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Dr. Dean Ho is currently Provost’s Chair Professor and Head of the Department of Biomedical Engineering in the College of Design and Engineering, Director of The Institute for Digital Medicine (WisDM) at the Yong Loo Lin School of Medicine, and Director of The N.1 Institute for Health (N.1) at the National University of Singapore.His central argument is that medicine has always been built on population averages — and that this is no longer sufficient. With AI and digital twins, he believes we now have the tools to treat every patient as a sample size of one.The conversation spans three registers: oncology (a blood cancer patient who entered the trial at eighty and is still thriving four and a half years later); commercialised drug combination design (Kyan's 91% predictivity vs a competitor's 52%); and personal healthspan (Dean ran an IRB-approved trial on himself tracking sleep, gut, metabolism, and supplementation).The through-line is a simple but radical idea: a single annual health snapshot tells you almost nothing. Dynamics — how your body changes hour to hour, day to day — is where the signal lives.TIMESTAMPS: 0:00 Introduction1:31 We Are Stories, Not Snapshots4:10 Why Population-Level Medicine Falls Short6:00 The Cancer Patient Who Defied the Odds9:15 Why Lower Doses Can Work Better10:45 Becoming the Test Subject12:00 One Day of Metabolic Data12:40 Sleep, Gut Health & the Delta Trial13:25 Singapore's Edge in Medical Innovation15:23 AI Regulation: The FDA Paradox16:22 What's Broken About the Old System18:12 Scaling N=1: The Real Bottleneck19:48 Why Doctors Resist — and Why They Shouldn't20:40 The Economics of Personalised Treatment21:30 Drug Combinations: 91% Accuracy vs 52%23:20 Advice for Healthy People24:08 Resting Heart Rate as a Sleep Signal27:49 The One Habit Change That Moves the Needle30:00 ClosingFeel free to mingle in the comments below or head to...Instagram: https://www.instagram.com/frontrow.65/Linkedin: https://www.linkedin.com/in/keith-yap/Website: www.ykeith.comEmail: keith@frontrow65.co
