Explainable Clinical Digital Twins: One Engine for Power Plants and Patients

The same software engine can run a 400 megawatt power plant and simulate whether a cancer drug will survive a real world patient population. That’s not two companies it’s one engine, built by a founder who came up not in medicine but in gas turbines and heavy industry.

In this episode, Dr. Junaid Kalia hosts with co-hosts Ed Marx and Dr. Harvey Castro a two guest conversation with Dr.-Ing. Amir A. Hashmi, founder of Xcelenz and creator of the GENEXIX digital twin platform, and Dr. Dania Amir, the internal medicine physician leading its clinical validation. GENEXIX carries an industrial reliability DNA traceability, baselines, failure-mode reasoning, “no black-box AI” from the power plant into the hospital, where the same engine models a patient’s physiology, predicts deterioration, and runs in silico drug simulations for research. The Signal & Symptoms question: does an industrial mindset actually earn a doctor’s trust at the bedside and what should a health system ask before it lets a digital twin, especially one born in industry, near a real clinical decision?

• One engine, two worlds
• Welcome + meet the two guests (Amir + Dania)
• From industry to medicine: Amir’s crossover
• The physician’s role: Dania on clinical validation
• Why build a digital twin? (the analogy)
• The clinical twin: modeling multi-organ physiology
• Under the hood: explainable architecture
• In the ICU: where the twin earns its value
• The stakes + the intelligence layer
• The future “don’t surrender to AI, learn AI”

DR GPT™ Harvey Castro, ER Physician, #DrGPT™

💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/

🔗 Website — https://www.harveycastromd.com/

📷 Instagram — https://www.instagram.com/harveycastromd/

📑 Substack — https://harveycastromd.substack.com/

Edward Marx, CEO, Advisor

💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/

🔗 Website — https://www.marxadvisory.com/

📹 YouTube — https://www.youtube.com/@EdwardMarx

Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

🔗Website - https://www.junaidkalia.com/

📹YouTube - https://www.youtube.com/@junaidkaliamd

Special Guest:

Dr.-Ing. Amir A. Hashmi — Founder & Advisor, Xcelenz (creator of the GENEXIX digital-twin platform)

💼 LinkedIn — https://www.linkedin.com/in/amir-a-hashmi-dr-ing-42354113/

Dr. Dania Amir — Director of Clinical AI & Internal Medicine Lead, GENEXIX-cDT (MRCP, UK)

💼 LinkedIn — https://www.linkedin.com/in/dr-dania-amir-a554208a

Visit our website: https://signalandsymptoms.com

Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/

Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.