, doctors will recommend it
430
00:23:10.319 --> 00:23:12.240
because they've got sales people in there. They hear a
431
00:23:12.240 --> 00:23:14.119
webinar or here's something they go, well, let me try
432
00:23:14.119 --> 00:23:16.880
this nitrocoxide pid or I saw a commercial on TV.
433
00:23:17.559 --> 00:23:19.880
And then they say, well to take this be product
434
00:23:19.880 --> 00:23:22.400
and then come back. Whether patient comes back and they go, well,
435
00:23:22.400 --> 00:23:25.440
this didn't help me, and then we lose. We lose
436
00:23:25.480 --> 00:23:29.480
the conversation. And it's not nitrocoxide didn't work for that patient.
437
00:23:29.480 --> 00:23:31.960
It's because that product cannot, did not and will not
438
00:23:32.079 --> 00:23:36.200
ever produce nitrocoxide in that patient because that product doesn't
439
00:23:36.200 --> 00:23:39.519
address the root cause of their deficiency, because they're either ignorant,
440
00:23:39.759 --> 00:23:41.920
and ignorance is fine, it's just a lack of knowledge,
441
00:23:42.279 --> 00:23:46.000
or they're deceptive and fraudulent, which any companies out there
442
00:23:46.240 --> 00:23:50.480
who are intentionally defrauding their customers because it's a it's
443
00:23:50.519 --> 00:23:52.759
a cheaper product that they can sell for higher profits
444
00:23:53.000 --> 00:23:56.039
and it cannot and will not produce nitrocoxide. And I
445
00:23:56.079 --> 00:23:59.559
think that's why these conversations are so important, because all products,
446
00:23:59.599 --> 00:24:02.400
not just notox have can be based on science and
447
00:24:02.480 --> 00:24:04.640
it has to be personalized. And that's why I like
448
00:24:04.680 --> 00:24:07.640
the functional integrative docs because they have time to spend
449
00:24:07.640 --> 00:24:11.160
with their patients to get an insight into their lifestyle,
450
00:24:11.319 --> 00:24:13.960
their diet, what are their deficiencies, what are their talks
451
00:24:13.960 --> 00:24:18.680
and exposures, and then develop personalized therapies for them. Well,
452
00:24:18.680 --> 00:24:20.960
if you go to standard allopathic doc, you get five
453
00:24:20.960 --> 00:24:23.519
minutes with you and which is oh, you got ed.
454
00:24:23.680 --> 00:24:24.839
Here's a sildenti fil.
455
00:24:24.799 --> 00:24:30.240
Or vitrop look at, give me some viagra, an.
456
00:24:30.079 --> 00:24:33.400
Acid hypn or arb for your hypertension. Here's some met
457
00:24:33.480 --> 00:24:37.160
foreman for your diabetes. And here's the ambient because you
458
00:24:37.200 --> 00:24:38.759
can't sleep, and then you wake up and you're on
459
00:24:38.839 --> 00:24:41.920
a dozen different medications, and people wonder where they're sick. Right.
460
00:24:42.559 --> 00:24:44.960
So you mentioned though that you're developing drugs.
461
00:24:45.000 --> 00:24:48.359
Now, so how did you cross that bridge to get
462
00:24:48.440 --> 00:24:52.680
to the allopathic community and get them to agree to
463
00:24:52.799 --> 00:24:57.839
work with you on on nitrogogxide in other words, including
464
00:24:57.920 --> 00:25:03.480
nitrogoxat in in an pharmaceutical side of the medical world.
465
00:25:03.720 --> 00:25:05.640
Well, I can tell you it was never my intent
466
00:25:05.799 --> 00:25:09.079
going into academia to be a developer of dietary supplements.
467
00:25:09.119 --> 00:25:12.559
That was never even online radar, right. But because we
468
00:25:12.599 --> 00:25:15.720
had developed a way to produce nitrocoxide, and because I
469
00:25:15.799 --> 00:25:18.599
knew how to do this through natural products and through
470
00:25:18.640 --> 00:25:22.000
food and through modification of the microbiome and affecting the
471
00:25:22.319 --> 00:25:24.839
structure and function of the enzyme, we could do this
472
00:25:24.880 --> 00:25:28.000
through natural products and through dietary supplements. But the goal
473
00:25:28.079 --> 00:25:31.319
all along was to develop drug therapy how to deliver
474
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nitro patient setting. So we're not convincing the allopathic community
475
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to work with us because they can't because we don't
476
00:25:38.240 --> 00:25:40.599
have an FDA drug approved on the market. So what
477
00:25:40.640 --> 00:25:43.400
we do is we go to the FDA we have
478
00:25:43.480 --> 00:25:45.640
meetings with the FDA. So look, here's what we want
479
00:25:45.680 --> 00:25:47.359
to do. We want to go after schemic car disease.
480
00:25:47.680 --> 00:25:51.079
Here's our nitric oxide releasing drug that when we take this,
481
00:25:51.200 --> 00:25:54.599
we dilate the blood vessels, we relieve the schemic pain
482
00:25:54.640 --> 00:25:57.119
known as ANGEL and we can prolong exercise induced agen
483
00:25:57.519 --> 00:25:59.759
And by the way, it works better than isosorb by
484
00:25:59.759 --> 00:26:03.160
diet nitrade or nitroglycery, and it's safer, so we can
485
00:26:03.200 --> 00:26:05.640
miss the FDA. We're gonna design a clinical trial. We're
486
00:26:05.640 --> 00:26:07.920
gonna test this in a double blind fall seabook controlled study,
487
00:26:08.480 --> 00:26:11.319
and if we hit our endpoints, the FDA agreed that
488
00:26:11.440 --> 00:26:13.400
they'll approved this drug, and then we've got a new
489
00:26:13.440 --> 00:26:16.279
drug indication for a scheme of card disease. We did
490
00:26:16.279 --> 00:26:19.279
the same thing with Alzheimer's. You go all the FDA go. Look,
491
00:26:19.519 --> 00:26:22.319
Alzheimer's is a metabolic master of disease. We're developing a
492
00:26:22.359 --> 00:26:26.200
nitrocoxet releasing drug that improves glucose ub take that improve
493
00:26:26.279 --> 00:26:29.759
the profusion of the brain, overcomes focal a schemia, we
494
00:26:29.759 --> 00:26:32.519
don't get misfolding of proteins, and it addresses the root
495
00:26:32.559 --> 00:26:35.599
cause of dementia. Alzheimer's. So we're gonna design a clinical trial.
496
00:26:35.680 --> 00:26:39.519
We're gonna test it in a placebo controlled randomized clinical trial,
497
00:26:39.880 --> 00:26:43.720
and if we hit these endpoints, well, can we agree
498
00:26:43.720 --> 00:26:47.119
to approve this drug based on the design of this study.
499
00:26:47.839 --> 00:26:49.440
It's we have to go to the FDA, we have
500
00:26:49.440 --> 00:26:52.359
to design clinical studies, we have to do the clinical studies,
501
00:26:52.799 --> 00:26:55.759
and these are tens of millions of dollars and take many.
502
00:26:55.599 --> 00:26:59.759
Many years. I was just about to saying this is very.
503
00:26:59.599 --> 00:27:03.400
Cost It's very costly, you know. And I've intentionally avoided
504
00:27:04.039 --> 00:27:07.279
private equity money of venture capital money because I don't
505
00:27:07.319 --> 00:27:11.160
want these people interfering with the science, because they're more
506
00:27:11.200 --> 00:27:14.799
interested in making money than advancing the science. And exactly utually,
507
00:27:14.839 --> 00:27:16.359
for me, I'm not doing this for the money. I've
508
00:27:16.359 --> 00:27:19.039
made enough money in my career to live happily ever
509
00:27:19.079 --> 00:27:21.640
after so I can be bought and I will not
510
00:27:21.759 --> 00:27:23.599
be bought. But it's taken me a little bit longer
511
00:27:23.640 --> 00:27:26.759
because I have to self fund these studies and go
512
00:27:26.799 --> 00:27:31.480
out and raise money from people, individuals who know what
513
00:27:31.519 --> 00:27:34.480
we're doing, who understand what we're doing, who understand the
514
00:27:34.480 --> 00:27:37.839
global impact if we're successful, not if we're successful when
515
00:27:37.880 --> 00:27:40.200
we're successful, how this is going to change the world.
516
00:27:40.559 --> 00:27:42.720
And we're not doing it for the money. We're doing
517
00:27:42.759 --> 00:27:43.680
it to do the right thing.
518
00:27:44.960 --> 00:27:47.559
So I want to ask you, because we talked about
519
00:27:47.599 --> 00:27:50.559
the baseline, how do you measure and you said, okay,
520
00:27:50.640 --> 00:27:53.960
you look at the symptoms. I wanted a more quantitative
521
00:27:54.000 --> 00:27:56.319
measurement when we first met each other, so I asked
522
00:27:56.799 --> 00:28:00.559
cal Roy ed Hoy is a good friend of.
523
00:28:00.440 --> 00:28:02.960
Mine, and uh, you know, you know who.
524
00:28:02.799 --> 00:28:06.200
They are, and I assume that they're doing the glycocalyx
525
00:28:06.240 --> 00:28:10.359
and the they have a they have a nitric oxide product,
526
00:28:10.440 --> 00:28:11.359
and I.
527
00:28:11.319 --> 00:28:14.200
Asked them, they don't have a nitrocoxide product. They get
528
00:28:14.240 --> 00:28:19.000
potassium nitrate in a capsule. Nitride is not nitrocoxide. Okay,
529
00:28:19.240 --> 00:28:21.359
that's the record that I want to always keep.
530
00:28:21.240 --> 00:28:23.240
String Okay, sorry about that.
531
00:28:23.519 --> 00:28:27.559
We can electrocoxide product, but it's not a product.
532
00:28:30.400 --> 00:28:33.359
But however, they used the strips and I just had
533
00:28:33.400 --> 00:28:37.519
one right here, which I did right this morning, uh before,
534
00:28:37.559 --> 00:28:39.400
but I did it after I ate and I realized
535
00:28:39.400 --> 00:28:41.359
you slosed to do these on an empty stomach, and
536
00:28:41.400 --> 00:28:43.359
I so I probably I didn't do it right.
537
00:28:43.759 --> 00:28:47.880
But this is the one that Ed sent me and you.
538
00:28:47.799 --> 00:28:51.039
Said you developed those strips twenty five years ago and
539
00:28:51.079 --> 00:28:54.119
that you don't really use them as a measurement.
540
00:28:54.240 --> 00:28:57.119
So why is that? And and you know.
541
00:28:57.599 --> 00:29:00.279
If you wanted just a quick like, okay, how am
542
00:29:00.319 --> 00:29:02.960
I doing? And you know, yeah, I don't have any
543
00:29:03.000 --> 00:29:06.880
symptoms that you just described. I'm perfectly uh, you know,
544
00:29:07.119 --> 00:29:10.079
seemed perfectly fine. But I want to know, you know,
545
00:29:10.279 --> 00:29:12.640
is this product that I take, which I take your
546
00:29:12.720 --> 00:29:16.960
lodgingery every day, is this making a difference? And you know,
547
00:29:17.319 --> 00:29:19.880
and you know, we are a kind of a quantitative
548
00:29:20.759 --> 00:29:22.960
for sure. We always like to compete with each other
549
00:29:23.000 --> 00:29:26.440
and know what where what our score is, right, So this.
550
00:29:26.559 --> 00:29:28.920
Is one of the ways you do that. So so
551
00:29:28.960 --> 00:29:31.960
what else what can we do? If you don't, I'll
552
00:29:31.960 --> 00:29:32.359
tell you.
553
00:29:32.440 --> 00:29:34.799
I'll tell you the story, the backstory with those test strips.
554
00:29:35.640 --> 00:29:38.200
So when I launched my very first product technology, no
555
00:29:38.200 --> 00:29:41.240
one knew what nitrocoxide was. And the number one question
556
00:29:41.319 --> 00:29:43.519
we had, and we did market uh focus groups in
557
00:29:43.599 --> 00:29:45.720
market research, was how do I know if I need it?
558
00:29:46.599 --> 00:29:48.200
So the only way to do this, I mean, we
559
00:29:48.240 --> 00:29:50.640
could draw blood and that's what we did in the
560
00:29:50.640 --> 00:29:53.000
research lab. And I've published over one hundred peeroview papers
561
00:29:53.039 --> 00:29:56.839
on mapping out these nitrocoxxide metaboloids. But I thought, well,
562
00:29:56.880 --> 00:29:59.400
I can develop a salary test strip. So in two
563
00:29:59.440 --> 00:30:02.759
thousand and nine, I developed the first and only non
564
00:30:02.799 --> 00:30:06.039
invasive point of care diagnostic for nitrocoxide. And it's that
565
00:30:06.119 --> 00:30:10.240
exact same chemistry that's on that test strip. Factorum, we
566
00:30:10.319 --> 00:30:13.279
launched them, I filed patents on it, and several years
567
00:30:13.359 --> 00:30:16.599
into By the way, it's very old chemistry. It's called
568
00:30:16.640 --> 00:30:19.119
the grease reaction. It's probably over one hundred year old
569
00:30:19.200 --> 00:30:24.240
known chemical reaction. The chances of getting a patent on
570
00:30:24.279 --> 00:30:29.079
that chemistry was very low. So probably in twenty twelve
571
00:30:29.079 --> 00:30:31.400
twenty thirteen, when the bills were starting to come into
572
00:30:31.400 --> 00:30:35.680
the University of Texas on prosecuting that patent, and because
573
00:30:35.680 --> 00:30:37.680
we weren't making money on it, the university wasn't making
574
00:30:37.720 --> 00:30:40.640
money on it, agreed, Okay, let's abandon the patent because
575
00:30:41.240 --> 00:30:44.279
it's a tool, right you can. If you know what
576
00:30:44.359 --> 00:30:47.440
you're measuring, it's a useful tool. If you don't know
577
00:30:47.480 --> 00:30:51.680
what you're measuring, it's a deceptive tool. So number one,
578
00:30:51.759 --> 00:30:55.680
it is not a nitric oxide test trip. Now there's
579
00:30:56.240 --> 00:30:59.319
at least three or four companies out there selling my
580
00:30:59.440 --> 00:31:02.680
original salbrate test strips because I banon the patent and
581
00:31:02.759 --> 00:31:05.319
they certainly can do it, but they're still using it,
582
00:31:05.880 --> 00:31:09.240
and so what they're measuring, it's not measuring nitrocoxide. The
583
00:31:09.319 --> 00:31:12.880
chemistry is called the grease reaction. You put acidified sulfonillamite
584
00:31:12.920 --> 00:31:15.559
on that test strip, it reacts with nitrite in the
585
00:31:15.680 --> 00:31:18.880
saliva and it forms a diazo compound. It turns pink
586
00:31:19.640 --> 00:31:22.440
the five hundred and forty enemes, So if it turns pink,
587
00:31:22.519 --> 00:31:26.000
it tells us that your saliva's enriched did nitrite. It's
588
00:31:26.039 --> 00:31:29.559
nothing to do with nitrocoxide. But if you understand the
589
00:31:29.880 --> 00:31:34.759
metabolism sentaro salbrat circuit, that what it's really measuring is
590
00:31:35.599 --> 00:31:38.079
do you have the right oral bacteria and if you're
591
00:31:38.079 --> 00:31:41.359
getting enough nitrate from your diet, are the bacteria in
592
00:31:41.400 --> 00:31:45.119
your mouth on your tongue converting that nitrate into nitrite.
593
00:31:45.720 --> 00:31:49.559
That's what we're detecting. But it's also detecting the immune
594
00:31:49.559 --> 00:31:52.799
response to an oral infection. So if you have an
595
00:31:52.799 --> 00:31:55.279
active oral infection, if you've got infected root canals, if
596
00:31:55.279 --> 00:31:59.440
you've got cavitations, if you've got oral dyspiosis and there's
597
00:31:59.440 --> 00:32:03.519
an immune rey action occurring, our immune cells, macrophages, neutrophils,
598
00:32:03.519 --> 00:32:06.720
and monocytes produced nitric oxide so oxidized to tride in
599
00:32:06.759 --> 00:32:09.680
your saliva and you're picking up a local immune response.
600
00:32:10.680 --> 00:32:12.839
So the one of the reasons I abandoned that is
601
00:32:12.880 --> 00:32:16.599
because we would see people come in with high blood pressure,
602
00:32:17.119 --> 00:32:20.440
ten years of rectile dysfunction, they were diabetic, they were obese,
603
00:32:20.839 --> 00:32:24.160
they had a fatty fatty liver disease, and was say, here,
604
00:32:24.680 --> 00:32:26.400
use this test trip and they would light it up
605
00:32:26.480 --> 00:32:29.079
like a Christmas tree. You could see I make plenty
606
00:32:29.200 --> 00:32:32.680
nitric oxide and they go, no, we send him to
607
00:32:32.720 --> 00:32:35.079
a Dennis. We do a three DCT cone. He's eat
608
00:32:35.160 --> 00:32:38.319
up with oral infections. Right, and now we know that
609
00:32:38.440 --> 00:32:42.279
most people are walking around with asymptomatic infections and it's
610
00:32:42.319 --> 00:32:45.799
a it's a false positive, and it's a very dangerous
611
00:32:45.839 --> 00:32:48.240
false positive. So that's why I tell people, if you
612
00:32:48.400 --> 00:32:51.279
understand what that's measuring, and now you can interrogate it.
613
00:32:51.359 --> 00:32:54.000
If you're low, they're not a false negatives. And that's
614
00:32:54.000 --> 00:32:56.240
really if there's any utility to it, if you spit
615
00:32:56.319 --> 00:32:58.880
on it and it's low. You're low, you're nitric oxide
616
00:32:58.920 --> 00:33:02.480
deficient because you have any field dysfunction. Is it because
617
00:33:02.480 --> 00:33:04.680
you don't have the right oral bacteria. Is it because
618
00:33:04.680 --> 00:33:06.799
you're not getting enough nitrate from your diet. Is it
619
00:33:06.880 --> 00:33:09.079
because you take in acids or your stomach's not making
620
00:33:09.119 --> 00:33:11.880
stomach acid? Is it because you have a you know,
621
00:33:12.160 --> 00:33:16.759
silent receptor transported blockage in the in the salavary glands,
622
00:33:16.880 --> 00:33:19.519
because you have chogrin syndrome. I mean, there's a laundry
623
00:33:19.599 --> 00:33:22.400
list of things that could explain why you're nitric oxide defission.
624
00:33:23.400 --> 00:33:25.200
But then if you don't understand that, how do you
625
00:33:25.279 --> 00:33:29.680
fix it? Then telling you you're low, but don't understand
626
00:33:29.720 --> 00:33:32.759
the physiology about chemistry of why you're testing low, and
627
00:33:32.759 --> 00:33:34.720
they want to get they think they can fix your
628
00:33:34.799 --> 00:33:37.920
problem based on that test trip. I mean, it would
629
00:33:37.920 --> 00:33:39.599
be humorous if it wasn't dangerous.
630
00:33:40.759 --> 00:33:44.559
That's pretty amazing that you could get a bright pink result,
631
00:33:44.680 --> 00:33:47.079
think you're ok, you're great, and yet it's really an
632
00:33:47.200 --> 00:33:51.200
oral infection that's causing you to get this bright pink result.
633
00:33:52.359 --> 00:33:54.119
You know, and then people just going about their business,
634
00:33:54.160 --> 00:33:56.680
they never go see a biological dentist to look deeper.
635
00:33:56.720 --> 00:34:00.079
Than an X ray into a CT and realize they
636
00:34:00.079 --> 00:34:03.519
have an asymptomatic osteomocrotic infection going on. That's going to
637
00:34:03.599 --> 00:34:09.119
cause enormous problems fibromyalgia, autoimmune disease, cancers. I mean, it's
638
00:34:09.320 --> 00:34:09.840
bad news.
639
00:34:10.880 --> 00:34:14.119
So let's start from the top. Okay, starting at the head,
640
00:34:14.559 --> 00:34:17.159
because I'm going to go from the head to the toe. Okay,
641
00:34:17.239 --> 00:34:20.480
so let's I'm probably starting with the biggest one of all,
642
00:34:20.519 --> 00:34:22.400
which is Alzheimer's because it's the brain.
643
00:34:22.519 --> 00:34:24.760
But why don't you start there and say, you know,
644
00:34:24.960 --> 00:34:26.719
explain how the influence of.
645
00:34:27.519 --> 00:34:32.440
Low nitric oxide can affect the result in the production
646
00:34:32.639 --> 00:34:38.239
of of of beta amyloid or let's just say Alzheimer's
647
00:34:38.320 --> 00:34:38.880
or dimension.
648
00:34:39.840 --> 00:34:42.440
Well, there's a progression of this, right, it's called mod
649
00:34:42.519 --> 00:34:48.599
cognitive impairment, called Bastard dementia, Alzheimer's disease exactly just like
650
00:34:48.719 --> 00:34:51.800
any any disease, there's a progression. And so if you
651
00:34:51.880 --> 00:34:53.639
catch this early on, what do we call it brain
652
00:34:53.719 --> 00:34:56.239
fog or MCI mon cognitive impairment. If you look at
653
00:34:57.639 --> 00:34:59.320
cerebral blood flow, and you can do this through a
654
00:34:59.360 --> 00:35:03.159
functional MRI, you can do it through spec scans, which
655
00:35:03.159 --> 00:35:05.840
I like spec scins and doctor Daniel Laman's word, because
656
00:35:05.840 --> 00:35:08.400
it really tells us what parts of the brain are
657
00:35:08.480 --> 00:35:12.039
perfused in which are not, and so in these mild
658
00:35:12.119 --> 00:35:16.239
cognitive impairments, really any neurological disease, there's what's called focal
659
00:35:16.280 --> 00:35:18.239
a schemium. So if you look at a spec scan
660
00:35:18.360 --> 00:35:21.480
and dementia or Alzheimer's, the prefone of cortex and parts
661
00:35:21.519 --> 00:35:23.800
of the brain are don't show up on the spec scin,
662
00:35:24.320 --> 00:35:25.920
and that's because that part of the brain is not
663
00:35:26.000 --> 00:35:31.000
getting perfused. So it's called vascular dementia. Why because there's
664
00:35:31.039 --> 00:35:34.559
a vaster component to the dementia. There's loss of regulation
665
00:35:34.639 --> 00:35:37.039
of blood flow. Just like if you lose the regulation
666
00:35:37.119 --> 00:35:39.239
of blood flow to the sex organs, they fail. If
667
00:35:39.280 --> 00:35:41.400
you lose regulation of blood flow of the brain, it
668
00:35:41.559 --> 00:35:45.400
fails and symptoms manifest depending upon which readiers of the
669
00:35:45.440 --> 00:35:49.320
brain develop a schemi or hypoxia. And then number two,
670
00:35:49.760 --> 00:35:53.320
and you've heard this called Alzheimer's, we called diabetes type three.
671
00:35:53.920 --> 00:35:57.719
It's insulin resistance in the brain. So number one, if
672
00:35:57.719 --> 00:36:00.280
you're not getting oxygen and nutrients to the parts of
673
00:36:00.320 --> 00:36:02.840
the brain and you can't get glucose into the cell
674
00:36:03.000 --> 00:36:05.199
for that cell to make ATP or cell your energy.
675
00:36:05.199 --> 00:36:07.719
If that's cell to do its job, you get misfolding
676
00:36:07.760 --> 00:36:11.039
a protein. And then what is that misfolded protein. We
677
00:36:11.119 --> 00:36:14.199
call that tau tangle. We call it amyloid plaque. That's
678
00:36:14.239 --> 00:36:16.599
what shows up in the later stages. So how you
679
00:36:16.719 --> 00:36:20.880
fix it. You perfuse the brain, You give nitrocoxide, you
680
00:36:20.960 --> 00:36:23.920
dilate the blood vessels. In twenty eleven, my research group
681
00:36:24.039 --> 00:36:26.400
was the first group in the history of nitrocoxide to
682
00:36:26.440 --> 00:36:30.960
show that nitrocoxide is required for insulin signaling. For insulin
683
00:36:31.000 --> 00:36:32.880
to do its job, it binds to the instant receptor,
684
00:36:32.920 --> 00:36:38.239
starts an intrasidar signaling cascade, activates nitrocoxide production. Nitrocoxide activates
685
00:36:38.280 --> 00:36:41.079
glute forourd glute four goes to the membrane brings glucose in.
686
00:36:41.559 --> 00:36:44.639
Without nitrocoxide production, glute four never gets the signal. You
687
00:36:44.719 --> 00:36:48.320
develop insular resistance. So instant resistance is a symptom of
688
00:36:48.440 --> 00:36:53.239
nitrocoxide deficiency. So when we give nitrocoxide to dementia patients,
689
00:36:53.280 --> 00:36:57.119
we dilate the bloodvessils, We perfuse the brain. We show
690
00:36:57.119 --> 00:37:00.960
the improvement on spec skins and NMRI, and we improve
691
00:37:01.039 --> 00:37:04.960
glucose ubtake into the cell. So if we're delivering oxygen,
692
00:37:05.000 --> 00:37:08.599
delivering nutrients, activating mitochondric getting glucose into the cell, so
693
00:37:08.639 --> 00:37:12.480
the mitochondric can make sailor energy and atp the proteins
694
00:37:12.519 --> 00:37:14.360
do their job, the enzymes do their job. You don't
695
00:37:14.360 --> 00:37:17.119
get misfolding of proteins. There's no tall tangle, there's no
696
00:37:17.239 --> 00:37:21.159
amyloid plaque, and there's no loss of cognition. That's why
697
00:37:21.280 --> 00:37:24.639
nitric oxide will be the end the cure to Alzheimer's,
698
00:37:24.679 --> 00:37:28.079
and that's why all drugs against Alzheimer's have failed, because
699
00:37:28.159 --> 00:37:31.760
amyloid plaque and tall tangles do not cause disease. They're
700
00:37:31.800 --> 00:37:35.639
the consequence of disease. And developing drug targets towards the
701
00:37:35.679 --> 00:37:39.800
consequence of any disease is a sure failure. And it's
702
00:37:39.880 --> 00:37:43.239
unfortunate that companies just spent billions and billions of dollars
703
00:37:43.320 --> 00:37:45.719
of taxpayer money on target.
704
00:37:46.599 --> 00:37:50.880
I know doctor Gale Brettison, who is the father of.
705
00:37:53.280 --> 00:37:58.920
The natural cures to Alzheimer's, which was on my podcast,
706
00:37:59.000 --> 00:38:00.800
and he said that same thing.
707
00:38:01.360 --> 00:38:04.679
You know that they're just missing what is it forty billion.
708
00:38:04.400 --> 00:38:07.519
Dollars or something like that has been spent on Alzheimer's
709
00:38:07.599 --> 00:38:09.599
drugs with no success.
710
00:38:10.039 --> 00:38:12.320
That that's like shameful and.
711
00:38:14.599 --> 00:38:16.280
Sorry, it's very predictable.
712
00:38:16.599 --> 00:38:20.360
Yeah, why why have they ignored NITROGOTSA.
713
00:38:20.440 --> 00:38:24.000
I mean, if they would be so easy to with
714
00:38:24.159 --> 00:38:28.480
the current drugs to now incorporate the knowledge that you're
715
00:38:28.599 --> 00:38:32.159
providing and the world you know of medicine is providing
716
00:38:32.239 --> 00:38:35.920
with nitrogotxa, why haven't they recognized that and done something
717
00:38:35.960 --> 00:38:36.320
about it?
718
00:38:37.440 --> 00:38:40.320
Well, Number one, these companies are for profit companies, right,
719
00:38:40.400 --> 00:38:42.320
and I have a number of patents on ways that
720
00:38:42.400 --> 00:38:45.159
we deliver nitrocoxide. Look, there's many ways to skin a cat.
721
00:38:45.239 --> 00:38:50.000
They can, there's other technologies out there. But in big business,
722
00:38:50.280 --> 00:38:53.159
there is no money in cures, right, the money and
723
00:38:53.280 --> 00:38:56.960
the trillion dollar big form of business is dependent upon
724
00:38:57.119 --> 00:39:00.719
monthly recurring revenue, getting people on drug and keeping them
725
00:39:00.800 --> 00:39:02.440
on drugs for the rest of em No matter what
726
00:39:02.559 --> 00:39:05.400
business you're in, a for profit business has two goals.
727
00:39:05.440 --> 00:39:07.840
Get as many customers as you can and retain the
728
00:39:07.920 --> 00:39:10.880
customer for as long as you can. Yeah, that's that's
729
00:39:10.920 --> 00:39:11.440
the big I.
730
00:39:11.440 --> 00:39:14.679
Mean, the drug companies have the best business model that
731
00:39:14.880 --> 00:39:18.159
exists in the world because they can't.
732
00:39:18.480 --> 00:39:20.239
They basically capture you.
733
00:39:20.440 --> 00:39:22.559
You know, you take one drug to help another drug
734
00:39:22.639 --> 00:39:26.000
that helps another drug, and you know, so basically, yeah,
735
00:39:26.039 --> 00:39:30.639
I mean it's crazy because they you're basically addicted to
736
00:39:30.800 --> 00:39:34.920
using pharmaceutical drugs and it's a it's a downward spiral,
737
00:39:35.000 --> 00:39:36.039
it's a big black hole.
738
00:39:36.760 --> 00:39:39.360
No, it's it's the best business model in the world,
739
00:39:39.519 --> 00:39:43.800
multi trillion dollar global economy. But what's the expense. The
740
00:39:43.840 --> 00:39:46.599
expense is our own health and drugs have made.
741
00:39:48.000 --> 00:39:51.719
Okay, so let's go to the nasal the next I'm
742
00:39:51.760 --> 00:39:52.880
heading down south.
743
00:39:52.960 --> 00:39:55.440
Okay, so we're going to end up at erectile dysfunction,
744
00:39:55.559 --> 00:39:56.960
but I want to make sure we have time to
745
00:39:57.039 --> 00:39:57.199
do it.
746
00:39:57.679 --> 00:40:00.840
So what about the nasal breathing and and versus the
747
00:40:01.079 --> 00:40:04.480
mouth breathing. Why is that beneficial? And what can people
748
00:40:04.559 --> 00:40:05.960
do to change their habit?
749
00:40:06.800 --> 00:40:09.360
Well, the same enzyme that's found in are endothelo cells
750
00:40:09.400 --> 00:40:12.960
that produces nitrocoxide. The nitrocoxide synthase enzyme is also found
751
00:40:13.000 --> 00:40:15.880
in our upper airways, the epithelial cells. So we do
752
00:40:16.039 --> 00:40:18.960
nasal breathing, it activates these epithilal cells and turns on
753
00:40:19.119 --> 00:40:24.719
nitro production. We do dasel breathing, we're actually delivering nitrocoxide
754
00:40:24.760 --> 00:40:28.159
gas into the pulmary circulation, so we're dilating the pulmonary arteries.
755
00:40:28.199 --> 00:40:32.199
Now we're matching ventilation to perfusion, and we're improving tissue oxygenation.
756
00:40:32.679 --> 00:40:36.119
But it's also dilating the bronchiles. So nitrocoxide is a
757
00:40:36.159 --> 00:40:39.920
smooth muscle relaxing, relaxes the smooth muscles on the blood vessels,
758
00:40:39.920 --> 00:40:42.960
relaxes smooth muscles around the bronchiles. So now we're dilating
759
00:40:43.000 --> 00:40:48.039
the bronochiles, dilating the arteries, improving oxygenation. But if the
760
00:40:48.199 --> 00:40:50.280
enzyme is uncoupled and not functional, so if you have
761
00:40:50.400 --> 00:40:54.039
nithenyal dysfunction, you have epithial dysfunction. And we tested this.
762
00:40:54.159 --> 00:40:56.440
We take young healthy individuals do nasal breathing. We can
763
00:40:56.480 --> 00:40:59.000
detect nitrocoxide out of the ease heal breath. We take
764
00:40:59.000 --> 00:41:01.679
a fifty year old person with EED do nase of breathing.
765
00:41:01.719 --> 00:41:05.199
There's no nitrocoxide. So again we have to focus on
766
00:41:05.400 --> 00:41:08.800
restoring the function of the nos enzyme. Rgentie didn't go
767
00:41:08.920 --> 00:41:11.840
fix it. Beats aren't gonna fix it. Centrally, it didn't
768
00:41:11.840 --> 00:41:15.360
go fix it. I have to understand the enzomology about chemistry. Now,
769
00:41:16.239 --> 00:41:19.360
if your mouth breathe, not only are you bypassing that
770
00:41:19.519 --> 00:41:23.800
nitrocoxide production pathway, but now you're you're completely oxygenating the
771
00:41:23.960 --> 00:41:27.599
oral cavity. You're changing the oral microbiome, You're acidifying the saliva.
772
00:41:28.039 --> 00:41:31.719
All the nitrocoxide producing bacteria go away, all the pathogens
773
00:41:31.760 --> 00:41:34.920
come in. Now you have chronic halatosis, you have an
774
00:41:34.960 --> 00:41:37.639
acidic saliva, you have carrious causing bacteria, you have paradonal
775
00:41:37.679 --> 00:41:41.559
disease causing bacteria. Performonis gingivite is all the really bad
776
00:41:41.719 --> 00:41:46.440
red pathogens you see on dental pathogens and start to
777
00:41:46.480 --> 00:41:49.840
show up. And you don't oxygenate at night, And so
778
00:41:50.199 --> 00:41:53.079
I mean in ten time increase in all cause mortality
779
00:41:53.119 --> 00:41:53.800
through mouthbreathing.
780
00:41:54.840 --> 00:41:55.719
So that means.
781
00:41:57.639 --> 00:41:59.679
What you do in the daytime, you know, you have
782
00:41:59.760 --> 00:42:02.400
to be aware of that, but at night it's when
783
00:42:02.480 --> 00:42:05.800
most people really are doing the wrong thing, which is
784
00:42:05.920 --> 00:42:09.679
mouth breathing. So tape do mouth taping, which I read
785
00:42:09.719 --> 00:42:13.800
about from a number of biological dentists that they're advocating that.
786
00:42:14.079 --> 00:42:17.000
So you can buy those you know mouth tapes and
787
00:42:17.199 --> 00:42:17.519
use them.
788
00:42:17.800 --> 00:42:20.920
Are you advocating that as a as a methodology from
789
00:42:21.000 --> 00:42:22.000
night for sleeping.
790
00:42:22.559 --> 00:42:25.039
Well, First of all, I encourage anybody who's a mouth
791
00:42:25.079 --> 00:42:29.480
breathering to go see an airway specialist, either at an ear,
792
00:42:29.519 --> 00:42:33.320
nose and throat doctor or a dentist who's an airway specialist,
793
00:42:33.400 --> 00:42:35.239
because you don't want a mouth tape if you get
794
00:42:35.239 --> 00:42:39.559
an anatomical obstruction, that's right. And because tape in your mouth,
795
00:42:39.599 --> 00:42:41.360
I mean you could literally suffocate. You have to have
796
00:42:41.440 --> 00:42:43.320
an airway for them to be oxygen exchange.
797
00:42:43.400 --> 00:42:43.760
That's right.
798
00:42:44.079 --> 00:42:47.039
Many people have anatomical issues, they have a small mouth,
799
00:42:47.679 --> 00:42:51.039
you know, right, they have an obstructed airways. So first,
800
00:42:51.119 --> 00:42:53.719
before you ever consider taping your mouth, go do the
801
00:42:53.880 --> 00:42:56.199
airway specialists and make sure you don't have an obstructive
802
00:42:56.199 --> 00:42:58.440
ay way. But yeah, if you've got if you've got
803
00:42:58.480 --> 00:43:01.480
an open airway, mouth taping. I do it occasionally if
804
00:43:01.519 --> 00:43:03.679
I'm outside I've got allergies and i feel a little snuffy,
805
00:43:04.639 --> 00:43:06.119
but I've got an open airway, so I can do
806
00:43:06.239 --> 00:43:08.199
mouth taping and you know, you feel the difference of
807
00:43:08.280 --> 00:43:08.920
it the next morning.
808
00:43:09.280 --> 00:43:10.079
Yeah, for sure.
809
00:43:10.199 --> 00:43:12.159
I started doing it a little bit and it does
810
00:43:12.239 --> 00:43:14.159
make a difference, and I think how deep you sleep?
811
00:43:15.599 --> 00:43:15.920
All right?
812
00:43:16.039 --> 00:43:19.519
So now next is the microbio the oral microbiome. So
813
00:43:19.800 --> 00:43:22.639
can you give me a one minute description of how
814
00:43:22.679 --> 00:43:26.360
the nitrocoxide influences the oral microbion.
815
00:43:26.920 --> 00:43:31.079
Well, the oral microbiome is influencing nitrocoxide production. So we
816
00:43:31.239 --> 00:43:34.960
have what's called nitrate reducing bacteria that reduces nitrate to
817
00:43:35.079 --> 00:43:37.639
electron reduction to nitrite. And now we swallow it's aliva
818
00:43:38.079 --> 00:43:41.079
and make nitrocoxide. But without the bacteria, you know, we
819
00:43:41.199 --> 00:43:44.239
lose the cardioprotective benefits of diet, we lose the cardioprotective
820
00:43:44.239 --> 00:43:48.119
benefits of exercise. So when we do things like have
821
00:43:48.239 --> 00:43:50.519
flouride in our toothpaste, which kills all the bacteria in
822
00:43:50.519 --> 00:43:53.360
your mouth. When we use antiseptic mouthwashed, which two out
823
00:43:53.360 --> 00:43:56.639
of three Americans usee mouthwashed everythy killing the bacteria, it
824
00:43:56.960 --> 00:44:00.239
shuts down nitrocoxide production and your blood pressure goes up.
825
00:44:00.719 --> 00:44:02.800
Blood pressure goes up, the number one driver, the number
826
00:44:02.840 --> 00:44:05.440
one killer of men and women worldwide. So and we
827
00:44:05.760 --> 00:44:07.880
and others a publish that if you destroy the microbiome,
828
00:44:07.960 --> 00:44:11.920
it's causal for high blood pressure. So if you're using mouthwashed.
829
00:44:11.960 --> 00:44:15.199
You have to stop, use a fluoride free toothpaste, and
830
00:44:15.320 --> 00:44:18.079
then start doing things that restore and support the microbiome
831
00:44:18.119 --> 00:44:19.559
instead of destroying them.
832
00:44:20.480 --> 00:44:23.239
You know, I'm so shocked when I go to these dentists,
833
00:44:23.280 --> 00:44:27.000
I do you know, I have a biological I mean,
834
00:44:27.079 --> 00:44:32.280
a regular hygiene and they're not. They're more you know,
835
00:44:32.920 --> 00:44:35.119
in tune to allopathic approaches of but ye.
836
00:44:35.920 --> 00:44:38.880
So you know, they open up their cabinet at the
837
00:44:39.000 --> 00:44:41.559
end of a session and they want to give you
838
00:44:42.119 --> 00:44:45.119
a goodie bag, you know, to take home, and it's
839
00:44:45.239 --> 00:44:46.760
flora tice paste.
840
00:44:46.519 --> 00:44:51.639
It's chloro hexacrene or whatever that mouth I mean, it's
841
00:44:51.679 --> 00:44:52.639
all the stuff that's so.
842
00:44:52.719 --> 00:44:53.239
Bad for you.
843
00:44:53.400 --> 00:44:55.960
And then when you do any kind of procedure, they
844
00:44:56.039 --> 00:44:57.880
want you to use an antibiotic.
845
00:44:58.000 --> 00:44:59.760
And that's the first thing they do when you.
846
00:44:59.800 --> 00:45:02.519
Walk is you know, they want It's like it's like candy,
847
00:45:03.239 --> 00:45:05.639
and I always stuff them in my pocket.
848
00:45:05.760 --> 00:45:07.480
You know, they think I'm taking it, but I never do.
849
00:45:08.000 --> 00:45:11.400
But you know, the these are the things to be
850
00:45:11.559 --> 00:45:11.960
aware of.
851
00:45:12.119 --> 00:45:16.440
I mean, traditionally the dentists you're going to go to
852
00:45:16.679 --> 00:45:19.360
most people are not going to biological dentists.
853
00:45:19.400 --> 00:45:22.239
So you're going to be offered. And then we still
854
00:45:22.280 --> 00:45:24.840
have the government dealing with the fluoride in our water
855
00:45:25.599 --> 00:45:28.159
and our and the truth pasted is just a byproduct
856
00:45:28.199 --> 00:45:32.599
of that. So it's a it's a it's a slippery slope.
857
00:45:32.719 --> 00:45:36.960
I mean, you really, you have to navigate your own
858
00:45:37.280 --> 00:45:41.239
journey and make your own decisions. But if anybody that's
859
00:45:41.320 --> 00:45:47.159
watching today is still using mouthwash, alcohol based mouthwash, throw
860
00:45:47.239 --> 00:45:47.480
it in.
861
00:45:47.559 --> 00:45:51.880
The trash, right, get rid of it. And and even
862
00:45:52.360 --> 00:45:53.840
what do you think about oil pulling?
863
00:45:54.039 --> 00:45:54.639
Is that? Is that?
864
00:45:54.800 --> 00:45:55.119
Okay?
865
00:45:55.480 --> 00:45:57.960
The coconuta you know, the short answer is, we don't
866
00:45:58.000 --> 00:46:00.079
know because we've never done the experiment. But you know,
867
00:46:00.119 --> 00:46:01.679
I don't think it's an a septic. I think it's
868
00:46:01.679 --> 00:46:05.880
a it's a good practice that many biological dyonists and yeah, recommend,
869
00:46:05.920 --> 00:46:07.440
but I don't see any downside to it. But we
870
00:46:07.559 --> 00:46:07.880
just don't know.
871
00:46:09.159 --> 00:46:11.679
Okay, So the next one down I'm saying would be,
872
00:46:12.119 --> 00:46:17.039
uh oh, he's telling me hold on, okay, he's.
873
00:46:16.880 --> 00:46:19.760
Telling me we're out of time. Oh dude, Well you
874
00:46:19.840 --> 00:46:22.000
know what, Nathan, We're going to have you back. I'm
875
00:46:22.079 --> 00:46:24.039
so sorry. I wanted to go down through all the
876
00:46:24.480 --> 00:46:25.000
you know, the.
877
00:46:25.719 --> 00:46:30.159
The organs and particularly the gut microbione and the heart
878
00:46:30.280 --> 00:46:33.880
of course, and well and of course the erectile issue.
879
00:46:33.920 --> 00:46:37.440
But we'll make that happen in another session. Are you
880
00:46:37.519 --> 00:46:39.000
okay with doing another.
881
00:46:40.159 --> 00:46:42.679
I love these conversations. These are very important conversations people
882
00:46:42.880 --> 00:46:43.320
I know, and.
883
00:46:43.400 --> 00:46:45.719
You're doing such an important thing for all of us.
884
00:46:45.880 --> 00:46:48.599
Really, I just before we go, I really want to
885
00:46:48.800 --> 00:46:51.400
just tell everybody if you want to order, and I'm
886
00:46:51.440 --> 00:46:54.960
not everybody knows I'm not commercial, but when I take
887
00:46:55.039 --> 00:46:58.239
a product and I know the difference, I want to
888
00:46:58.360 --> 00:47:00.920
share it with other people. And I've been using since
889
00:47:00.960 --> 00:47:02.960
I met you a year and a half, a little
890
00:47:03.000 --> 00:47:06.199
over a year ago, I've been using your N.
891
00:47:06.239 --> 00:47:09.199
One oh one the Lozengers. That's the only product I
892
00:47:09.280 --> 00:47:12.079
ever got, But I know you have many others. So
893
00:47:12.199 --> 00:47:13.039
go check out.
894
00:47:13.760 --> 00:47:18.079
Nathan's website and Tony's our producer is going to put
895
00:47:18.079 --> 00:47:21.000
it on the screen for everybody, and my assistant will
896
00:47:21.039 --> 00:47:23.159
have it in the show notes. So if you want
897
00:47:23.199 --> 00:47:25.840
to order any of his products, you can do so
898
00:47:26.039 --> 00:47:29.559
using the affiliate My affiliate code with you right, which.
899
00:47:29.440 --> 00:47:32.280
Is gives you a ten percent So I will get
900
00:47:32.320 --> 00:47:32.960
you the code.
901
00:47:33.119 --> 00:47:36.039
I don't have it right with me today, but we
902
00:47:36.119 --> 00:47:38.280
will add that in so that people know how to
903
00:47:38.360 --> 00:47:39.119
get your products.
904
00:47:39.159 --> 00:47:41.880
So Nathan, thank you so much. And I'm really sorry
905
00:47:41.920 --> 00:47:43.719
I have to cut his short, but I love what
906
00:47:44.400 --> 00:47:44.639
I think.
907
00:47:44.679 --> 00:47:46.920
We covered a lot of ground today and it's very,
908
00:47:47.079 --> 00:47:50.840
very compelling information. So what you're doing is you're on
909
00:47:50.960 --> 00:47:56.559
a mission and you have not deterred from your path.
910
00:47:57.800 --> 00:48:02.199
You are an evangelist of outside and I truly, as
911
00:48:02.280 --> 00:48:06.360
one individual, I truly appreciate your passion. So thank you again,
912
00:48:06.920 --> 00:48:10.559
and and everybody check out Talk Doctor magazine coming up
913
00:48:10.679 --> 00:48:12.320
in about another week or so.
914
00:48:12.880 --> 00:48:14.119
Okay, take care.
915
00:48:14.639 --> 00:48:14.920
Thank you,