ABOUT THIS EPISODE
Drs Ken Saag and Michael Pillinger explore the chicken-or-egg question connecting gout with cardiovascular, kidney, and metabolic conditions.
Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Gout and Pseudogout https://emedicine.medscape.com/article/329958-overview
Gout: Global Epidemiology, Risk Factors, Comorbidities and Complications: A Narrative Review https://pubmed.ncbi.nlm.nih.gov/39702222/
The Fifth Element: Is Vascular Dysfunction an Intrinsic Feature of Gout? https://pubmed.ncbi.nlm.nih.gov/40021439/
Hyperuricemia Induces a Primary Renal Arteriolopathy in Rats by a Blood Pressure-Independent Mechanism https://pubmed.ncbi.nlm.nih.gov/11997315/
The Environment and Disease: Association or Causation? https://pubmed.ncbi.nlm.nih.gov/14283879/
Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial https://pubmed.ncbi.nlm.nih.gov/18728266/
Expert Consensus and Evidence-Based Recommendations for the Assessment of Flow-Mediated Dilation in Humans https://pubmed.ncbi.nlm.nih.gov/31211361/
Reading Mendelian Randomisation Studies: A Guide, Glossary, and Checklist for Clinicians https://pubmed.ncbi.nlm.nih.gov/30002074/
Effects of Allopurinol on the Progression of Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/32579811/
Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout https://pubmed.ncbi.nlm.nih.gov/31079535/
Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout https://pubmed.ncbi.nlm.nih.gov/41587055/
Risk of Venous Thromboembolism With Gout Flares https://pubmed.ncbi.nlm.nih.gov/36808284/
Cardiovascular Events in Patients With Gout Initiating Urate-Lowering Therapy With or Without Colchicine for Flare Prophylaxis: A Retrospective New-User Cohort Study Using Linked Primary Care, Hospitalisation, and Mortality Data https://pubmed.ncbi.nlm.nih.gov/39708831/
Comparative Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drug Versus Colchicine Use When Initiating Urate-Lowering Therapy Among Patients With Gout: Target Trial Emulations https://pubmed.ncbi.nlm.nih.gov/40415645/
Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia https://pubmed.ncbi.nlm.nih.gov/33342914/
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