Matters Microbial #35: Clostridioides difficile: From Bench to Bedside and Back Again

Today, Dr. Vincent Young of the University of Michigan Department of Internal Medicine and Infectious Disease Division in Ann Arbor, joins the #QualityQuorum to chat about the ecology of the human gut as it relates to a serious bacterial disease caused by Clostridiodes difficile. He will also discuss what it is like to be a medical scientist with both MD and PhD degrees.

Host: Mark O. Martin

Guest: Vincent Young

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• Backyard DNA sequencing—is this a possibility? Here is a source of information. And Sebastian Cocioba is a great source of information.
• The company Giant Microbes makes a C. diff plush toy.
• An introduction to C. difficile the bacterium.
• An introduction to the disease caused by C. difficile.
• Some journal articles by Dr. Young and his colleagues and discussed in this podcast: "Viewing Bacterial Colonization through the Lens of Systems Biology," "Capturing the environment of the Clostridioides difficile infection cycle," "Microbiome therapeutics for the treatment of recurrent Clostridioides difficile infection," and "Longitudinal genomic surveillance ofcarriage and transmission of Clostridioides difficile in an intensive care unit."
• Dr. Young's colleague Dr. Madeline Barron, who writes wonderful essays about microbiology for the American Society for Microbiology.
• An informative interview with Dr. Young. Here is another good interview.
• A good biography of Dr. Young from ASM.
• Dr. Young's faculty website.
• Dr. Young's laboratory website.

Intro music is by Reber Clark

Send your questions and comments to mattersmicrobial@gmail.com