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Bryan Johnson recently announced that he has been diagnosed with autoimmune gastritis, an autoimmune condition that, in his words, means his “stomach is eating itself.”So what does this have to do with rapamycin?Bryan took rapamycin for about four years before stopping it, attributing changes in his lipids, blood glucose, resting heart rate, and soft-tissue infections to the drug. But given the hundreds of other interventions in his protocol, can we actually know that rapamycin was responsible?In this episode of Longevity Science, I look at what we actually know about Bryan’s diagnosis, his history of autoimmune thyroid disease, and the biology of rapamycin and sterile inflammation.There’s also an interesting twist: rapamycin is a potent suppressor of sterile inflammation, and there is evidence suggesting that it may be beneficial in some autoimmune and inflammatory conditions. So if rapamycin played any role in Bryan’s autoimmune disease, is it possible that stopping it was more important than taking it?I also discuss a larger problem illustrated by Bryan’s experiment-of-one: when you’re taking dozens of drugs, supplements, and other interventions while constantly changing the protocol, it becomes nearly impossible to confidently attribute an outcome—good or bad—to any single intervention.The point isn’t that rapamycin caused Bryan’s disease, or that stopping rapamycin caused it. We simply don’t know. The point is that speculation shouldn’t be presented as scientific certainty.And there may be an even bigger lesson here: despite spending enormous resources on health optimization and being perhaps the “most measured man on Earth,” a significant medical condition appears to have gone undetected for years. #Rapamycin #BryanJohnson #Longevity #LongevityScience #AutoimmuneDisease #AgingDISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
