Beyond Weight Loss: Exploring the Next Generation of Longevity Peptides

WEBVTT
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The real risks now and the confusion in the world
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of peptides is that so many people are using research
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use only peptides, and so if that is you stop
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that immediately because that is putting the brakes on the
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entire industry to be able to move things forward in advance,
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because these are very dangerous and getting your peptides from
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licensed pharmacies and pharmacists that is the best way to
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access these instead of just treating like all the systems
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at once. If you can strategically target different pathways with peptides,
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then you can clear up one pathway and then treat
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another pathway. And that's where we have you on different
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cycles of peptides. Come into one of our events, get
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some use cells, get some stem cells.
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It's a great way of resetting your bodies.
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Overall hardware, and then the peptides help reset the software.
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All right, everybody, Welcome to the Health Exceller.
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Today we're going to be talking about beyond weight loss
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with peptides in the next generation of longevity. So we'll
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be talking about SS thirty one mat C. I'm Reagan Archibald,
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your host, so good to be here. Hope you guys
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are having a phenomenal summer. And so really when we
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take a step back, like right now, the FDA is
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meeting on what peptides or category one category two, and
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so if you guys have had a chance to go
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over there and look at some of the forum that
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is going on with the FDA, some of the they're
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looking for anyone's input and especially from each point of
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you on your thoughts on peptides and why some of
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these peptides that were according to RFK were illegally moved
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from a category one into a category two, if they
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should be placed back into a category one, which is
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generally recognized as safe and it's okay for pharmacists to
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compound those Many of you have asked like, well, how
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are you guys able to continually compound like VPC.
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Because it got put on the category two lists.
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And the way we're able to do that is to
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where you have a different kind of salt that it's
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compounded with, because they had the originate version and so
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we just did the acetate version, if that makes sense.
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So you know, these these peptides are naturally occurring in
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the body, they're targeting very specific pathways for some ether resilience,
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and then probably the biggest area you know, as we
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look at this, you know, for the FDA to have
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a complete day where it's just where they want to
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analyze everything that's going on in the world of peptides
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and determine, you know, if there are risks from peptides
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and and if if they are and effective, and how
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should they be treated because they're kind of fall in
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this gray area between are they a nutriceutical or a.
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Supplement or are they more like a drug.
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And so in order for something to be a drug,
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it needs to go through the clinical trials that the
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FDA is lined out, and there has to be a condition,
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a medical condition that it's used to treat, and you
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have to prove that that drug is safe and it's effective. Yes,
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you've got your phase one, Phase two, now you know
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it's safe and effective. And then phase three is where
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it's is it safer and effective than other drugs that
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are already on the market that treat the same condition.
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And so for a peptide, or for anything to be
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FD approved, it has to go through that process. And
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so what we've done over the last decade is we've
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looked at peptides is falling more on the generally recognized
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as safe these Category one substances.
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But the real risks now and the confusion in the world.
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Of peptides is that so many people are using research
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use only peptides and so if that is you stop
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that immediately, because that is as putting the brakes on
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the entire industry to be able to move things sport
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in advance. Because when the FDA takes in concerns from people,
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it's very hard for them to know did that come
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from a research use only compound not for human consumption,
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or was that from a compounding pharmacy. And in most
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cases what we're finding is the peptides that are coming
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from research use only, from your local influencer virtual influencer,
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these are very dangerous and so one reason we started
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a pharmacy at the end of last year and that
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launched called Ageless Pharma RX, so that not only could
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we make sure that we've got the world's best source
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peptides in our protocols at Ageless Future, but also because
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our pharmacies that we're working with, while they're great, they
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could not keep up with the demand and they didn't
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have the customer service that you deserve, and so it's
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been a big undertaking. But one thing we are seeing
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is that a lot of people are using these research
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use only peptides, and that's where a lot of these
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side effects are coming from. And so for those of
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us who are very serious about our health, today we'll
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be talking about some of these pretty cool peptides for longevity.
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And you know, when you think of longevity, you want
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to think of all the interconnected biological systems, and so
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instead of just treating, like you know, all the systems
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at once, if you can strategically target different pathways with peptides,
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then you can clear up one pathway and then treat
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another pathway. And that's where we have you on different
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cycles of peptides. You'll notice that, you know, things change
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from cycle one to cycle two, because not all peptides
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address every single aspect of healing. But in your body,
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you've got roughly three hundred different types of peptides or
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seven excuse me, seven hundred different types of or seven
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thousand different types of peptides, and maybe about ten percent.
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Of those have been sequenced, and so we've.
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Got a lot that we're learning on these pathways, and
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so one of the biggest areas studied are the mitochondria
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in your cells, and so these are the power plants
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of your cells. And one of the peptides that got
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e FTY approval last year for Barth syndrome, this was
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September of twenty twenty five. This was SS thirty one
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or alama protide and alama protride. It protects the cells
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power plants. So if you think of like an air
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duct that allows air, cooling air or heating air to
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come through your house. If an air duct's blocked, you're
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not going to get air, no matter how much you
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turn the thermostat on, no matter how much that engine
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cranks out the air. And that's what happens in the
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electron transport chain. This onto it that feeds energy into mitochondria.
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And what happens is that that cell membrane starts to collapse.
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There's a protein in there called cardiolipin, and cardiolipin turns
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on the pathway to help create a more robust energy
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transmission in the electron transport chain. And so what SS
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thirty one does, or a lamprotide, is it binds to
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the cardiolipin receptors. It activates the five cytochromes in the
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electron transport chain and it turns on the mitochondris. So
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now it's just a gentle nudge this four amino acid sequence.
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So you know, peptides are just little chains of amino acids,
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and just with a little nudge you turn on cardiolipin
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and now you have kids who had no mitochondrial health
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these or kids with Barth syndrome. The FDA put it
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through the accelerated fast track and they got approval in
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record time because it was so safe and so effective.
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But one thing they notice is that the kids just
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after taking I believe it was seven doses of a
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lamaprotide or SS thirty one, they were able to walk
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from one side of the room to the other in
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half the time, and so they sped up their walking
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speed by almost one hundred percent. And so that's one
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of the conditions, one of the indications that you look
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at for mitochondrial disease, and it's also a condition for frailty.
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So I'm going to encourage all of you to grab
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the Fitness fifty at h one hundred benchmarks and try
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those out.
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See how well you do on the benchmarks.
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But also make sure you're doing kind of a check
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in on your physiology because one of the tests, and
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there's eleven exercises the fitness fifty at H one hundred,
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but one of the tests is sit to rise.
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Can you get up off the ground without touching your
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hand on the ground.
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That would be a big thing to try. So SS
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thirty one a lamiprotide. This one's interesting because it helps
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with acute kidney damage. It's also really helpful for like
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neurodegenerative disease. It's actually there's a clinical trial for Alzheimer's
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and type two diabetes. It helps with energy output, but
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it's more of a reparative peptide for the mitochondria.
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Think of it as they're reparative.
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But one of the peptides that turns on the pathways
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for mitochondria in the muscle specifically is d and mot
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c is.
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It's a mitochondrial.
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Encoded peptide, so it works on a completely different different pathway,
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different mechanism of action. And the beautiful thing about mot
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c is is it's been studied for metabolic flexibility where
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you'll see better levels of insulin sensitivity on MotC This
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is the closest thing to an exercise mimetic that I've
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ever seen.
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You'll see in the studies where there's lowering a blood sugar.
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You'll see where they you've taken old mice and compared
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the speed at which old mice can run and also
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the distance they could run, and after seven days of
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being on MOTZ, they could run the same distance as
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the young mice, so very promising. Mot C is Also
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it is a milest and inhibitor, so you're going to
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get more ballast at and release, so it could help
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increase your muscle building capabilities. And then it also helps
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with exercise adaptation because when you activated, you turn on
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the gene for heat shot proteins, and so you can
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get in the sauna, you can exercise for twenty minutes
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and you can have roughly four to five percent greater
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levels of circulating MOTZ and really phenomenal. And then the
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other thing that happens is you get the secondary energy
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system called AMPK, and that's where you start to see
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next explosion.
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In your energy.
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So matt C one of the peptides I'm currently taking.
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I noticed a huge boost in energy, metabolic, flexibility, endurance,
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and especially if you stack it with SS thirty one.
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Now for those of you who have more immune issues,
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would be careful stacking those, but once again talk to
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your provider and we can help you.
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Navigate the best strategy for you.
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Penelion this is not a motochondri peptide, but from a
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longevity perspective, you know we hit SS thirty one or
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a lamic protide, we hit modic that's like your exercise mimetic.
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It helps with muscle building, metabolic flexibility, endurance. Peneleion was
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discovered by doctor cobbnsis one of the Russian peptides and
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it comes from the pineal gland and the peneal gland
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is what helps us keep our circadian rhythms healthy. And
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one of the benefits of penelion that doctor Cobbinson found
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is that it helps regulate the immune response to the
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body and so by it working through that circadian rhythm,
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now your body has better abilities to sleep, better cognitive
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function because you've reduced neuro inflammation. This is one that
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doctor Huberman's talked about his sleep improvement with. It seems
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to be very safe, no no inside effects with this one,
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whereas with SS thirty one.
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Matt C.
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This is where we want to watch out for tissue
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irritation side of injection immunogenetic response where sometimes your immune
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system can get hives. But those are very small risks
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that we've seen small small population that have those. Penelion
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seems to be very safe. It's best used as an injection,
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but there are a lot of people, especially in the
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Cobbinson group, that use it orally. We just have not
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seen the same benefits oarly. We've seen it internasally and injection.
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But penelion is a very powerful peptide. And then epatalon.
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This is another longevity peptide because it does seem to
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have tilomerase activity.
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In my tilomerase.
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Activity, I mean, there's got it says more than forty
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years of research on the protective properties against cancer on
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your cells and so pitalent it's four amino acids. So
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it comes from the pathalami, which comes from the brains
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of bovine brains from caves and this tetrapetpad. What it
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does is it turns on the tilomerase enzymes. Research shows
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that it turns on collageen one in college in three synthesis.
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It helps with lastin so you have better skin texture,
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skin quality. It also in doctor Cobbinson's research, he found
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that people using epitalent he actually lived about seven years
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longer than people who didn't, and they were using other
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bioregulators in his study. But this one is also one
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of the peptides that he brought in with the Russian
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military who were getting cancer, they were aging much faster,
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they were ending up with metabolic disease. You know, they're
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putting a lot of demand on these the military personnel,
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and they wonder they said, well, maybe epeitel would give
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us an ability. They learned about that, they brought in
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doctor Cobinson, and sure enough they found that the soldiers
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fared better who did epittalent. And this is this is
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one of those peptides where if patients have had other
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types of sleep drugs or sleep aids fell, or if
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they've been a long history of insomnia, Eputalion just seems
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to just reset everything. I like using this peptide at
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least twice a year. If I'm traveling a lot, I'll
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throw in an extra dose. But phenomenal peptide that's done
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more primarily as an injectable. It's a very small you know,
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once again formino acid, so maybe it could be used
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or I have seen that application, but you know, when
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you're using an injection, it's just a little more potent.
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Let's talk about thymusin alpha one. You know, when you're
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thinking about longevity, there's a lot of different pathways that
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we can address.
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And how many of you have actually used up a.
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Talent dimysin alpha one or any of these peptides we're
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talking about as a you know, I love to hear
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what you're what you've experienced with them. But thymysin alpha
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one is naturally occurring thymic peptide. It's got approval in
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I think thirty different countries. At one time, it had
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FDA approval as orphan drug status.
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They used it for autoimmune disease.
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They use it as a vaccine adjunct, so it actually
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helped improve the vaccine's effectiveness. It's a phenomenal peptide when
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it comes to those people who've had like long COVID
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lime or mold exposures, history of allergies, thymyson alpha one
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is something that you want to cycle into your protocol
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and it's OK. We've seen this, especially people who struggle
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a lot with like histamine response, because what thymosin alpha
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one does helps regulate that TH one to TCH two
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balance in the body. And then thymosin alpha one, especially
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if you're stacking it with epitalenty, it helps prevent one
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of the big issues of aging, which is called immunosinessence,
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and that's where your immune cells start to become sinescent
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and they just completely trip up the wiring system and
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so your immune system loses intelligence, poor signaling, But thymys
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and alpha one can help you get back there. One
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of the things that we use this a lot during
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COVID we use slank thymysin alpha one.
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And it's hard to say did it help did it not.
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It wasn't no scientific basis on it, but I can
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tell you our clients who were on it, they.
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Did fare better as far as symptomatically.
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Many of them still got COVID, but they didn't get
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the sickness that other clients have, and maybe it was
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from the thymyson one. It allowed their body to understand
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the threat of the virus and create the antibodies, and
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then the virus didn't really.
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Place a lot of damage on their system.
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The silank we'd use that because not only did it
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help anxiety, because you guys, remember everything was shut down,
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it was a really weird time to be on Earth.
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But we'd use it because selink helps stop viral application.
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It's a great peptide, all right. So if you're looking
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at longevity, you know, if you compare these, it's like
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we want to think beyond just like singular treatments. And
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that would be one of the fun things is you know,
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read a true tide, which I've talked about this on
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multiple occasions, and by the way, thanks for everyone's support
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on my new YouTube channel. It's just been really fun
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to see it grow and to see our community thrive there.
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But if you look at these five peptides, these pathways
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that we've talked about today, SS three one.
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This is lama protide.
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It helps with mitochondri membrane integrity, so it's a reparative.
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Mott C is going to be a metabolic signaling, so
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this is where you're going to get the muscle growth,
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the body composition change, the endurance I think fitness. Penelion
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is for neurobiology, so it's great for the brain and
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the immune system and great for sleep. Epitalion is for
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the tilomeres so DNA silencing and if you haven't read
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David Sinclair's book, it is phenomenal. It's called Lifespan, but
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he talks about the tilomere biology and this ability to
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have this tight replication of cells.
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Epictalion can help you get there.
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It helps with collagen synthesis, cholesterol, all kinds of inflammatory
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markers come down. And then thymosinopha one is for your
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immune regulation. That TH one THH two T seventeen balance
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keeps you from having immuno sinesence where you don't recognize
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the threat. And so if we look at the twelve
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Hallmarks of aging, we're capturing some of the major themes.
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You know.
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The one thing you'd want to add in here is
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like muse.
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Cells, these multilineage undifferentiated stem cells.
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And for those of you who have not been to.
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One of our health summits, our health retreats, our next
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one is coming up July.
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Seventeenth, I think it is the sixteenth and seventeenth. Just
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go to Ageless Future. I'll hit the events and you'll
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be able to see it.
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And so so yeah, hopefully today you know, if you
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want to build better motochondria.
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You know, to start putting some of these things into action.
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Well, first thing, if you have to add blood labs around,
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run your blood labs, get with the team, make sure
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you stay on the protocol because I can tell you
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that health is the one asset that we cannot live without.
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You know, a lot of us we put a lot
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of effort into improving our wealth and we forget about
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our health along the way. So working with a team
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where you know there's some of the most expert expert
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longevity medicine practitioners here at Ageless Future. Getting your peptides
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from licensed pharmacies and pharmacists, that is the best way
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to access these. And then come into one of our events.
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Get some use cells, get some stem cells. It's a
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great way of resetting your bodies overall hardware, and then
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the peptides help reset the software. And so here's your
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challenge for the week. So move every day twenty to
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thirty minutes. Make sure you're getting all your food within
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about a twelve hour window. Get morning light within thirty minutes,
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so wake up, get outside, even if it's for two minutes,
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just get outside. Don't wear sunglasses and prioritize protein. Make
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sure you're getting roughly one gram of protein per pound
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of body weights. You're shooting for twenty five to thirty
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five grams per mil and then you know a couple
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of twenty to thirty gram snacks protein, and then you know,
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finish with some recovery breathing time. So appreciate you guys,
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thanks for being part of the community. I'm Reagan Arshwall'll
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see you next week. H