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Insights:
Increased susceptibility to encapsulated bacterial sepsis (side note, in Bruton agam, also increased risk of this)
Child greater than adults (fewer memory B cells)
Immune reasons: fewer antibody responses to blood bourne pathogens, fewer phagocytes (side note, in Bruton agam, also increased risk of this)
Need for vaccines against encapsulated bacteria (pneumovax, HiB, MenACWY, MenB)
References
Abbas, A., Lichtman, A., Pillai, S., Baker, D. and Baker, A. (n.d.). Cellular and molecular immunology. 9th ed.
Kumar, V. (2017). Robbins basic pathology international edition. S.l. Elsevier - Health Science.
Increased susceptibility to encapsulated bacterial sepsis (side note, in Bruton agam, also increased risk of this)
Child greater than adults (fewer memory B cells)
Immune reasons: fewer antibody responses to blood bourne pathogens, fewer phagocytes (side note, in Bruton agam, also increased risk of this)
Need for vaccines against encapsulated bacteria (pneumovax, HiB, MenACWY, MenB)
References
Abbas, A., Lichtman, A., Pillai, S., Baker, D. and Baker, A. (n.d.). Cellular and molecular immunology. 9th ed.
Kumar, V. (2017). Robbins basic pathology international edition. S.l. Elsevier - Health Science.
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Insights:
Cranial has its own origin, migration pattern and differentiation.
Circumpharyngeal has a special distribution around pharyngeal arches, has two key branches (cardiac and vagal) and runs anteriorly to supply hypoglossal nerve (video says vagus by mistake)
Trunk has unique directions o…
Insights:
Sepsis 6
Encapsulated bacteria (ANTIBIOTICS)
Hemodynamic problem (increased vasc permeability by loosening tight junctions between ECs) (FLUIDS, MEASURE URINE OUTPUT)
Metabolic disturbances (hyperglycaemia, insulin resistance, high cortisol, lactic acidosis (OXYGEN, VBG)
Acute kidney in…
Insights:
The skull is a unique structure, organised by pharyngeal arches and reinforced with neural crest cells.
The skull is divided into neurocranium and viscerocranium. They are further subdivided into a membranous cranium (where bones form via intramembranous ossification) and cartilaginous …
Insights:
Concept of sepsis as an overwhelming infection where our body CANNOT mount a sufficient antibody response against it (usually in SPLEEN if bacteraemia). The course of damage occurs due to release of overwhelming amount of pro-inflammatory cytokines.
First it’s TNFalpha and IL-1b that ki…
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