ဤအပိုင်းအကြောင်း
Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores statins, PCSK9 inhibitors, plaque progression, supplements, insulin resistance, and the evolving role of GLP-1 medications in obesity treatment and long-term cardiometabolic health.
Dr. Spencer Nadolsky is a physician specializing in obesity medicine, lipidology, and cardiometabolic health, with a strong focus on preventing chronic disease before it develops. His approach combines evidence-based medicine with individualized risk assessment, helping patients make sense of cholesterol, metabolic health, body weight, medications, and lifestyle without relying on one-size-fits-all recommendations. Known for translating complex medical research into practical guidance, he emphasizes sustainable health decisions, meaningful clinical outcomes, and finding the balance between being proactive about longevity and becoming overly consumed by it.
SAMSON Trial: Statin, Placebo, and No Treatment — James P. Howard et al. / Imperial College London
https://pubmed.ncbi.nlm.nih.gov/34531021/
Multi-Ethnic Study of Atherosclerosis (MESA) — National Heart, Lung, and Blood Institute / NIH
https://www.nhlbi.nih.gov/science/multi-ethnic-study-atherosclerosis-mesa
Framingham Heart Study Offspring Cohort — National Heart, Lung, and Blood Institute / BioLINCC
https://biolincc.nhlbi.nih.gov/studies/framoffspring/
Repatha (Evolocumab) — Amgen
https://www.repatha.com/resources-and-support
Ezetimibe — Mark Cuban Cost Plus Drug Company
https://www.costplusdrugs.com/medications/ezetimibe-10mg-tablet/
Rosuvastatin — Mark Cuban Cost Plus Drug Company
https://www.costplusdrugs.com/medications/rosuvastatin-10mg-tablet/
Psyllium Fiber / Metamucil — Procter & Gamble / Metamucil
https://www.metamucil.com/en-us/articles/psyllium-fiber/psyllium-fiber-in-metamucil
Docs Who Lift Podcast — Dr. Spencer Nadolsky & Dr. Karl Nadolsky
https://docswholift.com/podcast/
Vineyard — Dr. Spencer Nadolsky
Dr. Spencer Nadolsky on Instagram — Dr. Spencer Nadolsky
https://www.instagram.com/drnadolsky/
Dr. Spencer Nadolsky on X — Dr. Spencer Nadolsky
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:29 Reconnecting And Lipids Focus
00:46 Why Switch To Repatha
02:42 Diet Limits And ApoB Goals
04:03 Ezetimibe And Statin Rationale
05:07 Family History Wake Up Call
06:26 Nocebo And Cleaner PCSK9
10:31 Lp Little A Not A Factor
11:47 Oura Ring And Biohacker Stress
13:33 Dropping Pitavastatin And CoQ10
17:20 Bempedoic Acid And Combo Therapy
20:18 LDL ApoB Discordance Explained
23:37 How Low Is Too Low
26:10 Optimal Targets And When To Start
29:13 Can Ultra Low Prevent Plaque
31:09 Why People Ignore Cholesterol
32:23 Can Plaque Regress
33:16 Vitamin K2 Reality Check
34:00 Mechanisms vs Outcomes
34:58 Lp(a) Drug Disappointment
37:08 How to Use Lp(a)
40:23 HDL Myths Explained
43:11 Triglycerides and Insulin
45:35 Oxidized LDL and NMR
47:33 Supplements That Matter
48:51 Berberine Benefits and Risks
51:50 GLP-1 Stacking Debate
56:41 Microdosing and Plateaus
59:34 Longevity and Alcohol Effects
01:00:36 Future of Anti Obesity Drugs
01:02:00 Wrap Up and Where to Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.
This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.
Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary
(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as
Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect with Dr. Mike Hart
Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
