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Is more protein really better for healthy aging—or could eating less protein help us live longer? In this episode, Dr. Matt Kaeberlein joins me as co-host to examine some of the most debated and emerging areas of longevity science. Matt is a leading researcher in the biology of aging whose work has explored interventions that may improve healthspan and extend lifespan.
We explore:
• Whether high-protein diets are supported by longevity research • The potential tension between preserving muscle and extending lifespan
• Why the effects of protein depend on calories, diet quality, exercise and age
• What studies in mice can—and cannot—tell us about protein restriction in humans
• How specific amino acids interact with mTOR and other aging pathways
• What FGF21 is and why it may mediate some effects of protein restriction
• New research using FGF21 gene therapy to extend healthspan and lifespan in mice
• Whether existing interventions could offer similar benefits with less risk
• How Montana’s expanded Right to Try framework approaches experimental therapies
• The challenge of balancing patient access, scientific evidence and safety
Whether you’re focused on building muscle, improving metabolic health or living longer, this conversation offers a more nuanced way to think about protein—and a look at where longevity research may be heading next.
Read Lamming's paper: https://www.cell.com/cell-press-blue/fulltext/S3051-3839(26)00077-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS3051383926000770%3Fshowall%3Dtrue
Read about FGF21 gene therapy: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(26)00469-7
Read Montana’s expanded Right to Try: https://montanabio.org/sb535-right-to-try-montana/
The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests or co-hosts may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.
