ABOUT THIS EPISODE
Mariëlle van Kooten (CEO and co-founder of Powerhouse Biology) joins to make the case that mitochondria are the best place to start engineering the human body. Her team builds virtual mitochondria models to predict how a fix will behave before it ever touches a patient. Marielle is passionate about treating disease and human enhancement.
In this episode, we discuss:
- Why mitochondria might be the most tractable place to start engineering human biology
- The difference between building a virtual mitochondria model and the industry-wide race to build a virtual cell
- Why a protein fix for one disease (say, Parkinson's-linked muscle weakness) could work across totally unrelated tissues
- The difference between Science vs. Engineering: why she left academia
- The case for human enhancement: longevity, resilience, and why the ethics conversation is stalled
Credits:
Created by Greg Kubin and Matias Serebrinsky
Host: Matias and Greg
Produced by Nico V. Rey
Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank
English
United States
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OTHER EPISODES IN THIS PODCAST
Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer’s trials.
In this episode, we discuss:
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Matias and Greg interview Ying-Hui Fu, PhD, is a Professor of Neurology at UCSF and a world leader in the genetics of sleep. Her lab has discovered the first-known genes behind “natural short sleepers”. Her work bridges human genetics and neuroscience to uncover how to modulate sleep for brain heal…
Greg and Matias interview Natalie Yivgi-Ohana of Minovia. Natalie is a life science entrepreneur with twenty years’ experience in mitochondrial research and received her PhD in Biochemistry at The Hebrew University in 2007, after which she performed her postdoctoral fellowship at the Weizmann Insti…
Matias and Greg interview Justin Mares, co-founder of TrueMed and Kettle & Fire on current US healthcare and how startups have the opportunity to change the system.In this episode, we discuss:
How the US system profits from chronic illness
Fixing the food system, environmental toxins, pharma i…
Matias interviews Rob Malenka.
In this episode, we discuss:
Why progress in psychiatry is slow because the brain is the most complex organ and many disorders are highly heterogeneous
The bottlenecks including weak replicability in research, academic politics, perverse incentives, and pharma’s avoi…
Disclaimer: The podcast and artwork embedded on this page are from Greg Kubin & Matias Serebrinsky, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.
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