WEBVTT
00:00:58.479 --> 00:01:08.640
So in the previous episode we were having breakfast together and we're talking about what starts to happen as soon as you eat that food.
00:01:09.200 --> 00:01:11.759
So let's you and I have a meal together.
00:01:12.479 --> 00:01:13.679
Take a bite.
00:01:13.920 --> 00:01:15.439
Maybe it's oatmeal.
00:01:15.679 --> 00:01:17.359
Maybe it's eggs and toast.
00:01:17.599 --> 00:01:19.679
Maybe it's yesterday's pizza.
00:01:19.920 --> 00:01:21.679
I'm not judging.
00:01:22.000 --> 00:01:26.159
You chew, swallow, digestion begins.
00:01:26.479 --> 00:01:31.599
Nutrients that were sitting on a plate are about to become part of your internal environment.
00:01:31.840 --> 00:01:34.239
And that's when our mystery begins.
00:01:34.560 --> 00:01:44.000
Because your muscles weren't at breakfast, your liver didn't see the plate, and your fat cells have absolutely no idea what you ordered.
00:01:44.239 --> 00:01:47.359
Yet all of them are about to change their behavior.
00:01:47.680 --> 00:01:48.319
How?
00:01:48.640 --> 00:01:51.120
Let's follow one part of the meal.
00:01:51.439 --> 00:01:53.599
The carbohydrate is digested.
00:01:53.840 --> 00:01:58.479
Eventually, glucose begins to make its way into circulation.
00:01:58.960 --> 00:02:04.480
The metabolic environment is changing, and your body needs to coordinate what happens next.
00:02:04.719 --> 00:02:08.959
One of the most important signals involved is insulin.
00:02:09.280 --> 00:02:14.000
You've probably heard insulin described as the hormone that lowers blood sugar.
00:02:14.319 --> 00:02:16.719
That's true, but it's incomplete.
00:02:16.959 --> 00:02:20.560
I want you to start thinking about insulin as information.
00:02:20.800 --> 00:02:25.199
Insulin is telling tissues something about the metabolic environment.
00:02:25.519 --> 00:02:29.360
Fuel has arrived, conditions have changed.
00:02:29.680 --> 00:02:34.800
Respond accordingly, and different tissues will respond in different ways.
00:02:35.039 --> 00:02:37.439
Your liver has decisions to make.
00:02:37.599 --> 00:02:41.360
Same with your skeletal muscle and your fat tissue.
00:02:42.000 --> 00:02:55.199
Over the next several episodes, we're going to follow this message where insulin comes from, how it gets released, where it goes, and how cells hear it, and what they do once they receive it.
00:02:55.759 --> 00:03:01.840
Eventually we'll understand insulin resistance, but we're not going there yet.
00:03:02.159 --> 00:03:09.599
Because saying someone is insulin resistant isn't very useful if we don't understand what insulin was trying to do in the first place.
00:03:10.079 --> 00:03:12.879
So let's begin at the beginning.
00:03:13.199 --> 00:03:22.560
Somewhere behind your stomach sits an organ called the pancreas, and scattered inside that organ are tiny islands of cells.
00:03:22.879 --> 00:03:27.120
One particular cell has been waiting for breakfast to arrive.
00:03:27.439 --> 00:03:29.680
Meet the better cell.
00:03:30.479 --> 00:03:33.359
We'll talk more about that in the next episode.
00:00:58.479 --> 00:01:08.640
So in the previous episode we were having breakfast together and we're talking about what starts to happen as soon as you eat that food.
00:01:09.200 --> 00:01:11.759
So let's you and I have a meal together.
00:01:12.479 --> 00:01:13.679
Take a bite.
00:01:13.920 --> 00:01:15.439
Maybe it's oatmeal.
00:01:15.679 --> 00:01:17.359
Maybe it's eggs and toast.
00:01:17.599 --> 00:01:19.679
Maybe it's yesterday's pizza.
00:01:19.920 --> 00:01:21.679
I'm not judging.
00:01:22.000 --> 00:01:26.159
You chew, swallow, digestion begins.
00:01:26.479 --> 00:01:31.599
Nutrients that were sitting on a plate are about to become part of your internal environment.
00:01:31.840 --> 00:01:34.239
And that's when our mystery begins.
00:01:34.560 --> 00:01:44.000
Because your muscles weren't at breakfast, your liver didn't see the plate, and your fat cells have absolutely no idea what you ordered.
00:01:44.239 --> 00:01:47.359
Yet all of them are about to change their behavior.
00:01:47.680 --> 00:01:48.319
How?
00:01:48.640 --> 00:01:51.120
Let's follow one part of the meal.
00:01:51.439 --> 00:01:53.599
The carbohydrate is digested.
00:01:53.840 --> 00:01:58.479
Eventually, glucose begins to make its way into circulation.
00:01:58.960 --> 00:02:04.480
The metabolic environment is changing, and your body needs to coordinate what happens next.
00:02:04.719 --> 00:02:08.959
One of the most important signals involved is insulin.
00:02:09.280 --> 00:02:14.000
You've probably heard insulin described as the hormone that lowers blood sugar.
00:02:14.319 --> 00:02:16.719
That's true, but it's incomplete.
00:02:16.959 --> 00:02:20.560
I want you to start thinking about insulin as information.
00:02:20.800 --> 00:02:25.199
Insulin is telling tissues something about the metabolic environment.
00:02:25.519 --> 00:02:29.360
Fuel has arrived, conditions have changed.
00:02:29.680 --> 00:02:34.800
Respond accordingly, and different tissues will respond in different ways.
00:02:35.039 --> 00:02:37.439
Your liver has decisions to make.
00:02:37.599 --> 00:02:41.360
Same with your skeletal muscle and your fat tissue.
00:02:42.000 --> 00:02:55.199
Over the next several episodes, we're going to follow this message where insulin comes from, how it gets released, where it goes, and how cells hear it, and what they do once they receive it.
00:02:55.759 --> 00:03:01.840
Eventually we'll understand insulin resistance, but we're not going there yet.
00:03:02.159 --> 00:03:09.599
Because saying someone is insulin resistant isn't very useful if we don't understand what insulin was trying to do in the first place.
00:03:10.079 --> 00:03:12.879
So let's begin at the beginning.
00:03:13.199 --> 00:03:22.560
Somewhere behind your stomach sits an organ called the pancreas, and scattered inside that organ are tiny islands of cells.
00:03:22.879 --> 00:03:27.120
One particular cell has been waiting for breakfast to arrive.
00:03:27.439 --> 00:03:29.680
Meet the better cell.
00:03:30.479 --> 00:03:33.359
We'll talk more about that in the next episode.
