Mast Cells

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Hello and welcome to Trifecta Collective, Finding the Root.

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I am Megan Abbott, owner and founder of the holistic health practice, Trifecta Collective.

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And today it's just me.

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And what we're gonna be talking about today is mast cells and histamine issues.

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And this is coming up, recording this not too long after we did the mold mast cells and
histamines webinar and master class.

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That went super well.

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uh If you missed it, it is no longer free.

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We are offering it.

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It's about two hours, just over two hours worth of information here.

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We're going to be selling this for just $11, just a really low tier offer if you want
access.

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we did say it was not going to be free after the fact.

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Unfortunately, because there was so much time and effort and the level of education that
went into creating this course was

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pretty significant.

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very low, low cost.

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And there is so much information.

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I do give like some really specific protocol recommendations, testing information, like
all that kind of stuff that I'm not going to be going over today from a mold standpoint.

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I'm really just going to be focusing on mast cells and histamines.

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And, you know, for me,

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What, like my passion came from this from a point of, especially right now, I am seeing a
massive, massive influx of information and people talking about histamine issues, which

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one, I am super glad to see and really excited that this is becoming a more popular topic
because I think it impacts.

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so many people and I personally, I would say I suffered from Masselle issues, although
kind of question mark kind of in there in the heat of my journey.

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I mean, this was something no one ever mentioned to me.

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It's something I learned really more as I was going through my Mold education where
Masselle's was really talked about a whole lot more in certain courses.

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Certainly not in all of them, which I think is a huge mistake if you're not talking about
mast cell issues when you're talking about mold.

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Huge disservice because mast cell issues are pretty much always an issue when it comes to
mold.

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It's just really the level of issues that we're really dealing with.

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the histamine piece though, it's something I personally really, really struggled with.

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I was on allergy medication forever.

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The weaning off process was

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extremely challenging and very, very difficult to do.

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I'll also say that mold was not my root cause of histamine issues, my immune system.

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And if we kind of did, know, generally speaking, the immune system was my issue.

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And if we dig a little bit deeper into that, you know, we can say trauma, nervous system
dysregulation, heavy metal overload and parasite overload were my big root causes.

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for my histamine issues.

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And that can certainly be the case for a lot of people.

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And mold does play a really, really big role in this.

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So I am gonna touch on that piece here, but I really want to dive into more of the mast
cell and histamine piece.

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And I'm gonna start with mast cells because mast cells often, mast cell dysregulation
issues often lead to histamine issues.

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And with the...

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just with the amount of people talking about histamine issues right now, it's very
frustrating for me at times with just knowing everything that I know and having so much

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practical experience.

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We've worked with hundreds and hundreds of clients over the years with mold, mast cell and
or histamine type issues.

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They are some of the most common issues, especially right now over the last.

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probably two years within our practice.

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And once again, just the level of practical experience along with all of my educational
background, it's very frustrating for some people who don't, we'll just say it politely,

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don't quite have the same level of experience, whether that's education and or practical
experience, bruntness.

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So I wanna dive deeper into this and help explain really where a lot of the gaps.

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that I'm seeing when it comes to this kind of stuff happen.

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And I also want to acknowledge that, you know, sometimes, and this is something that I'm
very passionate about and have always been very passionate about when it came to creating

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the practice and streams of revenue and all that kind of stuff.

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And I don't think this is necessarily a bad thing.

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And I would encourage you to be aware.

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So a lot of these people that are talking about a lot of the histamine issues have their
own supplement brands that they own and sell from and obviously make a profit.

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And once again, not a bad thing, but there are a lot of people who have this and a lot of
people who are coming out now with rebranding.

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And a lot of times what happens is there's a relabeling process of pretty common
supplements in this space that people can

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relabel under their own name and then sell.

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And they can make money off of that.

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Once again, not necessarily a bad thing.

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It's something that I'm pretty against.

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uh By and large, if there was something that I, if there was really something on the
market that I felt like was missing, this would be a little bit of a different story.

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But especially when it comes to the histamine based products, I think there's a lot of
people just trying to sell supplements.

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and keep people on supplements long-term because they're symptom managing histamine issues
and histamine symptoms versus looking at the bigger picture into understanding why and how

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these things are happening and then how do we support the body in a variety of ways.

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Cause I still think there's a lot of, a lot of different ways to do this to help the body
heal.

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So let's start by diving into more of the mass cell issues here first.

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Cause once again, I think this is going to lead more into the histamine.

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piece.

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And I will probably spend more time on the histamine piece just because I think that it's
becoming so popular that I want to make sure I give that piece the time and detail that I

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would really like to give it.

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So mast cell issues.

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So let's like really strip this down.

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What are mast cells?

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So

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we all have mast cells, there is a very, very, very small percentage of people who don't,
and it is a genetic issue.

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And I can tell you that you do not, you would know pretty much right away, and you would
have been diagnosed at a very, very young age if you were born without mast cells, because

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they're so prominent in the body and they're so important, they do so many things.

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So if you don't know, you have them.

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So almost everyone has mast cells and mast cells are at the most basic level, they are
immune cells.

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So they're a type of white blood cell.

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So they're specialized immune cells.

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They are located almost throughout our entire body, which I'm gonna dig into this a little
bit more so we can start to understand a lot of mast cell symptoms and why this can be

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very challenging.

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to get a more formal diagnosis.

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And I'm also gonna talk about that piece too, cause I have a lot of feelings and I've
worked with lot of people who have gone through the official diagnosis process and have

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largely regretted it because of the challenges with it.

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So I am gonna talk about that too, but yeah, mast cells are really located throughout
entire body.

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And the important thing to understand is because they are immune cells, they are triggered
by

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stress.

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And I'm going to leave it there for this moment, but I am going to come back around to
this concept of stress because I think this is really, really important to understand.

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And I know I talk about this on certain types of platforms and during certain
conversations.

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And this is definitely one of the conversations where I think it's very worthwhile to dig
into this again.

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But I wanted to first

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into the location and kind of more of the specific roles of mast cells here first so we
can get a better understanding of why mast cell issues can become so systemically

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dysregulating to say it really nicely.

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So the first big place that we'll often see mast cells located are mucosal and lining
tissues.

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So those are things like

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the nose, the sinuses, eyes, mouth, all throughout your digestive tract, your lungs and
your bladder.

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So I'm gonna go through a couple of symptoms here kinda as we go along.

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And I'm also gonna do a little bit larger rundown, a quick rundown of a list of common
mast cell symptoms.

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And they are, once again, pretty widespread here.

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But because mast cells are located

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in all of these mucosal linings and tissue linings.

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These alone can present as pretty systemic and seemingly random issues.

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So nose, sinuses, you know, we think about histamine issues for sure.

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And I'll talk about the connection here, but sinus pressure, sinus congestion, lot of
post-nasal drip, just a lot of congestion, sneezing, sinus headaches, all that kind of

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stuff, eyes, dry, watery eyes.

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ah Eyes that produce just like are really strain almost all of the time.

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I've also worked with a handful of people.

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This is not a ton of people, but a handful of people with some like weirder meaning
they're just not super common eye issues.

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And these have been more degenerative kind of eye issues.

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Eye issues where certain pieces of the eye

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especially like behind the eye, there's a lot of pressure.

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There can be a lot of fluid build up behind there.

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Just putting a lot of pressure on the eyes and you know, very fortunately we've been able
to reverse a lot of this and or stop progression so much so that I had one client where we

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were able to do this.

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She had so much fluid build up behind her eye that they were getting ready to do a spinal
tap to drain the fluid.

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because it was impacting her body so much.

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And we were able to avoid that and not have to go through that kind of procedure, which
can be very, very painful.

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And no one wants needles stuck in their spine.

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you know, not saying that would be the case for everyone.

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And we have seen that on a handful of occasions of some people coming in with some more
unusual kind of eye issues, and we've been able to reverse them.

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and, and, or stop the progression, which is obviously amazing.

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And, you know, eyesight is a hugely important thing and being able to maintain our eye
health, super valuable and super important here.

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And if we think about the mouth, so the mouth that we can see things like sores, like
mouth sores, I would say would be some of the most common.

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We can also see in this, this isn't specifically mast cell related, but a lot of times
we'll end up with like thrush and oral kind of issues, like the white coating on the

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tongue.

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potentially even white sores, white pockets throughout the entire mouth and the tongue.

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And just painful, almost like seemingly like very painful, very sensitive mouths and or
tongues.

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We can throw the tongue in there too, because I've seen that a lot too.

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Digestive tract, obviously all kinds of digestive issues we can end up with.

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Lungs, breathing issues, all kinds of breathing issues, feeling like you can't take.

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a full and deep breath.

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now their digestion can also play a role in this, especially if we have a lot of like SIBO
type issues.

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we're very constipated, this can definitely contribute as well, but so can just mast cell
issues because it's going to impact, you know, if you've like, if you uh release all of

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your bowels really early, sometimes this will be the case if you have what would be
considered like very fast motility, extra fast motility, leaky gut kind of issues because

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that's...

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a whole of the mucosal lining of your small intestine.

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So we can end up with all kinds of digestive issues here and the bladder.

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UTIs and UTIs can be rooted in more yeast and fungal type issues too.

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I see intercistinal cystitis.

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It can definitely be see an overactive bladder.

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Just some bladder discomfort, know, painful urination, just a lot of discomfort when
trying to urinate.

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Frequent urination also not uncommon.

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So the mast cells can impact all of those things.

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Mast cells are also located in our blood vessels and cardiovascular tissues.

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So the heart palpitations is one of the most common mast cell issues.

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It can also be in your veins, your capillaries, your arteries.

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And we can see all kinds of variety of issues among these areas.

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Connective tissues in tendons, ligaments, bones and joints.

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So connective tissue,

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disorders, things like hypermobility, EDS, Ehlers-Danlos syndrome, not uncommon at all
when it comes to especially significant mast cell issues.

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Lymphatic system.

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Lymphatic system, so all kinds of swollenness in your glands, not uncommon.

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can be, and keep in mind, you have a lot of glands in your face and neck, in your armpits,
uh right around your breast tissue, especially women, we see a lot of issues.

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and inflammation right around their breasts, even denser breast tissue as a result of
this, that then subsides after we've gone through the healing process.

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And then there's quite a few in your groin as well.

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And we can see just like pain and discomfort around the groin.

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That's not necessarily groin related, but it's from these lymph nodes, kind of around the
groin area.

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And we can end up with a lot of drainage type issues because the lymphatic system does a
lot with drainage among other things as well here.

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So that can be a huge, huge thing.

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The skin.

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Skin issues are another one of those things where we, is a very, very common symptom when
it comes to mass cell issues.

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And this might be rashes, hives, eczema, psoriasis, itching skin, the one of the most
common ones that I often tell people and people be like, I've told so many people this

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symptom and they all think I'm crazy, but almost feeling like you're itchy on the inside,
but you go to scratch and there's nothing visible on the skin.

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I almost feel like there's like bugs crawling on you or inside of you or under your skin,
that there's definitely not anything there and you're still just really, really itchy.

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So that is a very common thing.

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We can also see a lot of issues with acne.

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Now acne also has a variety of root causes.

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So just because you have acne does not mean you have mass cell issues.

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So these are...

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This is also another thing.

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It's because these issues are so widespread, we have to dig into understanding why and
what is going on because a lot of these symptoms do overlap.

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And we do understand that.

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And also say from a marketing perspective, we do get a handful, I would say a ton, but a
handful of comments on a variety of videos, especially when we list symptoms of like,

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well, I have all of the things because I have all of these symptoms.

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And it's like, no, and a lot of symptoms overlap and a lot of symptoms also overlap
because

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If you're symptom managing and looking at bigger root causes, well, these bigger root
causes often cause similar issues and varieties of dysfunction within the body that

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present very, very similar, which is where working with someone on the bigger approach,
like root cause approach, which is what we do, can go such a long way in actually being

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able to heal and then, as we always say, more importantly, staying healed long-term.

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You also have mast cells in your hair follicles.

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This is another one and this is an interesting one.

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My partner who's going through chemo, know, his hair has started to hurt.

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He shaved his head and has shaved his head for a little while now, but he's like, my hair
follicles hurt.

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And you know, for me, the first thing I immediately think of is mass cell issues.

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It's not his hair is getting ready.

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He's starting to lose some of his hair.

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Not that he has a ton to begin with, but you know, on his head.

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So.

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But that's always the immediate thing that I think of whenever he says like, hair
follicle, it feels like my hair follicles hurt.

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Like, well, that is a very common mess up issue, but not necessarily in your case because
he's getting ready to lose his hair as a side effect of the chemo here.

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having almost feeling like your hair follicles hurt, like feeling like your hair hurts is
another pretty common one that can seem a little outrageous.

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And you can tell a lot of people and they can really just look at you like you're crazy.

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and you're not because that is there are mast cells in your hair follicles.

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So once again, not uncommon to see this.

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And then the last big place we'll see mast cells are in the nerves and nerve tissues and
then in the brain.

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So if we think about mast cells in your nerves, mean, nerve pain, all kinds of nerve pain.

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And once again, especially as a personal trainer, I dealt with a lot of chronic pain type
issues because I specialized in that for several years.

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And nerve pain can be nerves being blocked.

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can be structural kind of issues going on.

200
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I personally dealt with sciatica issues for many, many years.

201
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I lost feeling in my right leg.

202
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And then when the feeling did come back, was terribly painful and very uncomfortable.

203
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And sciatica was something I struggled with for a very long time before I figured out my
root passes and how to fix those.

204
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And that was not, those were both inside and outside of my body.

205
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but a lot of nerve issues, nerve pain, feeling just certain nerves are very, very
sensitive is often kind of the way it's described to me, but that is not uncommon.

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And then mast cells are in the brain.

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So of course we're gonna see cognitive issues, trouble focusing, trouble concentrating,
trouble with memory, trouble with recall, all those kinds of things that, you know.

208
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it can present similar to ADD or ADHD.

209
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And yes, I believe that is a real thing.

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And I also believe that many people are misdiagnosed because I've seen it.

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And I've seen people be diagnosed with ADD and or ADHD.

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And then we do a lot of the work and they no longer have any of those symptoms anymore.

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And it was because of mast cell typically mast cell and or toxin overload issues going on.

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that we were able to address and help their bodies heal so that they no longer have those.

215
00:19:29,349 --> 00:19:37,792
And that is not the case for everyone because I do, have worked with enough people at this
point that I do firmly believe in that.

216
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So just a little side note there, but I think it is overdiagnosed, especially in the adult
population right now.

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The other piece of the brain is neurotransmitter production and retransmitation.

218
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And because both the gut and the brain can be impacted here,

219
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we will often see a lot of mental and emotional struggles when it comes to mast cell
issues.

220
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I would say anxiety is probably a little bit more common and that doesn't mean depression
and OCD.

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Some of these other things can also present because I do also see all of those things.

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I would say anxiety is probably just the most prominent one that we will often see within
our practice when it comes to clients with mast cell issues.

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So when we look at kind of, so those are where mast cells are located.

224
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Now, what are the roles of mast cells?

225
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Now, we, already talked a little bit about a couple of these, but there's a couple that
other ones they do wanna go through that may explain a few other symptoms that you may be

226
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experiencing with mast cell issues.

227
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So obviously because mast cells are immune cells,

228
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they play a big role in our immune system.

229
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And most of our immune system is housed in our gut about 70, 70 to 80 percent, depending
on who you talk to.

230
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And so if our gut's already impacted and then our immune system is impacted, obviously
we're to have all kinds of immune issues.

231
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And this can honestly, this can go kind of both ways.

232
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One, you can get sick very, very often.

233
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Now, I've seen people, especially people over supplementing with vitamin D.

234
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go listen to our blood cell or blood testing part two episode if you want to dig more into
that vitamin D piece.

235
00:21:19,755 --> 00:21:28,118
But oversupplementing with vitamin D can heighten your immune system and so you can feel
better and you can almost never get sick.

236
00:21:28,118 --> 00:21:31,760
And that is also not necessarily a good thing.

237
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If you were never ever getting sick, that is also showing us some things going on in your
body that aren't quite right.

238
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Now you also should not be getting sick, you know.

239
00:21:42,608 --> 00:21:45,601
every month, every other month, like five or six times a year.

240
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I'd say once or twice is pretty standard, pretty normal for the average person,
especially, you know, if you have kids, young kids, maybe a little bit more as a starting

241
00:21:56,251 --> 00:22:01,826
point, but still it shouldn't be crazy, but we can definitely see immune function issues.

242
00:22:02,027 --> 00:22:04,569
Wound healing and tissue repair.

243
00:22:04,830 --> 00:22:07,764
So if you get a cut or a scrape,

244
00:22:07,764 --> 00:22:13,204
you might have trouble healing or it take you a really long time for it to heal.

245
00:22:13,204 --> 00:22:23,944
Maybe you're left with a scar that seems to be maybe a little bit more exaggerated than it
should be, quote unquote, it should be based on the level of the injury.

246
00:22:23,944 --> 00:22:26,264
So that can play a big role.

247
00:22:26,264 --> 00:22:36,392
The other thing we can see, and this is where sometimes iron issues can come into play and
people can come in and be like, oh, I just bruised really easily.

248
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and it's because of my iron levels.

249
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Maybe that could be playing a role and we'll often see people with mast cell issues have a
hard time healing, wound healing, and we'll often end up with a lot more bruising and the

250
00:22:52,186 --> 00:22:54,629
bruising lasts for a longer period of time.

251
00:22:54,629 --> 00:22:57,721
So once again, we just have to, we have to like look at the bigger picture.

252
00:22:57,721 --> 00:22:59,473
We also need to look at tests.

253
00:22:59,473 --> 00:23:03,236
We need to have a lab test to understand more as to...

254
00:23:03,412 --> 00:23:04,692
What is really going on?

255
00:23:04,692 --> 00:23:05,532
Why is it going on?

256
00:23:05,532 --> 00:23:06,872
How's it going on?

257
00:23:06,872 --> 00:23:09,692
What are the bigger things that we need to address here?

258
00:23:10,272 --> 00:23:11,412
Defending us from infections.

259
00:23:11,412 --> 00:23:14,852
Once again, you can get sick and sick very often.

260
00:23:14,852 --> 00:23:22,112
is, once again, like one of the more common symptoms that we'll see is just getting sick a
lot, a lot throughout the year.

261
00:23:22,232 --> 00:23:29,372
Building connective tissue, joint pain is a really big one that can come along with this.

262
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I'd say joint and or muscle pain.

263
00:23:30,852 --> 00:23:33,652
I'd say joint pain, probably a little bit more common.

264
00:23:33,726 --> 00:23:36,018
brain cognitive function issues.

265
00:23:36,018 --> 00:23:39,120
once again, you know, we can end up with those kinds of issues.

266
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cells also create new brain cells.

267
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So if we think about learning something new, trying to brain rewire, retrain our brain,
things like that can be very, very challenging if we're not creating these new brain cells

268
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because we've got mass cell issues.

269
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So that can be making it very challenging.

270
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And a question I get a lot is,

271
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You know, I just had a conversation with one of my personal clients here earlier this
week.

272
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you know, if we have all of these issues and our nervous system is dysregulated, do we
need to do the nervous system regulation first or do we need to do the other work first?

273
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And my answer is neither.

274
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We have to do both at the same time.

275
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And a big reason, especially with chronically ill people, especially with a lot of people
with mast cell issues is that

276
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our nervous system, when our nervous system is dysregulated, we can end up with all kinds
of stuff patterns and all of these issues.

277
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And yes, like we have to regulate our nervous system to be able to heal.

278
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And if we don't do the physical work to help stabilize our body, to help it heal
internally and physically, it can also be impossible to regulate our nervous system.

279
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And so it's a catch 22 of which one do you do first?

280
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It's neither.

281
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have to do both at the same time.

282
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Otherwise, what I have seen in my personal experience has been it once again, it's very
challenging to heal, fully heal and stay healed long term if you're not doing both.

283
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And mass law issues can play a really, really big role in this.

284
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And the last big one I wanted to mention is for the women, regulating our menstrual
cycles.

285
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And when we get to the histamine piece, I'm gonna dive deeper into this because once
again, I'm seeing a lot, we're getting a lot of questions.

286
00:25:32,089 --> 00:25:37,181
I'm seeing a lot of misinformation in regards to hormones and histamines.

287
00:25:37,461 --> 00:25:39,552
And once again, I think it's important to understand.

288
00:25:39,552 --> 00:25:46,785
So mass cells, one of their big roles is to regulate our menstrual cycles.

289
00:25:47,085 --> 00:25:54,704
So when we have menstrual cycle issues, it can, at least in part,

290
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not for everyone and for many people, be mast cell related.

291
00:25:58,996 --> 00:26:08,990
So if we, once again, if we only look at specific hormones, we're missing the bigger
picture here because if mast cells are playing a role, you can supplement, you can do all

292
00:26:08,990 --> 00:26:11,911
of the things you can supplement with all this stuff.

293
00:26:11,911 --> 00:26:15,973
You can do HRT, BHRT, all of these things.

294
00:26:16,233 --> 00:26:22,636
And you may never see real long lasting shifts in your hormones and in your menstrual
cycles.

295
00:26:22,962 --> 00:26:26,454
and it can be mast cell related.

296
00:26:27,135 --> 00:26:28,486
Something to think about here.

297
00:26:28,486 --> 00:26:32,498
And this is very, very common misunderstanding.

298
00:26:33,599 --> 00:26:44,126
So I'm gonna go through a very quick rundown of mast cell symptoms that we will often see
in some of many of these I've already mentioned, some of which I have not.

299
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And I also, once again, I just want to acknowledge just because you have a couple of these
symptoms,

300
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does not necessarily indicate that you have a mast cell issue.

301
00:26:56,160 --> 00:27:08,339
And if you do have a handful of these symptoms, it is absolutely worthwhile to dig a
little bit deeper into the mast cell piece here and understanding that piece and if that

302
00:27:08,339 --> 00:27:15,455
piece is playing a role with you and your body so that you can properly support your body
throughout the healing process.

303
00:27:15,675 --> 00:27:16,966
So here we go.

304
00:27:17,320 --> 00:27:29,679
Sinus pressure, sinus headaches, any sort of sinus issues, hives, rashes, sneezing,
congestion, post-nasal drip, any sort of this like nose, sinus congestion, all of that

305
00:27:29,679 --> 00:27:30,970
kind of stuff.

306
00:27:31,270 --> 00:27:34,102
Swelling, and this can be just generalized swelling.

307
00:27:34,102 --> 00:27:39,156
Hands and feet, I'd say are most common, and that is not necessarily the only places.

308
00:27:39,156 --> 00:27:44,960
All kinds of cognitive issues, joint pain, hypermobility issues, fatigue, inflammatory
issues,

309
00:27:45,108 --> 00:27:49,628
This is a big one to sensitivities to things.

310
00:27:49,628 --> 00:28:01,088
I'm just going to say across the board, I am going to list a few, a handful of these, but
this is a really common one to so sensitivities to smells light being around a lot of

311
00:28:01,088 --> 00:28:04,028
people, supplements, medications, EMFs.

312
00:28:04,028 --> 00:28:14,814
I've had many people come to us saying that you're going to think I'm crazy, but anytime I
get close to a router or around a cell phone tower, I just it feels like I'm

313
00:28:14,814 --> 00:28:18,707
buzzing on the inside, it's an EMF sensitivity.

314
00:28:18,908 --> 00:28:25,754
Heat, sun, and or other environmental factors, all kinds of food sensitivities, muscle and
or joint pain.

315
00:28:26,015 --> 00:28:30,724
Osteoporosis is a big one here.

316
00:28:30,724 --> 00:28:39,218
And once again, I think there's a lot of other factors for many other people, for many
people when it comes to osteopenia and or osteoporosis.

317
00:28:39,442 --> 00:28:50,237
Flushing, I'll also say like redness, like getting a really bright red and or flushing and
you know, kind of depending on where you flush, it may be more just presenting as bright

318
00:28:50,237 --> 00:28:58,650
red versus like a, if we think about flushing in the face, usually it's going to be more
cheek kind of area and then our lips will kind of stay the same color, which would

319
00:28:58,650 --> 00:29:00,221
indicate more flushing.

320
00:29:00,281 --> 00:29:04,923
Hair loss, I'll also say hair thinning, hair being really brittle, things like that.

321
00:29:04,923 --> 00:29:07,474
Skin issues, eczema, psoriasis.

322
00:29:07,580 --> 00:29:10,841
along with the rashes in the hives and or acne.

323
00:29:11,002 --> 00:29:13,603
Chest pain and or heart palpitations.

324
00:29:13,723 --> 00:29:17,945
Fainting and or dysontonomia type issues, including POTS.

325
00:29:17,945 --> 00:29:23,406
This is another pretty big one with people with more significant mast cell issues.

326
00:29:23,406 --> 00:29:27,449
We are commonly gonna come with some dysontonomia issues.

327
00:29:27,449 --> 00:29:33,772
Constipation and or diarrhea, acid reflux and or heartburn, abdominal pain, abdominal
cramping.

328
00:29:33,772 --> 00:29:34,246
uh

329
00:29:34,246 --> 00:29:38,279
all of those kind of digestive GI related kind of things.

330
00:29:38,279 --> 00:29:40,531
Headaches or migraines is another really common one.

331
00:29:40,531 --> 00:29:43,904
Tinnitus, so ringing in your ears, super, super common.

332
00:29:43,904 --> 00:29:47,647
uh Mental health struggles, anxiety, depression, OCD, things like that.

333
00:29:47,647 --> 00:29:50,155
Shortness of breath and or asthma.

334
00:29:50,155 --> 00:29:52,881
Once again, asthma can have many root causes.

335
00:29:52,881 --> 00:29:56,194
Just because you have asthma doesn't mean you have mast cell issues.

336
00:29:56,434 --> 00:30:00,147
And it's not uncommon to be very short of breath oftentimes.

337
00:30:00,147 --> 00:30:03,730
Once again, that feeling of you can't take a full and deep breath.

338
00:30:04,240 --> 00:30:06,841
and or a full on asthma attack.

339
00:30:07,182 --> 00:30:11,732
Painful periods and overall hormone imbalances just across the board.

340
00:30:11,732 --> 00:30:13,765
Once again, I'm gonna dive a little bit deeper into that.

341
00:30:13,765 --> 00:30:22,419
uh Urinary tract issues including pain and or UTIs, nausea, vomiting, rapid changes in
blood pressure that can go either way.

342
00:30:22,419 --> 00:30:29,092
I'll say more commonly it comes down versus up and I've seen it go up plenty of times.

343
00:30:29,336 --> 00:30:30,507
for all kinds of stuff.

344
00:30:30,507 --> 00:30:36,162
And when we think about when high blood pressure, we'll often look at minerals and mineral
balancing first.

345
00:30:36,162 --> 00:30:42,346
That is often a big root cause and we need to look at stress, of course, coming along with
nutrition and all that kind of stuff.

346
00:30:43,667 --> 00:30:50,422
So before I dive into how mast cells and histamine are related, I wanna talk about two
things.

347
00:30:50,422 --> 00:30:55,636
So one is testing for mast cell activation syndrome or MCAS.

348
00:30:57,374 --> 00:31:07,207
So when your mast cells become chronically dysregulated, we can end up with a quote
unquote disorder called mast cell activation syndrome, meaning that your mast cells are

349
00:31:07,207 --> 00:31:12,528
chronically activated and are turned on, which is not what they're supposed to do.

350
00:31:12,528 --> 00:31:20,731
They're supposed to turn on when they're supposed to, when the timing is right, and then
they're supposed to turn off when they're supposed to for a period of time.

351
00:31:20,731 --> 00:31:25,524
And the issue with mast cells really comes into play is when our mast cells become

352
00:31:25,524 --> 00:31:28,884
chronically dysregulated and are turned on.

353
00:31:29,004 --> 00:31:31,784
You know, this is really across the board when we see these issues.

354
00:31:31,784 --> 00:31:35,764
So, you know, we think about nervous system regulation issues, dysregulation issues.

355
00:31:36,044 --> 00:31:44,164
You know, we have these coping patterns and specific patterns, fight, flight, freeze,
fawn, that are normal and natural.

356
00:31:44,164 --> 00:31:47,844
And that is what our body is supposed to do.

357
00:31:48,044 --> 00:31:51,506
And the issue comes into play is when our body gets stuck.

358
00:31:51,506 --> 00:31:57,359
there and can't kind of flow in and out of the parasympathetic into the sympathetic state.

359
00:31:57,559 --> 00:31:59,761
And it's really similar with mast cell issues.

360
00:31:59,761 --> 00:32:05,743
We're supposed to kind of be able to flow in and out of these states where they turn on
when they're supposed to, and then they turn off when they're supposed to.

361
00:32:05,764 --> 00:32:15,259
But when they turn on chronically, when we talk about stress, and I'm gonna get it, that's
the other thing I want to talk about before I dive into the histamine piece, this is where

362
00:32:15,259 --> 00:32:17,770
the issue really comes into play.

363
00:32:17,890 --> 00:32:20,712
And so in order to test,

364
00:32:21,703 --> 00:32:33,159
for MCAS and kind of get a more official diagnosis, typically I'll recommend going either
to an allergist or some sort of immune specialist.

365
00:32:33,159 --> 00:32:34,690
Not all of them will test.

366
00:32:34,690 --> 00:32:40,803
I'll tell you, even all of them know what mast cell issues are and or what MCAS is.

367
00:32:40,803 --> 00:32:51,649
So do some research, do your due diligence before scheduling an appointment and also
recognize that, especially with these more specialized types of people,

368
00:32:52,005 --> 00:32:58,488
you're going to wait a good amount of time usually to get an appointment with them, let
alone to be able to test for this.

369
00:32:58,488 --> 00:33:02,969
So there are some blood markers that can be run.

370
00:33:03,870 --> 00:33:15,695
However, it's not always super accurate and you have to be in a very, very active flair to
test positive.

371
00:33:15,695 --> 00:33:20,137
And I've had several people go through the process to get properly tested.

372
00:33:20,273 --> 00:33:24,465
and get the official diagnosis because it was very important to them, which I totally get,
totally understand.

373
00:33:24,465 --> 00:33:36,602
And it was so miserable and they almost always regretted it because the support that
they're getting afterwards is not great.

374
00:33:36,943 --> 00:33:47,799
And the amount of pain and discomfort they had to go through to get the diagnosis was
significant to say the least and lasted for a significant period of time.

375
00:33:48,227 --> 00:33:54,892
So you have to be in an active flare, meaning you have to purposely put yourself into a
flare and that can be a variety of things.

376
00:33:54,892 --> 00:34:04,828
You also have to be off all antihistamines, any sort of immune modulators, which can also
be very uncomfortable for many people when you have mast cell issues.

377
00:34:04,828 --> 00:34:06,430
So keep that in mind.

378
00:34:06,430 --> 00:34:10,612
And usually you have to be off of those for at least seven to 14 days.

379
00:34:10,612 --> 00:34:15,365
And then once again, put yourself in an active flare to be properly tested.

380
00:34:15,365 --> 00:34:17,817
And once again, the testing is not super accurate.

381
00:34:17,821 --> 00:34:28,281
Always in my personal opinion, I fully support, know, if someone's really passionate about
getting this diagnosis, I'm totally on board with that and happy to support before,

382
00:34:28,281 --> 00:34:30,401
during, and after this process.

383
00:34:31,441 --> 00:34:38,521
And, you know, the medications that they'll often get don't do a whole lot.

384
00:34:38,521 --> 00:34:41,049
And so often it's not worthwhile.

385
00:34:41,049 --> 00:34:42,991
So that is something to think about.

386
00:34:42,991 --> 00:34:46,649
It's not something we do in our practice, because once again, it's a symptom.

387
00:34:46,649 --> 00:34:56,381
I can tell if someone has mast cell issues just by talking to them, and then we can see
inflammatory issues and other things like that in blood work among other testing.

388
00:34:56,381 --> 00:34:58,663
So we personally don't test.

389
00:34:58,663 --> 00:35:00,944
I'm not a huge fan of testing.

390
00:35:01,525 --> 00:35:06,429
In my opinion, it's not usually worth the cost that it takes.

391
00:35:06,429 --> 00:35:10,411
And I'm not talking monetarily costs, I'm talking for you to go through that process.

392
00:35:10,411 --> 00:35:15,375
And then usually it takes anywhere between two to four weeks uh to recover from that too.

393
00:35:15,375 --> 00:35:22,580
So, I mean, you're putting yourself out for potentially like a month, month and a half,
depending on you and your body and all that kind of stuff.

394
00:35:22,580 --> 00:35:25,983
And once again, if someone wants to do it, fully support that process.

395
00:35:25,983 --> 00:35:31,947
And typically it's not something we will openly recommend because it mass cell issues are
a symptom.

396
00:35:32,387 --> 00:35:35,129
So that's what testing usually looks like.

397
00:35:36,303 --> 00:35:45,561
Now let's talk about the stress piece here because once again I think there's just a lot
of misconceptions about stress and when people talk about stress then all the things when

398
00:35:45,561 --> 00:35:56,660
it comes to stress you know we think about external stresses you know a great example in
my own life right now you know my partner this person that I love so much has cancer and

399
00:35:56,660 --> 00:36:05,607
is going through chemo to destroy his body and it's a lot you know and understandably
there's no control over this it oh

400
00:36:05,607 --> 00:36:08,078
happened and we're going through the process.

401
00:36:08,078 --> 00:36:14,492
He's responding really well, which is very fortunate and great to hear his last PET scan
was awesome, which is so good.

402
00:36:14,492 --> 00:36:23,477
And at the same time, he still is going through 12 rounds of chemotherapy and all of the
side effects and all of the things that kind of come along with that.

403
00:36:23,477 --> 00:36:27,030
That's physical, mental, emotional, all that kind of stuff.

404
00:36:27,030 --> 00:36:30,602
so stress is high and that is a non controllable.

405
00:36:30,602 --> 00:36:33,145
I have zero control over that.

406
00:36:33,145 --> 00:36:35,027
It is, there is nothing we can do.

407
00:36:35,027 --> 00:36:41,192
We are doing everything in our power to support him, to support me, to support this whole
situation.

408
00:36:41,192 --> 00:36:43,705
And it's just a stressful situation.

409
00:36:43,705 --> 00:36:48,939
And here's the thing, stressful situations happen and they're always gonna happen.

410
00:36:49,040 --> 00:36:51,462
There are so many uncontrollables in life.

411
00:36:51,462 --> 00:36:59,663
And so for me, when I think about stress and how to manage stress, and one of the things
that has helped me so much, especially with all of my chronic issues,

412
00:36:59,663 --> 00:37:05,455
And if you know my story, spent years and years and years trying to regulate cortisol
levels.

413
00:37:05,455 --> 00:37:16,120
The level of trauma I've been through is pretty high and to regulate my nervous system has
been a whole process and continues to be a process and something that I really focus on.

414
00:37:17,333 --> 00:37:22,903
And that gives me more capacity for stress.

415
00:37:23,243 --> 00:37:26,434
And when we think about stress, I like the analogy of a stress bucket.

416
00:37:26,434 --> 00:37:27,791
So let's talk about

417
00:37:27,791 --> 00:37:30,932
you know, are things that can be stressful inside and outside of the body?

418
00:37:30,932 --> 00:37:33,182
So obviously uncontrollable situations.

419
00:37:33,643 --> 00:37:38,854
Well, there are some controllable situations in here that just cause extra stress, you
know?

420
00:37:38,854 --> 00:37:47,106
And then once again, some of these are controllable, some of them are not controllable and
uncontrollable stressors, external stressors are going to happen throughout our entire

421
00:37:47,106 --> 00:37:47,396
life.

422
00:37:47,396 --> 00:37:57,051
And so it's how do we set ourselves up to be able to handle that for our bodies, to be
able to handle that and not go into these crazy flares of any sort, whether that's

423
00:37:57,051 --> 00:38:07,879
know, autoimmune, eczema, psoriasis flares, uh know, mast cell flares, cortisol flares,
whatever it may be, how do we make sure that our body doesn't go through that?

424
00:38:07,879 --> 00:38:10,981
And that's, need to look at the total stress picture.

425
00:38:10,981 --> 00:38:13,933
And we do have a lot of control over a lot of these stressors.

426
00:38:14,414 --> 00:38:16,135
So we have external stressors.

427
00:38:16,135 --> 00:38:25,181
We also have, we talk about basic internal stressors, nutrient deficiencies, eating a lot
of inflammatory foods and that...

428
00:38:25,181 --> 00:38:34,181
super depends on the person and I'm not talking let's eat 100 % paleo or whole 30 all of
the time because it's super anti-inflammatory.

429
00:38:34,181 --> 00:38:43,841
No, I also think that can be a stressor in and of itself, which is why we don't typically
recommend elimination diets or restrictive dieting within our practice.

430
00:38:44,581 --> 00:38:52,381
And we also do need to look at food and food quality and making sure we're getting, you
know, a couple of things I always look at.

431
00:38:52,381 --> 00:38:53,841
Are we getting enough calories?

432
00:38:53,841 --> 00:38:56,261
Are we eating too many calories potentially?

433
00:38:56,261 --> 00:38:58,062
Are we getting enough essential nutrients?

434
00:38:58,062 --> 00:38:59,553
Proteins and fats are essential.

435
00:38:59,553 --> 00:39:02,083
Carbohydrates technically are not.

436
00:39:02,083 --> 00:39:06,525
And especially for many people, especially for menstruating women, we need some carbs.

437
00:39:06,525 --> 00:39:10,466
I find most people do much better with carbs than without.

438
00:39:10,606 --> 00:39:14,397
And without carbs can be quite stressful.

439
00:39:14,397 --> 00:39:17,468
I'd say postmenopausal women, little different.

440
00:39:17,468 --> 00:39:20,248
And sometimes we'll see a lower carbohydrate diet.

441
00:39:21,693 --> 00:39:25,433
actually be a little bit more supportive and a little bit more anti-inflammatory.

442
00:39:26,073 --> 00:39:32,253
You know, so, so all of that, all of the chemicals in food, are you cooking all of your
food in plastic and on Teflon?

443
00:39:32,253 --> 00:39:35,513
Like what, what about toxin levels, toxin exposure?

444
00:39:35,513 --> 00:39:38,413
Do you live in a place with a bunch of mold?

445
00:39:38,413 --> 00:39:40,513
What about heavy metal levels?

446
00:39:40,513 --> 00:39:42,733
Are you using a bunch of things where you're being exposed to heavy metals?

447
00:39:42,733 --> 00:39:49,133
What about all the endocrine disruptors and skincare products and beauty products are
being exposed to that?

448
00:39:49,133 --> 00:39:51,533
All of that is very stressful on the body.

449
00:39:51,697 --> 00:39:53,377
Are we getting enough sleep?

450
00:39:53,518 --> 00:39:55,738
And once again, that super depends on the person.

451
00:39:55,738 --> 00:39:59,139
For me, I like a good eight to nine hours.

452
00:39:59,139 --> 00:40:04,201
I can do okay with seven and my body very much prefers eight to nine.

453
00:40:04,201 --> 00:40:07,542
Are we getting quality sleep?

454
00:40:07,542 --> 00:40:11,693
Are we breathing appropriately and enough?

455
00:40:11,693 --> 00:40:19,545
You know, a lot of people who are under a lot of stress, we are chest breathing and not
breathing fully and deeply and getting the level of oxygen that we really need.

456
00:40:20,061 --> 00:40:22,181
And that is a stressor.

457
00:40:22,181 --> 00:40:23,681
Are we drinking enough water?

458
00:40:23,681 --> 00:40:26,861
Are we getting some natural light in our eyes?

459
00:40:26,861 --> 00:40:29,601
Are we sitting all day every day?

460
00:40:29,601 --> 00:40:31,761
What is your history of antibiotic use?

461
00:40:31,761 --> 00:40:33,481
How many medications are you on?

462
00:40:33,481 --> 00:40:35,261
How many supplements are you on?

463
00:40:35,261 --> 00:40:39,121
Keep in mind, all supplements and medications have to go through the liver.

464
00:40:39,261 --> 00:40:41,781
What other kind of stress are we putting on the liver?

465
00:40:41,961 --> 00:40:43,621
Are we drinking a lot?

466
00:40:43,621 --> 00:40:45,701
What are our coping mechanisms?

467
00:40:45,701 --> 00:40:46,901
Are we going on walks?

468
00:40:46,901 --> 00:40:49,221
Do we have chronic pain and inflammation?

469
00:40:49,231 --> 00:40:52,852
Why do we have all of that, but all of that is stressful all at the same time?

470
00:40:52,852 --> 00:40:56,023
Are we overdoing it on the caffeine?

471
00:40:56,403 --> 00:40:58,394
What is our relationships like?

472
00:40:58,394 --> 00:41:02,635
Are we the person who takes care of everything for everyone else?

473
00:41:02,635 --> 00:41:05,805
And maybe we don't do a great job at caring for ourselves.

474
00:41:05,926 --> 00:41:07,446
That is a stressor.

475
00:41:07,446 --> 00:41:10,067
Do you have a way to manage stress?

476
00:41:10,067 --> 00:41:11,457
Have you been through a lot of trauma?

477
00:41:11,457 --> 00:41:17,041
Are you stuck in chronic nervous system dysregulation, trauma based patterns?

478
00:41:17,041 --> 00:41:20,623
Are you chronically people pleasing and over giving of yourself?

479
00:41:20,623 --> 00:41:22,153
Are you, how do you fill up your cup?

480
00:41:22,153 --> 00:41:22,924
Is your cup full?

481
00:41:22,924 --> 00:41:26,585
Are you consistently giving from an empty cup?

482
00:41:27,386 --> 00:41:31,227
All of these things are stressors.

483
00:41:31,587 --> 00:41:36,800
And so I think we just need to expand this definition of what stress is.

484
00:41:36,800 --> 00:41:39,661
And when we look at, you know, I like to think about a bucket.

485
00:41:39,661 --> 00:41:40,852
We all have a bucket.

486
00:41:40,852 --> 00:41:44,253
By the way, all of our buckets are different sizes too.

487
00:41:44,253 --> 00:41:48,713
You may have a teeny tiny bucket, in which case you overfill really quickly.

488
00:41:48,713 --> 00:41:55,273
You may have a giant bucket, in which case you're handle a whole bunch and not feel super
stressed and your body may not feel super stressed.

489
00:41:55,273 --> 00:41:56,233
And that's amazing.

490
00:41:56,233 --> 00:41:58,113
And you might be somewhere in between.

491
00:41:58,473 --> 00:42:01,413
We can also change the size of our buckets, by the way.

492
00:42:01,413 --> 00:42:03,173
And we'll talk about that here in a sec.

493
00:42:03,173 --> 00:42:09,853
But if we're putting all of these stressors inside of this bucket, at some point it's
gonna start to overflow.

494
00:42:10,053 --> 00:42:12,733
And when it starts to overflow,

495
00:42:12,965 --> 00:42:15,626
is when we'll start to see these issues.

496
00:42:15,626 --> 00:42:23,880
And this is really where the mass cell issues can come into play is when we're throwing
all of these things in our bucket and our bucket is constantly overfilled and overflowing,

497
00:42:23,880 --> 00:42:27,551
because our body cannot keep up, cannot handle all of this.

498
00:42:27,891 --> 00:42:36,785
This is when we look at stress and mass cell issues, this is really the way I like to look
at it is, okay, what are all of the stressors that are going on right now?

499
00:42:36,785 --> 00:42:41,179
And especially when things started, like what was that?

500
00:42:41,179 --> 00:42:44,411
that moment, that period of time and things kind of started.

501
00:42:44,411 --> 00:42:55,775
And once again, we'll often see a significant increase in stress around that time and
stress, it could be one or many of these variety of things that can happen here.

502
00:42:56,936 --> 00:43:08,221
When we start to decrease our stress and really do this systemically inside of our body,
really caring for our liver, really caring for like hydration levels,

503
00:43:08,221 --> 00:43:15,841
getting all of our nutrients, getting proper sleep, that piece alone can help our bucket
become a little bit bigger.

504
00:43:15,841 --> 00:43:21,621
One, it's taking things out of our bucket and it can give us more capacity within our
bucket itself.

505
00:43:21,981 --> 00:43:33,421
I'll also say, for me specifically, and I've been in this industry for over a decade, so
even when I had all my chronic issues, I had really solid foundation I was coming in from.

506
00:43:33,701 --> 00:43:38,121
And the nervous system piece and the trauma healing piece,

507
00:43:39,035 --> 00:43:44,989
That is the real way, in my opinion, to really increase the size of your bucket.

508
00:43:45,790 --> 00:43:56,338
As I do deeper and deeper healing work and really make potentially some tough choices, you
know, if I look at my life last year and all of the changes and all of the shifts of

509
00:43:56,338 --> 00:44:05,245
leaving a marriage, selling a house, like leaving my life, leaving the place I had lived
for essentially my entire adult life, leaving the people that I was around.

510
00:44:05,713 --> 00:44:06,934
That was very stressful.

511
00:44:06,934 --> 00:44:18,963
And I'll tell you that my bucket got a lot bigger when I left and when my situation, when
I made the tough decisions to make a lot of these changes and my bucket, you know, if I

512
00:44:18,963 --> 00:44:24,106
look from now, I'm almost coming up on a year since I laughed, which is crazy.

513
00:44:24,307 --> 00:44:27,233
And just a while to look at my last year.

514
00:44:27,233 --> 00:44:32,733
But if I look at kind of where I feel like my, how big my bucket was last year,

515
00:44:32,733 --> 00:44:38,153
coming last June when I left versus where it is now, my bucket's definitely way bigger.

516
00:44:38,153 --> 00:44:52,393
And I feel like I, while not perfect, feel like my body's very much handled the stress of
all of our current situations and with my partner and the cancer, we're going through a

517
00:44:52,393 --> 00:44:56,353
lot of business shifts right now and changes and all that kind of stuff, which is amazing
and great.

518
00:44:56,353 --> 00:44:58,273
And yes, it is also quite stressful.

519
00:44:58,273 --> 00:45:01,333
And there's just a lot going on, lot of moving pieces.

520
00:45:02,429 --> 00:45:09,749
and I can handle it, my body, I'm not going into crazy cortisol dysregulation type issues.

521
00:45:09,749 --> 00:45:17,929
I don't feel this internal sense of doom or crazy sense of overwhelm or crazy sense of
anxiety.

522
00:45:18,989 --> 00:45:24,409
My sleep largely is still really, really, really good.

523
00:45:24,409 --> 00:45:30,149
And that doesn't mean I don't have an occasional night where it's maybe not the best for
some reason.

524
00:45:30,149 --> 00:45:33,652
And I think that's totally normal and totally natural to happen every once in a while.

525
00:45:33,652 --> 00:45:35,975
And it's not a regular thing that happens for me.

526
00:45:35,975 --> 00:45:37,456
And so that's a huge thing.

527
00:45:37,456 --> 00:45:47,916
know, with all this stuff going on my thyroid, I'm not having any thyroid issues from, you
know, chronic fatigue issues or the cognitive issues, hair loss, like none of that is

528
00:45:47,916 --> 00:45:56,373
happening, which once again, with the history of autoimmunity, history of thyroid issues,
I'm pretty amazing that none of that has flared up.

529
00:45:56,441 --> 00:46:00,183
And once again, you know, I've got some, I would consider mild hormone imbalances.

530
00:46:00,183 --> 00:46:01,481
They're not crazy.

531
00:46:01,481 --> 00:46:04,035
And I can tell they're off and they're not the best.

532
00:46:04,035 --> 00:46:07,577
My progesterone is just a little bit lower than feels good for me.

533
00:46:07,577 --> 00:46:11,025
And that is definitely playing a role in my overall health.

534
00:46:11,025 --> 00:46:13,800
And I can feel it, especially in the second half of my cycle.

535
00:46:13,800 --> 00:46:19,233
And if that's really the only thing, I'm like pretty okay with it.

536
00:46:19,233 --> 00:46:20,664
And it's not the biggest deal for me.

537
00:46:20,664 --> 00:46:24,478
And that's because my bucket is much larger than it used to be.

538
00:46:24,478 --> 00:46:26,321
And I just have so much more comp-

539
00:46:26,321 --> 00:46:29,342
capacity for quote unquote stress.

540
00:46:29,782 --> 00:46:36,124
And so yeah, what for me like the more someone regulates their nervous system, the bigger
the bucket is.

541
00:46:36,124 --> 00:46:42,786
And so that's a real tool and strategy to help increase the capacity of your bucket.

542
00:46:42,786 --> 00:46:46,287
So mass issues triggered by stress.

543
00:46:46,287 --> 00:46:52,028
When we think about the stress, we think about the whole bucket and everything that's
going into the bucket and then also the size of your personal bucket.

544
00:46:52,028 --> 00:46:54,229
So those are all some some things to think about.

545
00:46:54,767 --> 00:46:57,329
So then we'll begin into the histamine piece.

546
00:46:57,329 --> 00:46:58,619
So how does this relate?

547
00:46:58,619 --> 00:47:14,909
Well, when mast cells are chronically turned on, chronically dysregulated, they will often
start producing histamine and high levels of histamine, which is why when we think about

548
00:47:14,909 --> 00:47:21,653
histamine issues, one of the first things I always dig into, especially from a symptom
perspective is

549
00:47:21,775 --> 00:47:26,356
Okay, is this really just from a mast cell issue that's then triggering histamine issues?

550
00:47:26,356 --> 00:47:33,688
And we really need to stabilize the mast cells to address the histamine issues versus
looking at the histamine issues alone.

551
00:47:34,369 --> 00:47:49,179
And that is a crucial piece that most people who are talking about chronic histamine
issues do not understand and are severely missing the boat.

552
00:47:49,179 --> 00:47:53,970
when it comes to helping people heal from these histamine related issues.

553
00:47:54,150 --> 00:48:01,112
Now, just because you have histamine issues does not mean you have mast cell issues.

554
00:48:01,112 --> 00:48:09,194
And it is the first place I would recommend starting, especially if you have a bunch of
chronic type issues.

555
00:48:09,255 --> 00:48:11,455
Let's rule out the mouse mast cell issues.

556
00:48:11,455 --> 00:48:18,907
And then let's, if we decide that there are mast cell issues, okay, looking at the bigger
picture, why do we have mast cell issues in the first place?

557
00:48:19,133 --> 00:48:25,218
And when we look at all of this mold needs to be rolled out first and foremost, not saying
mold is the only root cause of this.

558
00:48:25,218 --> 00:48:29,441
And if mold is present, mycotoxins are present within the body.

559
00:48:29,822 --> 00:48:32,304
Nothing else matters until we get rid of that.

560
00:48:32,304 --> 00:48:42,202
And feel free to go back and listen to our three part mold episode or get the masterclass
because we, do dive a lot, a lot more into this mold piece, which once again, I'm not

561
00:48:42,202 --> 00:48:47,135
going to really touch on this other than we need to roll that in or out first.

562
00:48:47,836 --> 00:48:48,717
So.

563
00:48:49,285 --> 00:48:52,697
Masseau issues, MCAS definitely play a big role in histamine issues.

564
00:48:52,697 --> 00:49:00,463
We can also just have an overload of histamine related issues, meaning our body's
producing too much histamine for whatever reason.

565
00:49:00,463 --> 00:49:09,219
And I'll say the biggest reason I often see with this is gut overgrowth issues,
specifically parasite overgrowth issues.

566
00:49:09,219 --> 00:49:15,613
And once again, really important to understand, and I'll just, I'm gonna breeze over this
just really quickly.

567
00:49:15,613 --> 00:49:18,481
We've done two episodes on parasites.

568
00:49:18,481 --> 00:49:28,764
Go listen to those if you want to dig a little bit more into this, but parasites are known
to really dysregulate and start to produce and increase histamine and histamine related

569
00:49:28,764 --> 00:49:30,065
type symptoms.

570
00:49:30,065 --> 00:49:38,427
This was the big thing for me is my parasite load was crazy high and missed because most
people don't know how to test for it.

571
00:49:38,427 --> 00:49:43,665
Stool testing, blood testing, direct blood testing, not great ways to look at parasites.

572
00:49:43,665 --> 00:49:50,827
We really want to look at the differential part of a CBC and look at the monocytes,
deosinophils and basophils to look at parasite load.

573
00:49:50,827 --> 00:49:53,348
And even that is not perfect.

574
00:49:53,348 --> 00:49:58,989
There is no, and in my, all of my education and practice, there's no perfect way to look
at parasites.

575
00:49:58,989 --> 00:50:01,950
Symptoms also can go a long way when we look at this.

576
00:50:01,950 --> 00:50:04,871
So parasites can be a really, really big one here.

577
00:50:04,991 --> 00:50:07,932
Another big piece is a lack of DAO.

578
00:50:07,932 --> 00:50:13,597
So DAO is something that our body naturally produces and DAO breaks down histamine.

579
00:50:13,597 --> 00:50:15,319
It's a big thing that it does.

580
00:50:15,319 --> 00:50:17,751
And you can find DAO in a variety of things.

581
00:50:17,751 --> 00:50:20,824
The most common thing that we'll often see it in is kidney.

582
00:50:20,824 --> 00:50:34,716
So if you think about like a beef kidney, kidney type supplements, bovine, you know,
bovine, is beef, uh bovine kidney, these are the primary DAO supplements that are

583
00:50:34,716 --> 00:50:35,697
typically recommended.

584
00:50:35,697 --> 00:50:39,348
lot of people come to us on kidney because they're like, this is gonna break down on my
histamine.

585
00:50:39,348 --> 00:50:41,001
I'm like, yes, and.

586
00:50:41,251 --> 00:50:44,723
might be some other stuff going on that we might want to look at and not that that's bad.

587
00:50:44,904 --> 00:50:47,786
It can absolutely help, especially if you have some seasonal allergies.

588
00:50:47,786 --> 00:50:51,514
DAO, just a little extra DAO can go a long way for a lot of people.

589
00:50:51,514 --> 00:50:58,943
It's very natural and it's, you know, some people only need that for a short period of
time and then they don't have to worry about allergy meds or anything like that.

590
00:50:58,943 --> 00:51:02,456
Just take some kidney for a few weeks and be good to go.

591
00:51:02,456 --> 00:51:08,430
And the lack of DAO, you know, once again, the question is, okay, but why are we not
producing enough DAO?

592
00:51:08,430 --> 00:51:09,961
And, and, or

593
00:51:10,053 --> 00:51:18,446
are you overproducing histamine and also not producing enough DAO, in which case we can
have a very high histamine load and we need to look at nutrient deficiencies and why

594
00:51:18,446 --> 00:51:21,617
nutrient deficiencies and gut overgrowth and all these other things.

595
00:51:21,878 --> 00:51:33,622
The other important thing to understand when it comes to histamine levels and histamine in
general is estrogen and histamine attach to the same receptors.

596
00:51:33,943 --> 00:51:39,745
So there's a lot of people talking about histamine, histamine levels,

597
00:51:40,313 --> 00:51:46,156
mental and emotional health when it comes to histamine levels in regards to our menstrual
cycles.

598
00:51:46,156 --> 00:51:48,608
And this is really specifically for menstruating women.

599
00:51:48,608 --> 00:51:57,503
Well, let's for sure add in perimenopausal type women because we can't see histamine
issues increase also during perimenopause.

600
00:51:57,503 --> 00:52:07,338
And this is for a few different reasons and there's a few different mechanisms and largely
depends on the person as to why this is happening, especially when it increases and gets

601
00:52:07,338 --> 00:52:09,429
worse during perimenopause.

602
00:52:09,771 --> 00:52:17,717
and just doing hormone work during perimetopause because of histamine levels, once again,
like we're missing the bigger picture here.

603
00:52:18,278 --> 00:52:32,989
So if we have estrogen dominance, and I use that term pretty loosely here because estrogen
dominance is actually not as common as you might think.

604
00:52:33,570 --> 00:52:38,726
And when we actually do testing, blood testing is not good for hormones.

605
00:52:38,726 --> 00:52:41,566
It's just, is not, not, not good.

606
00:52:41,566 --> 00:52:53,332
I would never recommend anyone do anything from, especially from an estrogen standpoint
and trying to oh detox or lower estrogen levels just based on blood work.

607
00:52:53,332 --> 00:53:04,997
That is a huge mistake because estrogen and progesterone levels especially change so much
day to day, week to week, hour by hour, minute by minute.

608
00:53:04,997 --> 00:53:08,758
And just looking at a moment in time, which is what blood work is,

609
00:53:08,952 --> 00:53:14,884
is not an accurate measure when it comes to sex hormones, especially in menstruating
women.

610
00:53:15,165 --> 00:53:26,059
So estrogen dominance, meaning that is a true estrogen dominance, meaning that
progesterone looks good, testosterone looks good, and it is really just estrogen that is

611
00:53:26,059 --> 00:53:32,872
significantly high and not being, we'll say detox or metabolize out of the body
appropriately.

612
00:53:32,872 --> 00:53:38,534
And the question here is, okay, or is our body producing too much estrogen?

613
00:53:39,088 --> 00:53:40,629
which is something else to look at.

614
00:53:40,629 --> 00:53:42,239
Why is our body producing too much estrogen?

615
00:53:42,239 --> 00:53:43,630
It's definitely trying to fix something.

616
00:53:43,630 --> 00:53:55,566
The question was why and what, and or are we not metabolizing and or detoxing, depending
on the verbiage you would like to use, enough of the estrogen out.

617
00:53:55,566 --> 00:54:05,006
We can also, there's also many varieties of estrogen pathways, which is where some of the
functional medicine testing is so valuable when it comes to sex hormones.

618
00:54:05,006 --> 00:54:06,357
and sex hormone metabolites.

619
00:54:06,357 --> 00:54:09,570
We think about something like the Dutch test, which is a urine test.

620
00:54:09,570 --> 00:54:12,132
It's either an all month or an all day test.

621
00:54:12,132 --> 00:54:19,517
So we get a really, really solid view of hormone levels and really truly where they are.

622
00:54:19,786 --> 00:54:30,682
And also, excuse me, how they're being metabolized because not all estrogen metabolism
pathways are ideal.

623
00:54:30,682 --> 00:54:38,484
there are some non-ideal ones and some ones that can be a little bit more dangerous and
can trigger some issues.

624
00:54:38,484 --> 00:54:49,487
And we do know that there is a uh one specific pathway that is known to turn on and
contribute to estrogen-based breast cancer.

625
00:54:49,507 --> 00:54:53,488
And so we can kind of see that and that cancer is very, very complex.

626
00:54:53,488 --> 00:54:59,410
And we do know this pathway, this one specific pathway that does show up in the Dutch
test.

627
00:54:59,706 --> 00:55:00,756
can be very dangerous.

628
00:55:00,756 --> 00:55:04,110
And so we need to understand estrogen levels.

629
00:55:04,110 --> 00:55:13,517
Do we have true estrogen dominance and or do we have estrogen just going through the wrong
pathways which can also trigger some histamine type issues or what is actually more

630
00:55:13,517 --> 00:55:14,818
common.

631
00:55:14,818 --> 00:55:19,101
And this is why it's so dangerous to mess with your hormones.

632
00:55:19,101 --> 00:55:24,934
And I see too many people in the quote unquote health space.

633
00:55:24,934 --> 00:55:37,458
and this is largely people who are uneducated in the functional medicine space, especially
in the functional testing space, recommend DIM, D-I-M, which is known to help support

634
00:55:37,458 --> 00:55:40,859
extra estrogen out of the body.

635
00:55:40,893 --> 00:55:52,322
And here's the thing, if you present with estrogen dominant symptoms, one of the big ones
is breast tenderness, which is pretty darn common when it comes to menstruating women.

636
00:55:52,708 --> 00:55:55,220
It actually may not be an estrogen dominance issue.

637
00:55:55,220 --> 00:56:07,569
It may actually be just a lowered progesterone issue that can then lead to symptoms of
estrogen dominance because the ratio of estrogen to progesterone is way off.

638
00:56:07,569 --> 00:56:14,914
And so you're presenting as estrogen dominant, even though you actually, when we test, you
are not.

639
00:56:15,074 --> 00:56:20,678
And if we do use something like DIM when we're not actually truly estrogen dominant,

640
00:56:20,678 --> 00:56:29,378
Now we're decreasing our estrogen too and then our hormones are going to be really low and
that is very stressful on the body.

641
00:56:29,378 --> 00:56:34,078
And that can be very challenging to come back from.

642
00:56:34,198 --> 00:56:44,398
I, and once again, I say this as someone who's just seen too many people injured by people
who are not super well educated, especially when it comes to hormones, be put on something

643
00:56:44,398 --> 00:56:50,104
like DIM, DIM in particular, and they shouldn't be, and they've been hurt.

644
00:56:50,104 --> 00:56:50,975
as a result of that.

645
00:56:50,975 --> 00:57:02,263
So just be very, very, very careful and make sure you get the proper testing done before
supplementing with anything that can mess, really directly mess with your hormones.

646
00:57:02,263 --> 00:57:12,530
If you are also doing any sort of hormone supplementation, please start really low, really
slow and make sure you're checking in regularly with whoever you're working with because

647
00:57:12,530 --> 00:57:13,570
hormones are.

648
00:57:13,754 --> 00:57:21,270
very sensitive and once again, was in pre, I was in perimenopause before the age of 30 and
was able to reverse myself naturally out of that.

649
00:57:21,270 --> 00:57:24,263
And it's not, I mean, it's not fun.

650
00:57:24,263 --> 00:57:29,807
You do not, you do not want to be messing with your hormones in way that's not actually
supportive of your body.

651
00:57:29,807 --> 00:57:31,929
So just be very careful with that.

652
00:57:32,850 --> 00:57:37,644
So when we think about common histamine symptoms, there's quite a few here.

653
00:57:37,644 --> 00:57:42,950
You know, the sneezing, the nasal congestion, sinus pressure, sinus headache, headaches
and migraines, rashes, hives, eczema.

654
00:57:42,950 --> 00:57:47,552
So why is this itching, the flushing, difficulty breathing, things like that.

655
00:57:47,812 --> 00:57:58,718
Now, then we also can think of a lot of less obvious type symptoms that get into kind of
really overlap here with the mass cell issues.

656
00:57:58,718 --> 00:58:05,721
And once again, am gonna get into this hormone piece, continue to get into this hormone
piece a little bit deeper here, going over these symptoms.

657
00:58:05,781 --> 00:58:07,866
So less obvious symptoms.

658
00:58:07,866 --> 00:58:19,204
that can still present as histamine-related type symptoms, bloating, abdominal pain, bowel
movement issues, gas, nausea, vomiting, anxiety, depression, OCD, irritability, dizziness,

659
00:58:19,204 --> 00:58:30,712
blood pressure issues, especially the low blood pressure, heart palpitations,
palpitations, irregular heartbeats, fatigue, sleep issues, joint pain, and then hormonal

660
00:58:30,712 --> 00:58:36,226
shifts that can present as something like PMDD,

661
00:58:36,674 --> 00:58:47,449
Um, you know, especially like increased irritability, uh, within your cycle, uh,
especially in the second half of your cycle, just a lot of irritability, a lot of people

662
00:58:47,449 --> 00:58:52,221
almost feeling like, you know, you feel like pretty decent during the first half of your
cycle.

663
00:58:52,221 --> 00:59:02,876
And then you're turning into a totally different person in the second half of your cycle,
usually about seven to 14 days before the start of your period is, kind of usually what

664
00:59:02,876 --> 00:59:04,056
this looks like.

665
00:59:05,390 --> 00:59:13,958
And this is where a lot of people are coming in with the histamine related issues, where
if you feel like this other person with PMDD and you just like take a Zyrtec or take an

666
00:59:13,958 --> 00:59:17,211
Allegra, this is the way to fix it.

667
00:59:17,211 --> 00:59:19,132
And you notice all your symptoms go away.

668
00:59:19,132 --> 00:59:22,024
Cool.

669
00:59:22,465 --> 00:59:28,110
It's a great test to understand, okay, is this playing a role?

670
00:59:28,110 --> 00:59:32,494
Does, is histamine an histamine overload?

671
00:59:32,684 --> 00:59:40,404
Is this playing a role in a lot of the mental and emotional hormonal type shifts that are
going on?

672
00:59:40,404 --> 00:59:41,946
Which is great to know.

673
00:59:41,946 --> 00:59:42,987
Once again, great to know.

674
00:59:42,987 --> 00:59:45,070
Eats test, pop in an allergy pill.

675
00:59:45,070 --> 00:59:46,332
Do you notice a difference?

676
00:59:46,332 --> 00:59:48,644
If you do notice a significant difference.

677
00:59:50,562 --> 01:00:00,087
Yes, you can absolutely once again, your choice symptom manage with allergy medication for
the whole time for just part of your cycle, whatever you feel called to.

678
01:00:01,068 --> 01:00:09,972
And you're symptom managing, which once again, like if that is what you would like to do,
like that is totally your call.

679
01:00:10,353 --> 01:00:12,244
And you know, that's not what we do.

680
01:00:12,244 --> 01:00:20,418
And that really isn't what holistic health and functional medicine is supposed to do in
my, in my perspective.

681
01:00:20,694 --> 01:00:36,840
And by the way, I see a ton of practitioners in the holistic health space symptom managing
this particular issue, but using histamine DAO type supplementation.

682
01:00:36,841 --> 01:00:49,075
And here, here's where my opinion really differs and how our approach when it comes to
health really differs is in our opinion, there really should not be a lot of supplements

683
01:00:49,075 --> 01:00:50,796
that you're on long-term.

684
01:00:51,044 --> 01:00:57,336
You know, we are big fans of, you know, some sort of multivitamin long-term.

685
01:00:58,336 --> 01:01:04,358
Outside of that, if you don't have a gallbladder, you definitely need to be on some ox
bile for bile support.

686
01:01:05,799 --> 01:01:08,600
And really, it shouldn't be much else.

687
01:01:08,600 --> 01:01:16,422
You know, this is where the blood work comes into play here kind of as a maintenance
standpoint and, you know, every six or 12 months, you know, checking in on your labs.

688
01:01:16,582 --> 01:01:17,702
What's going on?

689
01:01:17,702 --> 01:01:18,982
What are the labs showing?

690
01:01:18,982 --> 01:01:21,122
Do you need maybe a little extra support somewhere?

691
01:01:21,122 --> 01:01:30,902
You know, for me, you know, that might be, you know, I was injured many years ago by a
functional health practitioner with my iron levels and I was still largely dealing with

692
01:01:30,902 --> 01:01:31,802
those even last year.

693
01:01:31,802 --> 01:01:36,922
They were finally in an okay place, not where I'd like them to be, but finally in an okay
place.

694
01:01:36,922 --> 01:01:41,342
And I've been, I don't know, five years at that point.

695
01:01:42,462 --> 01:01:46,202
And outside of that, you know, like everything,

696
01:01:46,242 --> 01:01:47,313
is pretty good.

697
01:01:47,313 --> 01:01:52,946
And, you know, like if we need a supplement here and there, know, magnesium, probably not
a bad idea for most people.

698
01:01:52,946 --> 01:02:01,511
And if you're eating a magnesium rich diet and managing your stress and your adrenal
health, do you really need it?

699
01:02:01,511 --> 01:02:08,334
You know, having some support when you do go through it, heightened periods of stress,
especially uncontrollable stress.

700
01:02:08,548 --> 01:02:09,518
No, not a bad idea.

701
01:02:09,518 --> 01:02:13,719
You know, I added in adrenal cocktails that are very supportive for the adrenals.

702
01:02:13,719 --> 01:02:14,940
I think that's really helpful.

703
01:02:14,940 --> 01:02:21,352
I am taking magnesium glycinate because I feel like that does help me relax and I take
some reishi.

704
01:02:21,352 --> 01:02:25,223
I do like lion's mane to help with cognitive function.

705
01:02:25,223 --> 01:02:28,764
I don't really take it every day anymore.

706
01:02:28,764 --> 01:02:31,464
Take it a few times a week and no, that's not the most ideal.

707
01:02:31,464 --> 01:02:34,778
And I feel like my brain is still in a pretty good spot.

708
01:02:34,778 --> 01:02:37,966
I do start to use it more regularly when I feel a little bit

709
01:02:38,214 --> 01:02:41,094
boggy and maybe stress is a little bit higher.

710
01:02:41,094 --> 01:02:48,114
Maybe in the second half of my cycle when that, that my project, I feel my pressure on
dropping more than feels good for me.

711
01:02:48,114 --> 01:02:58,454
You know, yeah, a little extra support here and there, but on a routine basis, no, I, my,
my body responds pretty well because I've done this bigger work and I do no liver support

712
01:02:58,454 --> 01:02:59,734
a couple of times a week.

713
01:02:59,734 --> 01:03:01,794
I manage my stress and do nervous system regulation.

714
01:03:01,794 --> 01:03:03,294
I eat pretty well.

715
01:03:03,294 --> 01:03:04,334
I sleep pretty well.

716
01:03:04,334 --> 01:03:05,954
Most of the time I hydrate pretty well.

717
01:03:05,954 --> 01:03:07,014
Most of the time.

718
01:03:07,014 --> 01:03:11,414
I'm doing all of these things and that's really what it's supposed to look like.

719
01:03:11,614 --> 01:03:18,314
So if you are having to take supplements for extended periods of time, why?

720
01:03:18,414 --> 01:03:20,874
You know, are you being symptom managed?

721
01:03:20,874 --> 01:03:23,414
And what is what else is going on?

722
01:03:23,414 --> 01:03:24,434
Why?

723
01:03:24,634 --> 01:03:26,014
Why do you have to be on these?

724
01:03:26,014 --> 01:03:29,694
What is still going on in your body that you need these things?

725
01:03:29,694 --> 01:03:33,854
And once again, if you choose to stay on these things, that is totally fine.

726
01:03:33,854 --> 01:03:35,526
And if you don't want to,

727
01:03:35,526 --> 01:03:37,246
There are other options here.

728
01:03:37,246 --> 01:03:50,606
And this is really the histamine piece that bothers me is people are just willy nilly,
take GAO, take something that's gonna manage your overall histamine levels, whether that's

729
01:03:50,606 --> 01:03:54,946
homeopathic and or nutrient based supplements.

730
01:03:55,606 --> 01:04:02,336
And I, you know, I just, I'm not a huge fan and this is not people's...

731
01:04:02,336 --> 01:04:09,950
who are trying to represent themselves as root cause healers, as holistic health healers,
this is not holistic health.

732
01:04:09,950 --> 01:04:11,591
That is not holistic healing.

733
01:04:11,591 --> 01:04:22,427
That is symptom managing in just a little bit of a different way that maybe it's not
medication and just you're having to still spend money on the supplement to manage this

734
01:04:22,427 --> 01:04:24,338
issue versus looking bigger picture.

735
01:04:24,338 --> 01:04:24,608
Why?

736
01:04:24,608 --> 01:04:26,539
Why do we still have this issue?

737
01:04:26,660 --> 01:04:31,266
So when it comes to histamine issues, once again, I like to look one

738
01:04:31,266 --> 01:04:33,187
Is there mast cell piece?

739
01:04:33,367 --> 01:04:37,749
Two, okay, what else is going on within the body?

740
01:04:37,789 --> 01:04:42,871
Toxin overload, definitely a big piece and a huge contributor to mast cell and histamine
issues.

741
01:04:42,871 --> 01:04:46,553
And that might be mold, heavy metals, and or environmental toxins.

742
01:04:46,553 --> 01:04:50,554
Mold absolutely should be rolled in or out first.

743
01:04:50,554 --> 01:04:54,616
That it's such a big one and it is so often missed.

744
01:04:54,776 --> 01:04:58,916
Then I will look at gut health, especially

745
01:04:58,916 --> 01:05:01,628
And once again, stool testing, not a great way.

746
01:05:01,628 --> 01:05:04,109
A direct blood test for parasites, not a great way here.

747
01:05:04,109 --> 01:05:11,693
We wanna look at monocytes, ESNFs, and basophils in the differential part of the CBC,
couple that with symptoms, still get the parasite load.

748
01:05:11,693 --> 01:05:13,994
Then we can start looking at some of the other things.

749
01:05:13,994 --> 01:05:25,521
I'll tell you that 99 plus percent of the time we're dealing with toxin overload issues
and or gut overgrowth issues, often both.

750
01:05:25,521 --> 01:05:28,362
And once we address those,

751
01:05:28,698 --> 01:05:34,860
then we no longer have the hormone, histamine, the mast cell, all the other stuff.

752
01:05:35,681 --> 01:05:42,383
It just goes away because the body is in a better place where it can heal and once again
stay healed long term.

753
01:05:42,884 --> 01:05:47,876
So I think that is everything when it comes to mast cell and histamine.

754
01:05:47,876 --> 01:05:51,828
It's a really good overview and starting place here.

755
01:05:51,828 --> 01:05:53,308
Thank you for listening.

756
01:05:53,308 --> 01:05:57,441
As always, please like, subscribe, follow if it resonates, five star reviews.

757
01:05:57,441 --> 01:05:59,664
really, really, really mean the world to us.

758
01:05:59,664 --> 01:06:01,916
Thank you for listening and I hope to see you next time.

759
01:06:01,916 --> 01:06:02,987
Bye.