# John Vane
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Sir John Robert Vane (29 March 1927 – 19 November 2004) was a British pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and blood vessel disease and introduction of ACE inhibitors. He was awarded the Nobel Prize in Physiology or Medicine in 1982 along with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances".
== Education and early life ==
Born in Tardebigge, Worcestershire, john vane was one of three children and grew up in suburban Birmingham.
John Vane
Sir John Vane (1927 - 2004) received the 1982 Nobel Prize in Medicine for discoveries that reach into the medicine cabinet of almost every home. For generations, we have known that aspirin relieves pain, but how and why it works remained a baffling mystery until 1971, when Dr. Vane determined that …
3. Professor Salvador Moncada - Starting work in John Vane's_laboratory, 1971
From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 ca…
John Vane
Sir John Vane (1927 - 2004) received the 1982 Nobel Prize in Medicine for discoveries that reach into the medicine cabinet of almost every home. For generations, we have known that aspirin relieves pain, but how and why it works remained a baffling mystery until 1971, when Dr. Vane determined that …
3. Professor Salvador Moncada - Starting work in John Vane's_laboratory, 1971
From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 ca…
Starting work in John Vanes laboratory, 1971
Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada
John Vane
Sir John Vane (1927 - 2004) received the 1982 Nobel Prize in Medicine for discoveries that reach into the medicine cabinet of almost every home. For generations, we have known that aspirin relieves pain, but how and why it works remained a baffling mystery until 1971, when Dr. Vane determined that …
Prostaglandins and related compounds prostaglandins and their related compounds- I prostacyclins
prostaglandins and their related compounds-
I prostacyclins (PGl), thromboxanes (TXA),
leukotrienes (LT) and lipoxins are collectively
known as eicosaniods, since they all
contain 20 carbons (Creek : eikosi-twenty).
Eicosanoids are considered as locally acting
hormones with a wide range of biochemi…
NSAIDs, Part 2: The Dawn of the Anti-Inflammatories
In this episode, we dive into the story of aspirin and the development of ibuprofen, ending with the experiments that showed the mechanism of how aspirin actually works.
Intro 0:12
Review of part 1 0:28
In this episode 1:04
Blocking prostaglandins and willow leaves 2:26
Edward Stone 3:45
Jo…
Dr. Eduardo Cardona-Sanclemente – Ayurveda for Obesity and Gut Health
Dr. Eduardo Cardona-Sanclemente, integrative medicine doctor with a focus on Ayurveda, has joined me (again) to share his brilliant insights. Please join us as we discuss:
the inspiration behind his book: Ayurveda for Obesity and Gut Health
his insights on the body/mind connection
his philos…
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