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How do we move from generalized diagnoses to truly personalized mental health care for children and youth?
In the first episode of Precision Rewired, host Dr. Kathleen Pajer speaks with Dr. Paul Arnold, Professor of Psychiatry at the University of Calgary and Principal Investigator of the PAN-GEM initiative (Pan-Canadian Initiative Linking Genomic, Environmental and Mental Health Data in Children and Youth).
Dr. Arnold unpacks a major national effort to transform care by combining genome sequencing with clinical and environmental data from 11 large Canadian studies. This collaborative initiative brings together experts in psychiatric genetics, pharmacogenetics, data science, and health policy, alongside diverse youth populations, to better understand how mental health conditions develop and progress.
Together, they explore how this work is advancing precision mental health care—where treatment moves beyond single data points and is tailored to each child's unique biology, lived experience, and environment.
In this episode, you'll learn:
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How genomics + environmental data are reshaping child and youth mental health care
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Why large-scale, pan-Canadian collaboration is critical to innovation
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The importance of inclusive research across diverse populations
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How AI and data are helping clinicians deliver the right care at the right time
If you're interested in precision psychiatry, child mental health innovation, genomics, or AI in healthcare, this episode is a must-listen.
You can read the full transcript here
About Dr. Paul Arnold
Dr. Paul Arnold is a prominent figure in the field of child and adolescent psychiatry, with a focus on obsessive-compulsive disorder (OCD) and anxiety disorders. He is the inaugural Director of the Mathison Centre for Mental Health Research & Education at the University of Calgary and holds the Alberta Innovates Health Solutions (AIHS) Translational Research Chair in Child and Youth Mental Health. His research is centered on the genetics of childhood psychiatric disorders, particularly OCD, and he has been funded by major external grants from the Canadian Institutes of Health Research (CIHR) and the National Institutes of Health (NIH). Dr. Arnold is also a Staff Psychiatrist within the Department of Psychiatry at SickKids and the head of the Anxiety Disorders Program.
