# Janus Kinase
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Diperbarui:
janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named "just another kinase" 1 and 2 (since they were just two of many discoveries in a PCR-based screen of kinases), but were ultimately published as "janus kinase". The name is taken from the two-faced Roman god of beginnings, endings and duality, Janus, because the JAKs possess two near-identical phosphate-transferring domains.
Investigational Agents in Ulcerative Colitis: JAK Inhibitors and S1P Receptor Modulators
Inflammatory bowel disease, which includes ulcerative colitis (UC) and Crohn's disease, affects an estimated 3 million adults in the United States. Although numerous therapies are available for the treatment of moderate to severe UC, many patients still suffer poor quality of life and suboptimal ou…
Can vitamins and supplements lead to healthier skin? Plus online reviews drive cosmetic procedures; and rituximab for pemphigus vulgaris
Skin appearance is a sign of internal health, and patients who have appropriate vitamin levels naturally have healthier skin. Dr. Vincent DeLeo talks with Dr. Gary Goldenberg about the data on vitamins and supplements that have been shown to improve the skin's appearance and health. Dr. Goldenberg…
Can We Simplify the Treatment of Myelofibrosis?
In this randomized trial, momelotinib was non-inferior to ruxolitinib for spleen response but was less effective in controlling symptoms.
Related Article: SIMPLIFY-1: A Phase III Randomized Trial of Momelotinib Versus Ruxolitinib in Janus Kinase Inhibitor–Naïve Patients With Myelofibrosis
Prithviraj Bose, MD / Jeanne M. Palmer, MD - State-of-the-Art Solutions for Myelofibrosis: The Intersection of JAK Inhibitors, Allogeneic Transplant, and Other Strategies for Patient Care
Go online to PeerView.com/UQB860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, a panel of experts in the management of myelofibrosis (MF) offers learners an update on the modern diagnostic and risk assessment strategies that ha…
David T. Rubin, MD - Transforming the Management of Inflammatory Bowel Disease: A Closer Look at the Role of JAK Inhibitors and the Patient’s Perspective in Achieving Therapeutic Goals
Go online to PeerView.com/QDR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. The past decade has brought substantial advances in the management of IBD. Nevertheless, under current therapeutic options, half of patients with moderate to severe u…
Prithviraj Bose, MD / Jeanne M. Palmer, MD - State-of-the-Art Solutions for Myelofibrosis: The Intersection of JAK Inhibitors, Allogeneic Transplant, and Other Strategies for Patient Care
Go online to PeerView.com/UQB860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, a panel of experts in the management of myelofibrosis (MF) offers learners an update on the modern diagnostic and risk assessment strategies that ha…
Author Interview: Dr Kehinde Sunmboye, 2024
Join Professor Peter Nash from the Griffith University in Brisbane, and Dr Kehinde Sunmboye, a consultant rheumatologist at the University Hospitals of Leicester NHS Trust, in this episode of the Author Interview series. Dr Sunmboye discusses his recent paper 'Cardiovascular safety of Janus Kinase …
[Journal Club] Baricitinib immune therapy for new onset type 1 diabetes
![[Journal Club] Baricitinib immune therapy for new onset type 1 diabetes](https://cdn-images-3.listennotes.com/podcasts/pomegranate-health/journal-club-baricitinib-QsN1Vmr_8eE-Ao34D9LwRN5.300x300.jpg)
Type 1 diabetes has a very high treatment burden in terms of direct costs, inconvenience and lost productivity for patients and their carers. Further, all the glucose checking, hormone replacement and consults don’t abolish the vascular complications associated with poor glycaemic control. Only in …
Podcast - NICE News - July 2024
The video version of this podcast can be found here:
· https://youtu.be/kYcJ3Ym3C0A
This episode makes reference to guidelines produced by the "National Institute for Health and Care Excellence" in the UK, also referred to as "NICE". The content on this channel reflects my professional interp…
How Much Monitoring Is Enough in Psoriasis Care?
Dr Steven Feldman joins Drs Jennifer Cather and Brad Glick to discuss how much monitoring systemic psoriasis treatments really require in modern practice.
Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-psoriasis-s4-ep3-2026a10006h…
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