MIC Pilot: Exploring Carbapenemase screening, and Faecal Microbiota Transplants

In this episode we explore two fascinating papers, one on the ethics of carbapenemase screening, and one on faecal microbiota transplants. We also discuss feasibility studies.

Dr Rooney’s article on CPE screening can be found here Carbapenemase-producing Enterobactericeae screening: Focused patient insights - ScienceDirect

Dr Merrick’s paper (FERARO) is here Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial - Journal of Infection

What is a feasibility study? Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework | PLOS One

Guidelines for feasibility studies: Guidance for conducting feasibility and pilot studies for implementation trials - PMC

Dr Merrick referenced 2 FMT trials, PREMIX Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement - PMC and RGNOSIS A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial - PubMed

For a major paper on Recovery Associated Bacteria (RAB), see here Metagenome-wide association analysis identifies microbial determinants of post-antibiotic ecological recovery in the gut | Nature Ecology & Evolution

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