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In this podcast coauthors Nipuni D. Nagahawatte and Leo K. Cheng discuss their research titled "High-energy pacing inhibits slow-wave dysrhythmias in the small intestine." Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, with pacing, the glucagon-induced dysrhythmias were suppressed and spatially entrained for the first time with a success rate of 85%. The ability to suppress slow-wave dysrhythmias through pacing is promising in treating motility disorders that are associated with intestinal dysrhythmias.
High-energy pacing inhibits slow-wave dysrhythmias in the small intestine Nipuni D. Nagahawatte, Recep Avci, Niranchan Paskaranandavadivel, and Leo K. Cheng
American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G676-G686
Inglese
Stati Uniti
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