Listen Score
LS 27
Global Rank
TOP 10%

ABOUT THIS PODCAST 🔗

Update frequency:
biweekly
Average audio length:
44 minutes
Guest interviews
English
United States
70 episodes
since Nov. 18, 2021
episodic

LATEST EPISODE 🔗

Tom Masterson, COO of Deep Genomics, on AI drug discovery where precision beats creativity. He explains how the company's siRNA model picked an approved cholesterol drug out of 3,500 candidates for a target it had never seen, why it designs toxic molecules on purpose, and how a COO runs a company w…

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PREVIOUS EPISODES

Paul Kedrosky of SK Ventures says AI capex is driving up to 70 percent of US GDP growth, and most of it is now borrowed. He walks through the money map, the 2029 maturity wall, why AI tokens are a deflationary commodity, and three ways the AI bubble reaches companies that never touch a data center.…
Lior Eldan, co-founder and COO of Moburst, has reinvented what his agency sells three times, from app store optimization to AI products. He explains why replacing people with AI is backwards, why managers have to do the work, and why automating a broken process just gets the AI blamed. In this epis…
Part 2 of 2. Part 1 is here: https://betweentwocoos.com/65 In part 1, Joe Yaffe explained how an orbital data center works. This time, the question is whether it works as a business. In this episode, Joe and Michael discuss: Why Cowboy Space measures itself in cost per GPU hour, not cents pe…
Part 1 of 2. Part 2 drops later this week. Joe Yaffe had climbed as high as the ladder goes. Fifteen years at Latham & Watkins, then Skadden, managing partner of the Palo Alto office, 31 years advising founders and CEOs. By his own account, his idea of a midlife crisis was moving from one me…
Riikka Söderlund is the chief operating officer at Katana Cloud Inventory, a Finland-based platform that helps small product businesses run inventory, manufacturing, and multi-channel sales. She and host Michael Koenig discuss how AI search is affecting product discovery, why an out-of-stock produc…
Rick Marini, co-founder of Rails and former COO of Grindr, joins Between Two COOs to explain why he would rather be a great COO than a good CEO. He and host Michael Koenig cover the CFIUS-forced sale that put Grindr in play, the day-one culture reset that ended two and a half years later in a $2 bi…
Michael Koenig talks with Wade Foster, co-founder and CEO of Zapier, about running the company for 14 years without a CEO safety net and without ever naming a COO. Wade explains why he thinks hiring a chief operating officer from outside a company is a coin flip, why Zapier put AI transformation in…
Zulema Quintans runs operations at an energy company, and she has a clear theory about why goals fail. This is a conversation about making OKRs actually work, and how AI is changing the operator's job. In this episode, Zulema and Michael discuss: - Why most OKRs never get done, and the one link t…
Watch on YouTube. Peter Rojas has built new things at almost every scale there is, and he planted the seed for this show years ago in an email to Michael. In this episode, Peter and Michael discuss: How building new products inside a big company differs from a startup, and why you have to inv…
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