OVER DEZE AFLEVERING
Aging begins when cellular quality-control systems lose their precision.
In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective lysosomal degradation pathway essential for proteostasis—progressively declines with age, triggering downstream failures across neuronal and metabolic tissues.
Reduced LAMP2A availability, impaired lysosomal docking, and disrupted protein triage lead to toxic proteotoxic burden, mitochondrial dysfunction, and metabolic inflexibility.
Emerging evidence shows that preserving CMA activity can improve healthspan, attenuate neurodegenerative pathology, and restore metabolic homeostasis.
Learn more about Dr. Ana Maria Cuervo:
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OUDE AFLEVERINGEN ZOEKEN
Zoek naar eerdere afleveringen van Longevity Roadmap.
ANDERE AFLEVERINGEN IN DEZE PODCAST
In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine.
She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the …
Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging.
She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that …
In this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers.
He emphasizes the importance of regular movement, introducing the concept of 'movement snacks'—short bursts of activity that c…
This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging.
He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes.
The conver…
In this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity.
We explore the role of GLP-1 medications in weight management, the evolution of bariatric surgery, and the innovative SIPS procedure.
Dr. Roslin emphasizes that obesity is not merely a result of poor li…
Disclaimer: De podcast en de illustraties die op deze pagina zijn ingesloten, zijn afkomstig van Buck Joffrey, eigendom van de eigenaar en niet gelieerd aan of goedgekeurd door Listen Notes, Inc.
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