Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric Verdin

What if aging is not just damage — but a biologically regulated process shaped by metabolism, inflammation, and gene expression?

In this episode of Decoding Longevity, Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging, joins us for a wide-ranging conversation on the molecular biology of aging.

We explore how metabolism influences epigenetics, why immune aging may be central to healthspan, and what today’s longevity science actually tells us about extending healthy human life.

From NAD+ and ketone bodies to inflammaging, biomarkers, rapamycin, metformin, and epigenetic reprogramming, this episode breaks down some of the most important ideas shaping the future of longevity research.

We also discuss the growing hype surrounding longevity medicine — and why rigorous science, clinical trials, and evidence still matter.

Featuring:Dr. Eric VerdinHosted by Dr. Raghav Sehgal & Dr. Macsue Jacques

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Buck Institute of Aging: https://www.buckinstitute.org/

Eric Verdin's LinkedIn: https://www.linkedin.com/in/eric-verdin-490212/