WEBVTT
00:00:00.839 --> 00:00:37.840
Today we talk about egg your embryologist says an egg is I'm Dr. Mark Amols, and this is One of the things that happens after you undergo an egg retrieval is you usually get a call the next day telling you how many of your eggs fertilized.
00:00:37.840 --> 00:00:48.118
But before they can fertilize, And if you had, let's say, got fourteen eggs retrieved.
00:00:48.118 --> 00:00:53.679
And the thought is that maybe But what does that mean, mature?
00:00:53.679 --> 00:01:07.489
Well, in today's episode, what what it means by maturity and mature, and things like GV, MI, you and your egg quality?
00:01:07.489 --> 00:01:21.090
Because when you have fourteen ten are mature and only understandably, the next happened to the other seven?
00:01:21.090 --> 00:01:24.650
And then you start thinking things like, "Were they bad eggs?
00:01:24.650 --> 00:01:26.170
Did the doctor mess up?
00:01:26.170 --> 00:01:30.010
Was my trigger not timed well?" And the answer is pretty simple.
00:01:30.010 --> 00:01:31.730
It's actually many things.
00:01:31.730 --> 00:01:43.489
Because IVF is not one event; egg has to be retrieved, has to then develop into an embryo.
00:01:43.489 --> 00:01:51.688
Then that embryo has to reach And then that embryo that to be chromosomally capable.
00:01:51.688 --> 00:02:07.700
Then it has to implant and then So as you can see today we're one part of this process, and we're going to talk about the So here's the wild part.
00:02:07.700 --> 00:02:14.060
Before a woman is even born, many started the process of meiosis.
00:02:14.060 --> 00:02:20.060
While you're in your mother's process called meiosis.
00:02:20.060 --> 00:02:27.180
Meiosis is kind of like a Mitosis is when cells divide.
00:02:27.180 --> 00:02:38.300
Meiosis is a special type of sperm reduce the number of So instead of having forty six chromosomes, they go down to twenty three.
00:02:38.300 --> 00:02:43.098
And that's because when they to forty six.
00:02:43.098 --> 00:02:50.340
Now, for sperm, you take one happens is it divides.
00:02:50.340 --> 00:02:52.860
Then those cells divide again.
00:02:52.860 --> 00:02:58.669
That gives you four actual But eggs are different.
00:02:58.669 --> 00:03:14.628
The egg doesn't actually finish It starts meiosis and then it the state called prophase I, is released, meiosis resumes.
00:03:14.628 --> 00:03:26.990
Stimulation starts to unpause it And as the follicle grows during treatment, eventually they get to a size where they're ready to be mature.
00:03:26.990 --> 00:03:36.908
And the trigger shot tells them Now we use hCG, but that mimics the natural LH surge that occurs naturally.
00:03:36.908 --> 00:03:41.908
And then what happens is the egg will divide, but it divides unevenly.
00:03:41.908 --> 00:03:49.030
Unlike the sperm where you get cell and a tiny polar body.
00:03:49.030 --> 00:03:57.400
That small polar body contains are set aside, preserving the cell as the egg.
00:03:57.400 --> 00:04:03.000
At this point, this is a mature It can fertilize with the sperm.
00:04:04.038 --> 00:04:09.800
So let's start with three is a germinal vesicle.
00:04:09.800 --> 00:04:12.718
It is a very very immature egg.
00:04:12.718 --> 00:04:17.759
When you look at it under a the nucleus of the egg.
00:04:17.759 --> 00:04:27.439
If we see this, we know the egg is still frozen in the earliest phase of prophase I and has not started towards maturation yet.
00:04:27.439 --> 00:04:44.439
Next comes MI, which is The MI egg has already restarted The germinal vesicle is now The egg has now gotten the that it needs to finish meiosis.
00:04:44.439 --> 00:04:49.160
But the thing is, when you look there are no polar bodies.
00:04:49.160 --> 00:04:55.439
And that's because it has not yet It is paused at metaphase.
00:04:55.439 --> 00:05:04.769
And specifically that means the Now, some of these MI eggs will over the next several hours.
00:05:04.769 --> 00:05:09.850
Some will become MII, which are considered mature eggs, meaning fully mature.
00:05:09.850 --> 00:05:11.449
Some will not.
00:05:11.449 --> 00:05:20.528
And even when an egg matures have the same developmental on schedule in the ovary.
00:05:20.528 --> 00:05:30.129
So now we have MII, or metaphase It's completed the first stage of meiosis I and is now paused at the second stage of meiosis: metaphase II.
00:05:30.129 --> 00:05:33.449
This is a stage we call mature.
00:05:33.449 --> 00:05:37.730
The egg has completed meiosis one and pushed out its first polar body.
00:05:37.730 --> 00:05:42.810
It is this polar body that tells us the egg is now ready for the sperm.
00:05:42.810 --> 00:05:47.490
Now it's important to understand enough to fertilize.
00:05:47.490 --> 00:05:51.810
It does not mean genetically It doesn't mean high quality.
00:05:51.810 --> 00:05:54.850
It doesn't even mean it get an embryo.
00:05:54.850 --> 00:06:04.939
And it definitely does not It just tells us that it's a ready signal and ready for fertilization, but not a quality guarantee.
00:06:04.939 --> 00:06:30.379
So one question is: Why does an egg Well, this is where the DNA gets Before meiosis starts, the egg has that the rest of the body has, And it's arranged in twenty And before cell division, those chromosomes copy their DNA and split by meiosis, as I mentioned, we're reducing the number of chromosomes down to twenty three.
00:06:30.379 --> 00:06:42.699
When it comes to the egg, that uneven division preserves the cytoplasm, the organelles, and proteins in the main egg while it creates a smaller polar body.
00:06:42.699 --> 00:06:54.829
What matters here is that, once the egg reaches metaphase II, it has one chromosome set ready to contribute.
00:06:54.829 --> 00:07:01.149
It is paused exactly at the moment where a sperm signal can trigger it to finish meiosis II correctly.
00:07:01.149 --> 00:07:04.949
The sperm, on the other hand, comes in already at twenty three chromosomes.
00:07:04.949 --> 00:07:07.069
It doesn't need to divide again.
00:07:07.069 --> 00:07:12.269
It is the sperm entry that causes the activation of the egg.
00:07:12.269 --> 00:07:16.790
Basically, it creates a signal that causes calcium waves inside the egg.
00:07:16.790 --> 00:07:21.709
Those waves tell the egg you are Now finish meiosis II.
00:07:21.709 --> 00:07:29.550
At that point, the second polar body is released and the other piece of DNA creates the female pronucleus.
00:07:29.550 --> 00:07:38.189
At the same time, the sperm head starts to unpack and then the sperm DNA arrives, packed incredibly tight.
00:07:38.189 --> 00:07:51.509
The egg's cytoplasm then strips that allows the sperm DNA to And this is really important because it's not just about maturity having the right chromosome numbers.
00:07:51.509 --> 00:08:03.480
The cytoplasm has also matured, sperm entry, completion of the second polar body.
00:08:03.480 --> 00:08:08.319
Unpacking that sperm DNA allows the egg to build the male pronucleus.
00:08:08.319 --> 00:08:20.079
And then the next day, when they look at that embryo and they see that it did fertilize, they'll now see the two pronuclei one from the male and one from the female.
00:08:20.079 --> 00:08:24.560
Now, before we get into what back to those polar bodies.
00:08:24.560 --> 00:08:26.000
What are they?
00:08:26.000 --> 00:08:30.519
Well, they contain chromosome intentionally was not keeping.
00:08:30.519 --> 00:08:39.639
As I mentioned, it divides unequally, keeping nearly all the cytoplasm, the mitochondria, the proteins, and the cellular machinery itself.
00:08:39.639 --> 00:08:46.600
Polar bodies are small packages cytoplasm set aside by the egg.
00:08:46.600 --> 00:09:05.600
After meiosis I, the egg will After fertilization, the egg is That creates a second polar body And now we'll have two polar These findings help us assess fertilized or not.
00:09:05.600 --> 00:09:19.678
Now in the morning the next day, at your eggs, and then they look The first is, are there two If there are, We know that the egg fertilized.
00:09:19.678 --> 00:09:26.918
The next thing they look at are They want to see two: one from the maternal, one from the paternal DNA.
00:09:26.918 --> 00:09:30.360
We call that 2PB and 2PN.
00:09:30.360 --> 00:09:33.639
Now this appearance is only there for a short period of time.
00:09:33.639 --> 00:09:49.558
Both of those packages of combine and then will undergo If you have two polar bodies and Now it means it fertilized, but it doesn't mean it's going to keep growing.
00:09:49.558 --> 00:09:53.490
2PN does not mean the embryo is guaranteed to be chromosomally normal.
00:09:53.490 --> 00:09:57.570
It means the fertilization moment they looked at it.
00:09:57.570 --> 00:10:01.690
The same thing with seeing two That's what we want to see.
00:10:01.690 --> 00:10:06.928
But sometimes we see more or We’ll talk about that in a minute.
00:10:06.928 --> 00:10:12.288
But first, let's talk about Let's start with extra polar bodies.
00:10:12.288 --> 00:10:20.048
Sometimes the lab looks at the egg the next day and notices that there's an extra polar body—sometimes three, four, or even more.
00:10:20.048 --> 00:10:24.850
And that could be a little bit confusing because then it starts to wonder, does this mean it has extra chromosomes?
00:10:24.850 --> 00:10:57.658
And that's why there's extra It can, but it does not bodies can also be fragments and But it also could be an atypical So the polar body count is a Essentially we look at the whole We look at the number of appearance of the egg and how And then if we look back at the these embryos didn't make it, That may be why.
00:10:57.658 --> 00:11:04.139
But in the beginning, we can't say anything about what's going to happen to the embryo just because there's an extra polar body.
00:11:04.139 --> 00:11:15.460
Now, sometimes the pronuclei, instead of being 2PN, can be 3PN. And what this means is that there are three separate nuclear packages inside of that egg.
00:11:15.460 --> 00:11:21.500
Now, the most common explanation is that if you use conventional IVF, maybe two sperm got in there.
00:11:21.500 --> 00:11:38.740
With ICSI, another possibility that the sperm itself carried an Or perhaps the egg did not divide evenly and retained forty-six chromosomes. Then the 23 sperm chromosomes can combine, causing triploidy.
00:11:38.740 --> 00:11:44.139
Now, in the past, we would not transfer triploids because they were abnormal.
00:11:44.139 --> 00:11:55.870
But nowadays, with next-generation sequencing and SNP technology, we're able to find out if those 3PN embryos are really triploid or not.
00:11:55.870 --> 00:12:06.710
And sometimes we can even Now, does that mean they No. It just means that eventually the embryo after being biopsied, showed normal chromosome patterns.
00:12:06.710 --> 00:12:19.428
And that's why we were able to The same thing is true with what Sometimes we don't see another Does that mean it was missing Well, not necessarily.
00:12:19.428 --> 00:12:23.350
The pronuclei come and show themselves and then they disappear.
00:12:23.350 --> 00:12:39.190
So sometimes you just miss the The same thing can be true for Sometimes you look and you see You say, well, we know it fertilized, but then you only see cytoplasm and you don't see the pronuclei.
00:12:39.190 --> 00:12:47.028
Now that could be either abnormal fertilization or like before, the pronuclei could have disappeared like they normally do.
00:12:47.028 --> 00:12:49.038
And you may simply miss that window.
00:12:49.038 --> 00:13:01.480
And then the question is, well, And that is why its timing window Or did it not fertilize correctly or is it perfectly normal and we just missed the window?
00:13:01.480 --> 00:13:08.558
All of those possibilities remain Days later, we don't know what's until we see it.
00:13:08.558 --> 00:13:22.240
So next time you get your embryology report the day after your retrieval and they say, okay, of the fourteen eggs you had, seven were fertilized and six became embryos.
00:13:22.240 --> 00:13:34.759
Now you can ask the question fertilized, what was wrong with And at that point, they may tell you they were GVs or MI eggs, and they chose not to fertilize them.
00:13:34.759 --> 00:13:35.759
And that's reasonable.
00:13:35.759 --> 00:13:48.690
A lot of clinics do not Now, some will because it could mature later, but they don't always mature at the same rate, and they don't fertilize at the same rate.
00:13:48.690 --> 00:13:54.889
But in the end, what you care and 2PN.
00:13:54.889 --> 00:14:17.370
It doesn't matter if you start If only ten fertilized normally, Another point to keep in mind is little bit demoralizing when and only six fertilized, that can But the thing is, you got to ask the question how many were mature?
00:14:17.370 --> 00:14:22.490
Because if a whole bunch were mature in only six fertilized, that's disappointing.
00:14:22.490 --> 00:14:27.769
But if only six were mature and that's perfect fertilization.
00:14:27.769 --> 00:14:29.250
That's one hundred percent.
00:14:29.250 --> 00:14:40.850
And why it matters is because if you do another cycle, you can use that information to make adjustments on your next cycle to help improve maturation and fertilization.
00:14:40.850 --> 00:14:54.058
Now, in next week's podcast, from here and talk about what if What if the fertilization is What do you need to be thinking And what can cause that?
00:14:54.058 --> 00:14:58.220
Did the doctor just not trigger I'll give you a hint.
00:14:58.220 --> 00:14:59.820
It's not really always that.
00:14:59.820 --> 00:15:06.100
Sometimes it's just a human body that develops the eggs at different rates between different people.
00:15:06.100 --> 00:15:11.580
Even the trigger shot can maturation than others.
00:15:11.580 --> 00:15:17.980
But in the end, egg maturity the starting line.
00:15:17.980 --> 00:15:35.580
Normal 2PN fertilization tells us had a good hand-off, and But But neither one of those tells chromosomally normal, or whether implant or even become a baby.
00:15:35.580 --> 00:15:55.028
As I mentioned earlier, IVF is a It's not one grade, it's not one And it's definitely not one So if you're someone who's going embryology report and thought, I means, you're not alone.
00:15:55.028 --> 00:16:00.070
Ask for the story behind the numbers because the details matter.
00:16:00.070 --> 00:16:04.990
If you liked this podcast, as I always mention, please give us a five star review on your favorite platform.
00:16:04.990 --> 00:16:10.509
Tell your friends about us, especially if your friend is going through IVF and they're also wondering about their embryo report.
00:16:10.509 --> 00:16:27.908
And don't forget, we also now TacoBoutFertility.com, where you can questions and we'll help you Additionally, I'm looking views of what they want me to do that in the queue.
00:16:27.908 --> 00:16:34.548
But most of all, keep coming I look forward to talking to you again next week on Taco Bout Fertility Tuesday.
00:00:00.839 --> 00:00:37.840
Today we talk about egg your embryologist says an egg is I'm Dr. Mark Amols, and this is One of the things that happens after you undergo an egg retrieval is you usually get a call the next day telling you how many of your eggs fertilized.
00:00:37.840 --> 00:00:48.118
But before they can fertilize, And if you had, let's say, got fourteen eggs retrieved.
00:00:48.118 --> 00:00:53.679
And the thought is that maybe But what does that mean, mature?
00:00:53.679 --> 00:01:07.489
Well, in today's episode, what what it means by maturity and mature, and things like GV, MI, you and your egg quality?
00:01:07.489 --> 00:01:21.090
Because when you have fourteen ten are mature and only understandably, the next happened to the other seven?
00:01:21.090 --> 00:01:24.650
And then you start thinking things like, "Were they bad eggs?
00:01:24.650 --> 00:01:26.170
Did the doctor mess up?
00:01:26.170 --> 00:01:30.010
Was my trigger not timed well?" And the answer is pretty simple.
00:01:30.010 --> 00:01:31.730
It's actually many things.
00:01:31.730 --> 00:01:43.489
Because IVF is not one event; egg has to be retrieved, has to then develop into an embryo.
00:01:43.489 --> 00:01:51.688
Then that embryo has to reach And then that embryo that to be chromosomally capable.
00:01:51.688 --> 00:02:07.700
Then it has to implant and then So as you can see today we're one part of this process, and we're going to talk about the So here's the wild part.
00:02:07.700 --> 00:02:14.060
Before a woman is even born, many started the process of meiosis.
00:02:14.060 --> 00:02:20.060
While you're in your mother's process called meiosis.
00:02:20.060 --> 00:02:27.180
Meiosis is kind of like a Mitosis is when cells divide.
00:02:27.180 --> 00:02:38.300
Meiosis is a special type of sperm reduce the number of So instead of having forty six chromosomes, they go down to twenty three.
00:02:38.300 --> 00:02:43.098
And that's because when they to forty six.
00:02:43.098 --> 00:02:50.340
Now, for sperm, you take one happens is it divides.
00:02:50.340 --> 00:02:52.860
Then those cells divide again.
00:02:52.860 --> 00:02:58.669
That gives you four actual But eggs are different.
00:02:58.669 --> 00:03:14.628
The egg doesn't actually finish It starts meiosis and then it the state called prophase I, is released, meiosis resumes.
00:03:14.628 --> 00:03:26.990
Stimulation starts to unpause it And as the follicle grows during treatment, eventually they get to a size where they're ready to be mature.
00:03:26.990 --> 00:03:36.908
And the trigger shot tells them Now we use hCG, but that mimics the natural LH surge that occurs naturally.
00:03:36.908 --> 00:03:41.908
And then what happens is the egg will divide, but it divides unevenly.
00:03:41.908 --> 00:03:49.030
Unlike the sperm where you get cell and a tiny polar body.
00:03:49.030 --> 00:03:57.400
That small polar body contains are set aside, preserving the cell as the egg.
00:03:57.400 --> 00:04:03.000
At this point, this is a mature It can fertilize with the sperm.
00:04:04.038 --> 00:04:09.800
So let's start with three is a germinal vesicle.
00:04:09.800 --> 00:04:12.718
It is a very very immature egg.
00:04:12.718 --> 00:04:17.759
When you look at it under a the nucleus of the egg.
00:04:17.759 --> 00:04:27.439
If we see this, we know the egg is still frozen in the earliest phase of prophase I and has not started towards maturation yet.
00:04:27.439 --> 00:04:44.439
Next comes MI, which is The MI egg has already restarted The germinal vesicle is now The egg has now gotten the that it needs to finish meiosis.
00:04:44.439 --> 00:04:49.160
But the thing is, when you look there are no polar bodies.
00:04:49.160 --> 00:04:55.439
And that's because it has not yet It is paused at metaphase.
00:04:55.439 --> 00:05:04.769
And specifically that means the Now, some of these MI eggs will over the next several hours.
00:05:04.769 --> 00:05:09.850
Some will become MII, which are considered mature eggs, meaning fully mature.
00:05:09.850 --> 00:05:11.449
Some will not.
00:05:11.449 --> 00:05:20.528
And even when an egg matures have the same developmental on schedule in the ovary.
00:05:20.528 --> 00:05:30.129
So now we have MII, or metaphase It's completed the first stage of meiosis I and is now paused at the second stage of meiosis: metaphase II.
00:05:30.129 --> 00:05:33.449
This is a stage we call mature.
00:05:33.449 --> 00:05:37.730
The egg has completed meiosis one and pushed out its first polar body.
00:05:37.730 --> 00:05:42.810
It is this polar body that tells us the egg is now ready for the sperm.
00:05:42.810 --> 00:05:47.490
Now it's important to understand enough to fertilize.
00:05:47.490 --> 00:05:51.810
It does not mean genetically It doesn't mean high quality.
00:05:51.810 --> 00:05:54.850
It doesn't even mean it get an embryo.
00:05:54.850 --> 00:06:04.939
And it definitely does not It just tells us that it's a ready signal and ready for fertilization, but not a quality guarantee.
00:06:04.939 --> 00:06:30.379
So one question is: Why does an egg Well, this is where the DNA gets Before meiosis starts, the egg has that the rest of the body has, And it's arranged in twenty And before cell division, those chromosomes copy their DNA and split by meiosis, as I mentioned, we're reducing the number of chromosomes down to twenty three.
00:06:30.379 --> 00:06:42.699
When it comes to the egg, that uneven division preserves the cytoplasm, the organelles, and proteins in the main egg while it creates a smaller polar body.
00:06:42.699 --> 00:06:54.829
What matters here is that, once the egg reaches metaphase II, it has one chromosome set ready to contribute.
00:06:54.829 --> 00:07:01.149
It is paused exactly at the moment where a sperm signal can trigger it to finish meiosis II correctly.
00:07:01.149 --> 00:07:04.949
The sperm, on the other hand, comes in already at twenty three chromosomes.
00:07:04.949 --> 00:07:07.069
It doesn't need to divide again.
00:07:07.069 --> 00:07:12.269
It is the sperm entry that causes the activation of the egg.
00:07:12.269 --> 00:07:16.790
Basically, it creates a signal that causes calcium waves inside the egg.
00:07:16.790 --> 00:07:21.709
Those waves tell the egg you are Now finish meiosis II.
00:07:21.709 --> 00:07:29.550
At that point, the second polar body is released and the other piece of DNA creates the female pronucleus.
00:07:29.550 --> 00:07:38.189
At the same time, the sperm head starts to unpack and then the sperm DNA arrives, packed incredibly tight.
00:07:38.189 --> 00:07:51.509
The egg's cytoplasm then strips that allows the sperm DNA to And this is really important because it's not just about maturity having the right chromosome numbers.
00:07:51.509 --> 00:08:03.480
The cytoplasm has also matured, sperm entry, completion of the second polar body.
00:08:03.480 --> 00:08:08.319
Unpacking that sperm DNA allows the egg to build the male pronucleus.
00:08:08.319 --> 00:08:20.079
And then the next day, when they look at that embryo and they see that it did fertilize, they'll now see the two pronuclei one from the male and one from the female.
00:08:20.079 --> 00:08:24.560
Now, before we get into what back to those polar bodies.
00:08:24.560 --> 00:08:26.000
What are they?
00:08:26.000 --> 00:08:30.519
Well, they contain chromosome intentionally was not keeping.
00:08:30.519 --> 00:08:39.639
As I mentioned, it divides unequally, keeping nearly all the cytoplasm, the mitochondria, the proteins, and the cellular machinery itself.
00:08:39.639 --> 00:08:46.600
Polar bodies are small packages cytoplasm set aside by the egg.
00:08:46.600 --> 00:09:05.600
After meiosis I, the egg will After fertilization, the egg is That creates a second polar body And now we'll have two polar These findings help us assess fertilized or not.
00:09:05.600 --> 00:09:19.678
Now in the morning the next day, at your eggs, and then they look The first is, are there two If there are, We know that the egg fertilized.
00:09:19.678 --> 00:09:26.918
The next thing they look at are They want to see two: one from the maternal, one from the paternal DNA.
00:09:26.918 --> 00:09:30.360
We call that 2PB and 2PN.
00:09:30.360 --> 00:09:33.639
Now this appearance is only there for a short period of time.
00:09:33.639 --> 00:09:49.558
Both of those packages of combine and then will undergo If you have two polar bodies and Now it means it fertilized, but it doesn't mean it's going to keep growing.
00:09:49.558 --> 00:09:53.490
2PN does not mean the embryo is guaranteed to be chromosomally normal.
00:09:53.490 --> 00:09:57.570
It means the fertilization moment they looked at it.
00:09:57.570 --> 00:10:01.690
The same thing with seeing two That's what we want to see.
00:10:01.690 --> 00:10:06.928
But sometimes we see more or We’ll talk about that in a minute.
00:10:06.928 --> 00:10:12.288
But first, let's talk about Let's start with extra polar bodies.
00:10:12.288 --> 00:10:20.048
Sometimes the lab looks at the egg the next day and notices that there's an extra polar body—sometimes three, four, or even more.
00:10:20.048 --> 00:10:24.850
And that could be a little bit confusing because then it starts to wonder, does this mean it has extra chromosomes?
00:10:24.850 --> 00:10:57.658
And that's why there's extra It can, but it does not bodies can also be fragments and But it also could be an atypical So the polar body count is a Essentially we look at the whole We look at the number of appearance of the egg and how And then if we look back at the these embryos didn't make it, That may be why.
00:10:57.658 --> 00:11:04.139
But in the beginning, we can't say anything about what's going to happen to the embryo just because there's an extra polar body.
00:11:04.139 --> 00:11:15.460
Now, sometimes the pronuclei, instead of being 2PN, can be 3PN. And what this means is that there are three separate nuclear packages inside of that egg.
00:11:15.460 --> 00:11:21.500
Now, the most common explanation is that if you use conventional IVF, maybe two sperm got in there.
00:11:21.500 --> 00:11:38.740
With ICSI, another possibility that the sperm itself carried an Or perhaps the egg did not divide evenly and retained forty-six chromosomes. Then the 23 sperm chromosomes can combine, causing triploidy.
00:11:38.740 --> 00:11:44.139
Now, in the past, we would not transfer triploids because they were abnormal.
00:11:44.139 --> 00:11:55.870
But nowadays, with next-generation sequencing and SNP technology, we're able to find out if those 3PN embryos are really triploid or not.
00:11:55.870 --> 00:12:06.710
And sometimes we can even Now, does that mean they No. It just means that eventually the embryo after being biopsied, showed normal chromosome patterns.
00:12:06.710 --> 00:12:19.428
And that's why we were able to The same thing is true with what Sometimes we don't see another Does that mean it was missing Well, not necessarily.
00:12:19.428 --> 00:12:23.350
The pronuclei come and show themselves and then they disappear.
00:12:23.350 --> 00:12:39.190
So sometimes you just miss the The same thing can be true for Sometimes you look and you see You say, well, we know it fertilized, but then you only see cytoplasm and you don't see the pronuclei.
00:12:39.190 --> 00:12:47.028
Now that could be either abnormal fertilization or like before, the pronuclei could have disappeared like they normally do.
00:12:47.028 --> 00:12:49.038
And you may simply miss that window.
00:12:49.038 --> 00:13:01.480
And then the question is, well, And that is why its timing window Or did it not fertilize correctly or is it perfectly normal and we just missed the window?
00:13:01.480 --> 00:13:08.558
All of those possibilities remain Days later, we don't know what's until we see it.
00:13:08.558 --> 00:13:22.240
So next time you get your embryology report the day after your retrieval and they say, okay, of the fourteen eggs you had, seven were fertilized and six became embryos.
00:13:22.240 --> 00:13:34.759
Now you can ask the question fertilized, what was wrong with And at that point, they may tell you they were GVs or MI eggs, and they chose not to fertilize them.
00:13:34.759 --> 00:13:35.759
And that's reasonable.
00:13:35.759 --> 00:13:48.690
A lot of clinics do not Now, some will because it could mature later, but they don't always mature at the same rate, and they don't fertilize at the same rate.
00:13:48.690 --> 00:13:54.889
But in the end, what you care and 2PN.
00:13:54.889 --> 00:14:17.370
It doesn't matter if you start If only ten fertilized normally, Another point to keep in mind is little bit demoralizing when and only six fertilized, that can But the thing is, you got to ask the question how many were mature?
00:14:17.370 --> 00:14:22.490
Because if a whole bunch were mature in only six fertilized, that's disappointing.
00:14:22.490 --> 00:14:27.769
But if only six were mature and that's perfect fertilization.
00:14:27.769 --> 00:14:29.250
That's one hundred percent.
00:14:29.250 --> 00:14:40.850
And why it matters is because if you do another cycle, you can use that information to make adjustments on your next cycle to help improve maturation and fertilization.
00:14:40.850 --> 00:14:54.058
Now, in next week's podcast, from here and talk about what if What if the fertilization is What do you need to be thinking And what can cause that?
00:14:54.058 --> 00:14:58.220
Did the doctor just not trigger I'll give you a hint.
00:14:58.220 --> 00:14:59.820
It's not really always that.
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Sometimes it's just a human body that develops the eggs at different rates between different people.
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Even the trigger shot can maturation than others.
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But in the end, egg maturity the starting line.
00:15:17.980 --> 00:15:35.580
Normal 2PN fertilization tells us had a good hand-off, and But But neither one of those tells chromosomally normal, or whether implant or even become a baby.
00:15:35.580 --> 00:15:55.028
As I mentioned earlier, IVF is a It's not one grade, it's not one And it's definitely not one So if you're someone who's going embryology report and thought, I means, you're not alone.
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Ask for the story behind the numbers because the details matter.
00:16:00.070 --> 00:16:04.990
If you liked this podcast, as I always mention, please give us a five star review on your favorite platform.
00:16:04.990 --> 00:16:10.509
Tell your friends about us, especially if your friend is going through IVF and they're also wondering about their embryo report.
00:16:10.509 --> 00:16:27.908
And don't forget, we also now TacoBoutFertility.com, where you can questions and we'll help you Additionally, I'm looking views of what they want me to do that in the queue.
00:16:27.908 --> 00:16:34.548
But most of all, keep coming I look forward to talking to you again next week on Taco Bout Fertility Tuesday.
