7. The Sobriety Paradox
In this solo episode of Highly Functional, we explore the rapidly expanding cultural phenomenon of the sober curious movement, driven heavily by high-performing millennials. We dismantle the deeply ingrained corporate and social stigmas surrounding alcohol abstinence, examine the systemic neurotoxi…
Evidence suggests microdosing may only produce placebo effects
Today, psychedelic drugs are being used to treat mental health conditions.
Governor Gavin Newsom signed legislation in 2025, making it easier to study how psychedelics can treat conditions like PTSD and depression. This year, the federal government reclassified Marijuana, formally recognizing its …
How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys
Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addictive substances and behaviors, including alcohol, opioids, gambling, stimulants, nicotine, cannabi…
What America got wrong about drug addiction
The drug crisis in the United States did not begin with fentanyl. It began with a series of choices that seemed compassionate at the time — prescribing opioids for people in pain, scaling back punishment and trying to make drug use safer. But addiction spread, fentanyl changed the stakes, and the s…
Overdose Deaths Just Had Their Biggest Drop In History, with Keith Humphreys, Stanford Professor
For 25 years, overdose deaths in America climbed almost without interruption. Then, in the middle of 2023, they didn't. The reversal was sudden, dramatic, and almost completely unreported. By the end of 2025, deaths were down 40-45% from the peak. Keith Humphreys was on the research team that publi…
Wasted Audiobook by Maureen Palmer
Listen to full audiobook for free : https://litupbook.com/free Title: WastedSubtitle: An Alcoholic Therapist's Fight for Recovery in a Tragically Flawed Treatment SystemCategories: Biography, MedicalAuthor: Maureen PalmerNarrator: Maureen Palmer, Michael PondPublisher: Greystone BooksRelease date: …
EXTRA: The Opioid Tragedy — How We Got Here
An update of our 2020 series, in which we spoke with physicians, researchers, and addicts about the root causes of the crisis — and the tension between abstinence and harm reduction.
SOURCES:
Gail D’Onofrio, professor and chair of emergency medicine at the Yale School of Medicine and chief of eme…
590. Can $55 Billion End the Opioid Epidemic?
Thanks to legal settlements with drug makers and distributors, states have plenty of money to boost prevention and treatment. Will it work? (Part two of a two-part series.)
SOURCES:
Keith Humphreys, professor of psychiatry and behavioral sciences at Stanford University.
Stephen Loyd, chief medic…
589. Why Has the Opioid Crisis Lasted So Long?
Most epidemics flare up, do their damage, and fade away. This one has been raging for almost 30 years. To find out why, it’s time to ask some uncomfortable questions. (Part one of a two-part series.)
SOURCES:
David Cutler, professor of economics at Harvard University.
Travis Donahoe, professor o…
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