When Your Career Path Doesn’t Go as Planned | A Nonlinear Journey in Science

In this episode of The Next Step, we sit down with Makaia Papasergi-Scott, PhD, assistant professor of Biochemistry and Biophysics, as well as Pharmacology and Physiology, to talk about what happens when a carefully imagined career path doesn’t unfold the way you expect.Makaia shares her journey through graduate school, postdoctoral training, and into a research career shaped by obstacles, difficult decisions, and moments of uncertainty. Along the way, she reflects on the personal and professional challenges she faced, the mentors and community members who helped guide her, and how she learned to stay open to new directions—including teaching, emerging research technologies, and leadership opportunities.This conversation is especially relevant for prospective and current trainees who may be questioning their next steps, rethinking long-term goals, or wondering whether it’s okay to change course. Makaia’s story is a reminder that career paths in science and academic medicine are often nonlinear—and that growth can come from the unexpected turns.Topics covered include:00:00 Introduction and Makaia’s Career Background02:23 Early Inspirations and Initial Career Goals07:44 Navigating Challenges in Graduate School11:44 Major Decisions and Personal Struggles17:44 Finding Support Through Community and Mentorship20:00 Exploring Teaching as a Career Path23:24 Postdoctoral Training and Research Focus26:09 Looking Back on Unexpected Career Turns29:50 Rediscovering Passion in Scientific Research33:10 How Cryo-EM Is Changing Modern Science40:08 What It Takes to Build a Cryo-EM Center43:10 The Growing Pains of Running a Research Lab46:00 Advice for Trainees Facing Career TransitionsMore about Makaia: https://www.urmc.rochester.edu/people/112365117-makaia-papasergiPapasergi-Scott Lab: https://www.urmc.rochester.edu/labs/papasergi-scott