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Read the full show notes here: https://www.draimee.org/boosting-egg-quality-what-we-know-about-nad-and-fertility-with-dr-mark-ratner In this top performing episode of 2025, I'm honored to be joined by Dr. Mark Ratner, Chief Science Officer at Theralogix. We're diving deep into the science of NAD+ - what it is, why it matters for fertility, and how it might help improve egg quality and outcomes for those pursuing IVF or egg freezing. Dr. Ratner, a board certified urologist, brings a wealth of expertise in nutritional supplements and reproductive health, and I've been looking forward to sharing this conversation with you. Throughout our interview, we explore the fascinating roles of NAD+ and sirtuins in ovarian health, discuss the latest research (from mice to humans!), and break down what these findings could mean for anyone hoping to preserve or boost their fertility. We also touch on practical strategies, from supplements to lifestyle changes, and address common questions about safety, effectiveness, and the future of this exciting area of reproductive science. In this episode, we cover:
- What NAD+ is and why it's crucial for egg health and fertility
- The role of sirtuins as "master regulators" in our cells and their connection to ovarian reserve
- How age-related declines in NAD+ and sirtuins impact egg quality
- Insights from animal and human studies on NAD+ supplementation and fertility outcomes
- The difference between NAD+ supplements and precursors like nicotinamide riboside
- Dietary and lifestyle approaches to boosting NAD+ (and why caloric restriction isn't for everyone)
- The growing awareness among fertility specialists and what's next for research in this field
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