Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia

Insomnia and depression are two serious and debilitating conditions. Insomnia on its own is linked to an increase in suicide risk, and insomnia can also exacerbate the severity of depression.

Andrea Goldstein-Piekarski, assistant professor in the department of psychiatry and behavioral sciences at Stanford, and Adam Krause, post-doctoral research fellow in Stanford’s psychiatry department, are two of the authors of a recent study in the journal Neuropsychopharmacology. Cognitive behavioral therapy for insomnia, or CBTI, is the gold standard for treating insomnia, and it’s been shown to relieve depressive symptoms as well.

Read the full study here: https://www.nature.com/articles/s41386-026-02431-0

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