WS 516 All About PrEP

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It's whore school time, and apparently Craig has been muted.
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Oh my god, I'm so happy somebody did that. Yay.
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Having the random fucking bot start talking? Ugh. Not a fan.
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I was not a fan of that. That was very
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upsetting to me, and I did not like it. Making
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all my stuff posted all over the internet. All right, there.
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Good enough. It goes everywhere. We're going to talk about
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prep tonight because I found out some very interesting news.
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And if you were in Femdom Fridays this last Friday,
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you heard me talk about it just a teensy tiny
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bit because it upset me. If you are listening to
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the live show, thanks. You're in the Enchantrix Empire Discord.
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If you're not listening to this live, the fuck is
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wrong with you? I'm kidding. I'm kidding. I love you too.
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But you should join the Enchantrix Empire Discord so that
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you can listen to it live. It's basically a Discord
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chat where only I'm allowed to speak. And you can
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come and join us and hang out in the audience and,
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you know, participate live. You can be a part of
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the in-jokes. They're good for you. I'm joined tonight by Poovie, Mott,
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and Callie, the sweet girl, so far. And yes, Lucifer
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is around, although currently Lucifer is mad at me. She
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tried to sit in my lap earlier. Very cute. But
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then she decided she was just so happy she had
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to You know that thing where they do extremely slow
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biscuits where they just put their foot on you and
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then clench very slowly and drive their fucking sharp-ass claws
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through your flesh? She did that to me, so she
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got her toenails trimmed. And now she's hiding. I feel
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very proud of myself. Oh, to get rid of a cat.
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Trim her toenails. I also cleaned in between her toes
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and she thought that was very offensive. I was like, why? Why?
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You have too much fur between your feets. And she's
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just like, that's. Oh, that was mine. She took off running.
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All right, bye. Bye, bitch. So she got trimmed. Poovey
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pays a professional for their dog. So I got a
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tote bag and I cut five holes in it. Four
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in the corners for legs and one in the side.
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And I can put my little chihuahua. He's half chihuahua.
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I put him in the bag and then I dangle
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him from the shower curtain rod so I can do
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his toes. He hates it. He hates it. Hates it
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so much. I put him down in there and then
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he gets to go dangle because he's up in the
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air going, I can't run away. And then I do
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his toenails. I don't do that to the ancient dog.
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She's too old for that. Her, we go outside because
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then she's distracted by like being outside. She's very old.
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And then I can do her feets. And she's like,
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what just happened? I'm so confused. Oh, I smell something.
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I'm like, she's fine. If I tried to do that inside,
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it would not go nearly as well. She's very old
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and very senile. Very senile. And blind. Found that one out.
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Because she got a little confused on the way out
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the door yesterday. And walked into the wall. I shouldn't laugh,
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but also. So. My poor old lady. Poor critter. Alright. Ooh,
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somebody joined us. Addie! Addie joined us. Hi, girl. Hi.
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We're going to talk about prep tonight. P-R-E-P. What's prep?
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You may be asking yourself. Oh, boy, oh, boy. Prep
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is something that you should definitely be doing. Now, most
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of the time when it comes to stuff like sex,
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when somebody says, are you on prep? They're talking about
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a very specific thing. We're going to talk about that, too.
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But I'm going to start broad and then work down
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into that specific thing because it's neat. It's neat. PREP,
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as an acronym, stands for pre-exposure prophylaxis. And it's basically
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before you're exposed to an illness, you take a medication
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or do something in order to prevent the transmission of
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the illness. So, using condoms is a type of prep.
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It's preparatory. It's a pre-exposure prophylaxis. It's literally a prophylactic.
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It's in the fucking name. It is a medication or
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a thing that one does to help prevent or make
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less likely the transmission of illness. And this does mean
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that wearing a mask is a form of prep. It
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is a prophylaxis that helps to prevent the transmission of
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airborne illnesses. It's a condom for your nose and mouth.
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Your face holes. He says becoming a bubble boy is
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also the dream. Right? God. I want to be a
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bubble person. Then people would be able to touch me.
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Or come too close. Or breathe my air. Mott said,
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I'm bringing back the term Jimmy hat for a condom.
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Skin sleeve. So, um... Let's talk about viruses. Because... That's...
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The number one thing that most people, if you say,
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are you on PrEP? What they're asking about is specifically
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a drug regimen to help prevent the spread of HIV,
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which is human immunovirus. Which leads to AIDS, acquired immune
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deficiency syndrome. Mostly it's just HIV. The antiretroviral medications are
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so good nowadays that you... You'll probably be fine. Like,
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as long as you have insurance and can afford your
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medication and stay on your fucking medications, you'll be fine.
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Of course, an ounce of prevention is worth a pound
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of cure. And it is always better to prevent than
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it is to try to fix it. After the fact.
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Because no matter what, once you have an illness, you
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will have effects from that illness. They, nowadays, very mild.
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Extremely mild. Probably will not affect the rest of your life.
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Other than that whole, you should keep on taking your
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antiretroviral medications. So, let's talk about viruses. What's a virus?
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For most people, people don't really have to go through
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most of the time in your lived life knowing what
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a virus is. Right? Or a bacteria. Because unless you
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work in microbiology or are studying microbiology, why the fuck
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would you know that? I know that. I went to
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a very STEM-heavy school, and I was taking a very
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STEM-heavy course load. It's not what the advanced degrees are in,
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but it's what the bachelor's was in. So, Abby said,
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they're thingy-thingies. Not really dead, nor alive. Very no-no crowd.
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And Poovey says, I have to know about bacteria. Thank
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you very much. Temperature danger zone for the win. Right? Okay,
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so a virus, much like a bacteria, is a transmissible,
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meaning it can move from one person to the next
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through various mechanisms. Hacket of DNA. That's the fastest way
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to say that. It is a way for some DNA
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or RNA to move from one living organism to another.
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While it says viruses are on the top of the
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food chain on planet Earth, viruses eat us from the
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inside one by one. Kind of. The stuff that a
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virus does to us that we don't like, the negative
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side effects of a virus, the virus doesn't really give
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a shit about. By the time you experience the negative
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stuff from having caught a virus... You are now into
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the phase where you are spreading the virus to other people.
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The virus is done with you now. It's using your
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immune response and hijacking your immune response in order to
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travel from one to the other. It's not really that
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it's eating you. It's using you. So. A virus. Okay.
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Brace yourselves. A virus is a microscopic organism. It infects
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hosts like humans, plants, or animals. Pretty much if you
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have a cell, you can get a virus. They have
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a little piece of genetic information, either DNA or RNA,
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that is, deoxyribonucleic acid, or, uh, ribonucleic acid. They left
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off the deoxy. And they're inside a shell. And the
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shell is called a capsid. Remember that word. It's an
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important word. Some, but not all, viruses also have an
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envelope around the capsid. Viruses cannot reproduce without a host.
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If the virus is in your environment, but it never
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manages to infect you, the virus is shit out of luck.
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Common diseases are caused by viruses. The flu, the common cold,
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and a whole bunch more. Lots of things are caused
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by viruses. And you have definitely had a virus at
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some point in the past. Mott says, wash that ass.
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That would be bacterial. Addie said, that sounds mildly dehumanizing
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and objectifying and abusive. They use me? Just leave like that? Yeah. Sometimes.
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Sometimes they leave. Not all the time. Don't worry, I'm
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going to tell you about the types of viruses. You've
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got your influenza viruses. Orthomyoxyviridae. That's influenza A and B.
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That's the flu. So if you've ever heard somebody talking about, oh, no,
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the bird flu. Oh, swine flu. Oh, H1N1 is going
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to get you. Yeah. Those. That's a virus. That's one.
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It depends on the specific strain. So they're named after
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the species. the type of animal it was originally found in.
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So bird flus were first found in birds, like chickens.
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And the reason why bird flu is a problem, do
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you know how much of the food we eat in
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the United States is chicken? Where do eggs come from? Chickens. Eggs, chicken.
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So A farm that winds up with bird flu often
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has to put down all the birds, all of them,
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in order to stop the bird flu from spreading. Because
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if a human eats a piece of chicken that was
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infected with bird flu, it can make the jump from
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a bird flu into a human flu. hi Kylie, we're
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talking about viruses tonight. So, you don't want a virus
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that started originally in an animal to jump over into
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human-to-human transmission. Because it's mutated, something in it changed, now
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it likes people. Great. And we may or may not
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have an immune response to it. And so, um, Some
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influenzas can become extremely deadly. The Spanish influenza of 1912
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comes to mind. Uh-huh. Callie says the Spanish flu got
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wrongly named because countries didn't want to report their cases. Yep,
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and so they wound up blaming it on, oh, Spanish influenza,
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the Spanish flu, because they were like, hey, we have
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a problem. And everybody else went, nuh-uh, that's all you. Ah,
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it's your fault. Jackasses. It was probably a bird flu.
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And it popped on over to human transmission. And then, whoops-de-doodle,
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probably came from Kansas. It probably did actually originate in
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the U.S. So, herpes viridae. Herpes viridae. Okay. Okay. I
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say that real nice and slow, but it's herpesviruses. There's
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a bunch in the herpes family. There's simplexes 1 through 9.
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I'm not going to go over all of them. You
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can refer back to the episode of Horse School about herpes. Oral,
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genital herpes, chickenpox, shingles, Epstein-Barr, and cytomegalovirus are all herpesviruses.
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Aren't those great? You get a funny bump. It's probably
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a herpes somewhere on you. Epstein-Barr gives you muscle tremors
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and like shingles. Shingles is a mutation of chicken pox.
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Chicken pox give you bumps and sores all over your skin.
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And then shingles gets into the muscle sheaths Yay. You
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can also, by the way, you can get any of
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these herpes viruses. They have where they like to be
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on the body. So genital herpes likes to be on
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the genitals and oral herpes likes to be on the mouth.
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They can show up anywhere, including on the lining of
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your organs. Isn't that neat? Vaguely terrifying. Horrifying. Chickenpox is
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no fun. They have a vaccination for chickenpox now. If
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you have not had chickenpox or the chickenpox vaccination, go
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fucking get it. Because it also prevents shingles. There's a
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shingles vaccination as well. But I think you have to
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be a certain age to get the shingles vaccination. I'm
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not sure about that. Talk to your healthcare provider and
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be like, what can you shoot me up with? So,
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get that. Coronaviruses. There are lots of coronaviruses. They cause
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the cold, just like the influenza viruses cause influenza, the
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flu virus. coronaviruses cause the common cold. There are a
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bunch of coronaviruses out there, but currently the most famous
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one is SARS-CoV-2, COVID-19. There's also vaccines for that one,
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which you should also go and get and make sure
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that you're up to date. You can get a flu virus,
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you can get a chickenpox flu vaccine, chickenpox vaccine, shingles vaccine,
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coronavirus vaccine, and you should Hey, prisoner, welcome to the
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show tonight. All of those are viruses. All of those
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can be steeply ameliorated. Or if you catch it, even
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if you have been vaccinated, you get less sick. It's
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less likely to knock you on your ass and liquefy
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your lungs. Poovey, I can't repeat that joke. That is
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really funny. Jerk. Okay, human papillomavirus. Hey, guess what? HPV.
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There's a vaccine for that one too. And you should
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get it if you have sex. The human papillomavirus. I've
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covered this one as well. It is a sexually transmitted illness.
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There are no symptoms for HPV in men. on account
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of you don't have a cervix. Okay, no, cis men.
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Let's be clear. Cis men who do not have a
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cervix cannot suffer the negative effects of having human papillomavirus.
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But if you stick your diseased dick in a woman
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or a person who does have a cervix, you can
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give her or them an STD that will eventually cause cancer.
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Cervical cancer. Don't fucking do that. Men should absolutely get
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the vaccination. Persons who have a cervix should definitely get
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the vaccine. It's recommended for people who are under 45
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years of age. If you are older and you are
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still having risky sex, get it anyway. Bitches. Enteroviruses! Oh,
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we love a good enterovirus. Ugh. Those are the ones
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that go after your intestinal tract. An enterovirus is one
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of the viral infections that will cause you to become
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very good bestie friends with your toilet. Hand, foot, and
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mouth disease is an enterovirus. Ew. So is polio. But
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enterovirus is also one of the hallmarks of an enterovirus
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is you have to spend a lot of time sitting
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on the porcelain throne. Isn't that great? Flaviviruses. Flaviviruses. They're
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spread by mosquitoes most often. And isn't that just a
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fucked up bitch? That's some crap. We do not enjoy those.
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The flavivirus is fuck mosquitoes. Zika, West Nile, dengue fever,
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yellow fever. Again, you're going to be sick as shit.
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You're going to sweat a whole lot. For some people,
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compromised immune system, or if they're already weakened, it's real bad.
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Let's see if you can guess what this one is.
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Orthopox viruses. Ortho pox viruses. Can you figure out what
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those ones are? They're fun. Yup. Prisoner said if one
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cow or bull in England is diagnosed with hoof and mouth,
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the entire herd that cow or bull was a member
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of is slaughtered and cremated. Yup. Um, In the United States,
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if you have a herd of swine who wind up
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with swine flu, bye-bye piggies. All of your birds, if
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they wind up with bird flu, bye-bye birdies. Same thing.
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There's also, there's various things that aren't viral. So like
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prion disease. If you get prions in your cows, one,
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feed them a higher quality of feed. And two, Put
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them all down. Because prion disease, that's the one where
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you get holes in your brain. I don't like that.
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Orthopoxviruses cause blistering rashes. An orthopoxvirus would be monkeypox, smallpox, cowpox,
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those things. And again, cowpox refers to the fact that
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it was first found in cow's The hepatitis viruses. Hepatitis A, B,
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and C are the most common ones. Guess what part
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of your anatomy the hepatitis viruses attack? Your liver. You
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need that. You need a liver. You need that. Poovie
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says it happens to plants too. The T virus in
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bananas will mean entire orchard is destroyed. Yes. The tobacco
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mosaic virus, which started off in tobacco plants, but it
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can also show up in any nightshade. Would you like
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to know how much of the North American diet is
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composed of nightshades? Tomatoes, potatoes, all peppers, eggplants. All of
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those are nightshades. It's terrible. And then we have the retroviruses.
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A retrovirus is a virus that uses RNA and it
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has special proteins packaged in with it to make DNA.
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When you're infected with a retrovirus, it starts off as RNA.
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It uses part of your body's cells to make DNA.
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The DNA is inserted into your DNA and then your
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cells go, Okay, we make this stuff now? Great. And
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it will make whatever the viral DNA is said to do,
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which would be the parts of the virus. Yay. So
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then your body is making more of the virus. Just
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making it because now part of it has become part
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of you. HIV is a retrovirus. Human T lymphotropic virus
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is also a retrovirus. There are other retroviruses. which is
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why it's important to take antiretroviral medications. Oncoviruses. This is
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more of a broader group, and it encompasses several of
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the different types. The viruses that cause cancer, HPV, Epstein-Barr, HIV,
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hepatitis B and C, the human T lymphotropic virus, and
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human herpes virus, all can cause cancer. Which is why
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the fact that we have vaccines for HPV, hepatitis, and
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humans' herpes virus is kind of important. I think we have... No,
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we do not have a vaccine for herpes virus yet. So... Obvious.
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Mott said I'm taking a shower after horsecore. Mwahaha. Yeah.
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All of these viruses, they're not alive in the way that, like,
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you are alive. They are alive in that they exist.
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They consume resources. They replicate themselves. So they're kind of alive.
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They're kind of not alive. But they kind of are.
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They attach to cells. They have a mechanism built into.
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So it's got like these little legs that come off
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of the capsid. Think of the capsid as like a ball.
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And it's got this structure. looking off the side of
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it and it has legs and it hooks into your cells.
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Most of the time those little legs have specific shapes
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to them and they attach to specific shapes on your cells.
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This is why we say that they like certain types
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of tissue. They're looking for specific cell types and specific
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proteins on the surfaces of the cells. That's how they
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can tell the difference between genital tissue and a liver.
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In a pinch, most of these viruses will take whatever
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they can fucking get. But some of them are highly
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specialized and will only attach to specific receptors on your cells.
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They go, ooh, there's that receptor. I'm in. They attach
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and then there's kind of a spring mechanism in there
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that kind of pucks through the lining of your cell,
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and it squirts the contents of the capsid into your cell,
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at which point it begins to replicate itself by using
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your cell's stuff. Your cell comes along and goes, ooh,
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here's some DNA. Oh, okay, I should make more of this? Great.
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And keep in mind, though, your cell isn't really thinking
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because it's just one cell. It's just... doing stuff. Eventually
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it puts all the pieces together, and then it... gets
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out of your cell. Sometimes you can be infected with
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a virus and show no symptoms whatsoever. It's because it
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can go dormant in your body or it can just
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be silent and not do anything in there. Eventually there
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will be a trigger and it causes the cells to burst.
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And it spreads the viral particles into your body and
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infects other cells inside. It could be stress. It could
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be chemical signals. It could be temperature changes. This is why,
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if you have herpes, for example, this is why it
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comes back. Why the sores on your mouth or the
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sores on your genitals come back, especially if you're stressed out.
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You get an outbreak, right? It's in there. It's just
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gone dormant until it's not. And then it's active again.
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Most of these... viruses, you're more likely to spread when
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it is active than when it is dormant. Most of
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the time when it's dormant, you do not spread it.
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When it is active, you do spread it. Yeah, does
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that make sense? Addie said herpes is the one that
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most humans have, right? Yes. In some populations, it's up
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to 80% of the population has herpes, usually oral herpes.
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But keep in mind, there are nine versions, like nine
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herpes simplexes. And number eight is the one that causes cancer. Actually,
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Epstein-Barr is also a herpes virus, so two of them
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cause cancer. They're bad for you. Addie says, she's frantically
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raising her hand. Have I watched Cells at work? If
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I did, it was a while ago? Not recently. Okay.
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Tons of different shapes for viruses. Tons of different things
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that they do. But if you don't want a virus,
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how do you stop it? Right? That is kind of
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the quintessential human question. How do you stop something that
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you can't see and you can't smell it And you
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can't hear it. And it's just kind of there. How
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do you stop it? I'm so glad you asked. Through
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this process that we like to call prep. Pre-exposure prophylaxis. Basically,
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remember that that is any medication or process that you
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undergo to try to prevent or reduce the odds of
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catching or transmitting and illness, including viruses. Wash your hands
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with soap and water. Sing yourself happy birthday while you
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do it to make sure that you have soap on
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your skin for long enough. Real soap. Soap, soap. in
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00:33:28.309 --> 00:33:31.059
this harbor. Why do I have to use soap? Ah,
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you remember the capsid? I told you to remember that word.
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An awful lot of viruses have a capsid. In fact,
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all of them do. Some of them have an envelope
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to protect the capsid around it. The vast majority of them,
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00:33:48.250 --> 00:33:54.789
the capsid is made of fat. Basically, I am so
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00:33:54.869 --> 00:34:03.220
simplifying things. Soap breaks the bonds in fat. So before
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your virus has a chance to hook into your cell
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and squirt its guts inside of you, you can use
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soap to pop it like a bubble. Isn't that great?
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00:34:21.030 --> 00:34:29.530
Addie said, what about just a bit of spit? no
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soap soap and water for fuck's sake not spit no
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00:34:38.409 --> 00:34:42.599
please do not lick things it doesn't get them clean
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would you like to know all about the enzymes that
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exist in spit because i will tell you it's a
375
00:34:53.260 --> 00:34:56.909
threat Okay, do you want me to make you feel
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00:34:56.969 --> 00:35:00.090
vaguely grossed out about what's in your mouth? Because I
377
00:35:00.130 --> 00:35:10.590
can do it. I took way too many microbiology classes, okay?
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Organic chemistry, microbiology, and genetics. It's all about viruses. I
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00:35:19.940 --> 00:35:31.860
know what's in spit. Mm-mm. Nope. He said, why not?
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You've made us grossed out about the rest of our
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bodies so far. I would say, I'm sorry for that,
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00:35:44.630 --> 00:35:54.730
but I'm not. It would be a lie. Prisoners, it
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was the microbiology class to learn how to brew beer.
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00:35:58.010 --> 00:36:00.750
I mean, we did talk about yeast because yeast is
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a single cellular organism that is definitely alive in all
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00:36:06.170 --> 00:36:08.070
the ways that we think of things as being alive.
387
00:36:09.210 --> 00:36:15.559
Yeast is fascinating stuff. But no. We did talk about
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00:36:15.599 --> 00:36:23.449
brewing beer and making other alcohols. But no, that's not
389
00:36:23.489 --> 00:36:28.900
why I took the class. It was really fun. They
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00:36:28.920 --> 00:36:35.119
had us go and swab our bathrooms. And as a result,
391
00:36:35.539 --> 00:36:40.670
I have developed a lifelong habit. Always, no matter what,
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00:36:41.889 --> 00:36:49.250
before you flush the toilet, put the lid down. For
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00:36:49.309 --> 00:36:59.510
the love of fuck, that's Disgusting. So. Bud says, hey,
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00:36:59.570 --> 00:37:03.840
for no reason, fuck John Calvin. Hell yeah, fuck John Calvin,
395
00:37:03.880 --> 00:37:16.219
that asshole. We still hate him. Screw that dick monkey. Uh-oh.
396
00:37:16.800 --> 00:37:26.570
I broke something. Oops. It's fine. The computer will respond
397
00:37:26.590 --> 00:37:36.059
in a minute. Poovey said, you don't like making aerosol
398
00:37:36.119 --> 00:37:39.860
clouds of biomatter? Look, as soon as I learned what
399
00:37:40.000 --> 00:37:44.559
microspray is, I was like, oh, you're right. Note to self.
400
00:37:48.079 --> 00:38:03.139
That's disgusting. My toothbrush lives here. There it is. Found it. Uh-uh.
401
00:38:13.369 --> 00:38:20.559
So prep. Pre-exposure prophylaxis. Wearing gloves. A mask when you
402
00:38:20.639 --> 00:38:25.280
are around strangers is a form of pre-exposure prophylaxis, and
403
00:38:25.320 --> 00:38:33.349
it can prevent or ameliorate the transmission of influenzas and coronaviruses.
404
00:38:34.010 --> 00:38:35.969
And the reason I call those out is because those
405
00:38:36.010 --> 00:38:39.190
are the ones that are most likely to be spread
406
00:38:41.860 --> 00:38:46.639
by aerosolized droplets in the air aka you ever get
407
00:38:46.760 --> 00:38:49.570
really really into talking about something and discover that you've
408
00:38:49.619 --> 00:38:53.869
accidentally been spitting the whole time yep those are aerosolized
409
00:38:53.909 --> 00:39:08.829
droplets ew wear a mask wear a mask Because other
410
00:39:08.869 --> 00:39:20.739
people's exhalations are gross. Okay, well, it's just nasty. My
411
00:39:20.780 --> 00:39:32.260
dog's stomach is gurgling behind me. Holy crap. Okay. If
412
00:39:32.340 --> 00:39:44.869
you are interested in engaging in risky sex, and that
413
00:39:44.909 --> 00:39:50.920
can include sex with strangers, Sex with people who themselves
414
00:39:51.079 --> 00:39:58.539
engage in risky sex, including sex with strangers. You should
415
00:39:59.000 --> 00:40:03.059
probably speak to your primary health care provider about getting
416
00:40:03.440 --> 00:40:10.130
on one of any number of different types of PrEP,
417
00:40:10.969 --> 00:40:16.489
pre-exposure prophylaxis for HIV. You don't want HIV. You really
418
00:40:16.530 --> 00:40:24.000
do not want it. It causes several cancers and is
419
00:40:24.340 --> 00:40:28.780
bad for you. Like, it's not a fun one. This
420
00:40:28.909 --> 00:40:34.570
is not bragging rights. You want not to ever catch this. So,
421
00:40:35.090 --> 00:40:40.929
the first one, Truvada, was approved in 2012. If this
422
00:40:41.010 --> 00:40:45.389
is the first that you're hearing, Addie says, it causes cancers. Yes,
423
00:40:45.550 --> 00:40:49.900
several cancers. AIDS was such a big deal because people
424
00:40:49.920 --> 00:40:51.900
were like, what the fuck? Why are these people getting
425
00:40:52.079 --> 00:41:00.909
really weird, obscure, unusual cancers in clusters? Like weird cancer clusters.
426
00:41:00.929 --> 00:41:02.949
And they could not figure out what was causing this.
427
00:41:03.710 --> 00:41:09.829
It was HIV. It causes cancers. Like skin lesions that
428
00:41:09.869 --> 00:41:14.579
turn into cancers. Cancer of the like bits of your
429
00:41:14.599 --> 00:41:18.679
body that normally don't get cancer. Your liver usually doesn't
430
00:41:18.780 --> 00:41:27.610
really get cancer. Addie said, I thought it was just
431
00:41:27.650 --> 00:41:30.030
like your immune system and people were dying because of
432
00:41:30.590 --> 00:41:33.550
really basic diseases like the flu. I mean, that definitely
433
00:41:33.630 --> 00:41:40.670
did not help. It does. So HIV... They call it
434
00:41:40.730 --> 00:41:47.570
acquired immune deficiency because it does weaken your immune system drastically,
435
00:41:48.050 --> 00:41:50.320
which means you are more likely to catch anything that
436
00:41:50.340 --> 00:41:53.099
walks past. And as a result of that, you can
437
00:41:53.139 --> 00:41:58.099
wind up kicking off because you've caught everything. Would you
438
00:41:58.119 --> 00:42:00.079
like to catch two or three strains of the flu
439
00:42:00.340 --> 00:42:03.510
at the same time? Because that's possible. You can do that.
440
00:42:04.329 --> 00:42:09.170
But it also would give people cancer. weird cancers that
441
00:42:09.190 --> 00:42:10.869
they were like we don't have a cure for that
442
00:42:10.989 --> 00:42:17.480
because it's so rare so people would die from and
443
00:42:17.519 --> 00:42:21.900
it would like would you like blood cancer we can
444
00:42:21.920 --> 00:42:31.630
give you some of that like weird fucking cancers well
445
00:42:33.530 --> 00:42:38.360
the dogs are moving around mott said nightmare It was terrible,
446
00:42:38.659 --> 00:42:41.780
and in the 80s, late 70s, early 80s, all the
447
00:42:41.800 --> 00:42:46.840
way through the 90s, it was considered God's punishment for gays.
448
00:42:51.079 --> 00:42:54.739
It's terrible. Like, the history around AIDS is just awful.
449
00:42:55.360 --> 00:43:01.789
In 2012, Truvada was finally approved to use as pre-exposure prophylaxis.
450
00:43:02.789 --> 00:43:05.650
Most of you, if you have insurance, your insurance probably
451
00:43:05.690 --> 00:43:09.309
covers it. Because it is far cheaper in the long
452
00:43:09.349 --> 00:43:18.769
run to prevent an illness than to treat the illness. So,
453
00:43:19.289 --> 00:43:28.230
Truvada was the first one. It is... Let me make
454
00:43:28.250 --> 00:43:43.690
sure I can pronounce this. Impricitabine. tenofovir, tenofovir, brand name Truvada. Um,
455
00:43:43.869 --> 00:43:48.730
there's other names that it's also sold under. It is
456
00:43:48.949 --> 00:43:55.949
used for HIV prevention, HIV treatment, and hepatitis B treatment. Um,
457
00:43:58.449 --> 00:44:02.670
and if you have both hep B and HIV, hey,
458
00:44:02.690 --> 00:44:09.530
it works on both at the same time. Um, It's
459
00:44:13.210 --> 00:44:25.639
an antiretroviral medication. If you are not currently infected with HIV,
460
00:44:25.880 --> 00:44:35.179
you can take Truvada before exposure and it reduces your
461
00:44:35.360 --> 00:44:40.889
risk by at least 54%. on average, which is really
462
00:44:40.989 --> 00:44:49.300
fucking good, because without it, your risk, it's not super high.
463
00:44:49.880 --> 00:44:53.460
It's not like you're definitely going to get HIV if
464
00:44:53.480 --> 00:44:56.539
you fuck a man. It's only 1 in 200, but
465
00:44:56.599 --> 00:44:59.139
on Truvada, it's 1 in 400, which is better. Right?
466
00:45:08.929 --> 00:45:20.099
So that's that one. There is also... Where did it go?
467
00:45:20.119 --> 00:45:24.030
I have so many things open. You don't even know.
468
00:45:33.369 --> 00:45:40.329
There is... So that was the... amtricitabine and tenofovir. And
469
00:45:40.349 --> 00:45:44.289
then there's one that is the same thing, but it
470
00:45:44.369 --> 00:45:52.699
is tenofovir alafenamide, which is Descovy, which can also be
471
00:45:52.780 --> 00:46:02.369
used as PrEP. It is... Truvada is for everybody. Descovy
472
00:46:02.570 --> 00:46:07.010
is for cis men and trans women. because they have
473
00:46:07.070 --> 00:46:13.320
not assessed it for women doing receptive vaginal sex. So
474
00:46:14.320 --> 00:46:27.230
that's the difference between those. In 21, cabotegravir, abotegravir, aperitude,
475
00:46:29.150 --> 00:46:35.670
was approved. It is an injectable form of pre-exposure prophylaxis.
476
00:46:47.300 --> 00:46:52.420
whereas Truvada and Descovy are pills that you have to
477
00:46:52.500 --> 00:46:57.340
take every day, preferably for like a month before you
478
00:46:57.380 --> 00:46:59.340
engage in risky sex. So if you're thinking you might
479
00:46:59.420 --> 00:47:02.590
want to, you should probably go and get on it now.
480
00:47:02.610 --> 00:47:07.510
Aperitude is injectable, and you only have to have an
481
00:47:07.570 --> 00:47:13.570
injection once every two months. They were hoping that Aperitude
482
00:47:13.590 --> 00:47:16.789
would be more popular because it's just one shot every
483
00:47:16.829 --> 00:47:21.710
two months. So you're more likely to have people follow
484
00:47:21.789 --> 00:47:28.219
through with it and not forget or lose their pills
485
00:47:28.280 --> 00:47:38.880
or stop taking them for whatever reason. And then there is...
486
00:47:40.929 --> 00:47:48.369
Another one. This one's really super duper new. And again,
487
00:47:48.389 --> 00:47:54.909
we get a really wild fucking name. It is an
488
00:47:54.989 --> 00:48:10.230
extended release injectable Lenacapavir. Lenacapavir. It's branded as Yeztugo. Now, currently,
489
00:48:10.820 --> 00:48:12.880
This is the one that I was talking about for
490
00:48:12.940 --> 00:48:16.690
Femdom Fridays, because they've managed to get my attention and
491
00:48:16.809 --> 00:48:22.809
piss me off at the same time. Yezd Hugo is
492
00:48:25.710 --> 00:48:30.769
through Gilead Sciences. Pointing. What's with that name? Why is
493
00:48:30.829 --> 00:48:46.940
it called Gilead? What the shit? Hi, Chicago. We're talking about, uh... Viruses. Tonight. Okay.
494
00:48:47.440 --> 00:48:52.460
So Yez Tugo. From Gilead Sciences. They're in the process
495
00:48:52.500 --> 00:48:56.159
of going through. And getting full approval. For global release
496
00:48:56.199 --> 00:48:59.860
of this medication. And they've made deals. So that in
497
00:49:00.139 --> 00:49:03.880
lower income countries. They will release the shot. And it's
498
00:49:04.219 --> 00:49:06.840
two shots per year. So it's one shot every six months.
499
00:49:08.460 --> 00:49:14.309
that they will release it for $ 40 per shot in
500
00:49:14.429 --> 00:49:27.659
low-income countries. Fabulous, right? Yes, to go as PrEP before
501
00:49:28.039 --> 00:49:33.199
one is infected with anything, that sounds absolutely fabulous. A
502
00:49:33.320 --> 00:49:36.400
shot every six months, and it reduces your risk of
503
00:49:36.440 --> 00:49:42.119
catching HIV. We love that. Yes, please. It's also used
504
00:49:42.159 --> 00:49:46.139
for people who have HIV, but their strain of HIV
505
00:49:46.179 --> 00:49:53.570
has become medication resistant. And the trials for this medication
506
00:49:54.469 --> 00:50:00.239
for people who have a resistant strain of HIV, it's
507
00:50:00.300 --> 00:50:03.940
working very, very well. The problem is in first world
508
00:50:03.980 --> 00:50:10.050
countries like the United States, it's 42%. thousand dollars per
509
00:50:10.300 --> 00:50:21.190
year for treatment your money or your life and that
510
00:50:21.550 --> 00:50:26.429
is why medicines and frontiers or doctors without borders has
511
00:50:26.510 --> 00:50:35.250
launched a campaign to attempt to push um where did
512
00:50:35.269 --> 00:50:39.059
it go i have a link for this Here it is.
513
00:50:41.460 --> 00:50:48.409
Gilead Sciences into releasing the medication. Yes to go. Boom.
514
00:50:48.449 --> 00:50:54.050
Told you I had a link. For $ 40 per shot. Globally. Everywhere.
515
00:50:58.329 --> 00:51:00.949
Because that would be so much better. And you can
516
00:51:00.989 --> 00:51:08.389
see it's very simple. Lenacapavir. Two shots. $ 40. Everywhere. Everywhere. So,
517
00:51:09.019 --> 00:51:12.260
they're trying to put pressure onto Gilead Sciences to lower
518
00:51:12.300 --> 00:51:21.420
the fucking price. Lower the cost, you bitches. So, if
519
00:51:21.989 --> 00:51:23.650
they can manage to put pressure on them for that,
520
00:51:24.230 --> 00:51:33.369
that is huge. That's massive. That's so good. So, if
521
00:51:33.429 --> 00:51:36.360
you are about to go forth and engage in risky sex...
522
00:51:38.840 --> 00:51:43.800
Step one. Make sure that you have gone to your
523
00:51:43.860 --> 00:51:47.199
local health department and gotten tested recently so you can
524
00:51:47.260 --> 00:51:50.780
prove that you're clean. Demand that anybody you're about to
525
00:51:50.840 --> 00:51:56.860
do anything sexy with can also prove that they are clean.
526
00:52:01.949 --> 00:52:05.909
Have you been tested? How long ago? Have you had
527
00:52:05.969 --> 00:52:09.699
risky sex since then? Those are the questions you want
528
00:52:09.719 --> 00:52:12.280
to ask and then judge for yourself. Do you feel
529
00:52:12.420 --> 00:52:17.630
safe doing sexy stuff with this person? If yes, great.
530
00:52:18.230 --> 00:52:26.389
If no, examine what you're about to put inside of
531
00:52:26.429 --> 00:52:28.880
your body before you do so. If it looks like
532
00:52:29.239 --> 00:52:35.260
it's got a rash, don't fuck it. Funny bumps, funny smells.
533
00:52:36.519 --> 00:52:39.610
If it just the vibe's not right. You can say
534
00:52:39.670 --> 00:52:41.659
no at any point and say, you know what? I
535
00:52:41.699 --> 00:52:46.400
changed my mind. Why is your dick green? You know,
536
00:52:46.519 --> 00:52:48.340
you're allowed to do that. You're allowed to back out
537
00:52:48.480 --> 00:52:59.099
and just no. And if you know ahead of time
538
00:52:59.139 --> 00:53:01.449
that you're about to be engaging in risky sex, you
539
00:53:01.489 --> 00:53:06.280
can always, always go to your primary care physician, And
540
00:53:06.510 --> 00:53:12.360
ask for PrEP. It'll probably be Truvada. It is a pill.
541
00:53:13.679 --> 00:53:20.920
Oh no. Take it every day. And you'll drastically reduce
542
00:53:21.619 --> 00:53:25.719
the chances that if you do manage to accidentally have
543
00:53:25.780 --> 00:53:28.940
sex with somebody who happens to be positive, you won't
544
00:53:28.980 --> 00:53:39.949
catch it. It's like wearing a mask or your genitalia. Oh,
545
00:53:41.130 --> 00:53:48.710
and sign that campaign. Back them and be like, hey,
546
00:53:49.710 --> 00:53:54.039
lower that price because $ 42, 000 for the first year's treatment
547
00:53:54.119 --> 00:54:15.869
is a ridiculous price. Oh my god. Those greedy shits. Mm-mm. God. Pissed. Oh, how? Why?
548
00:54:16.730 --> 00:54:21.889
Why is it so expensive? It's the difference in the price, too,
549
00:54:22.070 --> 00:54:24.909
between it's one price in one country and a different
550
00:54:24.949 --> 00:54:31.590
price in another country, and that's just... I'm not a
551
00:54:31.650 --> 00:54:36.090
fan of that. I don't like that. Oh, by the way,
552
00:54:36.150 --> 00:54:40.690
would you like to know how Lenacapivir works? This is
553
00:54:40.750 --> 00:54:49.800
the cool shit. It's also Senluka, Yes2Go, and Yay2O. The
554
00:54:49.860 --> 00:54:53.599
way that it works. Okay, so remember I said capsid
555
00:54:53.699 --> 00:55:00.019
earlier and how capsid was an important word. Lenacapivir binds
556
00:55:00.119 --> 00:55:06.789
to the capsid protein subunits in... the HIV. So think
557
00:55:06.849 --> 00:55:09.590
of the subunits as like the building blocks of the capsid,
558
00:55:09.730 --> 00:55:13.690
and they are in rows, like ribs all the way around.
559
00:55:14.409 --> 00:55:19.610
When it's time, the HIV virus hooks into your cells, injects,
560
00:55:20.280 --> 00:55:23.719
and then kind of crunches down in order to inject
561
00:55:23.760 --> 00:55:28.139
what was in the capsid into you. Lenacapivir binds to
562
00:55:28.179 --> 00:55:33.059
the capsid and stiffens it and makes it so that
563
00:55:33.119 --> 00:55:40.409
it cannot eject a It can't. It can, it can
564
00:55:40.670 --> 00:55:43.030
hold onto your cells and it's like, okay, I'm ready
565
00:55:43.070 --> 00:55:49.309
to go. It's like, um, it's a ruined orgasm for
566
00:55:49.329 --> 00:55:54.449
the whole virus. It can't come. It can't. It's, it's
567
00:55:54.530 --> 00:55:58.440
too stiff. The capsid itself is so stiff it cannot
568
00:55:58.579 --> 00:56:05.480
collapse down and thus squirt into your cells. I kind
569
00:56:05.539 --> 00:56:14.949
of love that. I'm like, oh, good. Addie says, if
570
00:56:14.989 --> 00:56:17.530
I don't have sex, how often should I be getting tested?
571
00:56:17.670 --> 00:56:24.780
Just in case. Every six months. Easy answer. Every six months.
572
00:56:25.739 --> 00:56:29.300
The reason for that one is because you do want
573
00:56:29.340 --> 00:56:34.900
to have fairly recent test results. And some illnesses, remember,
574
00:56:35.320 --> 00:56:38.949
some of those viruses will go dormant. Some of them,
575
00:56:39.090 --> 00:56:43.150
if they're dormant in your body, they cannot be tested
576
00:56:43.250 --> 00:56:47.710
for because the viral bodies are so low, they're undetectable.
577
00:56:49.130 --> 00:56:51.869
And so you test every six months in case something
578
00:56:51.909 --> 00:56:55.929
has gone active and then it will catch. So every
579
00:56:55.969 --> 00:57:05.679
six months, test it. Boom. At least these all sound
580
00:57:05.699 --> 00:57:11.909
like names for Kanye West. Yeah, yeah. a little bit
581
00:57:16.050 --> 00:57:23.900
and it's yes to go y-e-z-t-u-g-o yes to go you
582
00:57:23.920 --> 00:57:27.019
just know eventually you're going to see an ad somewhere
583
00:57:27.840 --> 00:57:30.739
on something and it's gonna be some sassy person going
584
00:57:30.880 --> 00:57:35.929
yes to go And just so you know, that's what
585
00:57:35.969 --> 00:57:40.909
this is. It's an anti-HIV medication. It's an antiretroviral that
586
00:57:40.969 --> 00:57:46.670
is highly effective on HIV and hepatitis B. So that's
587
00:57:48.110 --> 00:57:54.090
all about PrEP. You have learned about viruses tonight. You
588
00:57:54.110 --> 00:57:58.530
learned about the types of viruses. You've learned about the
589
00:57:58.570 --> 00:58:06.289
importance of pre-exposure prophylaxis. Wear a mask when you're in public. Also,
590
00:58:06.309 --> 00:58:09.750
a common problem that I've heard people talk about is
591
00:58:09.809 --> 00:58:11.630
the fact that they think if the mask is good
592
00:58:11.670 --> 00:58:17.130
enough to prevent a virus from getting through it and
593
00:58:17.190 --> 00:58:21.570
into your lungs, then it must also prevent oxygen from
594
00:58:21.610 --> 00:58:23.780
getting through it and into your lungs. To which I
595
00:58:23.800 --> 00:58:27.340
can say, with authority, because I looked it up special
596
00:58:27.420 --> 00:58:36.190
just before the show, viruses are 300... to 1,300 times
597
00:58:36.570 --> 00:58:47.179
larger than oxygen. Just to be clear about size. Okay?
598
00:58:50.039 --> 00:58:53.900
Oxygen can get through the mask. Viruses cannot. Thank you.
599
00:58:55.340 --> 00:58:59.630
Wash your hands with soap. Stay six feet away from people,
600
00:59:00.250 --> 00:59:01.690
unless you want to fuck them, in which case get
601
00:59:01.730 --> 00:59:04.960
on PrEP. Wear a mask when you are in crowded
602
00:59:05.019 --> 00:59:09.360
locations surrounded by dirty, dirty people We're coming into cold
603
00:59:09.449 --> 00:59:13.710
and flu season. Make sure that your vaccinations are up
604
00:59:13.789 --> 00:59:18.289
to date. Go get your autism shots. Come on. That
605
00:59:18.349 --> 00:59:23.869
was sarcasm, by the way. CoreSchool will be back again
606
00:59:24.550 --> 00:59:30.639
next week with more... horrifying sex facts that you need
607
00:59:30.659 --> 00:59:37.969
to know. Thank you all for listening. I'll be back.
608
00:59:38.929 --> 00:59:39.389
Good night.