WEBVTT
00:00:02.720 --> 00:00:05.919
Getting more information from Less Tissue.
00:00:05.919 --> 00:00:12.320
A new analysis looks at the promise and limitations of multiplex immunofluorescence.
00:00:12.320 --> 00:00:17.440
Plus, a new series of interviews with CAP's newest committee chairs.
00:00:17.440 --> 00:00:23.120
First up, Neha Varshney, who is making plans for the New- in-Practice Committee.
00:00:23.120 --> 00:00:29.600
Welcome to CAP News for Thursday, November 5th.
00:00:29.600 --> 00:00:33.359
I'm Elizabeth McMahon of the College of American Pathologists.
00:00:33.359 --> 00:00:37.200
Here's what's making news in pathology and laboratory medicine.
00:00:37.200 --> 00:00:56.719
An upcoming article by the CAP Personalized Healthcare Committee explores how multiplex immunofluorescence, or MIF, is helping labs evaluate multiple protein markers on the same tissue section while preserving spatial relationships among cells on slides.
00:00:56.719 --> 00:01:05.920
The imaging technique can help pathologists better characterize tumor cells, immune cells, and the surrounding tumor microenvironment.
00:01:05.920 --> 00:01:10.239
This has the potential to identify therapeutic targets more quickly.
00:01:10.239 --> 00:01:23.840
But the article acknowledges that the technology likely won't replace traditional immunofluorescence because of the expense, infrastructure needs such as imaging platforms and software, and complexities in interpretation.
00:01:23.840 --> 00:01:29.200
Quote, MIF should not be adopted simply because it can generate more data.
00:01:29.200 --> 00:01:40.159
It should be adopted when the added information is reproducible, interpretable, clinically actionable, and worth the tissue, time, and cost required to produce it.
00:01:40.159 --> 00:01:48.879
Precision care will also top the agenda at next week's Association for Molecular Pathology Conference in Seattle.
00:01:48.879 --> 00:01:58.239
If you're attending AMP, don't miss the CAP's opening day session on how laboratory evidence can be used to address gaps in precision oncology.
00:01:58.239 --> 00:01:59.439
Led by Dr.
00:01:59.439 --> 00:02:03.040
Jordan Laser of the Personalized Healthcare Committee and Dr.
00:02:03.040 --> 00:02:17.919
Joel Moncur, Chair of the Council on Scientific Affairs, the 90-minute session will explore findings from CAP proficiency testing and practice studies involving neoplastic cellularity and next generation sequencing performance.
00:02:17.919 --> 00:02:28.800
The discussion will include insights into how the CAP applies these findings in its laboratory improvement activities, including in its upcoming Biomarker OneSource platform.
00:02:28.800 --> 00:02:32.159
That's slated to be released early next year.
00:02:32.159 --> 00:02:45.280
The CAP will welcome a new slate of leaders to nearly 20 of its committees in January, bringing fresh vision to the college's top priorities.
00:02:45.439 --> 00:02:45.680
Dr.
00:02:45.919 --> 00:02:53.840
Neha Varshney will lead the New- in- Practice Committee, a home for members who are adjusting to the realities of their first years out of training.
00:02:54.080 --> 00:02:54.400
Dr.
00:02:54.560 --> 00:02:59.840
Varshney, an assistant professor of pathology at Northwestern University, came to the U.S.
00:02:59.840 --> 00:03:02.319
from India as a resident in 2014.
00:03:02.319 --> 00:03:11.039
She got involved in the New-in-Practice Committee because she saw a need early on for a group that could support pathologists navigating their new careers.
00:03:11.599 --> 00:03:22.159
I think there's a gap because we do a lot of stuff for residents and fellows, and then we have a lot of things for like a more seasoned senior pathologist.
00:03:22.159 --> 00:03:24.560
But I thought there was a gap there.
00:03:24.560 --> 00:03:30.080
I was on visa, so I actually think that that's the area I could help with.
00:03:30.080 --> 00:03:34.879
So that's another thing I have been doing for many, many years now.
00:03:35.199 --> 00:03:35.439
Dr.
00:03:35.599 --> 00:03:47.680
Varshney says she's looking forward to continuing the committee's programs and initiatives, including job prep boot camp, career webinars, podcasts, and collaborations with other CAP committees.
00:03:47.680 --> 00:03:49.759
She praises her predecessor.
00:03:50.159 --> 00:03:52.000
We had an amazing chair, Dr.
00:03:52.000 --> 00:03:53.199
Yasmin Butt.
00:03:53.199 --> 00:03:54.879
She's fantastic.
00:03:54.879 --> 00:04:00.000
Obviously, just to kind of fill her shoes would be the aim.
00:04:00.000 --> 00:04:01.840
We have been doing brilliant work.
00:04:01.840 --> 00:04:06.319
We have very nice, very passionate, uh, very dedicated uh pathologists.
00:04:06.639 --> 00:04:11.680
Stay tuned to CAP News to meet other new committee leaders in the coming weeks.
00:04:11.680 --> 00:04:22.319
And finally, a first of its kind genetic test can now predict which men with prostate cancer will develop a life-threatening form of the disease.
00:04:22.319 --> 00:04:34.879
The new lab test, commercialized by GoPath Diagnostics, was developed from two major studies that tracked genetic and clinical outcomes for more than 14,000 prostate cancer patients.
00:04:34.879 --> 00:04:43.279
Unlike tumor tests that examine the biology of a biopsy sample, the testing method looks at a patient's inherited DNA.
00:04:43.279 --> 00:04:52.480
The genetic test adds a complementary layer of information to traditional evaluation, including gliesen grading and other tumor characteristics.
00:04:52.480 --> 00:04:58.480
Importantly, insurance coverage is expected to be available in the first quarter of next year.
00:04:58.480 --> 00:05:00.160
That's all for today.
00:05:00.160 --> 00:05:04.000
Be sure to check the show notes for more information on today's stories.
00:05:04.000 --> 00:05:06.720
Got a story you'd like to hear on the podcast?
00:05:06.720 --> 00:05:10.319
Write to us at stories at CAP.org.
00:05:10.319 --> 00:05:14.879
We're back at 5 AM Eastern for another episode of CAP News.
00:05:14.879 --> 00:05:16.560
I'm Elizabeth McMahon.
00:05:16.560 --> 00:05:18.240
Have a great day.
00:00:02.720 --> 00:00:05.919
Getting more information from Less Tissue.
00:00:05.919 --> 00:00:12.320
A new analysis looks at the promise and limitations of multiplex immunofluorescence.
00:00:12.320 --> 00:00:17.440
Plus, a new series of interviews with CAP's newest committee chairs.
00:00:17.440 --> 00:00:23.120
First up, Neha Varshney, who is making plans for the New- in-Practice Committee.
00:00:23.120 --> 00:00:29.600
Welcome to CAP News for Thursday, November 5th.
00:00:29.600 --> 00:00:33.359
I'm Elizabeth McMahon of the College of American Pathologists.
00:00:33.359 --> 00:00:37.200
Here's what's making news in pathology and laboratory medicine.
00:00:37.200 --> 00:00:56.719
An upcoming article by the CAP Personalized Healthcare Committee explores how multiplex immunofluorescence, or MIF, is helping labs evaluate multiple protein markers on the same tissue section while preserving spatial relationships among cells on slides.
00:00:56.719 --> 00:01:05.920
The imaging technique can help pathologists better characterize tumor cells, immune cells, and the surrounding tumor microenvironment.
00:01:05.920 --> 00:01:10.239
This has the potential to identify therapeutic targets more quickly.
00:01:10.239 --> 00:01:23.840
But the article acknowledges that the technology likely won't replace traditional immunofluorescence because of the expense, infrastructure needs such as imaging platforms and software, and complexities in interpretation.
00:01:23.840 --> 00:01:29.200
Quote, MIF should not be adopted simply because it can generate more data.
00:01:29.200 --> 00:01:40.159
It should be adopted when the added information is reproducible, interpretable, clinically actionable, and worth the tissue, time, and cost required to produce it.
00:01:40.159 --> 00:01:48.879
Precision care will also top the agenda at next week's Association for Molecular Pathology Conference in Seattle.
00:01:48.879 --> 00:01:58.239
If you're attending AMP, don't miss the CAP's opening day session on how laboratory evidence can be used to address gaps in precision oncology.
00:01:58.239 --> 00:01:59.439
Led by Dr.
00:01:59.439 --> 00:02:03.040
Jordan Laser of the Personalized Healthcare Committee and Dr.
00:02:03.040 --> 00:02:17.919
Joel Moncur, Chair of the Council on Scientific Affairs, the 90-minute session will explore findings from CAP proficiency testing and practice studies involving neoplastic cellularity and next generation sequencing performance.
00:02:17.919 --> 00:02:28.800
The discussion will include insights into how the CAP applies these findings in its laboratory improvement activities, including in its upcoming Biomarker OneSource platform.
00:02:28.800 --> 00:02:32.159
That's slated to be released early next year.
00:02:32.159 --> 00:02:45.280
The CAP will welcome a new slate of leaders to nearly 20 of its committees in January, bringing fresh vision to the college's top priorities.
00:02:45.439 --> 00:02:45.680
Dr.
00:02:45.919 --> 00:02:53.840
Neha Varshney will lead the New- in- Practice Committee, a home for members who are adjusting to the realities of their first years out of training.
00:02:54.080 --> 00:02:54.400
Dr.
00:02:54.560 --> 00:02:59.840
Varshney, an assistant professor of pathology at Northwestern University, came to the U.S.
00:02:59.840 --> 00:03:02.319
from India as a resident in 2014.
00:03:02.319 --> 00:03:11.039
She got involved in the New-in-Practice Committee because she saw a need early on for a group that could support pathologists navigating their new careers.
00:03:11.599 --> 00:03:22.159
I think there's a gap because we do a lot of stuff for residents and fellows, and then we have a lot of things for like a more seasoned senior pathologist.
00:03:22.159 --> 00:03:24.560
But I thought there was a gap there.
00:03:24.560 --> 00:03:30.080
I was on visa, so I actually think that that's the area I could help with.
00:03:30.080 --> 00:03:34.879
So that's another thing I have been doing for many, many years now.
00:03:35.199 --> 00:03:35.439
Dr.
00:03:35.599 --> 00:03:47.680
Varshney says she's looking forward to continuing the committee's programs and initiatives, including job prep boot camp, career webinars, podcasts, and collaborations with other CAP committees.
00:03:47.680 --> 00:03:49.759
She praises her predecessor.
00:03:50.159 --> 00:03:52.000
We had an amazing chair, Dr.
00:03:52.000 --> 00:03:53.199
Yasmin Butt.
00:03:53.199 --> 00:03:54.879
She's fantastic.
00:03:54.879 --> 00:04:00.000
Obviously, just to kind of fill her shoes would be the aim.
00:04:00.000 --> 00:04:01.840
We have been doing brilliant work.
00:04:01.840 --> 00:04:06.319
We have very nice, very passionate, uh, very dedicated uh pathologists.
00:04:06.639 --> 00:04:11.680
Stay tuned to CAP News to meet other new committee leaders in the coming weeks.
00:04:11.680 --> 00:04:22.319
And finally, a first of its kind genetic test can now predict which men with prostate cancer will develop a life-threatening form of the disease.
00:04:22.319 --> 00:04:34.879
The new lab test, commercialized by GoPath Diagnostics, was developed from two major studies that tracked genetic and clinical outcomes for more than 14,000 prostate cancer patients.
00:04:34.879 --> 00:04:43.279
Unlike tumor tests that examine the biology of a biopsy sample, the testing method looks at a patient's inherited DNA.
00:04:43.279 --> 00:04:52.480
The genetic test adds a complementary layer of information to traditional evaluation, including gliesen grading and other tumor characteristics.
00:04:52.480 --> 00:04:58.480
Importantly, insurance coverage is expected to be available in the first quarter of next year.
00:04:58.480 --> 00:05:00.160
That's all for today.
00:05:00.160 --> 00:05:04.000
Be sure to check the show notes for more information on today's stories.
00:05:04.000 --> 00:05:06.720
Got a story you'd like to hear on the podcast?
00:05:06.720 --> 00:05:10.319
Write to us at stories at CAP.org.
00:05:10.319 --> 00:05:14.879
We're back at 5 AM Eastern for another episode of CAP News.
00:05:14.879 --> 00:05:16.560
I'm Elizabeth McMahon.
00:05:16.560 --> 00:05:18.240
Have a great day.
