TENTANG EPISODE INI
How the nervous and immune systems communicate, using peptides and other signals, to regulate pain, itch, and inflammation.
TOPICS DISCUSSED:
- Nociception & Pathogens: Sensory neurons detect bacterial toxins within seconds, enabling rapid host-defense coordination ahead of immune-cell recruitment.
- CGRP & neutrophils: Nociceptor-release the peptide CGRP, which blocks neutrophil (immune cell) recruitment; pathogens exploit this in necrotizing fasciitis and meningitis.
- Pain sensitization: Inflammation can lower neuronal thresholds for pain, which sometimes becomes a chronic problem.
- Gut barrier protection: CGRP from gut nociceptors drives goblet-cell mucus secretion, supporting the protective “weep and sweep” response.
- Skin-to-gut allergy priming: Early skin exposure to allergens plus scratching may promote food allergies.
- Vagus nerve circuits: Distinct vagal sensory neurons selectively suppress TNF or induce IL-10, allowing precise inflammatory control.
- Brain inflammatory memory: Insular neurons encode site-specific immune responses that can later be recalled by reactivating those circuits. The brain remembers past inflammatory events.
ABOUT THE GUEST: Isaac Chiu, PhD is a professor in the Department of Immunology at Harvard Medical School. His lab studies nervous-immune system crosstalk in pain, itch, infection, and inflammatory disease.
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Mitochondrial peptide MOTS-c is a stress-induced signal that reprograms cell metabolism.
TOPICS DISCUSSED:
Mitochondrial Roles: Not just ATP production, but “speaker of the house” via communication molecules that “talk” to the rest of the cell.
Origin of Communication: Mitochondri…
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Blood-brain barrier as a dynamic interface allowing selective passage of nutrients, peptides, and gut hormones.
TOPICS DISCUSSED:
Blood-Brain Barrier Structure: Capillary endothelial cells with tight junctions, absent fenestrae, and minimal vesicles create a selective interface; s…
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GHK-Copper and peptides in skin care, aging, and general health.
TOPICS DISCUSSED:
Endogenous Decline: GHK-copper levels peak in young adulthood then fall with age, reducing natural support for skin repair and collagen maintenance.
Skin Penetration: Effective topical delivery depe…
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Ferroptosis, an iron-dependent cell death pathway driven by lipid peroxidation; chronoferoptosis, in which chronic stress sensitizes neurons gradually.
TOPICS DISCUSSED:
Cell Death Pathways: Apoptosis proceeds through regulated steps with surface “eat me” signals that enable non-i…
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