इस एपिसोड के बारे में
Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky.
LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov)
https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide
PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed)
https://pubmed.ncbi.nlm.nih.gov/18061177/
The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed)
https://pubmed.ncbi.nlm.nih.gov/9207295/
Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98
Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed)
https://pubmed.ncbi.nlm.nih.gov/30429357/
BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed)
https://pubmed.ncbi.nlm.nih.gov/18818478/
Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6
Show Notes
00:00 Welcome to the Hart2Heart Podcast
00:52 Oral Peptides Mythbusting
02:37 Protein Digestion Basics
03:31 PEPT1 Absorption Pathway
04:39 KPV and Carnosine Examples
06:12 Glutathione Exception
07:38 Garden Hose Local Actions
08:26 Linaclotide IBS Mechanism
09:37 Four Local Action Sites
11:25 SNAC Enables Blood Levels
13:26 Cyclosporine Oral Exception
14:35 Other Minor Pathways
15:43 BPC 157 Oral Mystery
18:10 Wrap Up and Safety Notes
19:57 Closing and Next Episode
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.
This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.
Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary
(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as
Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect with Dr. Mike Hart
Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
