OM DENNE EPISODE
Dr. Marschall Runge returns for a second conversation, this time about the people who will practice medicine next.
Marschall S. Runge, MD, PhD, is a practicing cardiologist who spent a decade as executive vice president for medical affairs at the University of Michigan, dean of the Medical School, and CEO of Michigan Medicine — running one of America's largest academic health systems while continuing to see patients.
He earned his PhD in cardiovascular molecular biology at Vanderbilt and his MD at Johns Hopkins, where he also completed his internal medicine residency, followed by a cardiology fellowship at Massachusetts General Hospital. He now leads a Michigan cohort combining epigenetic aging clocks, mitochondrial inheritance, cardiorespiratory fitness, and chronic inflammation in a single dataset.
He has authored more than 195 peer-reviewed papers and holds five healthcare patents. A third nonfiction book, on epigenetic clocks and biological aging, is in development with Forbes Books, alongside a forthcoming Substack (The Longevity Switch) and a University of Michigan MOOC on epigenetics and aging.
Chapters
00:00 Introduction and guest overview
01:12 AI's role in healthcare transformation
04:01 AI as a valuable assistant in medicine
05:08 Redefining medical curriculum for AI era
09:34 Openness of medical institutions to AI
11:47 Changing accreditation and certification with AI
16:08 Leadership in AI adoption in healthcare
18:39 International perspectives on AI in medicine
19:13 AI's impact on radiology and diagnostics
21:46 AI in clinical workflows and operations
24:49 The evolving role of nurses with AI
30:37 Digital twins and clinical trials
33:18 Transition period and future outlook
Hyperlinks:
The Great Healthcare Disruption: Big Tech, Bold Policy, and the Future of American Medicine (Forbes Books, 2025) — USA TODAY Best-Seller and Global Book Awards Gold Medal winner. An insider's account of the forces reshaping American healthcare.
Coded to Kill (Post Hill Press, 2023) — a techno-medical thriller.
OpenEvidence — the physician-only clinical AI Runge calls superb
University of Michigan Medical School
U-M Center for Academic Innovation
Anastassia Lauterbach - LinkedIn
First Public Reading, Romy, Roby and the Secrets of Sleep (1/3)
First Public Reading, Romy, Roby and the Secrets of Sleep (2/3)
First Public Reading, Romy, Roby and the Secrets of Sleep (3/3)
