OVER DEZE AFLEVERING
About the guest: Joshua Siegel, MD, PhD is a psychiatrist & systems neuroscience at New York University. He uses functional imaging to study the effects of psychedelics and other drugs on the human brain.
Episode summary: Nick and Dr. Siegel discuss: fMRI and how it works; relationship between neural activity and blood flow; functional connectivity & the default mode network of the human brain; the functional effects of psilocybin on the brain; the role that subjective & expectancy effects in psychedelics medicine; and more.
Related episodes:
- M&M #173: Psychedelics, Consciousness, Psychiatry, Psychology, Mental Health & the Entropic Brain Hypothesis
*This content is never meant to serve as medical advice
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IN DEZE AFLEVERING
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OUDE AFLEVERINGEN ZOEKEN
Zoek naar eerdere afleveringen van Mind & Matter.
ANDERE AFLEVERINGEN IN DEZE PODCAST
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Ferroptosis, an iron-dependent cell death pathway driven by lipid peroxidation; chronoferoptosis, in which chronic stress sensitizes neurons gradually.
TOPICS DISCUSSED:
Cell Death Pathways: Apoptosis proceeds through regulated steps with surface “eat me” signals that enable non-i…
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Mitochondrial peptide MOTS-c is a stress-induced signal that reprograms cell metabolism.
TOPICS DISCUSSED:
Mitochondrial Roles: Not just ATP production, but “speaker of the house” via communication molecules that “talk” to the rest of the cell.
Origin of Communication: Mitochondri…
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GHK-Copper and peptides in skin care, aging, and general health.
TOPICS DISCUSSED:
Endogenous Decline: GHK-copper levels peak in young adulthood then fall with age, reducing natural support for skin repair and collagen maintenance.
Skin Penetration: Effective topical delivery depe…
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Blood-brain barrier as a dynamic interface allowing selective passage of nutrients, peptides, and gut hormones.
TOPICS DISCUSSED:
Blood-Brain Barrier Structure: Capillary endothelial cells with tight junctions, absent fenestrae, and minimal vesicles create a selective interface; s…
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Endogenous peptide diversity, GLP-1 drugs, and methods for novel peptide discovery.
TOPICS DISCUSSED:
Peptide Structure & Production: Short amino acid chains (3-50 residues) cleaved from larger precursors by PCSK enzymes, stored in dense-core vesicles, and released upon stimul…
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