Exploring the Next Generation of Metabolic Health Innovations

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We're looking at some of the new era of metabolic medicine.
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The two big ones we're going to be comparing.
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Is or full forglapron it sounds like a.
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Transformer or like an alien, or forglaprone versus red a
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true tide.
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A lot of people are talking about this.
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It's an oral gop one, no injections required, and I
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think that's really attractive for a lot of people.
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I'm sure you guys would would agree.
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Sometimes in doing the daily or weekly injections aren't the
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most comfortable things. There's no fasting window before you take
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the medication. The thought is is it makes it easier
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for a patient compliance you take the capsule. That's a
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lot easier than doing an injection. Welcome everybody to the
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Ageless Future podcast. This is your host today, Kate Archibald.
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We're going to be diving in to interesting topic looking
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at some of the new sides of weight loss and
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metabolic activation. So much research and new new things from
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GLP to other drugs and medications on the market. We
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thought it would be an interesting podcast to just kind
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of showcase some of that new research and what we're
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looking at and maybe what you could look at and consider.
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So, like I said, we're.
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Looking at some of the new era of metabolic medicine.
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The two big ones we're going to be comparing is
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or full for glapron sounds like a transformer or like
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an alien, or forglapron versus red a true tide. And
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maybe you've you've probably heard us talk a little bit
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about retitrue tide before and maybe even or for lapron
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it is a mouthful, but I think they both are
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currently going through some of the clinical trials and research
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phases and it's super fascinating to see what's evolved.
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And some of those findings.
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So I'm going to talk to you about those today
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and then we'll give again some ways you can activate
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your your metabolic recharge metabolic reset for yourself.
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And so hopefully you'll have a good time here.
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So talking or full, I still have said it about
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thirty times even before I hopped on here. It's like
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or for glapron or foregloon, but it's a mouthful or
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floor Glapron versus retitrue tide. So you have a once
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daily pill now delivers GLP one benefit without use of injections.
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So that sort of for for glopron. It's a capsule
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based UH interacts similar to the g LP and so
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this is like a next gen peptide that can you know,
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has the potential to push some serious metabolic results. And
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it's it's been pretty crazy seeing how you know, first
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on the scene was semiglue tide or odic as most
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people know it as, and then next was Manjaro turzepetide,
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and there's been a lot of kind of different different
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iterations of that, and now the injectable side is red
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a true tide, and then they've come up with this
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compound or for glapron as a capsule based with similar effects.
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And so you know, the the real question is is
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which which approach fit's it's your biology and your goals
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as well as you know what what's what's given the
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best best results. A lot of people are talking about this.
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It's an oral goo p one, no injections required, and
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I think that's really attractive.
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For a lot of people.
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Obviously, you know a lot of the peptides that we utilize,
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most of them are injectibles. There's a few capsules that
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were confident in their outcomes and results.
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But you know, your your digestive system.
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Taking that in and being able to utilize it metabolically
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as you showed to have its challenges, but still, you know,
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we've seen some results. It's a little more mixed based
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on what we see in the gut, and so that's
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that's probably one thing I would I would caution as
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we're going through all this the research studies, I haven't
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seen anything that shows like they ran a really comprehensive
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digestive panel on the research candidates, but I would imagine
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that has a lot to do with how affect active
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some of these oral would react. And then you have retitruetide,
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which is triple agonist, meaning it's you have your GLP one,
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which is your glucagon like peptide or glucose like peptide.
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And then you have.
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GIP which that's g IP and GLP one that's turzepetide.
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And then with retitrue tide, they added a glucagon piece
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to it, and so really designed to target metatabolism very aggressively,
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and glucagon adds like helps with the reducing that muscle
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wasting that a lot of the negative side effects of
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the prior GLP ones had shown. So they're both aiming
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to improve weight, blood sugar, cardio metabolic health.
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So you know they're both similar goals.
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What makes or for lepron different it's a small molecule,
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not a peptide, which this is taken once daily without
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fasting requirements. It's designed to activate those same gop one
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pathways as the injectable meds, and so you know.
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Similar effects.
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Small molecule which from a peptide's small chain of amino
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acids versus just smaller, smaller molecule. And then what makes
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retitrudetade different. This is activating the three receptors instead of
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just the one. It's designed to influence the appetite energy
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regulations simultaneously, and so you're utilizing glucose more and more
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efficiently as well as boosting that metabolism, lowering the food
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intake like that satiation you get satiated faster. That's similar.
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With the fog Lepron still in its investigational phases, not
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yet FDA approved drug, which I don't even know what
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they'll be calling it once it hits the big market.
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That's an Eli Lilly drug or product. So interested to
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see that. I'm sure it's published somewhere. I just haven't
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haven't seen it, and so you know, there's the convenience
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factor with or fogula people really like I'm sure you
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guys would agree sometimes in doing the daily or weekly
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injections aren't the most comfortable things. I don't know, I've
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gotten used to them. I don't mind the injections, but
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I know it's it is one of those things that's
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a little more challenging than swallowing a pill. And there's
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no fasting window before you take the medication. And then
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the simplicity, you know, the thought is is it makes
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it easier for a patient compliance you take the capsule,
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that's a lot easier than doing an injection. So you know,
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with read a true TAD, you're activating three different receptors
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instead of just one versus or for more focus just
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on that GLP one And it had a question on
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is there supposed to be a asting window now? So,
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like ideally with most your peptides, specifically the growth hormone
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releasing peptides, definitely want to take it ninety minutes away
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from food, so like before and after, that's that's the ideal.
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You know, thirty sixty minutes still good. It just reduces
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the GHRP response there, but you know, and then similar
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to with with true tide or the GLP ones, we
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usually recommend doing it fasting. I'll say from personal experience,
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I don't necessarily like regulate that super closely. Still get
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similar responses. Yeah, and usually usually Dana, they'll they'll will
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have it on the script of like take away from
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food or things. But yeah, if you haven't seen that
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on the script, maybe may we may need to make
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sure that's updated. And then euretitrue tide. It's designed to
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influence the appetite. So let's talk about.
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Them head to head.
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So you know, or full or forglepron has shown to
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outperform oral semic glue tide in large phase three study greater.
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Reductions in your A one C and body weight.
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And then the benefits appeared early during the treatment, so
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they're seeing.
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Results pretty quickly or fro over.
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The prown a lot more productive than just the oral
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semic glue tide. I do believe it's it's a attacking
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kind of multiple pathways, not just the GLP. Let's let's
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dive in a little deeper there, just to fact check
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me and I agree. Who names these drugs was a
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comment that just came in. And I don't know who
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comes up with these names. I think they just want
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to create some tongue twisters, so we have to say
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it so many times and it gets stuck in our head.
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Maybe no idea.
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I'm sure there's big Farman's got all sorts of funny
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ways of doing their marketing. So why why you're at
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a truetad is creating so much buzz. So it's in
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its early studies showing really like substantial weight loss potential,
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significantly more than some of the other GLPS improvement scene
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in blood sugar, cardio metabolic markers as well, and they're
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they're viewing it as like this is the next generation,
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This is going to be the next big blockbluster. And
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I know the reason they're eli Lilly is really taking
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its time with these clinical trials, not just looking at
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a weight loss, not just looking at blood sugar improvement.
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They're looking at cardio metabolic so like cardiac markers, they're
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looking at even like osteoarthritis and some some treatment factors there,
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just because you know, blood sugars really impact arthritis. And
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I think you know what it seems like is they're
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trying to hit every possible condition that this this drug
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could be utilized as just to you know, they can
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kind of corner their market of being able to say, hey,
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this is what this drugs used for, and off label
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use is going to be a lot more difficult to utilize,
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so they can essentially, you know, have get as many
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as much use out of their drug as possible. If
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you look beyond the scale or the weight loss, that's
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that's just kind of one measurement of the metabolic health.
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Are also the researchers in these clinical trials, they're looking
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at tracking blood sugar, inflammation, lipid markers and showing you
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know that that success and you know, we've we've agreed
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with this all along. That weight loss is you know,
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just one factor of a really healthy regiment and you
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want to look at everything altogether with you know, similar
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to how these researchers are looking at it. As you know,
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see how blood sugars reacting, inflammation, lipid markers. It's it's
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pretty cool to see. I talked to someone in the
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CGM space, that's the continuous glucose monitoring space, which you
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were looking at getting those into your hands a lot
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easier in the future.
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But you can eat like.
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A meal that typically spikes blood sugars pretty significantly. When
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on red a true tide, this individual noticed like his
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spike was very minimal, and I think he reported his
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spike when he'd take a certain meal, he was seeing
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about twenty like fifty points on his blood gluecose versus
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when he was on red a true tade, he only
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saw it bump up about fifteen to twenty points, which
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that's pretty that's a significant marker when you're looking at
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like what blood sugar levels create in the body. When
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you have elevated blood sugars, you're just creating a whole
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host of inflammatory response. And so you know as you eat,
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especially if you eat like a high fruit toose mill
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if you got a lot of sugars in there, a
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lot of carbohydrates that convert into increase glucose in the
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in the body that can create inflammation. So if we
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can keep those levels, you know, at healthy normal levels
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as much as possible, that increases your metabolic crate, that
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that decreases inflammation and just creates a more healthy environment.
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So those are some key factors, and so some things
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that you should be considering to measure so no, and
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your your baseline metabolic numbers, your gluecose levels, your A
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one C tracking your body composition so kind of your
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fat percentages. And there's a few different ways you can
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do that from home. I actually I have the Hume scale.
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I think it's h u M. That's been a pretty
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pretty good one you have. There's a few other ones
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that a lot of gyms will have. Obviously, the prime
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like the best measurement would be a Dexas scan, but
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you know, not all of us can have one of those.
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You know, I think they're hundreds of thousands of dollars
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just implanted in our home. But if you can get
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measure that body composition over time through through some of
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those measurements can be really helpful. And then you know,
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quarterly or every even monthly you can get a Dexa
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scan and see like exactly how things are going. But
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you know, at least every three to six months is
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really helpful. So you know, both of these or fro
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golebron as well as a true tide, they've been they've
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shown they can both cause some some gi side effects.
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You know, the challenge.
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Especially getting into these g lp ones is your your
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motility slows down, so you're you're eating less with that
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as well as some of those peptizes just slow down
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the movement of your bowels and so you know, that's
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that's something you definitely got to pay attention to. And
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that's why you know, being on you know, one of
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these glp's just consistently all the time at high doses
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is probably that would not be our recommendation. Microdose small
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pulses cycling on and off, you know throughout is can
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you know that that's what we've seen to be the
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most effective to reduce some of those GI side effects.
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Everyone responds kind of differently obviously, and then lifestyle is
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still a big factor.
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What what I love about the.
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Some of these gl piece specifically like turzepetide ret true
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tide I have not tried or for myself, but you
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know what's nice about them is the lifestyle piece makes
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it easier to implement those, especially from an eating habits
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side of things. So if you're taking these, making sure
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you're make sure you're getting the adequate amounts of good
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quality proteins. That's probably the number one foundation is if
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you're getting enough protein protein that's your building blocks for muscle.
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And if you know you're on one of these GLP
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ones and all you're doing is eating a bunch of
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carbs and sugars, yes, your body can handle that better
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being on those peptides, but it's still going to create
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some metabolic deficiencies. And you know, like foods are you know,
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really a big factor as well as you know, working out,
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having the right good exercise regimen. Those are all still
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very critical while you're on these. So the question you're
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probably asking is which one's better? Which ones should you
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go after? And I can't tell you that with certainty,
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but I think everyone's a little different.
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Or for the PROWN that's going to.
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Win on ease of use and convenience. Taking a single
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capsule versus the injectible, you know it definitely one's there
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rede a true tide. They are seeing in these clinical
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trials greater metabolic potential, So it's activating the metabolism better,
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more weight loss, and just just a little a little.
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More potential there.
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And I think we'll probably continue to see that with
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any of these injectibles. They're they're going to be more effective,
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and I think the way reddit true tide's attacking each
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of those three different peptides.
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Is you know, just phenomenal.
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So the best choice really depends on what your health
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status is, your goals, what you're trying to accomplish, and
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then also your preference. Dude, do you mind doing the
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injectables or do you prefer the oral And so if
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you're looking at kind of big picture your future self,
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you know, if you're focused on improving you know, your
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metabolic health and not just chasing the trends, the biggest
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factor would be is know your data, know your numbers,
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get regular blood work so you can know exactly where
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things stand there, track your your body fat percentages and
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things you know, and you can start looking at does
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it makes makes sense to get a GGM, a continuous
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glucose monitor. That's there's there's a few different groups out there.
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We're actually working with us Stello to to get access
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to our patients a little easier and tie it into
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our new tech platform. Hopefully, if you're one of our clients,
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you've started experiencing some of our virtual visits through our
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new platform, and then we'll have a new portal rolling
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out in the next week.
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That well, I think you'll really like it. You can
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pull in all your wearable.
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Data and you can share that with us as well
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as have a really fun robust dashboard that's going to
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show you where things are trending and what to look
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for and look out for and everything. So that is
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some things to consider and yeah, hopefully this was this
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was helpful.
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I didn't necessarily.
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Say, hey, you should go get or Ford Lebron, or
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you should go get read a true TAD And obviously
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that would be between you and your your physician or
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whoever you're working with on the team. But I think
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it's fascinating to look at some of this recent data
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and research that's coming out about these new metabolic drugs
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that have really transformed you know, weight loss, metabolic health,
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and I think we can we'll start to see more
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and more visibility around that with you know, we've had
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an obesity epidemic with our younger generations, with you know,
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with age, you know, comes metabolic deficiencies, and so it's
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it's really exciting to see all these new new innovations
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with peptides and the safety and the there's really limited
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downsides and just a lot of potential upsides there. So
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hopefully this is helpful fun Thank you guys for joining live.
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We'll be back same time, same place next week and
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appreciate you guys.
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Have a great rest of your day.