Caffeine, Antidepressants, Fat Loss Creams & Peptide Stacking (Q&A)

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Welcome you guys to another episode of the Opticast.
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This is your Q ⁇ A episode every fucking Wednesday.
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What the fuck is wrong with my voice?
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Guys, you already know I'm sick as a motherfucker, but we still fucking rollin', guys.
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We still fucking roll as you can tell.
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I look absolutely great.
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I feel really good.
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Threw up yesterday.
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A little bit of a little bit of a heat up.
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I don't think it was a fever.
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I think I just started like overheating for some fucking reason.
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I was legitimately talking on the podcast with these guys.
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Just talking, talking, talking, and suddenly they just start feeling like damn, I'm really, really hot.
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Really, really hot.
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And then I start sweating like on my neck, on my face, and everything.
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And like I didn't take anything.
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And uh I start feeling really weird.
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So as soon as the podcast is done, I get up and I get up and I feel like I'm drunk.
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You know, like when when shit like moves super slow and lags behind it, so that's exactly what everything looked.
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And I was like, what the fuck is this?
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So I just start walking, I go to the bathroom and just throw up so much.
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Just throw the fuck up.
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So you get food poisoning or something?
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I've just been eating those pre-packaged uh meals pretty much.
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I did take Kratom, that was the only thing, but if it was Kratom, I wouldn't be feeling like this today.
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Yeah, I think you're just sick.
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I think I'm just sick, guys.
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Which is a great opportunity to to talk about the um masterclass that I'm recording as soon as I'm done being sick for the engine on acute illness.
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How do you actually solve this stuff?
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Because I'm gonna be fucking back to normal in like two days.
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So if I can uh teach you guys and contribute on that front, that's exactly what I would like to do to you guys.
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So um I've got a couple of questions.
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This one here today, we're gonna be talking about some tactical pharmacology, right?
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What do you actually need to quit caffeine?
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What do you do for focus when you're learning on when you're leaning on uh nootropics and stimulants a lot, antidepressants, right?
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What actually belongs in that conversation for us?
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Some topical fat burners like your hymn creams and stuff like that, and whether is that like a real thing or is that just bullshit in a jar?
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And also how to figure out if two peptides can go on the same syringe.
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So, um, that those are some of the questions that we're tackling today.
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So let's answer the first question here.
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Do I actually need to be off caffeine?
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So, a brief video of you mentioning caffeine is not good for you.
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I'm off of it.
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Just curious if that is necessary.
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Okay, so no, I don't think off being off of caffeine is uh is something that everyone needs to be off of it, right?
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I I think that caffeine is just uh if you're taking it like every single day just to like be able to like regulate yourself and feel normal.
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Like today, I haven't done any caffeine.
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I feel a little bit tired, but like going off of the caffeine is one of the easiest ways to tell how tired you actually are.
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So now when you look at something that I said and it's like, oh, that's coming from a short clip, right?
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Yeah, it can a short clip is always gonna make something sound worse or better than it actually is because there is no context, right?
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But that's not what I'm saying at all.
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My problem is with the dependence of it, right?
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When you're taking it every single day, most of what people are doing is just like they're they're they're using caffeine today to basically deal with the withdrawal from yesterday.
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So it feels like energy, but in reality, what you're doing is you're just getting back to your zero baseline, right?
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So you're paying for a hangover cure from the shit that you drank yesterday, right?
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And the the bigger thing for me is how much caffeine hides how tired you are, right?
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Like when when when somebody's tired, I want to know why, right?
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Like I want to know, is it your sleep?
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Is it iron?
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Is it your thyroid?
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Is it your training, right?
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Because caffeine is just sort of gonna like paint all over this shit, and uh, you're not gonna be able to tell what is doing what.
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So is it being off of caffeine like completely necessary?
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No, I don't think it is.
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Is it useful for a tre uh stretch, right?
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Like when you're trying to just like crank some stuff, like like yesterday I wasn't feeling so good, so I did a little bit of caffeine.
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No, I for a lot of people, I think that's very, very um useful.
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But I also think that people oversell the absolute living shit out of caffeine.
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So there's this study on neuropsychopharmacology with like almost 400 people in 2010.
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They were basically analyzing whether caffeine, uh, they were giving caffeine to one group and then not giving caffeine to another group.
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And the daily drinkers who were drinking caffeine, they got no uh gain in alertness.
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So, like uh, I think that that's pretty wild because when they go without caffeine, they were significantly like having reporting brain fog, and caffeine is basically uh like the thing that they were using in order to deal with that.
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But when you look at the actual outcome, it wasn't.
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So caffeine works very similar to nicotine, where the reported effects and the objective measures are very different.
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Like nicotine, people are going to report, oh, I smoke to calm myself down.
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No, you smoke to deal with the anxiety that you get from the withdrawal, from the setinine levels going down.
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But what you are doing, you are activating your adrenergic system.
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You are pumping a big, big, big blast of uh fucking nicotine all over, right?
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And people are like, oh, but I just do the pouches.
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Motherfucker, one four milligram pouch has more nicotine than a full cigarette.
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It's just delivered a little bit differently.
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And the form of caffeine and then of nicotine also matters.
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So with caffeine, also people report, like, yeah, like it gives me like I don't have as much brain fog and stuff like that.
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It's like, no, what you are experiencing is the brain fog from the withdrawal.
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You have to live with that shit for a while to be able to return to your baseline.
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And that's why I do phases where I don't do any stimulants whatsoever, right?
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There's another 2020 trial, I love this one, but I gave people caffeine three times a day for 10 days versus a placebo.
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There was no benefit in alertness at all.
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Their melatonin and their cortisol curves also didn't move either, right?
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So this is coming from Vibel in 2020.
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So I think the the cortisol stuff that is like because people assume like, oh, we're not doing uh caffeine because of cortisol, right?
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Like, you know, you want to wait for a little bit in the morning to do caffeine.
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I've had that recommendation for certain people for different reasons, but I I think that this is like hype as shit, right?
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We have a study where people were taking like 600 milligrams a day.
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They lost more most of the cortisol bump from the daily morning.
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So it was reduced, it was not eliminated, right?
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But the afternoon, an afternoon dose would still bump that.
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So your body always adapts to what you are taking.
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And it's not like you take it and you crash your adrenals.
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Like your adrenals are so much more resilient than this.
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The reason we'd we put people outside of the of caffeine when we're doing a power phase is because we want to deal with your actual power system, right?
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We want to power your mitochondria, we're gonna give you actual energy.
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Like I got one of the one message from a client today, uh yeah, this week, who uh he was like, dude, I don't understand how I have so much energy.
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I'm not taking anything.
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And I'm like, you are though.
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Like you're you're taking the things that are good for your actual energy, right?
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Like your B vitamins and all that type of stuff.
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The stuff that we're like, oh, that doesn't do shit.
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No, it doesn't do shit because you're cracked out of your skull.
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I know it because I live that, right?
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So it's um if you want to find out the actual baseline to fix it, this is what you do.
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And this is something that I do very different from other coaches because a lot of coaches, they are going to add things in order to get you fast improvements.
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I'm not gonna do that.
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I don't care if it goes slower.
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I care about actually restoring your capacity because your body responds better when your body has the capacity to deal with the demands that you're imposing on your system.
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So I just find it to be useful to pull caffeine out entirely during this phase and then reintroduce it slowly after that, right?
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Now, there is data on caffeine increasing the risk of heart attacks if you're doing like too much caffeine during the day.
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But uh, we also have data that shows that you are more likely to have a heart attack after doing THC.
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So, like, I don't really count that as much.
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Um, there's actually a pretty interesting study where they they they found that like whenever you get these extra beats on the heart that can throw your heart for a loop if you cause an arrhythmia, you can die.
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Uh, they basically cause like sudden death.
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So there's a drug, an anti uh anti-rhythmic drug, that's going to deal with the rhythm problem, right?
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So you would assume that once you fix the rhythm, you fix the deaths, but no, the deaths went up.
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So this is this is uh stuff that I'm covering in my course on how to read research, right?
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There's a course inside of the engine that's coming out this week on how to read research, how to actually understand this literature, because we're gonna look at evidence and it's gonna say, like, fuck, this shit, uh like everything in your pantry causes cancer, but also everything in your pantry heals cancer.
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And like, what happens when you when you're reading a study and like you you only find good results?
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It's like, well, because that's the problem of spinning in the and the and and the and the in the drawer, right?
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But nobody talks about these things.
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So we need to talk about these things so that we can have a better understanding of things like this, like caffeine, nicotine, and all this type of stuff.
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Because when you look at it, it's like, I am never afraid that someone is gonna do so much caffeine that's gonna fry their adrenals.
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But if someone is doing a function, a bunch of caffeine plus a bunch of stimulants, plus a stressful lifestyle, plus not plus overtraining, plus not sleeping, okay, that's something different, right?
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And I think caffeine does have a, does have a place, but honestly, I just use perizinthine so much more because it's already caffeine converted.
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About 85% of people are not gonna metabolize that well.
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Don't ask me for the figure.
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I know that I read it, I don't remember where I read it from.
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Um, but uh it was uh I forgot the name of the trial, but basically people convert caffeine into perizentine very poorly, which is not the case with nicotine and citamine.
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So, with in in in this case here, um I find it more useful to just deliver the thing that I want, which is the drive and the focus, and not deal with all the other things like the heart effects and stuff like that.
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Like, I don't want my heart rate going up.
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Like I find it annoying, it's distracting.
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So yeah.
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Any thoughts around caffeine?
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Because you stayed a pretty good stretch without caffeine because your adrenals were actually fucked.
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Yeah, I mean, I think I got down to one cup of coffee a day.
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I don't know if I ever went below that.
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There might have been a time when I did, but I yeah, I definitely resensitized myself to caffeine.
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And now if I drink a a cup of coffee, I feel it.
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Especially homemade coffee.
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For some reason, the coffee that I make at home is significantly like stronger or something.
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But I feel it, it feels uncomfortable, and but I'll still drink it.
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So I just started this week splitting half decaf, half caffeinated because I enjoy coffee and I like to have a little bit of caffeine.
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I think it gives me some energy, some focus or whatever.
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It's part of my routine, but I don't like feeling like my chest is cading in on anxiety.
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So that's my thoughts on caffeine.
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Yeah, and I I I just want to be fair here because there's also evidence showing that caffeine reduces all-cause mortality about 17%.
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When it comes to like training, I'm just uh it depends on the on the day, not the day that you asked me, it depends on what you are doing that day.
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So, like caffeine for a pre-workout, I don't find it super useful because you could just use alpha GPC, parazenthine, cytokoline, right?
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You can have so many things, Samax, methylene blue.
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There's so many things that you can use for that focus and the drive perizanthine there.
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I I think that's much more useful.
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But when you look at the trials that have caffeine, caffeine does seem to cause a mild bump in strength.
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However, when you combine perizentine with caffeine, the bumps in strength are even more significant.
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So I would love to see a pre-workout formulation that actually have that.
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But how I actually run this with my clients, I don't uh usually don't have people quitting cold turkey.
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Sometimes I do, but I'm gonna be cutting a fixed amount every week and titrating it down.
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Or I'm gonna be switching them with decaf plus a caffeine pill so we know exactly like what dose it's going in.
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And I I'll always warn them up front like the first two weeks are gonna feel like absolute shit, and then it's gonna start working around week three.
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Now, if a client is telling me like every fucking time that they're exhausted, caffeine is gonna be the first thing that I'm gonna pull.
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Not because it's like, oh, I understand that you are like holding yourself by the caffeine.
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The thing is we can't really see what's actually happening, right?
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So that's uh that's the thing that I would like to uh to point out.
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And I think that for a lot of people, it's the same thing with weed, is whereas for a lot of people it's like I really do think y'all are drinking it out of hype because you don't have good effect, like you just get anxiety and jitterness.
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Like, why are you drinking this thing?
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Yeah, when I was working uh at my previous job, I was drinking like five to six cups a day, and that was just because uh there was like stuff that I had to do that I couldn't not do you know, couldn't not do in quotes, and uh I just had to power through it.
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But it was really, really my energy levels were terrible.
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Like I really needed to take the time off and sleep, honestly.
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But I just powered through by chugging a bunch of coffee, but I couldn't like I couldn't stay awake in the afternoons without drinking coffee in order to work.
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It was pretty bad.
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Yeah.
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So after that after that when I started titrating down and then got all the way down to so little coffee, now I'm like, okay, my capacity, like I need a really one sleep because I can't I don't have anything to keep me awake during the day if I don't sleep.
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So I started prioritizing that more and then also just understanding my own humanity, and I'm not a robot, and I need to change my expectations for what I'm able to accomplish and how quickly I should be able to accomplish things.
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So but I also d didn't really do a lot of other nootropics or anything like that to kind of help my cognition or due to methylene glue, you had somax that you never used, but you had methylene glue and uh perizanthine.
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Yeah.
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I d and I would sometimes take those, but if I drank a cup of coffee, I wouldn't also take it because it would keep me up way too late.
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Yeah, yeah.
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And for me, the issue with caffeine is that I'm a slow metabolizer, right?
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I have a CYP variant there that uh it just like I'll drink the coffee and it'll actually hit me like two hours down the road.
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And it'll linger in my system for a really long time.
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So you know, don't love it.
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But on the strategy of like coming off of these things, like the the way that I'm coming off of nicotine is I'm basically reducing one hour every single day and replacing it with a nicotine-free vape.
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So basically, like I'm doing yesterday was until 9 p.m.
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Today is gonna be 8 p.m., tomorrow's gonna be 7 p.m.
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and then 6 p.m.
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and so forth and so on, until the point that I'm like a zero.
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You just wake up, take a puff, and you move on with your day, and then you just wake up and you don't take a puff anymore.
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I find that those strategies they work really well for these mild drugs.
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If we're talking like fucking alcohol and and heron and shit like that, that's not really the the right approach.
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But for some of these other compounds, I think that this is kind of like how it should be.
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Focus and do I need a detox?
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Also, anything for focus I can take.
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I'm just not there a lot of the time.
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I think I was relying on caffeine and nootropics too much.
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Maybe I need to detox.
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Yeah, I mean, detox first, right?
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Um, you can like just get a couple of weeks as your baseline, and then you can fix some of the boring stuff while you're at it, right?
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Your sleep, your iron, your thyroid labs, and then you just move one thing at a time.
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So I think you kind of answer your own question, right?
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Uh, if I remember correctly, this question was asked by Jen.
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Shout out, Jen.
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But I I like the here's the trap that you're gonna be in, right?
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Because caffeine withdrawal is going to cause problems with you concentrating, like brain fog.
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Like those are literally in the official like symptom list.
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So if you're if you're bouncing on and off caffeine or you're stacking five nootropics, you can't really tell which fog is yours and which fog is the drugs because you can also have drug induced brain fog.
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So it's all mush, right?
00:14:59.360 --> 00:15:06.240
So step one, just strip all of the shit out, simplify the fuck out of your stack, and just give it a couple of weeks and see what's left after that.
00:15:06.320 --> 00:15:12.080
And then I'm gonna be looking for why the focus is gone instead of just throwing random shit at.
00:15:12.480 --> 00:15:19.600
So we know that uh like caffeine is going to like affect your sleep quality.
00:15:19.759 --> 00:15:24.000
We know that's going to affect your uh fatigue levels and all this type of stuff.
00:15:24.240 --> 00:15:25.200
All very good.
00:15:25.440 --> 00:15:36.639
But like there is a trial here that was that took women who were not anemic and they got iron or they got a placebo, and their fatigue also dropped um significantly over the placebo.
00:15:36.720 --> 00:15:40.559
And the only ones who improved, they had a ferritin of 50 or under, right?
00:15:40.720 --> 00:15:53.360
So a normal hemoglobin is not going to clear you on this, but that is like, in my opinion, I think that is something that's telling us that, like, hey, your big boost of energy might actually come from your blood work, not from your nootropic, right?
00:15:53.440 --> 00:15:55.840
And you're looking at it from the nootropic side of things.
00:15:56.000 --> 00:16:06.159
I honestly haven't tried any single nootropic that I took, and I was like, wow, like high dose methylene blue, that's a separate topic because it is so fucking toxic, right?
00:16:06.240 --> 00:16:08.960
It flips from being antioxidant to being pro-oxidant.
00:16:09.039 --> 00:16:11.679
So it's not something that you should be using at all times.
00:16:12.000 --> 00:16:17.120
But if you push the doses of methylene blue, you can almost get like that feeling of Adderall.
00:16:17.519 --> 00:16:19.279
It's very, very fucking close.
00:16:19.519 --> 00:16:28.480
So I like to mix dihexa, nupept, methylene blue, phenyracetam, uh, hydrazide, and uh perizenthine and and uh acidicoline.
00:16:28.799 --> 00:16:32.399
I I work very, very well on the dose uh in that protocol.
00:16:32.480 --> 00:16:33.679
It just works very well.
00:16:33.759 --> 00:16:35.360
You just don't have that crazy drive.
00:16:35.519 --> 00:16:41.039
And if this is Jen, Jen has told me before that she really enjoys the high of Vivance, right?
00:16:41.120 --> 00:16:43.679
And I'm like, yeah, so do I.
00:16:44.080 --> 00:16:46.080
Problem is it goes away, right?
00:16:46.159 --> 00:16:50.000
It goes away like next week, like the day after you already don't feel it as much.
00:16:50.159 --> 00:16:53.440
So I think Vivance should be more of like a, hey, I got a big project coming up.
00:16:53.519 --> 00:16:54.720
It's gonna be two weeks of a push.
00:16:54.799 --> 00:16:56.240
Okay, Vivance is a good tool.
00:16:56.399 --> 00:17:04.079
But if it's like, hey, this next six months I'm working on this project and stuff, and mostly just answering emails and talking to people, and like, why do you need to be cracked out of your skull?
00:17:04.240 --> 00:17:05.039
Like, we don't need that.
00:17:05.119 --> 00:17:07.759
And that's something that I have to be learning myself, right?
00:17:07.920 --> 00:17:13.039
So, my order for people for someone like this is gonna be like, hey, let's take two to three weeks off of everything.
00:17:13.119 --> 00:17:20.240
Let's work on your sleep, get you like in bed for seven hours, but then like not in bed in seven hours and I scrolling for two fucking hours.
00:17:20.400 --> 00:17:21.440
And then pull your bloods.
00:17:21.519 --> 00:17:23.839
I want to see your ferrous, I want to see a full thyroid panel.
00:17:23.920 --> 00:17:30.480
And uh, I would actually do a creatine as well, because creatine is gonna combat a lot of the fatigue when you're doing like very, very, very high doses.
00:17:30.640 --> 00:17:33.440
So creatine it works acutely, right?
00:17:34.240 --> 00:17:39.039
The the the dose though, it has to be around like five times what people are used to taking it.
00:17:39.119 --> 00:17:43.839
So it's got to be like 20, 30 grams, not like fucking three to five grams like people are taking.
00:17:44.000 --> 00:17:48.079
I think exercise can help here, but obviously you'll probably already exercising, right?
00:17:48.160 --> 00:17:50.240
There's no big jump that you're gonna see here.
00:17:50.319 --> 00:17:58.640
And even on the podcast that I did with Drew and Anthony, like you just don't see a lot of reduction in mortality from the exercise in terms of heart disease either.
00:17:58.880 --> 00:18:03.039
So I think it's very uh context dependent, but finding a stack that works for you is good.
00:18:03.119 --> 00:18:06.400
You just need to like find what are the things that you need help with.
00:18:06.480 --> 00:18:09.359
Like for me, it's memory recall, it's verbal fluency, right?
00:18:09.440 --> 00:18:16.160
Uh, and it's a lot of like uh clearing out not so much a brain fog, but just giving me actual drive, give me actual umph.
00:18:16.400 --> 00:18:18.720
For a lot of other people, they don't have a fucking problem with their memory.
00:18:18.799 --> 00:18:22.799
They didn't smoke crack when they were 12 years old, so obviously their brains work fine.
00:18:22.960 --> 00:18:25.200
But for me, that's that's what I fucking need, right?
00:18:25.279 --> 00:18:27.359
So I'm gonna be hammering these drugs always, right?
00:18:27.440 --> 00:18:32.319
Um, dihexa is the one that I'm trialing right now, and it's uh it takes about eight weeks for dihexa to hit.
00:18:32.400 --> 00:18:38.160
So it's really hard to like tell you how this thing is like working or or not working.
00:18:38.480 --> 00:18:40.880
What antidepressants work best?
00:18:41.119 --> 00:18:43.839
I think there's no best antidepressant, right?
00:18:43.920 --> 00:18:50.000
It's kind of like to asking me what's the best steroid or what's the best food, what's the best sex?
00:18:50.319 --> 00:18:51.279
Like, come on.
00:18:51.680 --> 00:18:53.039
There's no answer for that, right?
00:18:53.119 --> 00:18:57.839
They're they're all gonna be placebo, or a few of them are gonna be more well tolerated than the rest.
00:18:58.000 --> 00:19:03.680
And uh, this is all gonna come down to like your weight, your sex, your drive, your drive, your your sleep, right?
00:19:03.839 --> 00:19:06.079
And your uh your libido as well.
00:19:06.319 --> 00:19:12.000
So I'm just gonna be very careful here because I am not a psychiatrist, right?
00:19:12.079 --> 00:19:14.400
I don't prescribe anything, I only make suggestions.
00:19:14.559 --> 00:19:19.920
So uh don't stop your taking your antidepressants because of something that you hear on a fucking podcast.
00:19:20.079 --> 00:19:25.680
Uh especially don't stop on your own because coming off is gonna have its own set of problems, and I want to touch on that as well.
00:19:25.759 --> 00:19:32.240
But I can tell you the biggest data set that we have on earth it says that uh the this this the stuff here that should be a part of the conversation.
00:19:32.400 --> 00:19:38.160
Um I think that because of a lot of this shit, it never comes up in a 10-minute appointment when you have it in your doctor.
00:19:38.240 --> 00:19:40.079
So I think it it's useful for us to cover.
00:19:40.240 --> 00:19:44.400
So the big one here is uh the Cipriani uh 2018 uh trial.
00:19:44.480 --> 00:19:47.440
Uh it's called uh that was published in the Lancet Journal.
00:19:47.599 --> 00:19:50.880
Every single one of the 21 drugs that they tested beat placebo.
00:19:51.039 --> 00:19:55.599
The difference between them were very, very modest though, like not night and day.
00:19:55.839 --> 00:20:11.440
So I think that like the the the there's only three drugs there that landed on the more effective or the better tolerated list, and astropellotram, vortioxetine, and agomelatine, reboxing, trasodone, and fluvoxamine were all on the bottom of the effect.
00:20:11.519 --> 00:20:16.720
I tried fluvoxamine, fluvoxamine was I I couldn't even tolerate the the fucking stomach problems.
00:20:16.799 --> 00:20:21.920
I have so much fluvoxamine because obviously, you know, why would I purchase 30 pills?
00:20:22.000 --> 00:20:26.559
I have a fuck ton of fluvoxy, but uh coming off of them is one of the reasons why I don't like using.
00:20:26.799 --> 00:20:34.079
And also, I like methylene blue, so I don't really feel like I want to be using uh uh fluvoxamine or other antidepressants.
00:20:34.240 --> 00:20:37.119
I do take a microdose of an antidepressant, as a matter of fact.
00:20:37.279 --> 00:20:39.279
Why the fuck do I have haloperidol in my mind?
00:20:39.359 --> 00:20:40.400
That's a sedative.
00:20:41.119 --> 00:20:42.480
I don't remember.
00:20:43.119 --> 00:20:45.680
Well, I feel how the fuck do I forget this shit?
00:20:45.759 --> 00:20:48.480
Well, see, that's why I need to take my pills for my memory.
00:20:48.640 --> 00:20:54.079
There's sexual uh side effects is going to be mainly the thing that's gonna decide whether this thing works for you or not.
00:20:54.240 --> 00:20:56.079
Um, there's a sexual dysfunction.
00:20:56.240 --> 00:21:04.640
There's a study by Sereni in 2009 that is gonna map sexual dysfunction in a quarter up to 80% of the people who are taking the drug.
00:21:05.759 --> 00:21:08.400
So I'm not a huge fan of that.
00:21:08.559 --> 00:21:09.359
I don't love that.
00:21:09.440 --> 00:21:11.279
Are there things that we can do to combat that?
00:21:11.440 --> 00:21:12.000
Yes.
00:21:12.240 --> 00:21:19.680
But let me tell you, I haven't found someone that has like a bulletproof protocol for fixing their libido while they're on an antidepressant.
00:21:19.759 --> 00:21:20.559
I just haven't seen it.
00:21:20.640 --> 00:21:23.519
Probably someone has some fucking weird shit that we're gonna cover down the road.
00:21:23.680 --> 00:21:27.599
But we also have like, you know, weight, right?
00:21:27.759 --> 00:21:33.920
Uh we know that people lose weight on some medications, and you know that on some other medications, people gain weight.
00:21:34.160 --> 00:21:42.480
So it's it's very, very uh different for us uh in terms of like which drug you're gonna pick, um, because we also have like body composition goals.
00:21:42.559 --> 00:21:47.039
Uh, but I think that the something that is not brought up a lot here is the thyroid.
00:21:47.200 --> 00:21:56.400
So there is a star D trial where people had failed two antidepressants, and then they took T3 or lithium that was added to the antidepressant.
00:21:56.559 --> 00:21:59.680
And the remission was about 25% on T3.
00:22:00.160 --> 00:22:02.480
T3, only 16% on lithium.
00:22:02.640 --> 00:22:08.960
So that was not considered a significant difference, but few people quit off of the T3 side effects.
00:22:09.119 --> 00:22:12.720
You can actually get neurotoxicity from lithium, it's going to be absolutely fucking awful.
00:22:12.880 --> 00:22:15.680
You're literally going to have all the symptoms of someone that has a brain tumor.
00:22:15.920 --> 00:22:18.960
So it's it's not really a good option when you have T3.
00:22:19.279 --> 00:22:22.319
Testosterone is another one that I think it's super useful, right?
00:22:22.400 --> 00:22:33.680
There's uh on the GMA journal, Walter, I believe, published a paper on testosterone, rubble roughly doubling the odds of improvement in depressive symptoms.
00:22:33.759 --> 00:22:36.240
And there was this was always dose dependent.
00:22:36.559 --> 00:22:43.440
Also, people who don't respond well to uh antidepressants, they usually have higher elevated baseline of inflammatory markers.
00:22:43.599 --> 00:22:46.480
So fixing those is also going to be uh useful here.
00:22:46.559 --> 00:22:48.480
So these three things are just things that I want to consider.
00:22:48.559 --> 00:23:01.279
I want to optimize your thyroid, I want to optimize your testosterone, and I want to fix your inflammatory markers because those things are gonna make it so that you're able to take a smaller dose of an of an antidepressant or potentially come off of them entirely.
00:23:01.359 --> 00:23:15.599
If you don't know how to come off of them, dude, there's um uh basically uh people who were stopping antidepressants, it's only about like 2% of people that get side effects whenever you are coming off when they're doing it with a doctor.
00:23:15.680 --> 00:23:19.920
So don't cowboy that shit, just do that shit with your own doctor here.
00:23:20.160 --> 00:23:23.119
A couple of things that I also think are worth mentioning is creatine.
00:23:23.200 --> 00:23:31.680
Creatine, the more that I learn about creatine, the more I'm convinced that creatine just has muscle-building side effects, but it really is an antidepressive cognition type of tool.
00:23:31.839 --> 00:23:34.720
In in 2012, there was a trial on Eschetalopram.
00:23:34.880 --> 00:23:37.200
These guys got creatine or they got a placebo.
00:23:37.279 --> 00:23:41.759
The creatine group improved faster as early as week two of the study.
00:23:41.920 --> 00:23:45.920
It is a very small trial, but that's like a magnitude of the effect is significant, right?
00:23:46.079 --> 00:23:46.480
Uh St.
00:23:46.559 --> 00:23:50.880
John's worth, it also matched the SSRI response in a Cochrane review.
00:23:51.119 --> 00:23:58.640
So, but but the trials they're all like in in German-speaking countries, they are way more favorable than than uh all of the other trials, right?
00:23:58.720 --> 00:24:02.079
And it's gonna drop the levels of birth control and blood thinners as well.
00:24:02.160 --> 00:24:04.640
So you never ever stack with an SSRI.
00:24:04.720 --> 00:24:06.400
But if you want an alternative, St.
00:24:06.559 --> 00:24:09.920
John's worth is something to uh consider on your own.
00:24:10.079 --> 00:24:12.240
And also hard fucking training, right?
00:24:12.319 --> 00:24:16.079
Because that was ranked above uh SRIs on a BMJ analysis.
00:24:16.240 --> 00:24:23.519
I'm not saying swap one for another, but I'm saying if you are on meds and you're not training, you're kind of leaving a big lever on the table.
00:24:23.599 --> 00:24:33.279
So never tell, never tell anyone to stop to switch or do anything when it comes to like your fucking protocols for antidepressants because you could you could put these people in so much risk.
00:24:33.599 --> 00:24:35.680
Serotonin stacking is gonna be a hard no.
00:24:35.759 --> 00:24:38.079
So like methylene blue, 5 HTP, St.
00:24:38.240 --> 00:24:39.200
John's worth, right?
00:24:39.279 --> 00:24:42.799
Like on top of an SNRI or an SSRI is not something that you should do.
00:24:42.880 --> 00:24:46.319
Uh, the the exercise analysis on its own is pretty low.
00:24:46.559 --> 00:24:54.559
So you should also keep in mind that you should be doing exercise plus therapy plus working with your antidepressive with your doctor, right?
00:24:54.720 --> 00:25:00.880
And uh yeah, uh, I don't think that you should be uh trying to optimize like playing with these things on your own.
00:25:00.960 --> 00:25:02.319
Like pray playing with your brain, bro.
00:25:02.400 --> 00:25:04.960
I don't understand how people just like fucking take shit for their brain.
00:25:05.200 --> 00:25:07.119
It's like, oh, a guy on YouTube answered my question.
00:25:07.200 --> 00:25:08.480
Let me just fucking take that shit.
00:25:08.559 --> 00:25:09.759
I find that kind of crazy, man.
00:25:10.160 --> 00:25:11.519
Have you ever taken antidepressants?
00:25:12.160 --> 00:25:12.240
No.
00:25:13.359 --> 00:25:28.960
I was I was I guess given the option to take them, but I went for a supplemental anti-anxiety medication, which was just some type of like really strong Benadryl, I'm pretty sure.
00:25:29.359 --> 00:25:30.799
That would just make it.
00:25:30.960 --> 00:25:35.279
Yeah, I mean I mean the bupropion or butrin is used on both end of depression.
00:25:36.160 --> 00:25:39.039
It also is used to come off of nicotine.
00:25:40.240 --> 00:25:40.480
Interesting.
00:25:40.640 --> 00:25:47.599
Yeah, so but I it makes me want to uh uninstall the life.exe package, so I don't use it anymore.
00:25:50.160 --> 00:25:51.359
Okay, next question.
00:25:52.799 --> 00:25:53.759
God damn it, god, damn it.
00:25:55.119 --> 00:25:58.799
Have you ever used a topical for targeted fat loss?
00:25:59.039 --> 00:25:59.680
Fuck no, I'm not sure.
00:25:59.920 --> 00:26:04.559
Like a young bean or capsicine cysine cream.
00:26:04.880 --> 00:26:06.319
Capsaicin cysin cream.
00:26:06.400 --> 00:26:08.079
No, I never use it because I'm not a fucking idiot.
00:26:08.160 --> 00:26:09.599
I wouldn't spend money on any of this shit.
00:26:09.680 --> 00:26:11.200
I and I don't put my clients on it.
00:26:11.279 --> 00:26:15.200
Uh the theenbean cream is very interesting because people are selling it.
00:26:15.279 --> 00:26:17.359
Uh, but we have a trial on it and it failed.
00:26:17.440 --> 00:26:19.200
So that's what happens when you guys don't read studies.
00:26:19.279 --> 00:26:20.640
You guys end up spending a bunch of money.
00:26:20.799 --> 00:26:23.119
So I get why this is stem thing, right?
00:26:23.279 --> 00:26:33.119
I get messages every single week, especially if I'm working with someone who's post-menopausal or menopausal, they all all are like, What do I do with my visceral fat?
00:26:33.680 --> 00:26:35.440
What do I do with my visceral fat?
00:26:35.759 --> 00:26:37.519
Because I just got a little bit of visceral fat.
00:26:37.599 --> 00:26:40.400
I'm like, bitch, you had four kids, right?
00:26:40.480 --> 00:26:42.400
Like you had four fucking kids.
00:26:42.640 --> 00:26:43.680
You are lean.
00:26:43.839 --> 00:26:45.039
You need surgery.
00:26:45.200 --> 00:26:46.799
You don't need your him being green.
00:26:47.039 --> 00:26:48.559
That's just not gonna fucking work.
00:26:48.640 --> 00:26:51.279
It's it's I think stubborn fat is very real.
00:26:51.359 --> 00:26:56.880
Okay, it's uh uh it's the fat on your lower hips, on your lower belly, it's on your thighs, it's literally wired differently.
00:26:56.960 --> 00:26:58.559
I covered this on my thyroid course.
00:26:58.640 --> 00:27:06.960
I explained how and why you gain fat in these particular areas because those fats are more susceptible to the alpha-2 receptor, which is gonna put a break on uh fat loss.
00:27:07.039 --> 00:27:08.799
So your hymn being would target that.
00:27:08.880 --> 00:27:13.359
So on paper, it basically um it's gonna be blocking that uh block, right?
00:27:13.440 --> 00:27:15.119
It's gonna be preventing the block from work.
00:27:15.279 --> 00:27:17.839
So the problem is what happens when the people testing.
00:27:18.000 --> 00:27:29.119
So the guys who ran most of these studies, there were a researcher named Greenway back in the 80s and the 90s, and the women were using cream on the thigh and using a placebo on the other thigh.
00:27:29.200 --> 00:27:32.079
So each one was their own control group with internal validity.
00:27:32.240 --> 00:27:38.880
Across six fucking trials, almost every cream beat the placebo on the thigh girth, except one.
00:27:39.759 --> 00:27:40.880
Yohimbean.
00:27:41.039 --> 00:27:45.759
So the the one that everybody on Instagram is fucking selling, it doesn't work, right?
00:27:46.160 --> 00:27:49.359
The one that keeps showing up is gonna be aminophylline.
00:27:49.519 --> 00:27:53.119
So aminophylene is basically an asthma drug, right?
00:27:53.200 --> 00:28:00.319
And in uh we have a trial with 50 adults that their body weight drops the same as the people who are not taking the drug, right?
00:28:00.640 --> 00:28:01.759
They're losing a little bit of it.
00:28:01.839 --> 00:28:03.599
So, like, what the fuck is the cream doing?
00:28:03.680 --> 00:28:04.960
We we don't know, right?
00:28:05.039 --> 00:28:10.480
We have another trial of amoxilene and we have uh capsicine, like capstan barely gets to the fucking skin.
00:28:10.559 --> 00:28:22.319
Like, even from a super strong prescription patch, um, you're gonna get a small minority of patients having any detectable amount of capsicin in their uh in their blood levels, right?
00:28:22.480 --> 00:28:24.880
So, why stubborn fat is fucking stubborn?
00:28:24.960 --> 00:28:26.240
It's the fat under your skin, right?
00:28:26.319 --> 00:28:30.400
The break uh is going to outnumber the gas receptors about like three to two.
00:28:30.559 --> 00:28:34.079
So in the thigh fat cells, the adrenaline is going to act as the break.
00:28:34.240 --> 00:28:37.440
On your deep belly fat, the visceral stuff that's always going to respond.
00:28:37.519 --> 00:28:44.319
That's why visceral fat is going to come off in your uh first, but then your lower belly is going to come off fat uh last.
00:28:44.640 --> 00:28:47.839
Now, the kicker is on your hymn in general.
00:28:48.000 --> 00:28:56.559
So when you take it by mouth, most of the fat loss is gonna be coming from your whole body, uh norepinephrine, not from blocking the receptor in the fat cell.
00:28:56.720 --> 00:29:00.319
So the researchers call the fat cell part a minor component.
00:29:00.480 --> 00:29:03.440
That's the part that everybody talks about when they're talking about your hymn.
00:29:03.680 --> 00:29:06.000
That is not the thing that's doing the work in your hymn.
00:29:06.319 --> 00:29:09.759
So a cream is gonna give you the part that barely matters.
00:29:10.000 --> 00:29:12.240
That's the shit you're paying 40 fucking bucks for.
00:29:12.400 --> 00:29:14.480
40 you're paying 90 bucks for that shit.
00:29:14.640 --> 00:29:17.440
Oreo him bean, also it works fasted, right?
00:29:17.599 --> 00:29:24.960
We know that we need to take fast for that bumping noirpinephrine and spot reduction in general, it just doesn't exist with training either, right?
00:29:25.039 --> 00:29:28.559
It's not something that you can just do that and you're just gonna like just burn that fat there.
00:29:28.640 --> 00:29:34.559
So I think your hymn was the cream that failed on its own in the original trials, it's just like marketing, uh, so to speak.
00:29:34.720 --> 00:29:46.960
And uh, I think that like there is one thing with like real fat loss here, which is gonna be fat sitting that's next to a muscle that's working to get more blood flow and more fat breakdown than a resting muscle.
00:29:47.119 --> 00:29:56.880
We know that, but the effect is so fucking small that when you have someone train one leg and train the other, you don't see fat differences that are meaningless, meaningful um in between the two legs, right?
00:29:57.039 --> 00:30:02.400
So I'm not I'm not saying that the topic has uh no topic has ever moved it, right?
00:30:02.559 --> 00:30:09.839
Because the amino phylline did shrink girth in those green weight trials, but it was uh the tape, right?
00:30:09.920 --> 00:30:10.720
It wasn't the fat.
00:30:10.799 --> 00:30:13.759
Like the ultrasound uh trials say that it was flat.
00:30:13.839 --> 00:30:17.200
So there's no use for that, so to speak, for us.
00:30:17.359 --> 00:30:28.319
But I remember in Brazil back in the day, people used to buy these things from paraguay, these injections, just fucking put it in their stomach, it would cause a bunch of inflammation, it was supposed to like acidic to like eat up your fat tissue and all this type of shit.
00:30:28.480 --> 00:30:31.200
And like you also have like receptors in your fat cells, guys.
00:30:31.279 --> 00:30:34.880
Like, you have like blood in your fat cells, you have thyroid receptors in your fat cells.
00:30:34.960 --> 00:30:38.000
Like, I don't know if that's such a great idea, you know.
00:30:38.319 --> 00:30:42.880
But if you want to know like how to lose the last little bit of fat, lose more fat.
00:30:43.440 --> 00:30:44.160
That's it.
00:30:44.559 --> 00:30:47.200
You are only as lean as your fattest body part.
00:30:47.519 --> 00:30:48.799
That's the rule for bodybuilding.
00:30:48.880 --> 00:30:54.799
That's not the rule for normal people, but people want the flat stomach, but they want the fat ass.
00:30:54.960 --> 00:30:56.559
Like, you kind of gotta pick, dog.
00:30:57.039 --> 00:31:03.920
You're either gonna have a hard ass and a flat stomach, or you're gonna have a bubbly ass with a non-flat stomach.
00:31:04.319 --> 00:31:06.559
Or if you get surgery, you're gonna have the flat stomach.
00:31:06.720 --> 00:31:21.440
But in general, uh, I don't really put a lot of credit on these things, and I really don't think that uh I think these companies that are selling a bunch of these like uh cream stuff, I uh people are just buying BPC cream and all this shit, and I'm like, god damn, people love spending money on shit that doesn't fucking work, don't they?
00:31:22.480 --> 00:31:32.640
Because it's a lot easier to to put on lotion every day than it is to actually do a follow-up plan that will cause you to lose the fat that you're trying to lose.
00:31:32.720 --> 00:31:34.000
So I think that's why.
00:31:34.240 --> 00:31:35.119
Yeah, yeah.
00:31:35.440 --> 00:31:38.240
How do you know if two peptides can be mixed together?
00:31:39.279 --> 00:31:40.319
Mix them in the syringe.
00:31:40.400 --> 00:31:41.839
If it crashes, you can't mix them.
00:31:42.079 --> 00:31:44.960
If it crashes, meaning it's gonna become all crystallized.
00:31:45.119 --> 00:31:49.440
You literally see the crystals going from uh the bottom of the thing all the way to the top.
00:31:49.599 --> 00:31:54.240
I wish I had brought my DSIP uh here because you can see it with DSIP very easily.
00:31:54.400 --> 00:31:58.160
It it it uh crystallizes very, very fast, but uh insulin.
00:31:58.799 --> 00:32:00.480
So insulin actually works.
00:32:00.559 --> 00:32:07.920
The reason that uh the Atlantis it's gonna stay dissolved is because it's kept acidic at a pH of like four.
00:32:08.400 --> 00:32:14.799
So, like when it hits your tissues, it's gonna form a bunch of these little crystals under the skin, and that's what's gonna make it last all day.
00:32:14.880 --> 00:32:18.640
Like the acidity is the whole mechanism for the insulin there.
00:32:18.799 --> 00:32:20.160
Now, how do you decide?
00:32:20.319 --> 00:32:23.440
I think, like, okay, uh, is there compatibility data?
00:32:23.680 --> 00:32:25.599
No, not yet.
00:32:25.839 --> 00:32:33.680
But if there was compatibility data, you could look over the pH level of both things and then just figuring out whether they are in the same range.
00:32:33.759 --> 00:32:36.799
And if they are in the same range, you are safe to put them in the same syringe.
00:32:37.039 --> 00:32:40.079
If they're not in the same range, you are not safe to put them in the same syringe.
00:32:40.240 --> 00:32:41.440
How the fuck do I find a pH?
00:32:41.599 --> 00:32:44.960
Read the studies that say it's only about 800 from BPC.
00:32:45.759 --> 00:32:46.880
Or you can do my course.
00:32:47.279 --> 00:32:50.000
But whichever option you choose, I think you're gonna be fine.
00:32:51.279 --> 00:32:52.079
Rapid fire.
00:32:52.319 --> 00:32:53.599
Rapid fire, let's get it.
00:32:54.319 --> 00:32:59.279
How long does it actually take to reset caffeine tolerance and does it fully come back?
00:32:59.519 --> 00:33:05.839
Giuliani 2004, it takes about 10 days, but the peak of the withdrawal is gonna be about two days, okay?
00:33:06.079 --> 00:33:09.599
Your performance tolerance is gonna build up over the last few weeks.
00:33:09.759 --> 00:33:11.119
And uh, does it fully come back?
00:33:11.200 --> 00:33:13.200
Like for lifting and reaction time, it does come back.
00:33:13.279 --> 00:33:15.279
For for mental sharpness, it doesn't really.
00:33:15.440 --> 00:33:18.880
Like, even non-users, they got faster, but they didn't get smarter.
00:33:19.039 --> 00:33:25.279
So uh in practice, I just give two full weeks out, and people tell me that they're feeling like fucking great again in about three weeks.
00:33:25.519 --> 00:33:30.319
Is there a way to use stimulants long term without the dependence creeping in?
00:33:30.559 --> 00:33:36.400
So there's not anyone that has tried this like in a cycle to like uh to uh to put it in a trial or anything like that.
00:33:36.480 --> 00:33:41.519
So I'm kind of guessing alongside everybody else, but avoiding withdrawals is what's gonna keep the habit going.
00:33:41.599 --> 00:33:42.480
So that is the trap.
00:33:42.559 --> 00:33:43.440
It's it's pretty shitty.
00:33:43.680 --> 00:33:50.240
Caffeine use, people don't know this, but it's literally listed in the DSM 5 as a condition for further study.
00:33:50.400 --> 00:33:51.119
Yeah, dog.
00:33:51.359 --> 00:33:52.559
It is a fucking addiction.
00:33:52.640 --> 00:33:54.960
I don't understand how people are so fucking cool with it.
00:33:55.119 --> 00:34:01.680
I really don't because people have so many problems with all the other drugs that I use, and I'm like, dog, you're a fucking drug addict, just like me.
00:34:01.839 --> 00:34:05.359
Like you get your headache, you're you have a withdrawal, dog.
00:34:05.759 --> 00:34:07.599
You get irritable, you're having withdrawal.
00:34:07.759 --> 00:34:08.719
It ain't cute.
00:34:08.880 --> 00:34:09.920
You're you're weak.
00:34:10.000 --> 00:34:12.239
It's the same thing that I feel with nicotine, man.
00:34:12.400 --> 00:34:16.159
Well, not nicotine vapey, because I don't give a shit about nicotine, but I fucking love vaping.
00:34:16.320 --> 00:34:16.800
Yeah, man.
00:34:16.880 --> 00:34:22.079
So uh just use it as a job, don't use it as a as a as a drip, so to speak, and try to cut it earlier in the day.
00:34:22.480 --> 00:34:27.119
Does cutting caffeine improve sleep enough to be worth the two bad weeks?
00:34:28.159 --> 00:34:30.239
I mean, yeah, I I really do think so.
00:34:30.400 --> 00:34:33.920
400 milligrams six hours before sleep is gonna fuck your sleeps.
00:34:34.159 --> 00:34:35.599
You need at least a six-hour cutoff.
00:34:35.760 --> 00:34:38.079
And if you have genetic testing, you can figure out whether you need more.
00:34:38.159 --> 00:34:40.000
For me, I usually stop around 2 p.m.
00:34:40.239 --> 00:34:41.679
That's what's gonna do it for me.
00:34:41.760 --> 00:34:55.360
But if you have one cup in the morning, just lower your expectations because it won't change your total sleep or anything like that, but it will push Ren and uh down, and it will also you're more likely to wake up feeling more tired, which is gonna make you reach for coffee.
00:34:55.519 --> 00:34:57.440
So it creates that loop, right?
00:34:57.679 --> 00:34:58.159
Yeah.
00:34:58.880 --> 00:35:04.159
What's the difference between something that improves focus and something that just makes you feel alert?
00:35:04.400 --> 00:35:05.280
Good question, man.
00:35:05.440 --> 00:35:08.800
So alert is kind of like your engine revving focus as you're actually steering.
00:35:08.960 --> 00:35:11.119
It's stimulants, they rev, they don't steer.
00:35:11.280 --> 00:35:14.079
So in 2013, there was a study by Leva.
00:35:14.880 --> 00:35:22.320
They gave Adderall to uh healthy people and they saw no measurable boost, but they did feel like they did better.
00:35:22.559 --> 00:35:32.239
There's another study that was basically giving people methylphenidate, modafinil, or an amphetamine for a hard problem to be solved, and they tried harder and they did worse.
00:35:32.400 --> 00:35:35.840
Like they they literally worked their asses off, but the answers got shittier.
00:35:35.920 --> 00:35:38.480
And the top performers they dropped below the average.
00:35:38.719 --> 00:35:46.559
To be fair, there is a 2015 trial, a review actually that found modafinil did help on complex tests.
00:35:46.719 --> 00:35:52.559
So I don't think this is settled for modafinil, but feeling sharp and being sharp, those are not the same thing.
00:35:52.639 --> 00:35:58.559
You know, like when you're like you take all of your stimulus and like, man, I feel on top of the world, versus when you wake up and you're like, I just feel great.
00:35:58.719 --> 00:35:59.679
What the fuck?
00:35:59.920 --> 00:36:02.400
Like that is your capacity being restored.
00:36:02.559 --> 00:36:04.320
This year is you're pushing your capacity.
00:36:04.559 --> 00:36:08.239
Can you take a nootropic every day or do they need to be cycled?
00:36:08.400 --> 00:36:09.519
It depends, right?
00:36:10.079 --> 00:36:14.320
Like if you're taking dihexa, it's gonna take several weeks for you to feel anything.
00:36:14.559 --> 00:36:17.920
So slow builders like that, they're gonna need a lot of uh several weeks.
00:36:18.079 --> 00:36:18.960
Like bacopa.
00:36:19.280 --> 00:36:25.519
People are like buying bacopa and they're trying bacopa monieri for like a month for libido or cognition or whatever the fuck.
00:36:25.679 --> 00:36:29.599
In the trials that we have, it took 12 weeks to hit max effect.
00:36:29.920 --> 00:36:32.320
So you need to know how long these drugs work.
00:36:32.400 --> 00:36:39.360
Like when I'm working with anyone like blood work or a compound, I know how long it takes for these things to peak for every single fucking thing.
00:36:39.519 --> 00:36:42.320
I know what blood work is affected by other blood work and stuff like that.
00:36:42.400 --> 00:36:45.519
And I just I don't understand how some coaches don't have that.
00:36:45.599 --> 00:36:48.320
Well, I don't understand how coaches don't have tools like this.
00:36:48.400 --> 00:36:51.199
I don't understand like how the fuck do you know whether the thing worked or not?
00:36:51.280 --> 00:36:54.239
You're gonna fucking put Bacopa in and you're gonna pull it out and like what?
00:36:54.320 --> 00:36:55.039
Like, I don't know.
00:36:55.199 --> 00:37:01.440
Rhodiola, that is uh every single one was held high, like uh when they were taking it.
00:37:01.519 --> 00:37:08.800
So you don't need to take it continuously uh for rhodiola, but I do see the effects like when you were taking rhodiola around 10 weeks or so.
00:37:09.119 --> 00:37:13.280
Finibut, you can actually get Finibut withdrawal with as little as like a week of use.
00:37:13.440 --> 00:37:19.760
And then in the case reports, almost 50% of the people who are going through withdrawals from Finibut, they end up in the ICU.
00:37:19.920 --> 00:37:22.639
I mean, small data set, but holy shit, right?
00:37:22.719 --> 00:37:27.599
Uh, if you're gonna fuck with Finibut, be smart and please read that Feldman uh 2023 report.
00:37:27.679 --> 00:37:29.199
But yeah, Finibud is pretty fun.
00:37:29.280 --> 00:37:31.119
I like doing Finibud, but I don't do Finian.
00:37:31.280 --> 00:37:32.320
I think it sounds funny.
00:37:32.559 --> 00:37:33.360
Finibud.
00:37:34.159 --> 00:37:39.679
Do topical fat loss products do anything measurable or is it all water and blood flow?
00:37:39.920 --> 00:37:42.079
Yeah, it's mostly just gonna change your measurements.
00:37:42.159 --> 00:37:46.559
It's not gonna really change your fat because the most of the studies are also measuring girth.
00:37:46.719 --> 00:37:49.599
They're not measuring uh fat thickness with like an ultrasound.
00:37:49.679 --> 00:37:52.239
And when they do, a lot of the times you find no difference.
00:37:52.480 --> 00:38:04.800
I I think that when you're looking at like actual fat loss products, like if you're talking, you know, uh columbuterol, salbutamol, which I'm gonna start trying recently, uh soon after I'm done with this health phase, you know, um what else is pretty good?
00:38:04.960 --> 00:38:11.760
I mean, in the indirectly SLU, MOTC, 5 amino directly, I think those are all very useful.
00:38:11.840 --> 00:38:14.480
It's just about finding the one that's gonna work best for this person.
00:38:14.719 --> 00:38:16.239
I really do think that's the whole trick, right?
00:38:16.559 --> 00:38:28.000
Because like the it doesn't sound impressive when I just label a list of like fucking 15 different compounds, but the fact that I can pick the three that are gonna move the lever for you, like that's what you're paying for.
00:38:28.239 --> 00:38:34.159
Like that, that you're not wasting money on 15 different compounds and then having 14 different side effects.
00:38:34.400 --> 00:38:36.719
Like you're just taking the shit that's gonna work best for you.
00:38:36.800 --> 00:38:38.960
I think that's the um how we should think about this.
00:38:39.840 --> 00:38:44.719
How do you evaluate whether a supplement company is actually dosing what the label says?
00:38:45.440 --> 00:38:48.239
I can't trust that as well at all.
00:38:48.480 --> 00:38:59.440
Earl in 2017, the melatonin products they ranged under 83% on the compound dose and 478% over what the label said.
00:38:59.599 --> 00:39:06.960
And also, eight out of 31 of these melatonins, they had serotonin in them that wasn't accounted for.
00:39:07.679 --> 00:39:15.840
We know that from Gay or 2004, that 14% of regular non-hormonal supplements had undeclared steroids in them.
00:39:16.000 --> 00:39:20.480
And we also know that there are several companies that were selling pro hormones, about 20% of those.
00:39:20.719 --> 00:39:26.480
The FDA in the it flagged about almost 800 adulterated products over the course of the past 10 years.
00:39:26.639 --> 00:39:32.960
And in the like 90% of the of the muscle-building ones, they had steroid-like drugs in them.
00:39:33.119 --> 00:39:35.760
Some got re-spiked with new drugs after the warning.
00:39:35.840 --> 00:39:39.840
Like they literally got the fucking hand slap and they just moved on and put them put the rest in there.
00:39:39.920 --> 00:39:49.760
So, um, what I look for, I look for a third-party seal like an NSF certified for sport or informed sport, uh, or like a batch-specific test from an independent lab, like a proprietary blend.
00:39:49.840 --> 00:39:54.239
I don't fuck with anyone that uses a proprietary blend for absolutely anything.
00:39:54.880 --> 00:39:59.920
Is there a limit to how many peptides you can run at once before they start interfering?
00:40:00.079 --> 00:40:01.599
The limit isn't a mechanism, right?
00:40:01.679 --> 00:40:06.800
So the same receptor is gonna, if you're hitting the same receptor, is gonna mean redundancy and also faster burnout.
00:40:06.960 --> 00:40:12.000
Like a GH release peptide, you're gonna like decrease the amount that you get in every single time that you put in.
00:40:12.239 --> 00:40:13.920
Side effects, they also stack, right?
00:40:14.000 --> 00:40:19.039
Like GH peptides are gonna hit hit you very, very hard on prolactin and cortisol as well.
00:40:19.199 --> 00:40:26.639
If you stack three different, you know, GH secretagogues like I've seen of on a protocol from a very, very famous coach, it's kind of insane, right?
00:40:26.719 --> 00:40:28.400
You did get less and less effect.
00:40:28.559 --> 00:40:30.480
So the biggest limit is gonna be attribution.
00:40:30.559 --> 00:40:35.119
You run six fucking things, you feel better, and you have no idea which one did it or which one is causing the problem.
00:40:35.280 --> 00:40:37.760
So you credit all of them and you decide to run all of them.
00:40:37.840 --> 00:40:39.840
And then when you're feeling bad, you decide to run more shit.
00:40:39.920 --> 00:40:45.360
And you can just get these massive fucking lists of peptides and you're spending several thousand every couple of months on this.
00:40:45.440 --> 00:40:48.719
Like I find that you're creating too much receptor crosstalk.
00:40:48.880 --> 00:40:52.719
It's just it's not a clear signal that's being sent to the body.
00:40:52.880 --> 00:40:54.000
You want a clear fucking mission.
00:40:54.079 --> 00:40:56.639
Hey, do this and just have your body do it.
00:40:56.800 --> 00:40:58.960
Put your body in the mode of like fat wash, right?
00:40:59.039 --> 00:41:01.599
You start tracking your your food, ritual.
00:41:01.760 --> 00:41:04.400
You start fucking going for your walks, ritual.
00:41:04.559 --> 00:41:06.559
You start going for your cardio, ritual.
00:41:06.639 --> 00:41:09.360
You start fucking like checking yourself on the mirror, ritual.
00:41:09.440 --> 00:41:13.360
There's like all of these things are gonna keep you stuck in the in the process itself.
00:41:13.440 --> 00:41:22.559
I find that those things are the things that you should be seeking to get the most out of the program that you're getting out of, not uh just like trying to figure out how many you can run at once.
00:41:22.719 --> 00:41:23.840
I think that's kind of backwards.
00:41:23.920 --> 00:41:26.239
Like how many can you can run all of them, fucking trying.
00:41:26.480 --> 00:41:28.000
Like, I don't know what the fuck is gonna happen.
00:41:28.079 --> 00:41:29.280
I don't think it's good.
00:41:29.440 --> 00:41:32.559
But uh, that gave me the idea of doing that as an experiment.
00:41:32.639 --> 00:41:34.159
Just see what the fuck happens.
00:41:34.400 --> 00:41:39.519
If I just pull 10 units of everything that I have every single day and I just inject it, what the fuck is gonna happen?
00:41:39.840 --> 00:41:41.360
You're gonna waste a lot of money.
00:41:41.920 --> 00:41:48.719
Next question Does antidepressant use meaningfully change training results or body composition?
00:41:48.960 --> 00:41:57.840
Yeah, on a population level, not so much, but like on a person to person, like there are there, you're gonna find people that gain like 30 pounds on on taking an antidepressant.
00:41:58.079 --> 00:42:00.800
But the drugs that it matters more than the class, right?
00:42:00.960 --> 00:42:06.159
Boot propion versus such surchaline, that was a 13-pound difference between the two.
00:42:06.320 --> 00:42:10.719
And we also know that certain compounds like mytazipine, those are gonna drive your appetite.
00:42:10.960 --> 00:42:13.360
Now, on endurance, the data is very mixed.
00:42:13.440 --> 00:42:20.400
There's a small study on paroxetine that was cutting cycling exhaustion down to uh like five by almost like 30 minutes.
00:42:20.639 --> 00:42:29.119
And in the in the heat stuff, uh, there's another study that found no change in performance whatsoever, but they found higher body core temperature the whole fucking time.
00:42:29.280 --> 00:42:33.599
So just uh just just keep in mind for like summer training or training outside and stuff like that.
00:42:33.760 --> 00:42:44.000
And if you are on SSRI and you're popping like fucking ibuprofen every single time you have an ache, that combo raise the stomach bleeding risk of about 75%.
00:42:44.559 --> 00:42:46.159
So there's plenty of shit.
00:42:46.239 --> 00:42:54.159
I don't understand why we're so fixated on peptides when there's plenty of shit like this that will literally fucking kill you on an over-the-counter, you know, cocktail that people can just do it themselves, you know?
00:42:54.400 --> 00:42:56.000
Yeah, ibuprofen is awful.
00:42:56.159 --> 00:42:57.599
Yeah, it's fucking horrendous.
00:42:57.920 --> 00:43:02.880
What would make you tell someone to strip their stack back to nothing and rebuild it?
00:43:03.119 --> 00:43:11.840
Whenever I can't tell what the fuck is doing what anymore, like if something is working and I can't name it, sure I'm gonna keep it, I'm gonna figure out what it is.
00:43:11.920 --> 00:43:14.239
But if it's not, uh, I don't I don't like it.
00:43:14.480 --> 00:43:18.159
So I like to simplify everything and then start with a new clean baseline, right?
00:43:18.239 --> 00:43:24.960
Um, whenever a new symptom is gonna show up, you're you're that's usually you're going to start adding another thing.
00:43:25.199 --> 00:43:27.599
But you also have this add this thing in, add this thing.
00:43:27.679 --> 00:43:29.679
That is called the prescription cascade.
00:43:29.760 --> 00:43:32.880
And it's how people end up taking 75 different compounds.
00:43:33.039 --> 00:43:37.840
So I'm also gonna stop taking and I'm gonna clear things out whenever the labs start making sense.
00:43:38.079 --> 00:43:42.320
Like, you know, let's say you're taking your supplements, you're doing the labs, and you're like, oh, I don't remember what I took.
00:43:42.480 --> 00:43:47.840
Well, biotin, it's going to throw off uh like nine out of 23 lab results.
00:43:48.000 --> 00:43:50.800
So you might just need to retest it and come off of these things again.
00:43:50.880 --> 00:43:51.920
So that's another reason.
00:43:52.079 --> 00:43:57.199
And I also see uh that recovering is more of a removal process, not an addition.
00:43:57.280 --> 00:44:02.800
So when nothing is working more, I think the answer is a reset and not more drugs.
00:44:02.960 --> 00:44:04.960
So, guys, that is the episode for today.
00:44:05.119 --> 00:44:10.079
I'm about to go lay down and fucking try to relax a little bit because I am fucking wiped the fuck out.
00:44:10.239 --> 00:44:18.000
If there's one thread that's running through all of this episode, is this the stuff that you have on your shelf, it works best when you can actually tell what the fuck it's doing.
00:44:18.079 --> 00:44:25.840
Like the caffeine that's just getting you back to zero, the five new tropes that you can't teleport, the supplement that doesn't have what it says that it has, it's all the same problem.
00:44:26.000 --> 00:44:32.800
So strip things back, find your baseline, add one thing at a time, and make sure that the product has actually learned its spot.
00:44:32.960 --> 00:44:37.039
You need to have a clear goal, a clear job for this product, for this uh uh device.
00:44:37.119 --> 00:44:40.960
And you can always ask the question can I achieve this naturally without needing a supplement?
00:44:41.119 --> 00:44:43.039
And if you can, there's no place for the supplement.
00:44:43.199 --> 00:44:49.599
So if this episode hit you guys, bro, keep sending me your questions because this whole episode came straight from you guys and from my clients.
00:44:49.679 --> 00:44:51.519
So hit subscribe so you can catch the next one.
00:44:51.679 --> 00:44:52.960
And I'll talk to you guys soon.
00:44:53.119 --> 00:44:53.599
Peace out.
00:44:53.760 --> 00:44:53.920
Peace.