Circadian Rhythms, Mitochondrial Health & Visceral Fat | Dr Max on Fitness Wisdom Podcast

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Today we have a very exciting guest, Dr.
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Max Gulhain, and host of the Regenerative Health Podcast.
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Thank you for being on the Fitness Wisdom podcast, Dr.
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Max.
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Hey, thanks, Andreas.
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My pleasure to be here and speaking with you.
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My audience, as you know, they're very big followers of Dr.
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Jack Cruz and they're very excited about all things biophysics, circadian health, sunlight, and the body's internal medicine.
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So uh let's start off on that subject.
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I think this is gonna be like really mind-blowing for people.
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Do you mind talking about the body's internal medicine factory, what that is, and how that relates to sunlight?
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I think you know what I'm talking about.
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Yeah, and even more broadly and maybe more fundamentally, I think the body has all the tools it needs to heal and to operate efficiently.
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And what manifests, whether that's optimal health or chronic disease, is a function of the environmental inputs that someone places in front of themselves with respect to their light habits, with respect to their um rhythms, their food that they're intaking in, their environment, their air, then their their indoor environment, all these things will generate a response and a bodily response, and that's either optimal and everything will work properly, or it's compensatory and adaptive.
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What I try and explain to people is the body's never trying to kill you.
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Um and and I really reject all forms of premise that that there's something bad, inherently bad, whether that's the LDL particle, the LDL lipoproteins, you know, try there to try to kill you or whatever else.
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It the body's always making the best of a range of undesirable decisions when it comes to the development of chronic disease.
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And our job is to understand what the design specification was for our biological system and then optimize the inputs such that the body can can do its thing naturally.
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So the person that I think really framed this really well in my mind, and I think it's a great mental model for your listeners and everyone more generally, is an idea of this metabolic flight envelope.
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And the the analogy is to an aircraft and an aircraft design where the aircraft has a specific set of conditions by which it's optimized for, whether that's cruising altitude, whether that's cruising distance or the amount of distance that plane can fly, the air pressures, the servicing intervals, all these kind of things.
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And when you operate the aircraft in that range of uh variables, it will predictably run and reliably run without fault.
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But if you start running that that machine in a bunch of specifications that it wasn't designed for, then you can expect it will need servicing sooner and you can expect that it might even break.
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And what I think is happening in today's day and age is that because of the light environment that we've crafted for ourselves, because of the electricity grid and the electrified indoor and ext and outdoor environments, because of our invention of communications technologies that employ uh bands of uh electromagnetic um radiation that were never pretty uh we're never previously exposed to, because of the um disconnection that we have from the a natural world from forested areas that were rich in infrared light, rich in green light, and constant stress exposures through new newsfeeds and and uh you know information and uh social media.
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All these factors are the equivalent of running our uh plane in the wrong uh wrong engineering specification.
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And we can expect the same thing, which is accelerated aging, premature aging, and the development of chronic diseases.
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So my interest as a family medicine doctor is fundamentally how do we prevent chronic disease?
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How do we get people to maximize their health span to the point at which they are naturally our bodies are naturally able to live the maximum potential health span and then have a very short period of illness before before dying?
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And I think uh amongst these chronic diseases, metabolic dysfunction, and and you can and frame it, we can frame it so many different ways, um, I can define it more for you, uh, is that this idea of metabolic dysfunction, the accumulation of ectopic fat, fat in the wrong places, fat around the organs, fat in the liver, fat in the muscles, and this and the insulin resistance that comes along with that, this is one of the most important granddaddy kind of causes or root causes of of chronic disease.
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And that ties fundamentally to stepping outside of this metabolic flat envelope in all those areas that we've discussed.
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And to to answer your initial question about maybe this internal pharmacy as it relates to light, I think the most exciting area that I'm interested in is the intersection of how light and photobiology affects metabolic health.
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Because what we're seeing coming out of amazing researchers like um pr Professor Glenn Jeffrey out of UCL London, uh Scott Zimmerman and Bob Fosby, who's uh a professor of astrophysics and an astronomer, um looking at photobiological interactions with mitochondria, what we're seeing is that the light is so critically important to optimal mitochondrial function and therefore to uh metabolic health.
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And when you nail this light environment, when you are living in harmony with natural light cycles, when you're getting full spectrum sunlight that's appropriate to your skin type um every single day, then the mitochondrial function is optimized and mitochondrial ATP production is optimized, and you don't get the build-up of substrates of un I call it unburnt fuel.
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It's it's all it's like unburnt fuel, which ends up accumulating, and the body uh because it it can't oxidize that fuel at that time point, ends up storing it as fat.
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And when that happens over a time period, and depending on your age, depending on your circadian habits, depending on your hormonal profile, that will either go into safe storage or it will go into into visceral fat storage and start um contributing more quickly to disease.
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So and the the really cool thing is that light, once we employ it intentionally in a in a as part of our lifestyle protocol, can really quite significantly lower the threshold for developing these chronic diseases.
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And I think I think that is what the research is now showing and is excitingly demonstrating.
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Um and it's one of the most important tools in the the prevention of of cardiometabolic diseases.
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So yeah, happy, happy to go down any route specifically if you want me to, regarding that.
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But overall, if you're diabetic, pre-diabetic, or you're trying to prevent those conditions because you've got the family history and you're not using light and not being intentional about your light choices, then that's a massive, unaddressed um piece of your puzzle.
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Wow.
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Great breakdown.
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That was fantastic.
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Yeah, I think what you mentioned there, what was very important was about the adaptability of the organism, right?
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To its environment that is absolutely critical and key for people to understand that the body isn't doing anything by mistake.
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You know, as nature doesn't make mistakes, we are part of nature and we are adapting to the environment that is it's the environment is shaping us, literally.
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And we know that our modern environment is not conducive for health, unfortunately.
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And now we must make aggressive efforts to reconnect back with the natural world.
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Thankfully, yes, there are some technologies which can potentially uh bring nature to us, but they will never replace nature, and so the answer is always returning back to nature.
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Of course, we're living in a very technologically as advanced world, everything is very fast-paced, and as we were talking before the recording, our dopamine is constantly captured.
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Our and and uh attention is the greatest currency in the modern world right now.
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Everyone is literally fighting for your attention online.
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But the key is for you to be able to discern what is actually meaningful and important in your life.
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Um, is it serving your highest purpose, you know, the people around you, you know, your financial situation, your health, and and the world in general.
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And if it's not, then maybe it's not worth your time.
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But uh all of that begins with awareness and being present, really.
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And I fundamentally believe that when we do connect with nature, that actually makes us more present, that makes us more aware of our bodies and our situation, and we can feel if something is off in our body.
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And many of the things that you mentioned, a lot of the chronic diseases, the neolithic diseases specifically, the metabolic ones, I feel they come about because there is this lack of awareness in the body in the first place.
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Because if you were to be aware of your body, you start to realize what makes you feel like crap.
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And those are typically the things which are contributing to a lot of the things that you are talking about, like the artificial blue light, for example, the non-native electromagnetic fields, eating seed oils, fried foods, staying up late at night, not waking up with the sunrise.
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All these things make people feel bad, but then they just kick the can down the road, and eventually when they're 40, 50 years old, they manifest some heart attack or or some autoimmune condition or something like this, and they just think that it's random or it's genetic.
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But in reality, it's more like epigenetic.
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It's the way that you are living your lifestyle, which is programming your biology to manifest a specific set in a specific way, which is trying to be adaptive, it's trying to do the best that it can, it's altering its metabolic conditions so it can preserve energy and survive.
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So the name of the game is always survival, even if it means that you're in diseased survival, right?
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Instead of like thriving.
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So let's go down the road of like POMC, if you don't mind.
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Tell me like how does how does sunlight you know activate POMSC and what is the benefits of this uh for the human body?
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Yeah, POMSI pro opium lanocausin is a it's a it's a pro peptide um, it's a polypeptide pro hormone, essentially.
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It's uh the best the best kind of analogy.
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I mean, I've used analogies of things like a carnival ticket that gets cut up into different tickets depending on uh what tissue and what enzymes are are in play.
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And it's also been likened to uh say a leatherman, it's a like a multi-tool.
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And what what it is is it's it's a it's an adaptive tool to to light, to sunlight, and it gives an org the organism um a bunch of interrelated uh functions to deal with um sunlight and especially ultraviolet light.
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So what is relevant here is that there's this this radical different in difference in environment between the dark complete darkness on on planet Earth as as this earth is uh spinning and and the availability of sunlight and darkness means that um the organ organism needs to basically employ a whole bunch of very different uh physiological functions to complete darkness.
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So what POMC does is is it really joins things like um things like skin pigmentation, which was obviously necessary when you're dealing with ultraviolet light and the ionizing effect of ultraviolet uh ultraviolet light.
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So it needed to link the ability to tan and therefore provide some reaction, reactionary, um adaptive um melanin pigmentation uh in terms of reducing the uh exposure or to it to ionizing radiation.
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It linked that to things like uh re a reward pathway.
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And that's a really interesting one because it's recognizing both that this is a double-edged sword, which is something that is ben highly beneficial, ultraviolet light.
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We absolutely need it.
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It's critical for life.
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Um, that's why we we get this analgesic um opioid-like um beta-endorphin stimulation with with POMC, but it's also uh something that needs to be adapted or protected from, which is why we get uh a melanin pigmentation.
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And then there's immune regulatory functions that are linked into POMC.
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And you know, that's a fascinating one because ultraviolet light has uh has has contrasting and and I guess you could say immunomodulatory effects, which is um it has some uh it has differing effects depending on whether we're talking about the innate immune system or or the adaptive immune system.
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And it it seems to induce uh broadly quite an immuno uh immunosuppression or immune tolerance, which uh again is an adaptive response so that there isn't an excessive immune uh response to the reactive oxygen species and the um I guess DNA damage that occurs with temporarily and hormetically with ultraviolet exposure.
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And it and it also links things like metabolism.
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So the alpha alpha MSH, which is one of the peptides that gets cleaved off POM C and in the skin induces pigmentation, but in the brain induces satiety and um reduces energy intake.
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So making the recognizing or connecting this idea that when you're in full spectrum UV containing light, uh you're you you're necessarily plugged into this massive nuclear fusion reactor in the sky.
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You are you are generating or you're deriving um photonic energy, which the body is is using to become energetically more efficient in many ways during the period of exposure.
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And therefore it's gonna downtitrate or regulate appetite during that time.
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Um and then there's some other um peptide peptides like you know the lipotropins that potentially again are going to affect how fat fat is metabolized in recognition that that sunlight is a key influence on metabolism.
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And you know, that that is something that is missed.
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It's missed in mainstream conventional uh medicine when it comes to treating these cardiometabolic diseases, and it gets missed for the prescription of of medications, of of pharmaceutical drugs that want to uh usually increase insulin um either insul in insulin production or or you know induce things like GLP1 uh pharmacologically by by kind of injecting that.
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Um and it gets missed by I think a lot of the lifestyle medicine approach to cardiometabolic disease, which is that this is only a food story.
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Um they you emphasize carbohydrate restriction when we're when we're trying to solve metabolic disease, which is absolutely part of the puzzle, but it it ignores the reality that metabolism in the body is is fundamentally tied to light because um the light cycle and the organism is is optimized not only to respond to uh the presence of ultraviolet light, but also things like the photo period of the day length, and that is necessarily going to influence appetite, influence feeding time and and time of food consumption.
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So to give a mammalian example in terms of of and of animals, it's look at look at some of the behavior of of some mammals when it comes to uh winter, winter or autumn um onset, then there's all kinds of behaviors that lead them to consume certain types of foods so that they will put down enough fat for for winter.
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And then then when the temperature changes, photo period gets shorter, that triggers uh you know a reduction in in metabolic output, adjustment of all their thyroid hormones and and um and their their pituitary gland essentially to induce this this state of um you know top or or reduced metabolic output.
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So and we what what I guess I'm saying here is that the light signals are key in regulating metabolism.
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And what that means for people is that if you're on your iPhone first thing in the morning, you're you're you're going nowhere near uh an outdoor environment throughout the whole day.
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You're living in this circadian twilight where your circadian amplitude is blunted.
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You're not getting this nice sinusoidal deep circadian amplitude because there's that you've blurred the line between night and day.
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And instead of black and white yin and yang, you're you're running with two shades of gray where your daytime is not bright enough and your darkness is way too bright.
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So um that that light those light conditions cause absolute uh mitochondrial inefficiency, metabolic chaos, and eventually fat storage because um there any substrate, i.e.
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food that's getting shoved into your mouth in the in those circadian, in those light uh conditions, isn't able to be properly metabolized because there's so much chaos with respect to um time of day and um you know metabolic the metabolic timing of of insulin sensitivity and and and uh substrate oxidation that it that the body just puts it into storage.
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It limits the damage of and potential oxidative stress um that could be generated by simply shoving it into adipocite storage where it's going to do the least amount of damage.
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So, and I think that is again something that people need to keep in mind is when they're trying to lose weight or wondering why they got overweight in the first place or diabetic in the first place.
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It was like, okay, yeah, you were probably eating a bunch of crispy creams and um you know drinking too much alcohol, but what was the timing of that food consumption?
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Were you ever outside in bright daylight eating your lunch, or was it eating these high-carb meals at 10 p.m.
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at in the night in front of your TV?
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Because when it comes to reversing the process, that becomes extremely relevant.
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Yes, yeah, no, absolutely.
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It all comes to like lifestyle choices, habits, and behaviors, and how that's literally influencing the physics uh side of the equation.
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Uh, as you mentioned, like uh a lot of people talk and focus on food, which is great, and that is very important, same as exercise.
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That's also an important part of the puzzle.
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But there seems to be an order or a hierarchy to health, and it seems that light and the circadian health, circadian rhythm is actually at the foundation of health.
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And everything else is addressed.
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You can address it at the same time, but it's maybe more desirable if you're aligning your mitochondria, repairing your mitochondria beforehand before you introduce more metabolic stressors such as exercise, or it can be even be a nutritional stressor, like for example, eating less calories is a stressor on the body, for example, you know, or fasting is a stressor on the body.
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So sometimes before you introduce these stressors, you need to optimize your internal environment.
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And what you're referring to really is how the biophysical or the physics of nature or our environment, our light environment, our electromagnetic environment, whether that is native or non-native, uh is influencing the organization and the instructions which are given to the cells.
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And it can be chaotic, so there's like more inflammation, more reactive oxygen species, as you mentioned, and it's creating way too much damage for the mitochondria.
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And they cannot simply repair because, again, they're not making that melatonin, whether that's on a cellular level or on a pineal level, because of circadian disruption, because of not getting enough sunlight during the day.
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So we are damaging our engines, and now we're not able to process the fuel efficiently.
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Yes, the fuel contributes to the problem, but it's I feel like it's way less significant of a problem if your uh environment is way more optimized for your health.
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And this is why Dr.
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Max is really like overemphasizing the importance of the environment because it seems that every single wavelength carries its own unique benefit on our biology.
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And even if we don't understand many of the wavelengths yet and their benefits, you know, everything is working like an orchestra and it changes throughout the day, you know, like uh like a symphony, like a song.
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Maybe talk to people, tell people about the importance of uh circadian rhythm, uh, what it is, and all of the different areas of life that it actually influences when it's working well and also when it's not working.
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Yeah, so for again, the the fundamental functions of circadian biology is the sense, the sensing of external light cues to synchronize an internal timing process in the body.
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That that's that's what what this is about.
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So the body has its its an ongoing clock where it's coordinating into um bodily processes, but that that needs an external input so that they can essentially compare the the the the blueprint.
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Or the planning that's happening inside with the external conditions.
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And this is obvious because as the earth rotates around the sun, depending on what latitude you're living at, there's um there's variation and and the days will get longer and then shorter and um and this is becomes really, really important for uh optimizing uh pro bodily processes.
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And you know, one way of thinking about it is imagine if you were uh asked to be ready to do everything at at all all the time.
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You you think about how energy energetically demanding that would be.
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Um you you couldn't, you can't you can't do everything all the time.
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So the the circadian rhythm evolved to partition uh processes at a different part of the 24 hour cycle, and especially processes that are opposite or opposing, right?
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So that is that that's how this thing came about is it's an it's an energetically efficient to put the repair and recovery at a different time point to activity and you know, say food food consumption and and hunting, so to speak.
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And you know, interestingly, this is opposite in diurnal versus nocturnal um uh animals.
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Say melatonin, which for us is a promotes and an onset of sleep, triggers rest and recovery, and um obviously is a very strong antioxidant.
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In in a nocturnal mammal, it has a it has the opposite effect.
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I mean, it's still it's still a uh signal of of nighttime, the pineal melatonin, but the the the point here is that um depending on the activity design of that that animal, it it can have different effects.
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But you know, re realistically, the circadian rhythm is also about anticipation.
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It's it because the sunrise and sunset is and is uh the following of of darkness but from sunlight, that's been the the constant for all all of life on earth for three billion years.
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So the by by by the circadian function also allows the organism to anticipate and prepare for what is predictably going to come next.
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What what you see when it's specifically talking about human health is that circadian biology affects and circadian functions and circadian um clocks affect like the most critical uh aspects of human physiology.
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So reproduction, re the reproductive cycle, uh, immune system function, you know, we already talked about metabolism, uh, you know, stem cell, stem cell functions and stem cell depots, and it's cardiovascular physiology, so the peaking and rising of heart rate availability, blood pressure, all this kind of thing.
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And and then fundamentally hormonal secretion.
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And as I alluded to, the pituitary gland, which is um in a part uh key part of the hormonal axes, um is extreme has inputs from this part of the brain called the supracismatic nucleus, which accepts the light inputs from the retina from from the intrinsically photosensitive retinal ganglion cells.
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And um that makes that should make obvious sense that the hypothalamic pituitary thyroid axis, the hypothalamic pituitary gonadal, you know, ovarian or t or or testicular axis, the hypothalamic gonadal um adrenal axis, all all of these hormonal axes are taking their cue and their input at the beginning of the whole process from the the the light centers from the retina that's firing when there's blue light in the environment.
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And when did we have blue light in the environment is when we were seeing the sunrise historically and ancestrally.
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Um and that again coordinated body temperature, it coordinated immune function, it coordinated light-dark cycles, and it coordinated cancer defense and um cell proliferation, cell turnover.
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Uh it coordinated when the body would um repair, repair things like you know, the vascular endothelial progenitor cells, which heal up um arterial um blood vessel damage.
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Um that you know, all this is is running on these circadian clocks, which in different organs like the stomach or the pancreas or the kidneys, well, you mean I mean you name the organ and there will be a circadian 24-hour rhythm that it exhibits.
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They they are receiving a signal either hormonally or um otherwise from via the master clock in in the hypothalamus.
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So everything in the body is running on a circadian timing.
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So there's nothing that isn't, because all this body, the complex bodily processes that exist in a higher order organism like a mammal, have to be so finely tuned and finely coordinated that um it's always going to be regulated by the ambient light light conditions.
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And you know, when we we think about the hierarchy again, you mentioned the hierarchy of of health inputs and and where does light fit in this?
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The the the presence of circadian rhythms in single cellular organisms, you know, even even before the there was a formation of multicellular life, before the formation of the gut as we know it, was there was circadian input and and light regulation of of of the cell.
00:28:36.160 --> 00:29:06.720
So this has just been retained as a I I wouldn't call it a vestige of of evolution, because it's I think even more as important as ever in multicellular life in, you know, and in animalia in animals, as it was back then in in the you know, in the archaea that has to, again, or the or the photosight photosynthesizing cyanobacteria that has to um develop a circadian rhythm to understand when the best time is to photosynthesize.
00:29:06.960 --> 00:29:30.160
So it's it's so fundamental to life on earth, the the presence of of these circadian functions is just emblematic of this reality that we have such a um important pulsatile um phasing in and out of this huge energy source in the sky, um, which is fundamentally behind the rise of life on earth.
00:29:30.240 --> 00:29:36.800
Without the sunlight and in all of its wavelengths um and all of its energy, there wouldn't be life as we know it.
00:29:36.960 --> 00:30:00.560
And as much as dermatology uh wants to tell you to avoid this and this is a risk factor for disease, and if you drill down into the photobiology, if you drill down into the circadian biology, if you drill down into the evolutionary biology, and you know, you're looking at things like POMC and and and and the circadian mechanism, it's absolutely critical.
00:30:00.800 --> 00:30:35.279
So there's a disconnect here between what medicine and again I I I really want to lay the blame uh lay the explanatory obligation at the feet of dermatologists rather dermatology rather than say the other specialties, because in an attempt to try and prevent skin cancer, they are interfering with the correct uh lifestyle, optimal lifestyle approach that affects all the other medical specialties that regulate what what I've just talked about.
00:30:35.440 --> 00:31:00.400
So, you know, um hematology, gastroenterology, cardiology, endocrinology, all of those specialties who are regulating disease in this very siloed way, their pathologies would be ameliorated or prevented to a large degree if the person, the patient, had more optimal circadian programming because it is so upstream.
00:31:00.560 --> 00:31:04.880
And of course, there are other factors involved when it comes to development of these diseases.
00:31:05.039 --> 00:31:12.240
But you know, what what is the body expecting the most to try and coordinate the healing and the function of these organs?
00:31:12.400 --> 00:31:15.200
Again, it's correct circadian and light inputs.
00:31:15.440 --> 00:31:17.360
So, you know, that's how I think about it.
00:31:17.519 --> 00:31:20.880
This is this isn't a bit part player in health.
00:31:21.039 --> 00:31:26.000
This isn't a convenient side note when it comes to the optimal organism function.
00:31:26.080 --> 00:31:29.279
This is like this is the main, this is the main attraction.
00:31:29.759 --> 00:31:30.800
Yes, exactly.
00:31:30.960 --> 00:31:32.720
Wow, so many great points there.
00:31:32.880 --> 00:31:52.000
And I think to to highlight the the key point that you were trying to say there for the audience, specifically with the circadian mechanism, how important it is, the repair side of things and the regeneration and you know, to eat away the damaged cells and get rid of mutated cells and to detox the body, for example.
00:31:52.160 --> 00:31:56.720
So this balance of yin and yang of doing and not doing is so critically important.
00:31:56.800 --> 00:32:02.800
Because if you think about it, if someone, you know, a mitochondria was working 24-7, it would literally burn out, right?
00:32:03.039 --> 00:32:12.560
So uh once our mitochondrial function is gone, that's literally what we call death, is when we cannot produce energy anymore in our on a in our cells on a cellular level.
00:32:12.720 --> 00:32:16.000
So you can't expect like a factory to run 24-7.
00:32:16.400 --> 00:32:25.039
And so if your body is made up of millions and trillions of factories, then you need to give those times to rest and regenerate and to repair themselves.
00:32:25.200 --> 00:32:48.160
And that doesn't only require you just hitting your head on the pillow and just assuming because you're sleeping eight hours every night that you can somehow magically get away with the circadian rhythm disruption effects of artificial blue light or the non-native EMFs or not getting enough light outdoors, the quality of your sleep will be inevitably impaired, whether you want to admit it or not.
00:32:48.240 --> 00:32:53.200
I know many people they tell me, Oh, well, I sleep great, even though I look at my phone until right before bed.
00:32:53.360 --> 00:32:56.800
Yeah, you're sleeping because you're exhausted, not because you have high melatonin.
00:32:56.880 --> 00:32:58.400
There's like a really big difference.
00:32:58.560 --> 00:33:00.720
Like, how is your system operating?
00:33:00.800 --> 00:33:10.160
Is it is your uh mitochondria screaming for help, or is it actually are you aligning your body with the natural night and dark cycles and honoring that?
00:33:10.320 --> 00:33:18.160
Because when you do that, especially across the seasons, you see this beautiful shift in the length of the day as well and the temperature change.
00:33:18.320 --> 00:33:23.200
And there is something so beautiful and unique about that, which I have come to really appreciate over the years.
00:33:23.279 --> 00:33:31.519
At the beginning, when I got into circadian health, I used to think that it's better to avoid the winter times and move somewhere sunny and when it's all the time sunny.
00:33:31.759 --> 00:33:36.320
But I here in Cyprus, for example, where I am right now, we do experience winters as well.
00:33:36.400 --> 00:33:43.519
Like the UV light goes to close the UV2, uh UV1 in the wintertime, so we're not able to get so much vitamin D.
00:33:43.600 --> 00:33:45.200
Uh, but there's still sunlight, okay?
00:33:45.279 --> 00:33:46.480
It's still the infrared light.
00:33:46.640 --> 00:33:49.680
But there is more cold temperature and there is shorter days.
00:33:49.759 --> 00:34:03.600
And I really appreciate that because I noticed that my skin health and even my hair and everything really flourishes in a time of high melatonin, especially if you honor that melatonin, that pineal melatonin, and the cellular melatonin by getting the sunlight.
00:34:03.759 --> 00:34:05.519
But in the in the summertime, it's the opposite.
00:34:05.600 --> 00:34:10.880
You have more cellular melatonin, you have less pineal melatonin, but you have different demands on your body, right?
00:34:10.960 --> 00:34:19.920
So it just seems that nature has done everything so perfectly that it has balanced everything across the seasons, but also throughout the day as well, and also the temperature.
00:34:20.079 --> 00:34:26.639
And everything seems to have an important role on biology, even if we think it's something to be avoided or shielded from.
00:34:26.800 --> 00:34:31.519
For example, in the winter, people avoid the cold, they stay indoors, they put their heaters on, for example.
00:34:31.599 --> 00:34:34.400
But actually, we never evolved in indoor environments.
00:34:34.559 --> 00:34:36.719
We were always outdoors, grounded 24-7.
00:34:37.039 --> 00:34:40.400
Another question that people ask me is how much should I ground every day?
00:34:40.480 --> 00:34:42.719
How much how much did your ancestors ground?
00:34:42.800 --> 00:34:45.440
You know, before there were houses, before there were shoes.
00:34:45.599 --> 00:34:52.639
You were literally every animal on the planet is literally grounded 24-7, unless they're in flight, you know, if you're a bird or something like that.
00:34:52.800 --> 00:34:57.280
I feel like I went on a bit of a tangent there, but I think it was important to mention those things.
00:34:57.519 --> 00:35:03.599
Maybe let's talk about the importance of eyes and eye health as it relates to health.
00:35:03.840 --> 00:35:11.680
I think you already kind of touched on it previously where you were mentioning about the light going through the eyes, but how important do you think eye health is to our overall health?
00:35:11.920 --> 00:35:16.720
Yeah, eye health is critical, and the eye is an extension of the brain.
00:35:16.960 --> 00:35:23.200
And that's that's what you know, the the retina and these retinal ganglion cells, they are wired.
00:35:23.519 --> 00:35:39.440
They go, they go from the retina that which is at the the back of the eye, and they they go all the way to this, you know, optic chiasm, they cross over, and then they they plumb into the hypothalamus at at this and then they radiate to different parts of the brain.
00:35:39.599 --> 00:35:51.280
And in the retina, there's obviously there's the the visual photoreceptors, which is the rods and the cones, and the you know, the the the cones are vision forming during daytime.
00:35:51.360 --> 00:35:56.159
This is for what we call um you know photic conditions during the light time.
00:35:56.400 --> 00:36:02.240
Uh, and they have these different peaks, different types of cones, and they give us this image forming ability.
00:36:02.400 --> 00:36:10.320
They have a they're able to allow us to distinguish what is actually going on in front of us, like a like a uh a camera.
00:36:10.559 --> 00:36:45.360
Um and then uh the small percentage of of these retinal cells are like we talked about, are only variously firing in response to certain light wavelengths, and predominantly it's the it's in the blue, and which which are then uh programmed straight into into the circadian mechanism, and they're firing when daylight is present so that they can turn off pineal melatonin, um, stimulate uh daytime, stimulate the you know cortisol awakening response and and and have that really important effect.
00:36:45.599 --> 00:37:05.280
So the eye structure is expecting, uh, and I think this is an important point, is just like the every other organ in the body, just like the skin, the eye is expecting a certain spectral composition and a spectral timing at a certain time of day.
00:37:05.760 --> 00:37:15.440
What what I mean by that is it has the presence of uh of circ circadian variation in key structures, say like the cornea.
00:37:15.680 --> 00:37:22.480
It has um vitamin D receptors and the ability to activate vitamin D in those those structures.
00:37:22.639 --> 00:37:34.720
So and it has things like uh OPN5, which is a neuropsin, which is a UVA light detector, uh unlike uh melanopsin, which is in the in the blue.
00:37:34.880 --> 00:37:59.680
So the presence of these functions tell us that the light that the eye is expecting the day to start with low angle sunlight, which is richer in red and near infrared, um, but it's still expecting a large amount of scattered blue light in the sky, and it's also expecting the as the sun angle rises to have your ultraviolet light.
00:37:59.760 --> 00:38:06.559
And it's adaptive and it has functions in there to deal with the presence of ultraviolet light in the environment.
00:38:06.720 --> 00:38:21.280
And if we are living in an environment which our ancestors are adapted to, then you have the exact toolkit in your body and in your eyes to appropriately deal with um with that light.
00:38:21.519 --> 00:38:31.440
So viewing the sunrise and not using sunglasses in the early morning is going to be conducive to sending the appropriate signals to the eye.
00:38:31.680 --> 00:38:35.440
And what what what what else needs to be said about the eye?
00:38:35.519 --> 00:38:42.559
I think there's a really interesting property of of the eye which gives us an insight into what environment humans should be in.
00:38:42.639 --> 00:38:52.079
And that's this spectral sensitivity in the in photophotic vision uh of five over in the deep green.
00:38:52.240 --> 00:39:18.240
So it means that the visual acuity or the ability to discern things is the most um uh sensitive or uh able in the in this green range, and I think that's a relic of being in a treed environment, being in an undergrowth where there was lots and lots of green greenery, so that we could distinguish between things in amongst the foliage and amongst the the undergrowth.
00:39:18.559 --> 00:39:29.920
And what I think that tells us is that it's valuable for us to be in green environments and to be there in uh in in a situation where we have those natural wavelengths.
00:39:30.240 --> 00:39:36.159
So when it comes to eye health, what are people doing nowadays to disrupt you know their eye health?
00:39:36.320 --> 00:39:39.840
I I think it's there's happening on a on a range of different uh levels.
00:39:40.000 --> 00:39:46.800
One, they're depriving themselves of a long wavelength light, um particularly in the red and the near-infrared.
00:39:47.200 --> 00:39:58.320
And we there's evidence from the photobiomodulation literature that that absolutely affects things like um the development of myopia or refractory errors.
00:39:58.480 --> 00:40:07.039
And you know, something at I don't know 80%, 90% of East Asian teens now have are myopic and have reactive refractive errors.
00:40:07.280 --> 00:40:10.480
Um so it's it's and what do they do?
00:40:10.559 --> 00:40:15.280
They're always on screens, and they're never outside, they live in concrete jungles and and this kind of thing.
00:40:15.519 --> 00:40:18.079
There's the this affects the globe.
00:40:18.320 --> 00:40:32.639
It literally it affects the development and the length of of the globe, and it's and you you don't you're gonna concentrate the image incorrectly um when when you're deprived of these important light signals.
00:40:32.880 --> 00:40:43.039
So, you know, that is something that we're seeing is that if you get the light wrong, you're gonna absolutely negatively affect eye health as early as you know, a four-year-old child.
00:40:43.200 --> 00:40:59.840
You see the kids walking around with their glasses on and the iPad, and you can you know for sure you can make a diagnosis without even in interviewing the, you know, taking history that that is a child who has had insufficient outdoor time and is have way too much time in front of an iPad.
00:41:00.000 --> 00:41:19.440
And then, you know, going forward in the lifespan when we're exposed to too much isolated blue light without the red and infrared that would naturally occur in full spectrum sunlight, then you get a an imbalance in these photooxidizing shorter wavelength light.
00:41:19.519 --> 00:41:26.240
I mean, blue is also called high energy visible because it's right next to ultraviolet A on this on the spectrum.
00:41:26.480 --> 00:41:36.400
So although it's visible light, it's very it's high energy and it can do damage, it can photooxidize structures in the in the eye, in the in the retina.
00:41:37.039 --> 00:41:41.920
And I think leading to problems like vacuum degeneration.
00:41:42.079 --> 00:42:04.000
Um and when you combine the this this blue dominant light environment, the fact that people aren't having that true darkness when the sun goes down, they're kind of just spamming their eyes, they're asking them to continue to act as a as a daytime function when they're supposed to be resting, then you're gonna absolutely get them, you're gonna start burning them out.
00:42:04.079 --> 00:42:07.200
You're gonna get accelerated things like uh macular degeneration.
00:42:07.280 --> 00:42:20.720
And then when you combine that with a high carb, high sugar um processed foods food diet, um, then you've got a perfect recipe for you know cataract formation and uh yeah, and and and macular degeneration.
00:42:20.880 --> 00:42:33.920
So low seafood intake, which is obviously critical for providing things like retinol, um, vitamin A and DHA into that that are key for the for eye health and eye structures.
00:42:34.079 --> 00:42:59.920
So yeah, I mean I eye health is is massive and it's a it's a real clue potentially into someone's um overall health and maybe even brain health, that if they're having ocular problems you know early in life, that that this is a massively uh mismatched environmental signal signaling that they're potentially depriving themselves of or um even inappropriately exposing themselves to.
00:43:00.159 --> 00:43:00.960
Wow, wow, yeah.
00:43:01.280 --> 00:43:14.480
It just shows you again like how the body is so adaptive to the circumstances and signals that we are giving it and how I think it was really enlightening where you were talking about the oxidative effects of light and how close the the blue is to the UVA.
00:43:14.720 --> 00:43:24.400
Because uh I learned from Professor Thomas Seeger in our previous discussion just recently that you know how the UVB is responsible for building your you know your deep, your new melanin, right?
00:43:24.480 --> 00:43:29.519
And then the UVA is more for it oxidizes the melanin, so it makes it more brown.
00:43:29.599 --> 00:43:33.280
So the melanin that you already have on the surface, it basically browns it, right?
00:43:33.360 --> 00:43:36.320
And then that is what basically rubs off in the shower.
00:43:36.720 --> 00:43:47.680
Uh so you don't want only you know that UVA, but you want the UVB to build your your new melanin so you can build that foundation, that layer for your body to be able to protect you long term.
00:43:48.000 --> 00:43:50.320
And well, you see lots of issues with this, right?
00:43:50.400 --> 00:43:57.280
With now in tannin beds or salons, they are using mainly UVA and they are not combining it with red and infrared light.
00:43:57.440 --> 00:44:10.800
But specifically, what you are mentioning is that how the blue is so close to the UVA and its oxidative effects, and the fact that we are actually staring at a screen, and the the issue with a lot of these things is the prox the proximity and the duration that we are using these things, right?
00:44:10.960 --> 00:44:16.960
Uh so the inverse square law is so, so important when it comes to EMFs, uh non-native EMFs specifically.
00:44:17.119 --> 00:44:21.440
The closer we are to the source of the radiation, the greater the exposure, and the bigger the issue.
00:44:21.599 --> 00:44:27.680
And even if the exposure or the intensity of the exposure is small, then we are using them so many hours in a day.
00:44:27.760 --> 00:44:40.720
You see so many people, like now I saw some recent study where people are thinking it was in Spain or somewhere like this, where girls of like a you know, teenage girls you use their phone for like up to 40 hours a week or something like this.
00:44:40.960 --> 00:44:45.519
And so it's just People are using these devices as if it's their full time job.
00:44:45.599 --> 00:44:54.079
And something I like to tell people all the time is like if you're not getting something from it, meaning like you're not learning something from it, or if it's not making you money, like why are you using it?
00:44:54.240 --> 00:44:58.079
Because it's just like it's literally draining your health and it's stealing your dopamine.
00:44:58.240 --> 00:45:08.880
And your dopamine is so so important because it helps you create, you know, pick meaningful things in your life, uh, make appropriate decisions, which is driving you towards your true purpose.
00:45:09.039 --> 00:45:17.280
And I this I kind of under um overestimate this enough about the importance of purpose, because purpose is so so critically important for health.
00:45:17.440 --> 00:45:38.639
I feel because if we can talk about all the health things in the world, but if you if a human being doesn't have a purpose on this planet, like to feel like when they wake up in the morning, I'm gonna serve, I'm gonna create, you know, we have in us, um in our body and in our mind, we have this feeling and this deep design, uh desire and yearning to create things.
00:45:38.800 --> 00:45:45.519
And it's because we we all are parts of God, we are an extension of God, and God wants to create things, He wants to experience life.
00:45:45.680 --> 00:45:57.119
And so, together, when we come together, when we can contribute to each other, we can create a table, we can create a painting, we can create food, uh, we can create art, we can create art with our bodies, which is basically exercise.
00:45:57.280 --> 00:46:01.599
The body basically wants to create, and this is when we feel good, we get into that flow state.
00:46:01.680 --> 00:46:12.320
When when the body is in this state of just staring or gazing at something, we're not really like creating anything, we're just being sort of like brainwashed, MK Ultra, right?
00:46:12.559 --> 00:46:14.639
And we are just consuming, consuming, consuming.
00:46:14.720 --> 00:46:15.760
Yeah, and as Dr.
00:46:15.840 --> 00:46:27.119
Jack's uh Jack Cruz says that you know the screens are blue-lit by design, and it is 2026, and still all of the phones and all the tablets and all the screens are blue-lit.
00:46:27.200 --> 00:46:32.960
It's absolutely wild, even with all the information out there about the damaging effects of artificial blue light on eyes.
00:46:33.119 --> 00:46:35.360
I guess you could say that, yeah, exactly.
00:46:35.519 --> 00:46:38.400
We have a blue light-free technology which is fantastic.
00:46:38.559 --> 00:46:46.559
Uh, but the thing is that you know, no one is uh they are giving you the information, they're telling you that it's there, but it's it's your consent.
00:46:46.639 --> 00:46:48.800
You are giving your consent to use these things.
00:46:48.880 --> 00:46:57.680
Uh at least it's not as bad as you know, people pushing the jobs on you, but you know, it's still like it's the dopamine which is making you go and buy that stuff, right?
00:46:57.760 --> 00:46:58.800
You want the new technology.
00:46:58.880 --> 00:47:01.280
Don't get me wrong, like I absolutely love technology.
00:47:01.440 --> 00:47:09.119
I always used to love technology before I got into you know the work of circadian rhythms and quantum biology and biophysics because it's so addictive, you know.
00:47:09.200 --> 00:47:11.119
I think the human brain loves new things.
00:47:11.280 --> 00:47:17.840
We love to experience that something that we've never seen before, but then that robs us of the real beauty of life.
00:47:18.079 --> 00:47:25.680
And if you don't have that overstimulation, you start to notice the beauty, and you get overstimulated rather by nature.
00:47:25.760 --> 00:47:29.280
You start to notice the shape of a leaf, maybe the shape of a flower.
00:47:29.440 --> 00:47:32.400
Like, why does a flower have a specific color?
00:47:32.559 --> 00:47:34.240
Why does it have a specific smell?
00:47:34.400 --> 00:47:45.599
You see, you run all the more deeper and meaningful questions in your head rather than being a blank canvas which is filled with information that they actually want to program you with.
00:47:45.760 --> 00:47:49.920
Uh, you touched on a very important subject, which was DHA for the eyes.
00:47:50.079 --> 00:47:52.559
Uh, I think this is like really, really huge.
00:47:52.720 --> 00:48:01.599
Uh, what are the other functions of DHA in the body and why is it important for people to make sure that they eat enough fish food on a weekly basis or even daily basis?
00:48:01.840 --> 00:48:10.639
Yeah, I uh I if I may, I will harp on a point that you raised with respect to this idea of uh experiencing life and you know creating.
00:48:10.800 --> 00:48:15.680
And it goes it goes back to the origins of life.
00:48:15.920 --> 00:48:38.639
And when you speak to some of these researchers that are exploring the origins of life, it seems that life is a uh basically a emergent property of an energy source that is uh basically causes self-organization in uh you know basically inanimate uh component parts.
00:48:38.880 --> 00:48:54.720
And you know, where whether life evolved in these deep thermal vents where there was the you know just the right conditions, where there was a massive energy gradient, and then you know suddenly these these structures emerged to essentially dissipate the energy and as part of that create complexity.
00:48:54.960 --> 00:49:07.680
And as as life has progressed, it's been an ongoing process of engineering or engineering or developing more elaborate complexity to dissipate more energy.
00:49:07.920 --> 00:49:28.960
And um that that complexity has allowed these structures like say the single cell cellular um organism and now multicellular organism is to to um create more and more and more complexity in a in a coordinated manner, um, that is truly you know absolutely amazing.
00:49:29.280 --> 00:49:43.760
And when you pair that with some of the more um, I guess spiritual ideas about uh as you've as you alluded to, you know, you mentioned the idea of you know God is is something that um you know wants to experience itself.
00:49:43.920 --> 00:49:52.559
And and maybe you know, people philosophically or religiously or spiritually conceive of consciousness is we're here to experience ourselves.
00:49:53.680 --> 00:49:58.880
We're all one entity, but we're you know it's like it's like the fingers emerging from the the ground.
00:49:59.039 --> 00:50:06.159
Everyone's from the same hand, but we're just looking at each other, experiencing consciousness in independently or subjectively.
00:50:06.480 --> 00:50:12.480
But um life itself is I feel could be the goal of life is to create complexity.
00:50:12.639 --> 00:50:24.400
It's to experience, um, take take energy, dissipate the energy that it exists in in solar form, in in you know, amazing grass-fed beef or wild caught seafood.
00:50:24.559 --> 00:50:33.039
You take that energy and and the UV light that you've just been lying under with your feet on the ground, you take that energy and you create something amazing out of it.
00:50:33.200 --> 00:51:00.320
And you know, I think the create creation of human civilization and human culture, language, um, stories, it it's all a progression of this emergent complexity that occurs when when energy gets dissipated and um these organisms are able to hold this far from equilibrium state where we are we're not at well, I mean, it's it's probably 20 what 21 degrees where I'm sitting right now.
00:51:00.480 --> 00:51:02.639
You know, my body is not at 21 degrees.
00:51:02.800 --> 00:51:11.599
You you you made the point earlier about mitochondrial function and and the flow of electrons is what separates us from being a simply a dead corpse.
00:51:11.760 --> 00:51:36.880
So we're we're sitting at this electrical, um, electrically charged state where our mitochondria are maintaining this insane um energy, this voltage across the membrane to permit us to be temporarily for you know 90 years or a hundred years of of our time on this earth to exist and experience life, experience the world, experience what it is to be human.
00:51:37.039 --> 00:51:43.599
Um and and I agree that our job here is to create complexity in the service of each other.
00:51:43.760 --> 00:51:49.680
I think uh that that that to me is is a perspective on on what what the meaning of life is.
00:51:49.920 --> 00:52:11.599
And if we're gonna sit there and allow our brains to be filled with complete garbage or worse, just uh factors that are in service of corporate profit or ideal ideology that's seeking to divide us rather than unite us, then you're you're kind of you're kind of missing the the point, in my opinion.
00:52:11.840 --> 00:52:18.639
You're missing the point, you're missing an opportunity to to experience this amazing thing that is to to be alive.
00:52:18.960 --> 00:52:45.680
So um I all that to say is that I agree with I agree with what you've you've said, um Andreas, and it's a it's a massive call to put down the newsfeed and disengage from blue lit screens to in for time out in nature, yeah, long form content, reading physical books or you know getting yourself a daylight computer and loading it with scientific papers or poetry.
00:52:46.320 --> 00:52:50.960
Um so so but to answer your question about DHA.
00:52:51.599 --> 00:53:08.159
Before you're jumping, I just wanted to say mention that it's something critically uh like fascinating that you said about the mitochondria and exporting um I don't remember how you said it, but like what I heard uh through all of that is that you were saying that mitochondria are exporting entropy, pretty much.
00:53:08.400 --> 00:53:11.519
They are like through are they dissipating it through heat?
00:53:11.599 --> 00:53:12.400
Uh like what are they doing?
00:53:12.639 --> 00:53:24.159
Yeah, so so the person who kind of crystallized this for me was um was Bob again, Professor Bob Fosbury, when he he an analogized a biological system to to the sun.
00:53:24.559 --> 00:54:02.480
And you know, the sun is a star that maintains this uh essentially a uh far from equilibrium state where it's undergoing fusion and um it's essentially uh basically t fusing thing uh hydrogen into into helium and and the process it's creating um light and and it's actually exporting that that energy as as as light and starlight, and that starlight um leaves the sun um and it needs to leave the sun so that the sun can maintain its this this equilib this far from equilibrium state.
00:54:02.720 --> 00:54:09.200
And the the analogy that Fosbury made is that life emerges on the on the star's wasted energy.
00:54:09.440 --> 00:54:28.639
It's we're existing on the entropy that's been exported from the sun, and we we are ingesting photosynthetic products, which again is uh are photons, and then to to so that we can exist, we are we are emitting energy, we are dissipating that energy, and that's being emitted as longer wavelength light.
00:54:28.800 --> 00:54:32.639
Like you can pick it up on a thermal camera when you you know night vision goggles.
00:54:32.800 --> 00:54:34.559
So, um, and then Dr.
00:54:34.639 --> 00:54:48.720
Alexander Wunsch framed it in again in a different similar way, which is it which is sunlight is turning the wheel of life on planet Earth, and the input is these higher energy photons, and the output is is is longer wavelength light.
00:54:48.880 --> 00:54:58.480
And you can't put if you if you if you stop that process of light um dissipation and light re-emission, it'd be like putting the your hand on an exhaust pipe.
00:54:58.720 --> 00:55:02.639
So um Alistair Nunn of the Guy Foundation framed it in this way.
00:55:02.720 --> 00:55:38.559
He said, Yeah, you know, life evolved to accelerate the heat death of the universe, which is you know sounds like a crazy idea, but essentially to accelerate this process of um energy dissipation from a higher energy state to you know this longer and longer and longer wavelengths of of light that eventually gets um you know dissipated out into the into the universe until some period in billions of years in the future, you know, it's all at equilibrium in the same way that eventually a hot cup of bone broth coffee gets um uh eventually gets to room temperature.
00:55:38.720 --> 00:56:08.079
I mean, that's the end goal somewhere in the future when you and I are both um you know no longer in in this mortal realm, but that that seems to be the physics of of what's happening, and we are just a small part, a very temporary you know, blip in this grand theater, this grand biological process of where we're gonna do a little bit of um energy dissipation uh and yeah, hopefully create create some complexity along the way.
00:56:08.320 --> 00:56:21.920
You know what's even more wild that came to my mind as you were speaking, you know, I was building a story in my head, sort of like a movie, and I just thought to myself how yeah, the mitochondria are dissipating this energy and they are lowering entropy by doing so.
00:56:22.240 --> 00:56:30.000
And we are sort of as human beings, as a collection of trillions of cells, uh dissipating this entropy into creation.
00:56:30.079 --> 00:56:36.480
Uh so it almost feels like the creation is a is like the byproduct of it's like entropy leaving our body, pretty much.
00:56:36.639 --> 00:56:45.119
Like if you do it in that manner, it's almost like you know how you have this urge to create, or you have this you have uh this urge to have meaning and purpose in life.
00:56:45.200 --> 00:56:53.519
It almost feels like, yeah, that's it's like biologically designed, like built in within our system that we have to do something in order to actually feel better.
00:56:53.680 --> 00:56:55.039
You know, it's like it's wild.
00:56:55.280 --> 00:56:55.760
Absolutely.
00:56:55.840 --> 00:56:58.000
And and and what is what is that energy?
00:56:58.079 --> 00:57:00.720
It it is it's actually the same as sexual energy.
00:57:00.960 --> 00:57:14.240
And you know, you you see you see like orders of monks and in monasteries, uh, you know, they they're celibate because they're you know, they're diverting that energy into the you know the what they invented the first printing press.
00:57:14.400 --> 00:57:28.880
They were prior to that, they were scribing all these like beautiful tomes of of of literature, and and they're you know creating all this all these ideas and and uh you know all this literature and history.
00:57:29.599 --> 00:57:40.400
So so I think they're you know, they're they're one and the same thing is is is this it's it's literal creative life force that you can be can be directed in different ways.
00:57:40.720 --> 00:57:50.880
Yeah, I think it's helpful for people to actually acknowledge this, uh you know, simplify it to that level, you know, how it influences your everyday life, like how you channel your energy.
00:57:51.039 --> 00:58:06.880
Like think about modern life sucking your energy like an octopus in different directions, and again, going back to what we're saying, like being in alignment with nature and lowering our entropy, uh, so our you know, our death pretty much, you know, like how fast we go to like our grave.
00:58:07.039 --> 00:58:21.440
Uh basically depends on our environments and the inputs and the signals that we receive from the environment and how the byproduct of that on the mitochondrial level and how that's gonna, you know, result or reflect in the fate of the a the aging process.
00:58:21.599 --> 00:58:28.400
So if we want to be like preserving our age for as long as possible or delaying death for as long as possible, as Dr.
00:58:28.480 --> 00:58:36.880
Jack Cruz talks about, then we need to be making sure that we are in alignment with nature because no one is escaping entropy, eventually everything decays.
00:58:37.039 --> 00:58:51.200
So, and the cool thing how like magnetism and electricity like they go hand in hand, and how like magnetism is growth and electricity is decay, and basically when a fruit is ripening, that is basically it's already decaying.
00:58:51.280 --> 00:58:56.800
But you know, when we see a fruit like you know, before it's ripe, we're saying, Oh, it's unripe, it's not ready, it's not ready.
00:58:56.880 --> 00:59:01.920
It's a bit like a like an avocado, and then it's like, oh, it's too, it's too ripe now, you know, and now it's gone.
00:59:02.079 --> 00:59:03.760
And so this is pretty much life.
00:59:03.840 --> 00:59:09.680
We need to appreciate it while it's here because life is constantly running, the clock is constantly ticking.
00:59:09.760 --> 00:59:16.400
We just make must make sure that our clocks are fine-tuned so that there is this coherence inside the system instead of inflammation.
00:59:16.880 --> 00:59:36.559
Absolutely, and I really love how you brought up that point of slowing uh as as life being or good health being the slow slowest rate of death, because I absolutely 100% agree with that, which is that we are trying to slow the bioenergetic decline of our mitochondrial colony as much as possible.
00:59:36.880 --> 00:59:56.559
Because what happens in terms of death, um what what there was a nature paper maybe that came out a couple a year or two ago, and it looked at um it looked at death causes and it and it and and obviously organs are diseasing or breaking down or failing at different rates.
00:59:56.800 --> 01:00:04.559
And for for each individual, the a cause of death is going to be the one of their organs failing before the others.
01:00:04.800 --> 01:00:49.760
Um and the goal here is to try and preserve or especially our most mitochondrially intensive organs like heart, the brain, um, and the immune system, which I don't think many people talk about, but immunosinescence or premature aging of the immune system is a massive problem for longevity if you if your goal is longevity, because one, if your immune system isn't doing its job properly, you're going to get cancer because you you're gonna lack the um cytotoxic T cells ability to to identify and and and kill can't pre-cancerous cells, and you're obviously gonna be more um susceptible to infectious diseases, um, you know, pneumonia and and you know and a sepsis and the rest.
01:00:49.920 --> 01:01:08.000
So bioenergetics, and this is Doug Doug Wallace's work and and you know pioneering work that he did, bioenergetics explains the longevity protocol and the longevity strategy better than what you know people like David Sinclair or Brian Johnson are trying to do.
01:01:08.240 --> 01:01:27.039
Because if you if you're missing the centrality, which is the mitochondria in the whole story, then you're you're going to also miss the role of the environment and that metabolic envelope, the adaptive metabolic envelope, the ancestral environment in which the mitochondrial function is optimized for.
01:01:27.280 --> 01:02:03.039
So it all does come back to your light choices, your time in nature, your um all these critical grounding, all the other inputs, because those are the set of conditions which the mitochondrial energy output, the um the ATP production, the you know, the delta, the mitochondrial membrane potential, they're all going to be the reaction oxygen species production, the biophoton production, all of these uh outputs or of mitochondrial function are optimized under the strict set of conditions, which is the natural world.
01:02:03.200 --> 01:02:27.440
And when these futurists or you whatever their you know, I don't know what what's these various um utopian ideas of extending life indefinitely, what they critically don't understand is that Mother Nature has already given the blueprint over these billions of years for how you are going to optimize your life in this meat suit that you're sitting in now.
01:02:27.599 --> 01:02:32.960
And it's not by adding X1s and peptide or God knows whatever else.
01:02:33.119 --> 01:02:43.519
It's going to be by um aligning the organism into this situation where it can essentially optimize that that mitochondrial function for as long as possible.
01:02:43.760 --> 01:02:45.039
Yes, yes, absolutely.
01:02:45.280 --> 01:02:49.280
You can't biohack yourself to health because the original biohack is nature.
01:02:49.440 --> 01:03:01.760
Uh, when you look at animals in nature, you know, when they are close to their death, they you know, most of the times if they haven't been killed or had like some kind of infection or something, they'll just go and lie somewhere and they'll just pass away peacefully.
01:03:01.920 --> 01:03:14.240
Uh, human beings have probably done that as well for thousands of years, but it's only recently where we notice all of these issues, uh, these weird um neolithic diseases we're experiencing because of our modern life.
01:03:14.320 --> 01:03:16.559
Uh, and you know, there's just so much to it, right?
01:03:16.800 --> 01:03:34.480
It's not only just the blue lights and the EMF and the lack of sleep, but it's the processed food, it's the it's the information that we're receiving from every single direction, it's the spraying of the skies, it's the it's the glyphosate, it's the it's the sitting in the chairs, it's the toxic personal care products.
01:03:34.559 --> 01:03:36.240
You know, it goes so, so deep.
01:03:36.320 --> 01:03:41.119
And it takes so much unprogramming to remove all of these toxicities from your life.
01:03:41.200 --> 01:03:51.119
And really, what we are doing here on this show, we are teaching you how to be aware of all of the things which are disrupting your innate ability to thrive.
01:03:51.360 --> 01:03:54.720
Because there is an inbuilt mechanism within the human body, like Dr.
01:03:54.800 --> 01:04:01.440
Max mentioned throughout this entire episode, the program, the blueprint already exists within you, it's divine, you know.
01:04:01.599 --> 01:04:16.720
And if you disrupt that process, that coherence, that flow throughout the system, that is when you get chaos, inflammation, excessive ROS, then you start to manifest you know, diseases, mitochondrial dysfunction, and then everything pretty much begins to fall apart.
01:04:16.800 --> 01:04:19.360
So at the end of the day, it's all about awareness.
01:04:19.519 --> 01:04:22.639
This is why we do this show, this is why we have incredible people like Dr.
01:04:22.720 --> 01:04:23.599
Max on the show.
01:04:23.760 --> 01:04:31.280
Maybe let's close out with the last question with the with the DHA and the fish oils and why that's really, really important, and then I'll let you go and have a great Yeah.
01:04:31.360 --> 01:04:45.599
So I mean Omega these omega-3s omega-3 fatty acids from an from an evolutionary period point of view seem to be critical for the development of the humor of the of an of the nervous system or of neuronal function.
01:04:45.760 --> 01:05:12.559
And it was uh it marked a pivot from the use of light to it for uh photosynthesis, which is obviously the conversion of photonic energy into um developing carbon, carbohydrate, and you know, chains um to using light or harnessing photons for bioelectrical uh output.
01:05:12.800 --> 01:05:44.960
And and that is that's what this uh this um fatty acid, this polyunsaturated fatty acid to coosa hexanoic um uh acid actually does is that because of its unique structure with with these you know ring structures and these essentially um they're like delocalized electrons, it it actually and enables it to perform almost like a some some some unique uh uh quant quantum properties.
01:05:45.200 --> 01:05:58.639
And it allows this um this performance or this uh bi biophysical function that is extremely efficient at um allowing electron to flow like almost like a copper wire.
01:05:58.800 --> 01:06:19.280
Um for those who are really interested in delving into the biophysics, and there was a paper recently published by the I I guess you could say the Pope of the field who's Michael Crawford, PhD, who's the most one of the the he's the most well-regarded researcher in in DHA and um brain function.
01:06:19.599 --> 01:06:35.200
So what what happened was that this special um PUFA, this special uh molecule was actually necessary for the development of the most primitive nervous systems in dinoflagellate organisms.
01:06:35.360 --> 01:06:48.880
Um and interestingly, you can tweak the the structure, the chemical structure of the In certain ways, and you subtract subtract a hydrogen and carbon here and there, and and it's just not the same.
01:06:49.440 --> 01:06:50.559
It doesn't work the same.
01:06:50.800 --> 01:06:56.800
So it's it's so unique that it's been conserved over hundreds of millions of years.
01:06:57.119 --> 01:07:27.039
And what it it means for us as humans is that it was the difference between being essentially a um having um an average or moderate amount of brain tissue and gray matter relative to our you know mammalian and primate cousins, and growing this huge brain that is well in excess of any other um mammal or any other primate.
01:07:27.280 --> 01:07:36.240
So the question then was how did we concentrate so much DHA to facilitate such a you know this brain growth?
01:07:36.480 --> 01:07:42.079
Um and how, you know, w w what evidence do we have that that is the case?
01:07:42.240 --> 01:07:56.559
And again, Michael Crawford did this this research and showed that it that that uniquely it's the it's the amount of DHA that gets gets concentrated in in the brain that is unique for for human cognition.
01:07:56.720 --> 01:08:29.439
And the answer is in terms of this bioavailability was that it was an abundant food source during our ancestral past and it was feeding or eating from the marine food web where women who would have been pregnant would have ad libedum access to mussels, to oysters, um, with you know you can you can if anyone's been to a uh beachside rock rocky area, you just go with a with a rock and or you can dig up shellfish and you whack it with a rock and you eat it.
01:08:29.599 --> 01:08:32.319
I mean, a a two-year-old boy can do this.
01:08:32.639 --> 01:08:54.880
And uh what I think happened personally is that the pregnant women would have been scavenging at the seashore for the whole nine months of their gestation and prior to that, essentially having massive amounts of not only DHA, but also the other key marine derived nutrients which which are brain essential.
01:08:55.199 --> 01:09:08.239
And th this is really key because you can't grow a human brain that functions in the way that allows complex thought, language, etc., without these key nutrients.
01:09:08.319 --> 01:09:26.880
And they're not only DHA, but they're also these trace minerals, iodine, zinc, selenium, copper, iron, uh, and and vitamin D as well, which obviously we generate in our skin but comes pre-formed, especially when we're eating um you know certain cold water uh fish.
01:09:27.199 --> 01:09:35.680
So those these brain essential nutrients allowed and permitted the development of of our our brains as we as we know them.
01:09:36.000 --> 01:09:56.480
So the it's it's uh unsurprising that you can see um deficits or deficiencies of of those fatty acids is linked to poor IQ in uh in in infants of of women who uh you know eat had less um fish consumption.
01:09:56.720 --> 01:10:16.000
I mean, the the mouse data was that Crawford presents is showing how with a rat uh m rat model that was specifically fed insufficient uh relatively less DHA, you simply get less appropriate um neuronal migration of these cortical neurons.
01:10:16.079 --> 01:10:22.800
So so the neurons aren't migrating to the place that they need to go appropriately if they don't have these building blocks in place.
01:10:23.039 --> 01:10:24.720
So what else is it linked to?
01:10:24.880 --> 01:10:50.159
I mean, it's it's like it's there's evidence it's probably playing a role in neurodevelopmental disorders uh at ADHD and autism spectrum, which kind of which would m make sense and uh would be a obviously it's not the only cause, but it's a likely a strong component cause if if the mother rather than eating marine-dried nutrients is is sufficing on seed oil-rich drug foods.
01:10:50.399 --> 01:11:15.279
Um and then things like depression, mental health dis disorders, and um and probably and and the neurodegenerative disorders, they're all gonna have a degree which they're either preventable or prevented or improved by fixing or improving the amount of of DHA in in the system and and marine-derived nutrients in the system.
01:11:15.600 --> 01:11:31.680
The you know, the easiest way to check your own DHA level is through a a fatty acid index where you can simply get a blood test uh a card that posts it to you, and you drop your blood onto this card and post it off.
01:11:31.840 --> 01:11:43.920
And they analyze the fatty acid composition of your red blood cell and basically give you a percentage by which uh your your cell membrane have these uh you know DHA and EPA.
01:11:44.239 --> 01:11:55.600
So from that, the the evidence exists about the the prevalence or the risk of cardiovascular disease as well as neurodegenerative diseases.
01:11:55.840 --> 01:12:11.920
And the more you have these marine-derived uh fatty acids in your cell membranes and in your neurons and powering your body, the the better and more efficiently you're going to avoid those diseases.
01:12:12.239 --> 01:12:16.000
And, you know, the cardiovascular stuff is another whole story.
01:12:16.159 --> 01:12:25.600
I mean, we could be, we could talk for another two hours about cardiovascular disease and circadian regulation of of the cardiovascular system and and how that relates.
01:12:25.840 --> 01:12:36.399
But, you know, fundamentally, atherosclerotic cardiovascular disease or heart attacks is is driven by altered vascular biology.
01:12:36.640 --> 01:12:47.520
Um I know the emphasis from the mainstream absolutely is pointed at lipoproteins and and specifically these Apo B and LDL lipoproteins.
01:12:47.680 --> 01:12:58.560
Conveniently that they are medicatable targets, but really what's going on in the in the blood vessel with respect to the vascular biology is key.
01:12:58.720 --> 01:13:20.800
And what's going on with respect to the um the thrombotic environment or the likelihood of clotting is eventually what is going to dictate whether um uh uh endothelial injury becomes a a you know platelet aggregation, agation, a clot, and therefore uh acute myocardial infarct.
01:13:20.960 --> 01:13:42.640
And um but the the presence of these uh omega-3 fatty acids shifts the the in the inflammatory environment away from prothrombotic, uh in inflammatory to uh much less um the the opposite essentially.
01:13:42.800 --> 01:13:48.480
So um you know you can look at the Eskimos, the Inuit, they they ate with famous examples of this.
01:13:48.640 --> 01:13:52.960
They've really extremely low rates of cardiovascular diseases and AMI.
01:13:53.119 --> 01:13:59.920
Um despite you know eating massive amounts of uh whale, whale blubber and and the rest.
01:14:00.079 --> 01:14:08.000
They they just had such a high fatty uh omega-3 intake, um, and they had perfect, very, very good cardiovascular uh health.
01:14:08.319 --> 01:14:09.840
Wow, wow, that's fantastic.
01:14:10.000 --> 01:14:11.119
Yeah, it goes so deep.
01:14:11.199 --> 01:14:24.880
Uh, I think what fascinates me the most about the omega-3 and uh the DHA is its like bioelectric properties, uh, you know, because a lot of people focus on the anti-inflammatory stuff, and yes, that's also very, very important, as you were mentioning.
01:14:24.960 --> 01:14:30.960
And I definitely want to have you back on the podcast to talk about heart health because that that actually was one of my questions.
01:14:31.119 --> 01:14:36.960
But I realized there is so much to ask about heart health and how that's related to everything, right?
01:14:37.199 --> 01:14:44.159
Again, nothing is working in isolation in the body, everything is working together as a unified system, everything is feeding into each other.
01:14:44.319 --> 01:14:46.480
So definitely need to have you back on.
01:14:46.640 --> 01:14:50.640
And uh, yeah, that was a fantastic break breakdown on DHA and Omega 3s.
01:14:50.720 --> 01:14:50.880
Go ahead.
01:14:51.119 --> 01:14:55.359
Oh, I'll I'll make I'll expand on that point because we're we've we've got there this far.
01:14:55.840 --> 01:15:08.079
The the that exactly what you're saying, which is that the more DHA that you built into your cell membranes, the more you're able to uh essentially bioelectrically run run your body.
01:15:08.239 --> 01:15:13.359
Because as we talked about, it's a it's a it's a game of of photon harvesting.
01:15:13.520 --> 01:15:16.880
Um that that is what the human body was designed for.
01:15:17.039 --> 01:15:31.359
And whether we look at you know the upright stance, the loss of of body hair, the anatomical design of of this epidermal, dermal junction, it's all looks like and optimized for the collection of of solar photons.
01:15:31.600 --> 01:15:49.520
So it again it makes sense that if you are loading up your body with these key molecules um and fatty acids that are optimized for uh uh this this interaction, that you're going to optimize the bioelectric function of the body.
01:15:49.680 --> 01:16:16.399
And you know, in clinical practice, if I'm seeing someone who has chronic fatigue um, you know, from decades and and they've been put on all kinds of supplement protocols or you know, what whatever else, low dose, naltrexone, who, you know, who know whoever knows what, they but they haven't, we haven't ever looked at their seafood consumption, and we haven't, and that no one's looked at their light exposure or their light habits.
01:16:16.560 --> 01:16:34.399
You know, one of the most important things that person can do is start getting marine nutrients into their system, start eating fatty fish, mackerel, sa salmon, sardines, and building building upper solar callus, getting in full spectrum sunlight.
01:16:34.560 --> 01:16:48.960
And what that is doing is essentially plugging that mitochondrial colony into an external energy source, which is the sun, via those, those, that fat, those fatty acids by reshaping the composition of their cell membranes.
01:16:49.279 --> 01:16:51.600
And the lights come back on.
01:16:51.680 --> 01:17:04.960
You know, it's been it's like browned out, they've been brown-outed for you know however long, and then you you play with the electrical systems, you optimize, you plug them in back in, and suddenly the body starts starts working again.
01:17:05.119 --> 01:17:34.640
So, um, and especially if they're doing that grounded, that that is the holy, you know, the holy um trinity, and they're they're respecting nocturnal darkness, that suddenly their sleep improves, their daytime energy improves, obviously you've you've you've improved this acadian amplitude and everything, like I guess going back to the beginning of this conversation, all those functions that are uh regulated by light, um, which is ev which is the whole body, turn on again and they they start thriving again.
01:17:34.880 --> 01:18:07.680
So it's it's not rocket science, but it it relies on, I think, an an at least a cursory appreci understanding or appreciation of some of this fundamental physiology and biophysics that we weren't taught in medical school and isn't taught in undergraduate biology or isn't emphasized in undergraduate biology, but happens to be the missing link between human health, human health optimization, human disease, um, and and and the science.
01:18:07.760 --> 01:18:56.880
And it's it's just very unfortunate that it's taken people to have to look through the the scientific literature in such a I guess laborious way, and because the prevailing knowledge um mouthpieces have really directed science teaching research towards, I would say misdirected towards these other areas of you know biochemistry, the nuclear genome, and and and a bunch of uh profitable medicatable biochemical pathways, but away from these these f fundamental photobiological, biophysical properties and of the body that don't cost money to optimize.
01:18:56.960 --> 01:19:07.359
They cost very little, but they take intent and and some basic knowledge and and understanding um to follow through and and accomplish.
01:19:07.680 --> 01:19:12.000
Yes, and uh this is why we're doing this to give people the information now.
01:19:12.079 --> 01:19:29.840
They can make an informed decision whether they want to stay indoors and scroll their phones beyond the artificial blue light, or if they want to take the information and actually uh grow tall like a tree, like you were you were talking about, like our anatomy standing tall, growing tall like a tree, and we're sticking our branches out, our skin out, right?
01:19:29.920 --> 01:19:37.039
On to the towards the sun like a solar panel and eating that DHA and absorbing that photonic energy and optimizing our mitochondrial function.
01:19:37.119 --> 01:19:37.840
Thank you so much, Dr.
01:19:38.000 --> 01:19:38.319
Max.
01:19:38.399 --> 01:19:40.560
This was uh absolute honor and a pleasure.
01:19:40.720 --> 01:19:42.640
Uh, where can people find you and connect with you?
01:19:42.880 --> 01:19:44.880
Yes, uh, it was a very enjoyable conversation.
01:19:44.960 --> 01:19:46.000
So thank you, Andreas.
01:19:46.079 --> 01:19:55.359
Um, you can find me at uh drmaxgulhain.com and I have a podcast regenerative health podcast on all the podcast platforms.
01:19:55.520 --> 01:20:02.800
And if you type my name, Max Gulhain M D into uh X or Instagram, you'll you'll also find me there.
01:20:03.119 --> 01:20:03.359
Great.
01:20:03.520 --> 01:20:12.399
I'll make sure that I'll put all your links in the description below so they make sure they find that the real you unfortunately these days, there is like so many AI accounts, so many bots, so many scams.
01:20:12.720 --> 01:20:16.079
So I'll I'll make sure to put all your stuff there and please stay on the line when I understand.
01:20:16.319 --> 01:20:16.720
Thank you, mate.