INFORMAZIONI SU QUESTO EPISODIO
🧬 Rare Variant, Real Risk: EGFR T790M and Lung Cancer
Can lung cancer risk be inherited—even in never-smokers? 🫁🚭
In >3.3 million individuals, germline EGFR T790M was rare (~1 in 15,850) but strongly associated with lung cancer (OR 25.18). The association was particularly striking among never-smokers, and the variant showed remarkable lung-cancer specificity. A Southern Appalachian founder effect also revealed how genes, geography & history can converge on modern disease risk. 🗺️🧬
💡 A compelling case for refining genetic risk assessment and future targeted screening strategies.
Inglese
Stati Uniti
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Cerca gli episodi passati di Dr RR Baliga's "Got Knowledge Doc" Podkast.
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