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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.30.522289v1?rss=1
Authors: Zhao, Z., Liu, Z., Chen, L., Chen, W., Guo, H., Wang, J., Mai, Y., Wei, X., Ding, J., Ge, F., Fan, Y., Guan, X.
Abstract:
Adolescent cocaine exposure (ACE) induce anxiety and higher sensitivity to drug addiction in adulthood. Here, we show that the claustrum is crucial for control of these two distinct psychiatric disorders in ACE mice. In the process of anxiety test, the CaMKII-positive neurons in median portion of claustrum (MClaustrum) were obviously triggered, and chemogenetic suppressing these neurons efficiently reduced ACE-induced anxiety in adulthood. While, the CaMKII-positive neurons in anterior portion of claustrum (AClaustrum) were obviously activated in response to cocaine-induced conditioned place preference (CPP), and chemogenetic suppressing these neurons efficiently blocked cocaine CPP in ACE mice during adulthood. Our findings dissociating specific sub-portions of claustrum for drug-related anxiety and susceptibility of addiction, extending our understanding to diverse functions of claustrum subregions.
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http://biorxiv.org/cgi/content/short/2022.12.30.522289v1?rss=1
Authors: Zhao, Z., Liu, Z., Chen, L., Chen, W., Guo, H., Wang, J., Mai, Y., Wei, X., Ding, J., Ge, F., Fan, Y., Guan, X.
Abstract:
Adolescent cocaine exposure (ACE) induce anxiety and higher sensitivity to drug addiction in adulthood. Here, we show that the claustrum is crucial for control of these two distinct psychiatric disorders in ACE mice. In the process of anxiety test, the CaMKII-positive neurons in median portion of claustrum (MClaustrum) were obviously triggered, and chemogenetic suppressing these neurons efficiently reduced ACE-induced anxiety in adulthood. While, the CaMKII-positive neurons in anterior portion of claustrum (AClaustrum) were obviously activated in response to cocaine-induced conditioned place preference (CPP), and chemogenetic suppressing these neurons efficiently blocked cocaine CPP in ACE mice during adulthood. Our findings dissociating specific sub-portions of claustrum for drug-related anxiety and susceptibility of addiction, extending our understanding to diverse functions of claustrum subregions.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.29.522264v1?rss=1
Authors: Kleinfeld, D., Liao, S.-M.
Abstract:
The breathing rhythm serves as a reference that paces orofacial motor actions and orchestrates active sensing. Past work reports that pacing occurs solely at a fix…
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.30.522096v1?rss=1
Authors: Whitmarsh, S., Nguyen-Michel, V.-H., Lehongre, K., Mathon, B., Adam, C., Lambrecq, V. L., Frazzini, V., Navarro, V.
Abstract:
Epileptic seizures and interictal epileptiform discharges (IEDs) are stron…
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.28.522095v1?rss=1
Authors: Melo, M. R., Wykes, A. D., Connelly, A. A., Bassi, J. K., Cheung, S. D., McDougall, S. J., Menuet, C., Bathgate, R. A., Allen, A. M.
Abstract:
The preBotzinger Complex (preBotC), a key primary generat…
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.30.522216v1?rss=1
Authors: Regev, T. I., Casto, C., Hosseini, E. A., Adamek, M., Brunner, P., Fedorenko, E.
Abstract:
A left-lateralized network of frontal and temporal brain regions is specialized for language processing-spoke…
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