INFORMAZIONI SU QUESTO EPISODIO
For neurons to function, the appropriate ion-channel proteins must be present where they are needed, including in distal dendrites and axon terminals.
This requires energy, and the guest's group has developed a mechanistic mathematical model to investigate how neurons can reduce this cost by optimizing where proteins are synthesized within the cell—locally or at more distant sites.
The model's predictions agree with experimental findings, suggesting that energy optimization is a fundamental operating principle of neurons.
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Stati Uniti
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Cerca gli episodi passati di Theoretical Neuroscience Podcast.
ALTRI EPISODI IN QUESTO PODCAST
How can computational neuroscience contribute to developing neurotechnology to help people with brain disorders and disabilities?
This was the topic of a panel debate I hosted at the 34th Annual Computational Neuroscience Meeting in Florence in July this year.
Electric or magnetic recording and/o…
Neurons need particular sodium and potassium concentration gradients across their membranes to function. These gradients are set up by so-called ion pumps which require energy stored in ATP molecules to run.
ATP is the common energy currency in the brain and is produced from nutrients delivered by…
Historically, the analysis of neural recordings focused on responses of single neurons recorded by single-contact electrodes. Modern electrodes with multiple electrode contacts can instead record spikes (action potentials) from hundreds of neurons simultaneously.
Manifold analysis of the overall p…
An important discovery that has come out of computational neuroscience, is that cortical neurons in vivo appear to receive so-called balanced inputs.
In the balanced state the excitatory and inhibitory synaptic inputs to a neuron are about equal, and action potentials occur when a fluctuation temp…
Reproducibility is key for scientific progress. If research results cannot be reproduced and trusted, other researchers cannot build on them.
Reproducibility is a challenge also in computational neuroscience, and today's guest has worked on how this can be remedied, for example, through standardiz…
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