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What if the effects of psilocybin extend far beyond the brain and into the biology of aging itself?In this episode of Longevity Science, I sit down with Dr. Louise Hecker and Dr. Kosuke Kato, whose unexpected research on psilocybin has opened up a fascinating new question: Could psilocybin actually influence longevity?Their work started with a simple experiment. Treat aging cells with psilocin, the active metabolite of psilocybin, and see what happens. The result was a striking, dose-dependent extension of cellular replicative lifespan. They then took the much bigger step of testing psilocybin in aged mice, where treatment produced a surprisingly large survival benefit during the period they were permitted to follow the animals.We dig into those findings, the important limitations of the mouse experiment, and what they are learning about how psilocybin may be affecting aging biology. Intriguingly, some of the strongest effects appear to occur outside the brain, including persistent changes in inflammatory and immune pathways across multiple organs. Louise and Kosuke also share new details about their work with microdosing, effects on aging skin and hair in mice, non-psychedelic psilocybin derivatives, and efforts to develop topical formulations. One particularly interesting question is whether the potential effects on aging require the psychedelic experience at all, or whether the two can ultimately be separated.And perhaps most excitingly, this research is now moving into humans. Louise and collaborators are performing a Phase 1 clinical trial, which will test full psychedelic doses of psilocybin in healthy adults ages 60–85 and examine biological aging markers along with other measures of health and function.We also talk about why psilocybin research remains surprisingly limited, the challenges of doing rigorous science with a Schedule I drug, and the important distinction between recreational psychedelic use and studying psilocybin as a potential medicine.There is still a long way to go before anyone can say that psilocybin slows aging in humans. But the early findings are intriguing, and they're raising some fascinating questions about psychedelics, inflammation, cellular aging, and longevity.In this episode:🍄 How a conversation about magic mushrooms led to a longevity experiment🧬 Psilocin, cellular senescence, and telomeres🐭 What happened when aged mice received psilocybin🔥 Psilocybin's surprising effects on inflammation🧠 Does the psychedelic experience matter for longevity?💊 Microdosing versus full psychedelic doses🧴 Aging skin, hair, and topical psilocybin derivatives🔬 Parallels between psilocybin and rapamycin👨⚕️ The first human trial of psilocybin for healthy aging⚠️ What the science does—and doesn't—justify today#Psilocybin #Longevity #MagicMushrooms #Psychedelics #Aging #LongevityScience #GeroscienceDISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
