ОБ ЭТОМ ЭПИЗОДЕ
Welcome to the 29 th episode of the Building a Bulletproof Back podcast.
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This podcast aims to empower listeners with HOPE that healing is possible when you know how. We discuss strategic tools addressing mindset, movement & emotional health.
I am your host, Marion McRae, physiotherapist, psychedelic assisted therapist, & movement addict on a mission to see the existing model of treating back pain evolve.
In this round-table with Dr Guy Bewick (Univ. of Aberdeen), Prof Chih-Cheng Chen (Academia Sinica), Dr Robert Banks (Durham University), and Dr Jiann-Her Lin (Taipei Medical University Hospital), we explore research showing that chronic, muscle-type soreness, called “sng” in Taiwanese/Mandarin, runs on a separate physiological pathway from sharp, injury-type pain. The team describe how glutamate released in muscle can drive a distinct circuit, why standard painkillers often miss it, and how a newly identified glutamate receptor target could open drug development for conditions like fibromyalgia, DOMS, rheumatoid arthritis pain, and persistent pain post surgery.
Research Link - https://www.abdn.ac.uk/news/24440/
What we cover
- What “sng” means culturally and clinically, and how it differs from sharp pain.
- Evidence that proprioceptive pathways (not classic nociceptors) can carry sng-type signals.
- The muscle glutamate → unusual receptor mechanism; blocking it stopped chronic pain signalling in models.
Key takeaways
- Different pathway, different tools: The “ache/sour” sng signal often doesn’t respond to common analgesics because it’s not the same pathway as sharp pain. New drug targets are now on the table.
- Why some patients don’t fit the script: Post-surgery or long-standing back pain can persist as sng even when scans look fine and sharp pain has eased.
Guests
- Dr Guy Bewick, University of Aberdeen (neuroscience of muscle receptors & glutamate signalling).
- Prof Chih-Cheng Chen, Academia Sinica (pain biology; led the broader sng program).
- Dr Robert Banks, Durham University (long-time collaborator on muscle spindle physiology).
- Dr Jiann-Her Lin, Taipei Medical University Hospital (spine surgery; clinical observations of sng in patients).
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