00:00:00
Speaker 1: George Goginess, Welcome to you, probably one hundred mante thanks so much for coming in. I'm actually fascinated with this topic. This is a topic of supplements and what gets absorbed and what doesn't get absorbed, what's a waste of time, and what's really important that's not a waste of time, et cetera. And that's your area of expertise. But maybe you just explained quickly your qualifications and some of the experiences and some of the studies that you have been you have done and and or are you doing.
00:00:24
Speaker 2: I've got a science degree, so the major was in chemistry, physical and organic chemistry. I've been in industry since probably ninety three. Started off in the regulator to start with therapeutic goods administration, which taught me a lot over the following nine years, and then went into various various jobs in industry. Last one is Farma Go Biotechnologies, so we started started that company in twenty fifteen, and what we special in is taking average ingredients and basically supercharging them, so making them get absorbed by the body better, so better by availability, which which then means you can reduce to dose or you can have much faster results. What people don't realize is that not everything you're put in your mouth gets absorbed, and and ingredients that are what we classify as lipophilic ingredients. So what do I mean they like fat versus water soluble ingredients? You know, they you're lucky to get one percent absorption on those ingredients.
00:01:42
Speaker 1: If you don't have fat with them.
00:01:44
Speaker 2: If you don't fat helps or a meal helps, you know, to activate the enzymes in the stomach, But they still don't get absorbed as much.
00:01:56
Speaker 1: Are you saying that there are lots of supplements out there that, by virtue of the interaction with what goes on our stomach, et cetera, that they're just never going to get absorbed. Is that what you're saying?
00:02:10
Speaker 2: Absolutely? Yeah, we've got vitamin D three, it's a classic exam.
00:02:16
Speaker 1: D three D three. Yeah, that's a popular one of the mother with k D three k k K two.
00:02:22
Speaker 2: We've had instances of dark colored skin people that have been that their vitamin D three levels are so so low. So you're looking at like twenty five nanograms per per miller plasma, they should be seventy. People with a darker color skin, Yeah, darker complexion.
00:02:44
Speaker 1: Not Us Greeks. We're talking about maybe the North African or African that type of complexion of Indian Indian or people that are just Polenesians.
00:02:55
Speaker 2: Hiding from the sun. You know, there are another another group. And so the children no slip slop slap. But that campaign was very, very successful in that you know, if you haven't got a hat on, you can't go out right now. Vitamin D is a sunshine vitamin, So it's created in your skin with the sun, with the sun's help. So there's there's a conversion that happens from from cholesterol to D three.
00:03:26
Speaker 1: So cholesterol gets converted through this chemicaly action so to speak, in your skin as a result of the sun.
00:03:31
Speaker 2: That's activated by UV light.
00:03:34
Speaker 1: Yeah. So UV light from the sun activates this process to convert cholesterol into vitamin D three.
00:03:41
Speaker 2: Yeah.
00:03:41
Speaker 1: And just by the way, what is D three important for?
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Speaker 2: It?
00:03:44
Speaker 1: Is it important for something?
00:03:45
Speaker 2: Well, for everything. It's probably involved in about three hundred chemical reactions in your body. Its main important, well, use is for the calcium on your bone. Okay, So so your skeleton, your bone structure, that's basically a store for calcium, right, and calcium is used in many other reactions in your body.
00:04:13
Speaker 1: So when we think of calcium, we think of our bones and teeth and things like that, but really it's not just that, because our body actually borrows from that the calcium that's in those bones to do other things.
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Speaker 2: That's yeah, that's right, right, yeah. And then and then it also puts it back onto puts it back onto your skeleton, onto your bones, you know. So it's it's a continuous cycling of of calcium.
00:04:37
Speaker 1: Without D three, what happens.
00:04:39
Speaker 2: You've heard of rickets in children, So they get the bowed legs, you know, it's it's it's that's because the structure isn't isn't strong enough.
00:04:49
Speaker 1: To support the weight, and the bones start boeing.
00:04:53
Speaker 2: Yeah, yeah, but you don't see that these days other than than in developing nations. But yeah, going back to skin, skin tone, skin color, and other factors, you're not getting D three. So supplementation is important. The problem with supplementation is you can have people taking it for three months and they'll move from twenty five to twenty seven.
00:05:24
Speaker 1: What did you say number that you want them to get up to seventy seventy and would that be considered in a pathology sense, in the average or something like that. In the range.
00:05:31
Speaker 2: Yeah, you're at the at the medium to low end of the scale, you know.
00:05:37
Speaker 1: Even seventy Yeah, wow, so forty your way off, way way off. Yeah, and what would you feel.
00:05:43
Speaker 2: You know, you've heard of seasonal depression.
00:05:47
Speaker 1: Yeah, Northern Europeans suffer from this.
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Speaker 2: That's right, And that's why they've got D three in the margarine in their bread. You know. It's yeah, it's supplemented everywhere.
00:05:56
Speaker 1: So let's say we're taking the supplement. How do we know that is bio available? In other words, your body will make it biologically available once you ingest it.
00:06:08
Speaker 2: Once you ingest it, quite quite a few things happen. So, so you know, you start releasing light paces in your in your store to light paces. There they are enzymes that that break down fats.
00:06:21
Speaker 1: So your stomach detects this stuff.
00:06:23
Speaker 2: It detects that there's a fat present, so so it releases light paces um and and they'll go to to the source of the fat and start start breaking it down. Now, the problem with your stomach is that it's a watery environment. You're putting a fat into water a watery environment. What happens nothing. You know, all the fat clumps together. So as as it clumps together, the like pace has only got access to the to the surface area that's available to it outside the side. That's it. And at some point in time it gets spent and you have a globular fat just going through intestine unprocessed the other end. Yeah, what we do is we create technologies that stop that clumping. So we make tinier structures what we call my cells or liposomes, and these tiny structures because they are so small and they're now hydrophilic, so like water, when they go into the gut, they create a solution. And now your surface area from one big clump becomes a surface area of a million.
00:07:48
Speaker 1: Waller clumps, little droplets.
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Speaker 2: Yeah, so the body has got better access.
00:07:53
Speaker 1: But that fat that you've ingested, is that in the form of what fat like food, fat like yogurt or what are we talking about here? How does that go into your system in the first place? Where am I getting this fat from?
00:08:05
Speaker 2: Through a supplement? Yeah, so it's in the supplement, Yeah, yeah, together with with the fat, so vitamin D. Yeah, we would have vitamin D together with our what we call it aqua cell technology and the two together. Once they meet water they form the tiny droplets.
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Speaker 1: Wow, is it like a pill or what are we talking about?
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Speaker 2: Yeah, yeah, just in that instance, it would be a soft gel capsule.
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Speaker 1: Yeah, capua with the gel inside. Yeah, and the gel it's probably the fat bit and then the vitamin D is also in there as well.
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Speaker 2: The gel makes the skin of the capsule, right, and then inside is the liquid the liquid vitamin D three, Amiga three, fish oil K two, all those sort of ingredients that that are typically.
00:08:56
Speaker 1: So you use this format sort of suspend the actual vitamin or whatever the supplement is. We're inside.
00:09:03
Speaker 2: Yeah, we mix it with our with our tech and it's not until it hits water. So the capsule needs to be ingested. You'll take some water with it. The shell breaks open, releases the contents. But once the content's released, they go into the stomach hit water they form straight away. All our research, all our formulation, all our manufacturer happens in.
00:09:27
Speaker 1: Australia and you guys do it yourself.
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Speaker 2: Yeah, we do it. Some some more complicated situations will use universities. So there's about four or five local units that that we deal.
00:09:41
Speaker 1: With who do research on it for you.
00:09:44
Speaker 2: Yeah, that that can do more. So sometimes we'll know it works. We've tried it on humans and we get really good results, but we don't know why. We don't know how it works.
00:09:55
Speaker 1: Can I look at just one supplement that's like, it's pretty popular, look at a couple, but I look at one to start with. And I don't know if you guys haven't experienced this particular one. But let's look at m N yes, which is like the buzzword right now. Everybody's talking about this particular supplement, which is something that helps your energy system in terms of producing a thing called energy plus plus, which is something important for the electron transfer chain in the mitochondria. Yes, correct, yes, okay, so your parts pass on that bit. But if I'm taking NMM, which is a precursor to NAD plus, and what I'm trying to do is get more energy, you know, like you know, we get older and we just lack energy, what would you say I should be looking for in that supplement? Is this something I look like look for on the label apart from your brand? Can I feed that into AI? Will AI tell me that's the go to?
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Speaker 2: AI would typically take you down the paths of coupling the end amen together with an advanced delivery system. Yeah, okay. Now, in amen's water soluble, okay, And what that means is is that a lot more of it gets absorbed by the body, right, not one hundred percent.
00:11:17
Speaker 1: So it's good for byver and it turns it by.
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Speaker 2: On its own. It's good.
00:11:21
Speaker 1: Yeah.
00:11:22
Speaker 2: Yeah.
00:11:22
Speaker 1: It doesn't need to be put in a capsule with some special help. Yeah yeah, with the oil or whatever fat in there anyway.
00:11:29
Speaker 2: Yeah yeah, yeah, but it's still is still only absorbed about fifty sixty percent. The typical dose out there at the moment's about five hundred MiGs, right, So so five hundred your body is actually getting two hundred and fifty.
00:11:46
Speaker 1: But why does it absorber I don't understand. Why does it only and does it convert it into something else?
00:11:53
Speaker 2: It can't look that. The gut is a very hostile environment, you know. It's it's you've got chloric acid in there, and and it's its whole purpose is to break things down, take take what it needs, and get rid of the rest of it, you know. So so it applies the same principle what we do with advanced delivery systems is we force it to take more. So if you were to take the five hundred milligram and the men with our technology, you would be you would be absorbing about ninety five percent of it.
00:12:30
Speaker 1: But the point is you've got to people who are taking these things. They've got to make sure that the delivery system is right.
00:12:38
Speaker 2: Is right? That's that's that's the key to everything. And DOE and and dosage. Yeah, relative to delivery system, that's right, that's right. And that's that's the variable, the two variables. You know, sometimes you see the TGA places a restriction on a dosage and you're going, you know, you've placed the restriction on five hundred milligrams that I could deliver more just by adding a delivery system. So you're not achieving what you want to achieve, you know. So they've got to start looking at absorption, you know, by availability. They have to, because that's that's what's key.
00:13:18
Speaker 1: When you say delivery system for example of MN, would you say that it is like water, so like your gut system, is there something special you do to allow for that ENEMM to be absorbed up to ninety five percent?
00:13:32
Speaker 2: You're let into it before with the mitochondria. Okay, so the mitochondria are bodies that are inside cells. Your enemn has to make its way through the cell, through the mitochondria, so through the cell wall and into the mitochondri which.
00:13:51
Speaker 1: Every cell has a little mitochondria inside, a little has the energy energy factory inside and has to get through that as well. Side of that, that's right.
00:14:01
Speaker 2: In the meantime, the body is trying to get rid of it. Why because it's floating around in blood plasma. Yeah, it's detecting it as a foreign body. So it's doing its job right, you know, get it out.
00:14:14
Speaker 1: So there's this fight. So once you absorbed ninety five percent of it, I presume what do you mean by that, George? Is ninety percent of it for example, up to percent gets into your bloodstream? Does that mean you can I also then say ninety five percent of being absorbed into your mitochondry or there's that's a different process. It's got a higher chance, higher chance, higher chance. So it's about probability.
00:14:35
Speaker 2: Yeah, yeah, because you're you're getting more molecules now into your blood plasma. So say you got a million instead of instead of five hundred thousand, A lot more are going to find their way way in this This is where the delivery system comes comes into play. Now, now within the men in particular, we would use a technology called the light pozone. Okay, with with the liposomal technology, what it does is we we engineer these tiny balls that are made up of phospholipid membrane and inside inside the ball is a tiny core of water. And inside that core of water is the enemen. Okay, the enemen molecules. Now that membrane of the ball is made up of the same material that the membrane of your cells are made up.
00:15:31
Speaker 1: Of, so they're compatible.
00:15:33
Speaker 2: So when when it hits a cell, it's not looked at as a foreign body. It gets absorbed by the cell. The membrane ruptures, opens up, and the enemen goes into the cytoplasm.
00:15:48
Speaker 1: Of the cell and then then there's there. It changes just to go to mitochondria because a lot of people are using these injectibles because it looks quick. You put in your gut or wherever they put into you think, O, we'll get them a bloodstream. It's better than taking one of these supplements. Maybe you could explain that to me a bit better. I mean, am I on the right track there with what I was reading.
00:16:08
Speaker 2: If you're injecting with like Bosomall and their men, then then you that's different. That's different. If you're injecting with just then their men, you're back to the same situation of taking the capsule and absorbing fifty percent whatever, but then ten percent of the fifty percent is making its way to the mitochondria.
00:16:35
Speaker 1: So it's inefficient.
00:16:37
Speaker 2: Inefficient.
00:16:37
Speaker 1: Yeah, And when people build these supplements, they say, well, you know, take five milligrams. One tablet's five milligrams for I can say, you just take one of these tablets tablets. Is not like posoumaal delivery. When they build these things or manufacture this stuff. Are they manufacturing it on the basis that you only need ten percent of the fifty percent? Or are they doing it? Or I mean, where's the size sit there? I mean, so they don't tell us.
00:17:05
Speaker 2: If you're American, you like horsepower, So they go, it was five hundred megs without a system, there's five hundred megs with the system. You know, they don't get the fact that, hey, you can reduce it down to one hundred and have the same effect, you know, and save everybody money and everything else, you know, but that's where we strive to. So when we do do our studies to look at look at how much different you know, it is compared to a group of people that are just taking the basic enemen versus a group of people taking the loposomal and a men. We also start looking at the dose as well. Okay, so ALTHOUGHY will do a five hundred to five hundred comparison, will then will then start going, Okay, what's to fifty look like in comparison to five hundred? What does one hundred look like in comparison to to five hundred? And if we can get that part of the equation right, that's now called bioequivalents. So you got bioavailability by equivalents, and by what bioequivalence means is what dose of your formula is equivalent to the formula without anything, you know, it's just just the active ingredient just and the men in this case.
00:18:40
Speaker 1: So if I'm looking on the label, do I look for lipsal am? I looking for the delivery system.
00:18:47
Speaker 2: The companies that are that are clued in, Yes, there are other companies where they think they understand the liposume they think their clue in, they'll just put the word on the label.
00:19:01
Speaker 1: Do these things have to be proved by the TJ.
00:19:03
Speaker 2: They do. But the whole model with the TJ is a it's a bit of a self affirmation. So put your hand on your heart and say say this is a liposomal formula. The TJ doesn't come actively looking, you know, and saying, hey, you haven't got a light persone. The quickest way to work out as a as a consumer, is it liposomal or not.
00:19:33
Speaker 1: Even though it says it might be, even though it.
00:19:35
Speaker 2: Says it might be, is when you rip that that top off, put some into a spoon. If you can see little crystals in there, it's not a light perzone.
00:19:47
Speaker 1: With your naked eye, with your naked eye, a little Christians, you mean like little shiny things Vitamin C.
00:19:53
Speaker 2: They'll be wide orange sort of crystalline substances, you know. They it's the active ingredient that hasn't hasn't dissolved, right, And to make a light bosone, you really need to get that to dissolve to form the light posone, which is about one hundred and animeters in diameter.
00:20:19
Speaker 1: That's reasonable.
00:20:20
Speaker 2: Now, the visible wavelength of light is four hundred so you can't see it. So if you have a true light posomal formula and you've got it in a clear glass, it's going to guess what, it's going to be clear. Yeah, yeah, but if you can see little crystals floating around, chances are very very high.
00:20:41
Speaker 1: This where, it's this where is dangerous when people buy things online. Absolutely, you know. I mean I've seen it, berberine, berberinele glutethione libble.
00:20:52
Speaker 2: It's just like everything's like presuming everything.
00:20:55
Speaker 1: Yeah, yeah, and it's dangerous.
00:20:57
Speaker 2: It's very dangerous. That's why if if you're in Australia, just avoid it.
00:21:02
Speaker 1: Like the plague, do not buy buying online.
00:21:04
Speaker 2: Well, yeah, it's it's it's fraught with danger. You know, glued to thion From studies we've we've been doing, we know that after one month at room temperature, glued to thione drops to by about thirty forty of what's on the labe, and then again the next month, next month another thirty. Yeah, it's got a half life of the month. Within six months you go from one hundred milligrams of glutathion to four.
00:21:37
Speaker 1: Wow, So you basically got to take it straight away, the whole model, as soon as it's manufactured.
00:21:42
Speaker 2: Yeah.
00:21:42
Speaker 1: Yeah, And you don't know how long it's been manufactured for it, No, that's right exactly. It might have been use by date, but it doesn't matter. It's just manufactured.
00:21:49
Speaker 2: We know, if we refrigerate it, we can get twelve months, you know. But the same thing again, it's it's twelve months is great compared to two.
00:22:00
Speaker 1: So you guys involved in some berberine substances anyway, So how do you how do you differentiate your burbering? And maybe you can explain what burberene does or allegedly what it's supposed to do to us, especially given all the more recent studies on GLP one. Yeah, it's sort of like, as I under say, it's like a natural version of, you know, a zembi supposed to help you with it your you know, your appetite, et cetera. Look, could you tell me what it is?
00:22:29
Speaker 2: And berber comes from a plant which is native to India. It's in a particular region of India, and it's and it's from the bark, isn't it of that tree? It's from the roots the roots, isn't Yeah? Yeah, it's it's tightly controlled this this this plant you know, by by the Indian government.
00:22:50
Speaker 1: Really.
00:22:50
Speaker 2: Yeah, it helps with society in.
00:22:53
Speaker 1: Other words, appetite appetite. Yeah.
00:22:55
Speaker 2: So if if you, if you take a burbering with the delivery system, you can basically go until dinner without even thinking about food. Oh really, yeah, does that? I don't know, you don't know the mechanism. Oh, if you don't know the mechanism.
00:23:11
Speaker 1: But so, so you take burberin. Let's say you take it in the morning, proper berberine, and it has a proper delivery system. Let's talk about that delivery system. Is that liposomal again?
00:23:22
Speaker 2: No, I don't know if you have you ever tried to taste berberine.
00:23:25
Speaker 1: It is disgusting.
00:23:26
Speaker 2: It's the most bitter thing you've ever tasted in your life. I have.
00:23:30
Speaker 1: Yeah, it's dreadful.
00:23:31
Speaker 2: Yeah. So it doesn't make any sense to make it into a liposomea because you still can't can't take it by mouth, you know.
00:23:39
Speaker 1: Well, I've had it in a capsule. In a capsule, it said, I think the liposomes on the inside the capsule.
00:23:46
Speaker 2: Yeah. Again, to form a liposome, you're relying on your active ingredient, berbering in this case, to be able to dissolve in water. So if it doesn't dissolve in water, it doesn't matter how hard you try, you're not going to get You're not going to get a light berzone. What we do is we use a dispersion technology. So so burbrin powder is made up of tiny crystals, we coat those crystals with with our tech and and make them hydro hydrophilic.
00:24:20
Speaker 1: In other words, like water loving.
00:24:22
Speaker 2: Yeah, and because of that, the same thing again, under normal circumstances, berbrine would probably clump, clump together and create that surface area issue. But with the tech, you're not you're not getting that. You're getting free dispersion and then the body is just taking what what it needs.
00:24:42
Speaker 1: So it's how it needs inefficiently.
00:24:45
Speaker 2: Yeah.
00:24:45
Speaker 1: Yeah, so you're you're you are, because I mean, berberine is to me anyway, one of the more one of the more fascinating things that sort of is on the market today. How would you know you got that the correct active ingredients considering that it's controlled in India in some area, whatever the part of India is. We don't grow it in Australia, so we can't sort of look at Tom, you know where it came from?
00:25:08
Speaker 2: How do you know that?
00:25:09
Speaker 1: The answer to that, I mean, I know how you know, But how would someone like Mina?
00:25:13
Speaker 2: Look, sometimes you get what you pay for. There are people using berbering from different species. Okay, So so the one which is the pharmacologically active is the berberous aristata. That's that's the name of the plant. There are other ones from other regions, from Nepal, from China, et cetera, that can still yield burbering. So it's a bit like like coffee. You've got Arabica, you've got Robusta, et cetera. They've all got caffeine in them, you know, but this one's bitter, this one's a bit a bit sweeter, et cetera.
00:25:54
Speaker 1: You know.
00:25:54
Speaker 2: So there's those subtle differences that make the big difference. And all the research is on Burbersstata, right, they're not They're not on.
00:26:05
Speaker 1: The other ones. And and how would you know? How would someone know if they look on the laboring label again, if it should.
00:26:10
Speaker 2: Be on the label, should say if it's an Australian product, it should be on the label that.
00:26:15
Speaker 1: It is burberous aristarta can I just talk to you about quite question? Maybe you could explain why all the sudden has become popular and what the hell is it? Where's it come from? When do you take these things? With food? Without food? How do I know whether they should be having some fatty food like yogurt with it or something like that?
00:26:33
Speaker 2: Okay, so so on on on that one food or no food with with the advanced delivery systems, it doesn't matter, It doesn't matter. Yeah, you can take it whenever you want, right, And that's the beauty of them, right, because trying to remember, you know, take food and then take take it. You know, it's it's it's too hard for people.
00:26:54
Speaker 1: Okay, Well now what is carcert course, it's okay, where's it come from?
00:26:59
Speaker 2: Look, it's an interesting moleculars, it's what. It's in a class called polyp phenols. So it's a polyphonomic molecule. Whenever whenever you read any sort of research on any any inflammatory condition, they'll the conclusion will be almost the same, you know, across thousands of papers, and that is works in the test tube, doesn't work in humans. Wow, It's like why not? You know, And the reason being is that in the test tube. You can control the dose in the In the human you're you're left up to everybody's own devices. You know, someone will absorb one percent, this other goal will absorb point one, but it's always a low percentage, you know. So by increasing that percentage with a delivery system, you're getting you're getting the full benefits. Now querstin its main main function anti inflammatory, So it's in the same category as as Kirkman Amiga threes. You know, inflammation is multi multifaceted, so you can't get rid of inflammation just just with one substance. There's there's multiple that you have to have to take.
00:28:31
Speaker 1: And maybe you could explained that pony are the polyfannel piece, because lots of things are described as polyphannels. Olive ar, for example, there's lots of things blueberries. What are we talking about here, though? What is a polyphanel?
00:28:45
Speaker 2: Just generally speaking, a particular chemical structure that that is is that characterizes certain molecules, you know. So so yeah, Kirkman is retrol.
00:29:00
Speaker 1: As reservetrol does the same thing.
00:29:02
Speaker 2: They're all poly polyphenols, yeah, yeah, polyphenolics.
00:29:06
Speaker 1: Yeah, And now olive oil is one two, isn't it very low.
00:29:10
Speaker 2: Olive O is mainly made up of a substance called alayic acid. Yeah, something like seventy seventy percent of it's laic acid, so very high. But then it does you know, if it's the extra.
00:29:22
Speaker 1: Virgin depends on what their intensity is here.
00:29:26
Speaker 2: Yeah, that's right.
00:29:27
Speaker 1: What about blueberries? The skin very high, very high.
00:29:30
Speaker 2: Very high. Anything that you see that's in that red blue color range is high. Chances are very high that it's it's high in polyphenolics.
00:29:42
Speaker 1: And resveratrol is off the grapes skinners, is it right?
00:29:45
Speaker 2: That's one source, one source.
00:29:47
Speaker 1: Yeah, yeah, how do you find this stuff? You send people over so you's looking for all this stuff or we have it here locally.
00:29:52
Speaker 2: Yeah, look, there's there's there's roughly about two to three thousand ingredients that the TGA allows you to use. Okay, so the majority of those are herbal, but nonetheless it's it's a big number, you know. Is it? Is it possible to know everything? Not really, you know, but if you want to target a particular condition, you can. You can do quick research even with AI and say, you know what's good for senescence and cells for example, you know.
00:30:30
Speaker 1: Being the cells being dormant. Yeah, yeah, and how to get rid of siness and cells?
00:30:35
Speaker 2: Is that? So? What what substances would you know? Probably help? So yeah, AI will give you a list then you can say, okay, where do they come from?
00:30:46
Speaker 1: You know?
00:30:46
Speaker 2: So, so it's it's it's a bit of bit of research, you know, whether you're using AI or using PubMed or the research gate.
00:30:54
Speaker 1: Being published medical journals, yeah, supplications or research work.
00:30:59
Speaker 2: Yeah, it's a particular website that's run by the American the US Library.
00:31:06
Speaker 1: Yeah, and just for those people who might be listening apartment readings, published reports which usually done peer reviewed reports done at a scholarly level and perhaps even a peer in a journal and general and then you can work out whether or not it's a ranking journal or not, so whether or not you want to rely on that publication.
00:31:27
Speaker 2: That's that's right, Yeah, because there's there's a lot of journals that there is a ranking system. We typically look at journals at a five and above. Anything that's three and below it's not worth.
00:31:42
Speaker 1: Them because because generally speaking, the peer review process is fairly average in that because they do it for free, and so you're finding and what's interesting about that just for anyone who's listening. And I'd be interested to hear what you say about when you are using as a tool as opposed to the ultimate answer. But as a tool, it's worth saying to you in your instruction today, I just give me stuff that comes from ranked journals, as opposed to just going on there and have a look at an instagram. But I will do that sometimes it'll dish us from crap to you. Absolutely, so I always asked her to go. I asked it to look at published scholarly articles only you know which. The old Google scholar was always pretty good place to go to in the old days. But old day's only been a year ago, you can now. But now AI will help you. You've got to be careful to A tells you, because I will tell you what all the populist people who've got no idea on instagram sprooking that must kill your brain? Yes, yeah, I mean, what are some of the more popular things that you see that sort of aggravate your intellectual processes. I mean, what is around supplements for example? People should be careful perhaps.
00:33:02
Speaker 2: Or the life bozones is the big one, yeah.
00:33:05
Speaker 1: Life zonable delivery systems when it's not actually live zone.
00:33:08
Speaker 2: Yeah, and it's it's hard to validate. You know, there's companies out there that are worth, you know, five hundred million dollars US selling life pozons that are not life perzones.
00:33:22
Speaker 1: Yeah, I know some of those companies. I've seen them.
00:33:24
Speaker 2: Yeah, it's it's horrible.
00:33:27
Speaker 1: What about cerquit ten? What about its efficiency in delivery? And is a delivery system that you guys use for that? And I have noticed in capsules similar to what you're talking about some of the other other supplements. And is it something people should use only if they're taking statins or they should be using it generally.
00:33:46
Speaker 2: Yeah. Look, it's a substance that declines with age and as everything. The statins when they initially came out, they were combination products with coq ten.
00:33:59
Speaker 1: Are really there's inside.
00:34:00
Speaker 2: Yeah, it used to be used to be combo because they knew that the statins deplete your coke ten levels. Now it's it's not that the staaten uses up coke ten. It's more so the statin blocks the production of coke ten, and it blocks it in multiple paths, you know. So so it's it's pretty common that you're given statins to reduce your cholesterol, your bad cholesterol. But then ten years down the track you're dying from heart failure. Yeah, because you've depleted yourself of kke ten.
00:34:39
Speaker 1: You know. Wow, that's that's crazy.
00:34:42
Speaker 2: Yeah, it is, it is so so Yeah, if you're taking statin, definitely take coke ten.
00:34:49
Speaker 1: That's what about outside of your taking status just generally for general health. Unlets's say you're not you know, you're under forty or whatever.
00:34:56
Speaker 2: Well, it's it's it's sort of like like en the men. You know, you feel that energy burst and you can keep it going by by supplementation. It's just another another ingredient in the whole energy cascade.
00:35:16
Speaker 1: You know. Can you get it out of eating fruit or meat or.
00:35:21
Speaker 2: Naturally meat, Yeah, mainly from meat.
00:35:24
Speaker 1: From meat.
00:35:25
Speaker 2: I don't know how much you'd have to eat to get equivalent. It would have to be a lot, you know, and on a daily basis it would be a lot.
00:35:33
Speaker 1: Again, can I ask you? You might not want to answer this, but what do you take?
00:35:38
Speaker 2: What do I take?
00:35:39
Speaker 1: I mean, you're you're the dude like you're I mean, you're studying it, you're researching it, you're making it. You're passionate about it. We'll take a lot really so you live and breathe it.
00:35:52
Speaker 2: Yeah, yeah, yeah, absolutely.
00:35:54
Speaker 1: Give me an example of what you would.
00:35:56
Speaker 2: Well as a base. I take a Mega three what they call fatty acids. They're called a mega threes because there's a double bond at the number three position of this fatty acid. You know, they make up part of your cell membranes. So you know how earlier we said that the typical cell membranes made of phospholipids, phospholipids plus plus plus. You know, there's probably a thousand pluses, you know, and one of those is a mega threes. Phospholipids are quite rigid in in in their native state, so you need things like cholesterol Mega three, Mega six to give it fluidity. Yeah, So that's that's where a mega threes come in. They're they're they're in the in pretty much every cell membrane in your body. The problem we've got now is that where we've been needing so much Amiga sixers, it's a Mega six other fatty acids, but now that double bond, instead of being in the third position, it's in the sixth position. The significance of that is different reactions that go to play and the conversions that that happened. But Amiga six fats are pro inflammatory, Amiga three fats are anti inflammatory. Okay, So when you've got a cell and it's and it's viewing out inflammatory markers for whatever reason because someone punched you in the shoulder or whatever, those Amiga sixers are what create those inflammatory that process to happen. Okay, Amiga three will bring it back in line. Now, come down a bit, coming down now, because the Amiga sixers have recently, in the modern age, have become very popular. You know, your seed oils, you're cooking oils, et cetera. They're all Amiga six is compared to olive oil and all that sort of thing. Yeah yeah, all of the cheaper end of the oil scale. You know, your ratio has gone out of whack, right, So where it was one to one and that's the perfect ratio, it's now one Amiga three to six a Mega sixers or ten or twelve, you know, but it's way out of whack. So what's happening is is your cells in this continuous enti in this inflammatory process. You know, So by taking a Mega sixers, a Mega three. Sorry your trying to bring that balance back down again?
00:39:02
Speaker 1: And can you explain on the Amega three is? Where does because I'm confused? But E p A d h A finished that or has it got nothing to do with it?
00:39:12
Speaker 2: There are essential fatty acids and that chain length which you know, the double bond happens in the third position, so it's just a chain length, how big it is.
00:39:22
Speaker 1: But is that a way of taking is that a way of taking omega three or a mega three something separate to those those two things that all together E p.
00:39:30
Speaker 2: A d h A are a Mega three. Right, there's also d p A. There's there's a whole heap of them. But E p A d h A mainly comes from from fish oil, right and depending on what fish is it? Anchovy? Is the salmon? Is it? What grills it? Yeah? Real, the ratios are different, right?
00:39:54
Speaker 1: So that so if someone takes e b A g h A, that is a a Mega three supplement. Yes, reason for that is to balance out the potential intake of d h A and making just sure that maybe it hopefully gets to one to one ratio between the Mega sixers. Yeah, so what else do you take? Okay?
00:40:12
Speaker 2: So so mega threes D three, Kirkman and then risveratrol. So I take the Kirkman together with the risveratrol.
00:40:21
Speaker 1: In the same tablet or in the same Yeah.
00:40:24
Speaker 2: Yeah, my, My whole ideal world would be to make a tub of powder and take a scoop and.
00:40:31
Speaker 1: The everything's in there, everything's in there.
00:40:34
Speaker 2: Is it possible we should be able to come close?
00:40:37
Speaker 1: Like you just take a scooba powder and add water to or something.
00:40:40
Speaker 2: It's got your creatine and it it's got you know, it's got everything. Just add water.
00:40:45
Speaker 1: So what else do you take apart from the so so.
00:40:48
Speaker 2: Those they take berberine in the morning. Plus this other substance called oe A. It's short for oliol ethanola mine.
00:41:00
Speaker 1: So it helps you don't have to take olive all.
00:41:02
Speaker 2: Well, it comes from alayic acid, so it's a combination of alayic acid and ethanolamine. But it's it's a substance that that naturally occurs, occurs in your body and it affects it affects GLP one the naturally Yeah obviously not as not as hardcore as as a zeenpic and the other ones, but it's it's the body's natural approach to to GLP one. And what we also found is that, yeah, you hear about the gut microbiome, et cetera, there's a particular bacteria called Achamancia and and it influences that bacteria positively as well.
00:41:48
Speaker 1: You know, so it's sort of like a probiotic or something like that.
00:41:52
Speaker 2: I hate to say probiotic, but it's it's having a probiotic effect without being a probiotic.
00:41:59
Speaker 1: Yeah, So nutrition for the bacteria anyway, Yeah, a good bacteria.
00:42:03
Speaker 2: Yeah. Yeah.
00:42:04
Speaker 1: And on top of anything else, what are the things like vitamin C and.
00:42:09
Speaker 2: Take an iron working on putting together an iodine one as well, because iodine's completely overlooked.
00:42:19
Speaker 1: I feel it used to be in our salt all the time.
00:42:22
Speaker 2: It used to be, but you know, you had to stop taking salt because of your heart and yeah, making your arteries hard, et cetera. And the only place you can really get it from seafood, you know. So it's sort of like the omega three. You're not eating as much, you know, so you're not getting your omega three, you're not getting your iodine, et cetera.
00:42:41
Speaker 1: It's interesting and what is iod important for all.
00:42:44
Speaker 2: Your thyroid hormones. Yeah, so you're feeling tired, bit sluggish even after you've had a good night's sleep, et cetera. You know, chances are it's it's your balances there are out of whack.
00:42:57
Speaker 1: It's pretty complex all this stuff. Like I can see you even knew someone. You're a scientist and you know this stuff backwards and you're working on all the changes and right at the forefront of all this stuff. The average punter like me, it's a tough one to navigate. For us, it's impossible. Yeah, it is impossible. You've nearly got to be tactical, like you just got to go, oh shit out. Maybe I'll try this and just see what it does for me.
00:43:28
Speaker 2: I remember back in the eighties in at Uni and walked into my first lecture for biochemistry, and the professor said, oh, this is a good turn. Now there's three hundred of you, he said, By a second semester, there'll be one hundred and fifty of you. They said, by the end of second semester, there'll be ten.
00:43:49
Speaker 1: But people just drop out.
00:43:50
Speaker 2: They drop out because it's it's a damn difficult yeah subject and dry too, probably, And that was then back in the eighties, it's boomed in the last twenty is as a science. Yeah, I don't know how people do it.
00:44:06
Speaker 1: Because a lot of people bag this upplement industry, they say, and there's probably good reason for it in relation to some of the players generally speaking from what you're saying, George, supplements are important as long as you get the right ones and the right delivery system.
00:44:19
Speaker 2: Yeah, yeah, you can't. You can't need as much, and if you did, you'd be as big as a house.
00:44:25
Speaker 1: Especially as you get older. You just can't need as much.
00:44:27
Speaker 2: Yeah.
00:44:28
Speaker 1: I don't mean because you're going to get fat, You just don't have the same appetite. Your whole and your system becomes much less, much more inefficient in absorption anyway, just generally because you don't have as many things going on down there, things die off. Yeah, so you have to take supplements.
00:44:44
Speaker 2: Yeah, that's right, and it's only you know, like then Amends of this World that.
00:44:52
Speaker 1: Very recent research. Yeah, very very recent.
00:44:55
Speaker 2: So we still don't know what the outcome is going to be long term, but for the short term, like you said, you feel that hit of energy.
00:45:04
Speaker 1: Yeah, I do. I definitely do. I take a particular brand, but five hundred milligrams of what I take. I know you guys manufacture it. They come from you guys, but I honestly I've only been tall you for about maybe a month, and so I actually can turn you now. I have noticed a difference.
00:45:22
Speaker 2: Yeah, yeah, do the next thing. Stop taking it and.
00:45:25
Speaker 1: See, well I have done that. So I've done it on a week, take it for a week, and don't take it for a week.
00:45:29
Speaker 2: Yeah. You know.
00:45:30
Speaker 1: I try to maintain consistency in what happens otherwise in my life work, stress, you know, sleep exercisese other things. And I have noticed a difference on the weeks I take it compared to the weeks I don't take it. Yeah. Yeah, and therefore I now take it. Yeah, and I take it in the morning. I don't know if that's the right time, take it, Oh.
00:45:47
Speaker 2: Yeah that's the time.
00:45:48
Speaker 1: Yeah.
00:45:48
Speaker 2: Yeah. You don't want wanted to be energizing you while you're asleep.
00:45:52
Speaker 1: Well that's my issues. I wanted to make sure I sleep for me is very important, and I decided I don't want it. If this does work, I didn't want to be working at whilst I'm trying to get to sleep at night, So I take it in the morning and it tends to wear off, so to speak, by the time I go to bed at night. Do these things designed to have a half life?
00:46:11
Speaker 2: You know?
00:46:12
Speaker 1: I mean, do they sit in your system for a period or does that work?
00:46:16
Speaker 2: Yeah? You can design it to be immediate release or a sustained release or a long long release, you know, so so releasing just little bits every every hour sort of thing. What you're trying to do is when you're looking at the concentration of a substance in your blood plasma, you want to get away from from big peaks, spikes, spikes and then drops off.
00:46:45
Speaker 1: You don't have spikes and troughs.
00:46:46
Speaker 2: Yeah. You adapt the dose so that it becomes more of a little bit of a sort tooth, but not dramatic up and down.
00:46:54
Speaker 1: Yeah. So that's the volatility between the top and the bottom is much less. Yeah, and it's more or sort of evenly spread.
00:47:02
Speaker 2: Evenly spread. Yeah, But with repeated with repeated dosing, you know, you can't you can't do it with with one dose.
00:47:13
Speaker 1: Yeah, like give me in one tablet.
00:47:15
Speaker 2: Yeah.
00:47:15
Speaker 1: You need to take a capsule. Yeah, you need to take it every day, Yeah, every.
00:47:19
Speaker 2: Day or twice a day, you know, morning and night, you know, depends on what you're looking at. Something like Kirkerman where it's a very strong anti inflammatory. Yeah, that that that'll get absorbed within within a couple of hours and then over the next ten hours, you know, starts dropping dropping off. Now, if you're taking it for your inflame joints, you're getting that no pain and then pain slowly coming back, you know.
00:47:55
Speaker 1: And I tend to take that at night. Well take it both in the morning and right.
00:48:00
Speaker 2: Yeah, yeah, is what I'm saying, because you're going to get that peak as a dropping off, it's nighttime, you're back up again, right, you know, so you're not going to feel that waking up in the morning stiff and painful and whatever else, you.
00:48:15
Speaker 1: Know, which is commonplace as we age the hell.
00:48:20
Speaker 2: But if you take the right Kirkman, you're good.
00:48:23
Speaker 1: Well it's been fascinating George Cockiness and just repeat it. You're the founder, you're a chemist, but you're a founder of Farmaco Biotechnologies and doing great work made. But you know what's great about it, you're doing it here in Australia. Yeah, that's it's it's Australian based deep think deep thinking in relation to the supplement industry.
00:48:44
Speaker 2: Look, we've got we've got a great industry, a great regulator. The Unis are fantastic, top notch, and brand Australia is across the globe is really really good.
00:48:57
Speaker 1: It's funny, you know, I mentioned before I used to take them, I mean just brand, but I've now swept over to Future Labs and I'll say it now and and but prior to that me swapping over to the Milroe's Future Labs Supplements, I did know of another brand that actually had the quality of stuff that Momentous had the momentous being American brand, and it's been for me, it has been like a surprise and a delight to know that that's Australian based, because at the end of the day, when I'm putting inside me, I want to make sure it's it's the real deal and as most importantly, as prepared, probably not contaminated at least, and likely to have the effect that I'm expecting it to have. So and I know you guys involved with that organization Future Labs.
00:49:52
Speaker 2: Neil's Neil's a true visionary is great. It's once you feel that product and it's and it's doing different, different things for different people. You don't want to stop it. You know, you know that it's working.
00:50:13
Speaker 1: Do you make your own product?
00:50:15
Speaker 2: Do I?
00:50:16
Speaker 1: Not you, but your visitor.
00:50:17
Speaker 2: We're always experimenting. Yeah.
00:50:19
Speaker 1: Yeah, so you've got to make a lab table and yeah.
00:50:22
Speaker 2: We've got five labs, you know, so it's specializing in different things.
00:50:27
Speaker 1: I like the idea of that one scoop. Yeah, yeah, in the morning, one scoop at night, working and working on it. I might come in the lab and we might do it together. Collaboration. Really good to see George, Thanks much.
00:50:39
Speaker 2: That was great.
Speaker 1: George Goginess, Welcome to you, probably one hundred mante thanks so much for coming in. I'm actually fascinated with this topic. This is a topic of supplements and what gets absorbed and what doesn't get absorbed, what's a waste of time, and what's really important that's not a waste of time, et cetera. And that's your area of expertise. But maybe you just explained quickly your qualifications and some of the experiences and some of the studies that you have been you have done and and or are you doing.
00:00:24
Speaker 2: I've got a science degree, so the major was in chemistry, physical and organic chemistry. I've been in industry since probably ninety three. Started off in the regulator to start with therapeutic goods administration, which taught me a lot over the following nine years, and then went into various various jobs in industry. Last one is Farma Go Biotechnologies, so we started started that company in twenty fifteen, and what we special in is taking average ingredients and basically supercharging them, so making them get absorbed by the body better, so better by availability, which which then means you can reduce to dose or you can have much faster results. What people don't realize is that not everything you're put in your mouth gets absorbed, and and ingredients that are what we classify as lipophilic ingredients. So what do I mean they like fat versus water soluble ingredients? You know, they you're lucky to get one percent absorption on those ingredients.
00:01:42
Speaker 1: If you don't have fat with them.
00:01:44
Speaker 2: If you don't fat helps or a meal helps, you know, to activate the enzymes in the stomach, But they still don't get absorbed as much.
00:01:56
Speaker 1: Are you saying that there are lots of supplements out there that, by virtue of the interaction with what goes on our stomach, et cetera, that they're just never going to get absorbed. Is that what you're saying?
00:02:10
Speaker 2: Absolutely? Yeah, we've got vitamin D three, it's a classic exam.
00:02:16
Speaker 1: D three D three. Yeah, that's a popular one of the mother with k D three k k K two.
00:02:22
Speaker 2: We've had instances of dark colored skin people that have been that their vitamin D three levels are so so low. So you're looking at like twenty five nanograms per per miller plasma, they should be seventy. People with a darker color skin, Yeah, darker complexion.
00:02:44
Speaker 1: Not Us Greeks. We're talking about maybe the North African or African that type of complexion of Indian Indian or people that are just Polenesians.
00:02:55
Speaker 2: Hiding from the sun. You know, there are another another group. And so the children no slip slop slap. But that campaign was very, very successful in that you know, if you haven't got a hat on, you can't go out right now. Vitamin D is a sunshine vitamin, So it's created in your skin with the sun, with the sun's help. So there's there's a conversion that happens from from cholesterol to D three.
00:03:26
Speaker 1: So cholesterol gets converted through this chemicaly action so to speak, in your skin as a result of the sun.
00:03:31
Speaker 2: That's activated by UV light.
00:03:34
Speaker 1: Yeah. So UV light from the sun activates this process to convert cholesterol into vitamin D three.
00:03:41
Speaker 2: Yeah.
00:03:41
Speaker 1: And just by the way, what is D three important for?
00:03:44
Speaker 2: It?
00:03:44
Speaker 1: Is it important for something?
00:03:45
Speaker 2: Well, for everything. It's probably involved in about three hundred chemical reactions in your body. Its main important, well, use is for the calcium on your bone. Okay, So so your skeleton, your bone structure, that's basically a store for calcium, right, and calcium is used in many other reactions in your body.
00:04:13
Speaker 1: So when we think of calcium, we think of our bones and teeth and things like that, but really it's not just that, because our body actually borrows from that the calcium that's in those bones to do other things.
00:04:23
Speaker 2: That's yeah, that's right, right, yeah. And then and then it also puts it back onto puts it back onto your skeleton, onto your bones, you know. So it's it's a continuous cycling of of calcium.
00:04:37
Speaker 1: Without D three, what happens.
00:04:39
Speaker 2: You've heard of rickets in children, So they get the bowed legs, you know, it's it's it's that's because the structure isn't isn't strong enough.
00:04:49
Speaker 1: To support the weight, and the bones start boeing.
00:04:53
Speaker 2: Yeah, yeah, but you don't see that these days other than than in developing nations. But yeah, going back to skin, skin tone, skin color, and other factors, you're not getting D three. So supplementation is important. The problem with supplementation is you can have people taking it for three months and they'll move from twenty five to twenty seven.
00:05:24
Speaker 1: What did you say number that you want them to get up to seventy seventy and would that be considered in a pathology sense, in the average or something like that. In the range.
00:05:31
Speaker 2: Yeah, you're at the at the medium to low end of the scale, you know.
00:05:37
Speaker 1: Even seventy Yeah, wow, so forty your way off, way way off. Yeah, and what would you feel.
00:05:43
Speaker 2: You know, you've heard of seasonal depression.
00:05:47
Speaker 1: Yeah, Northern Europeans suffer from this.
00:05:50
Speaker 2: That's right, And that's why they've got D three in the margarine in their bread. You know. It's yeah, it's supplemented everywhere.
00:05:56
Speaker 1: So let's say we're taking the supplement. How do we know that is bio available? In other words, your body will make it biologically available once you ingest it.
00:06:08
Speaker 2: Once you ingest it, quite quite a few things happen. So, so you know, you start releasing light paces in your in your store to light paces. There they are enzymes that that break down fats.
00:06:21
Speaker 1: So your stomach detects this stuff.
00:06:23
Speaker 2: It detects that there's a fat present, so so it releases light paces um and and they'll go to to the source of the fat and start start breaking it down. Now, the problem with your stomach is that it's a watery environment. You're putting a fat into water a watery environment. What happens nothing. You know, all the fat clumps together. So as as it clumps together, the like pace has only got access to the to the surface area that's available to it outside the side. That's it. And at some point in time it gets spent and you have a globular fat just going through intestine unprocessed the other end. Yeah, what we do is we create technologies that stop that clumping. So we make tinier structures what we call my cells or liposomes, and these tiny structures because they are so small and they're now hydrophilic, so like water, when they go into the gut, they create a solution. And now your surface area from one big clump becomes a surface area of a million.
00:07:48
Speaker 1: Waller clumps, little droplets.
00:07:50
Speaker 2: Yeah, so the body has got better access.
00:07:53
Speaker 1: But that fat that you've ingested, is that in the form of what fat like food, fat like yogurt or what are we talking about here? How does that go into your system in the first place? Where am I getting this fat from?
00:08:05
Speaker 2: Through a supplement? Yeah, so it's in the supplement, Yeah, yeah, together with with the fat, so vitamin D. Yeah, we would have vitamin D together with our what we call it aqua cell technology and the two together. Once they meet water they form the tiny droplets.
00:08:26
Speaker 1: Wow, is it like a pill or what are we talking about?
00:08:29
Speaker 2: Yeah, yeah, just in that instance, it would be a soft gel capsule.
00:08:35
Speaker 1: Yeah, capua with the gel inside. Yeah, and the gel it's probably the fat bit and then the vitamin D is also in there as well.
00:08:41
Speaker 2: The gel makes the skin of the capsule, right, and then inside is the liquid the liquid vitamin D three, Amiga three, fish oil K two, all those sort of ingredients that that are typically.
00:08:56
Speaker 1: So you use this format sort of suspend the actual vitamin or whatever the supplement is. We're inside.
00:09:03
Speaker 2: Yeah, we mix it with our with our tech and it's not until it hits water. So the capsule needs to be ingested. You'll take some water with it. The shell breaks open, releases the contents. But once the content's released, they go into the stomach hit water they form straight away. All our research, all our formulation, all our manufacturer happens in.
00:09:27
Speaker 1: Australia and you guys do it yourself.
00:09:29
Speaker 2: Yeah, we do it. Some some more complicated situations will use universities. So there's about four or five local units that that we deal.
00:09:41
Speaker 1: With who do research on it for you.
00:09:44
Speaker 2: Yeah, that that can do more. So sometimes we'll know it works. We've tried it on humans and we get really good results, but we don't know why. We don't know how it works.
00:09:55
Speaker 1: Can I look at just one supplement that's like, it's pretty popular, look at a couple, but I look at one to start with. And I don't know if you guys haven't experienced this particular one. But let's look at m N yes, which is like the buzzword right now. Everybody's talking about this particular supplement, which is something that helps your energy system in terms of producing a thing called energy plus plus, which is something important for the electron transfer chain in the mitochondria. Yes, correct, yes, okay, so your parts pass on that bit. But if I'm taking NMM, which is a precursor to NAD plus, and what I'm trying to do is get more energy, you know, like you know, we get older and we just lack energy, what would you say I should be looking for in that supplement? Is this something I look like look for on the label apart from your brand? Can I feed that into AI? Will AI tell me that's the go to?
00:10:54
Speaker 2: AI would typically take you down the paths of coupling the end amen together with an advanced delivery system. Yeah, okay. Now, in amen's water soluble, okay, And what that means is is that a lot more of it gets absorbed by the body, right, not one hundred percent.
00:11:17
Speaker 1: So it's good for byver and it turns it by.
00:11:20
Speaker 2: On its own. It's good.
00:11:21
Speaker 1: Yeah.
00:11:22
Speaker 2: Yeah.
00:11:22
Speaker 1: It doesn't need to be put in a capsule with some special help. Yeah yeah, with the oil or whatever fat in there anyway.
00:11:29
Speaker 2: Yeah yeah, yeah, but it's still is still only absorbed about fifty sixty percent. The typical dose out there at the moment's about five hundred MiGs, right, So so five hundred your body is actually getting two hundred and fifty.
00:11:46
Speaker 1: But why does it absorber I don't understand. Why does it only and does it convert it into something else?
00:11:53
Speaker 2: It can't look that. The gut is a very hostile environment, you know. It's it's you've got chloric acid in there, and and it's its whole purpose is to break things down, take take what it needs, and get rid of the rest of it, you know. So so it applies the same principle what we do with advanced delivery systems is we force it to take more. So if you were to take the five hundred milligram and the men with our technology, you would be you would be absorbing about ninety five percent of it.
00:12:30
Speaker 1: But the point is you've got to people who are taking these things. They've got to make sure that the delivery system is right.
00:12:38
Speaker 2: Is right? That's that's that's the key to everything. And DOE and and dosage. Yeah, relative to delivery system, that's right, that's right. And that's that's the variable, the two variables. You know, sometimes you see the TGA places a restriction on a dosage and you're going, you know, you've placed the restriction on five hundred milligrams that I could deliver more just by adding a delivery system. So you're not achieving what you want to achieve, you know. So they've got to start looking at absorption, you know, by availability. They have to, because that's that's what's key.
00:13:18
Speaker 1: When you say delivery system for example of MN, would you say that it is like water, so like your gut system, is there something special you do to allow for that ENEMM to be absorbed up to ninety five percent?
00:13:32
Speaker 2: You're let into it before with the mitochondria. Okay, so the mitochondria are bodies that are inside cells. Your enemn has to make its way through the cell, through the mitochondria, so through the cell wall and into the mitochondri which.
00:13:51
Speaker 1: Every cell has a little mitochondria inside, a little has the energy energy factory inside and has to get through that as well. Side of that, that's right.
00:14:01
Speaker 2: In the meantime, the body is trying to get rid of it. Why because it's floating around in blood plasma. Yeah, it's detecting it as a foreign body. So it's doing its job right, you know, get it out.
00:14:14
Speaker 1: So there's this fight. So once you absorbed ninety five percent of it, I presume what do you mean by that, George? Is ninety percent of it for example, up to percent gets into your bloodstream? Does that mean you can I also then say ninety five percent of being absorbed into your mitochondry or there's that's a different process. It's got a higher chance, higher chance, higher chance. So it's about probability.
00:14:35
Speaker 2: Yeah, yeah, because you're you're getting more molecules now into your blood plasma. So say you got a million instead of instead of five hundred thousand, A lot more are going to find their way way in this This is where the delivery system comes comes into play. Now, now within the men in particular, we would use a technology called the light pozone. Okay, with with the liposomal technology, what it does is we we engineer these tiny balls that are made up of phospholipid membrane and inside inside the ball is a tiny core of water. And inside that core of water is the enemen. Okay, the enemen molecules. Now that membrane of the ball is made up of the same material that the membrane of your cells are made up.
00:15:31
Speaker 1: Of, so they're compatible.
00:15:33
Speaker 2: So when when it hits a cell, it's not looked at as a foreign body. It gets absorbed by the cell. The membrane ruptures, opens up, and the enemen goes into the cytoplasm.
00:15:48
Speaker 1: Of the cell and then then there's there. It changes just to go to mitochondria because a lot of people are using these injectibles because it looks quick. You put in your gut or wherever they put into you think, O, we'll get them a bloodstream. It's better than taking one of these supplements. Maybe you could explain that to me a bit better. I mean, am I on the right track there with what I was reading.
00:16:08
Speaker 2: If you're injecting with like Bosomall and their men, then then you that's different. That's different. If you're injecting with just then their men, you're back to the same situation of taking the capsule and absorbing fifty percent whatever, but then ten percent of the fifty percent is making its way to the mitochondria.
00:16:35
Speaker 1: So it's inefficient.
00:16:37
Speaker 2: Inefficient.
00:16:37
Speaker 1: Yeah, And when people build these supplements, they say, well, you know, take five milligrams. One tablet's five milligrams for I can say, you just take one of these tablets tablets. Is not like posoumaal delivery. When they build these things or manufacture this stuff. Are they manufacturing it on the basis that you only need ten percent of the fifty percent? Or are they doing it? Or I mean, where's the size sit there? I mean, so they don't tell us.
00:17:05
Speaker 2: If you're American, you like horsepower, So they go, it was five hundred megs without a system, there's five hundred megs with the system. You know, they don't get the fact that, hey, you can reduce it down to one hundred and have the same effect, you know, and save everybody money and everything else, you know, but that's where we strive to. So when we do do our studies to look at look at how much different you know, it is compared to a group of people that are just taking the basic enemen versus a group of people taking the loposomal and a men. We also start looking at the dose as well. Okay, so ALTHOUGHY will do a five hundred to five hundred comparison, will then will then start going, Okay, what's to fifty look like in comparison to five hundred? What does one hundred look like in comparison to to five hundred? And if we can get that part of the equation right, that's now called bioequivalents. So you got bioavailability by equivalents, and by what bioequivalence means is what dose of your formula is equivalent to the formula without anything, you know, it's just just the active ingredient just and the men in this case.
00:18:40
Speaker 1: So if I'm looking on the label, do I look for lipsal am? I looking for the delivery system.
00:18:47
Speaker 2: The companies that are that are clued in, Yes, there are other companies where they think they understand the liposume they think their clue in, they'll just put the word on the label.
00:19:01
Speaker 1: Do these things have to be proved by the TJ.
00:19:03
Speaker 2: They do. But the whole model with the TJ is a it's a bit of a self affirmation. So put your hand on your heart and say say this is a liposomal formula. The TJ doesn't come actively looking, you know, and saying, hey, you haven't got a light persone. The quickest way to work out as a as a consumer, is it liposomal or not.
00:19:33
Speaker 1: Even though it says it might be, even though it.
00:19:35
Speaker 2: Says it might be, is when you rip that that top off, put some into a spoon. If you can see little crystals in there, it's not a light perzone.
00:19:47
Speaker 1: With your naked eye, with your naked eye, a little Christians, you mean like little shiny things Vitamin C.
00:19:53
Speaker 2: They'll be wide orange sort of crystalline substances, you know. They it's the active ingredient that hasn't hasn't dissolved, right, And to make a light bosone, you really need to get that to dissolve to form the light posone, which is about one hundred and animeters in diameter.
00:20:19
Speaker 1: That's reasonable.
00:20:20
Speaker 2: Now, the visible wavelength of light is four hundred so you can't see it. So if you have a true light posomal formula and you've got it in a clear glass, it's going to guess what, it's going to be clear. Yeah, yeah, but if you can see little crystals floating around, chances are very very high.
00:20:41
Speaker 1: This where, it's this where is dangerous when people buy things online. Absolutely, you know. I mean I've seen it, berberine, berberinele glutethione libble.
00:20:52
Speaker 2: It's just like everything's like presuming everything.
00:20:55
Speaker 1: Yeah, yeah, and it's dangerous.
00:20:57
Speaker 2: It's very dangerous. That's why if if you're in Australia, just avoid it.
00:21:02
Speaker 1: Like the plague, do not buy buying online.
00:21:04
Speaker 2: Well, yeah, it's it's it's fraught with danger. You know, glued to thion From studies we've we've been doing, we know that after one month at room temperature, glued to thione drops to by about thirty forty of what's on the labe, and then again the next month, next month another thirty. Yeah, it's got a half life of the month. Within six months you go from one hundred milligrams of glutathion to four.
00:21:37
Speaker 1: Wow, So you basically got to take it straight away, the whole model, as soon as it's manufactured.
00:21:42
Speaker 2: Yeah.
00:21:42
Speaker 1: Yeah, And you don't know how long it's been manufactured for it, No, that's right exactly. It might have been use by date, but it doesn't matter. It's just manufactured.
00:21:49
Speaker 2: We know, if we refrigerate it, we can get twelve months, you know. But the same thing again, it's it's twelve months is great compared to two.
00:22:00
Speaker 1: So you guys involved in some berberine substances anyway, So how do you how do you differentiate your burbering? And maybe you can explain what burberene does or allegedly what it's supposed to do to us, especially given all the more recent studies on GLP one. Yeah, it's sort of like, as I under say, it's like a natural version of, you know, a zembi supposed to help you with it your you know, your appetite, et cetera. Look, could you tell me what it is?
00:22:29
Speaker 2: And berber comes from a plant which is native to India. It's in a particular region of India, and it's and it's from the bark, isn't it of that tree? It's from the roots the roots, isn't Yeah? Yeah, it's it's tightly controlled this this this plant you know, by by the Indian government.
00:22:50
Speaker 1: Really.
00:22:50
Speaker 2: Yeah, it helps with society in.
00:22:53
Speaker 1: Other words, appetite appetite. Yeah.
00:22:55
Speaker 2: So if if you, if you take a burbering with the delivery system, you can basically go until dinner without even thinking about food. Oh really, yeah, does that? I don't know, you don't know the mechanism. Oh, if you don't know the mechanism.
00:23:11
Speaker 1: But so, so you take burberin. Let's say you take it in the morning, proper berberine, and it has a proper delivery system. Let's talk about that delivery system. Is that liposomal again?
00:23:22
Speaker 2: No, I don't know if you have you ever tried to taste berberine.
00:23:25
Speaker 1: It is disgusting.
00:23:26
Speaker 2: It's the most bitter thing you've ever tasted in your life. I have.
00:23:30
Speaker 1: Yeah, it's dreadful.
00:23:31
Speaker 2: Yeah. So it doesn't make any sense to make it into a liposomea because you still can't can't take it by mouth, you know.
00:23:39
Speaker 1: Well, I've had it in a capsule. In a capsule, it said, I think the liposomes on the inside the capsule.
00:23:46
Speaker 2: Yeah. Again, to form a liposome, you're relying on your active ingredient, berbering in this case, to be able to dissolve in water. So if it doesn't dissolve in water, it doesn't matter how hard you try, you're not going to get You're not going to get a light berzone. What we do is we use a dispersion technology. So so burbrin powder is made up of tiny crystals, we coat those crystals with with our tech and and make them hydro hydrophilic.
00:24:20
Speaker 1: In other words, like water loving.
00:24:22
Speaker 2: Yeah, and because of that, the same thing again, under normal circumstances, berbrine would probably clump, clump together and create that surface area issue. But with the tech, you're not you're not getting that. You're getting free dispersion and then the body is just taking what what it needs.
00:24:42
Speaker 1: So it's how it needs inefficiently.
00:24:45
Speaker 2: Yeah.
00:24:45
Speaker 1: Yeah, so you're you're you are, because I mean, berberine is to me anyway, one of the more one of the more fascinating things that sort of is on the market today. How would you know you got that the correct active ingredients considering that it's controlled in India in some area, whatever the part of India is. We don't grow it in Australia, so we can't sort of look at Tom, you know where it came from?
00:25:08
Speaker 2: How do you know that?
00:25:09
Speaker 1: The answer to that, I mean, I know how you know, But how would someone like Mina?
00:25:13
Speaker 2: Look, sometimes you get what you pay for. There are people using berbering from different species. Okay, So so the one which is the pharmacologically active is the berberous aristata. That's that's the name of the plant. There are other ones from other regions, from Nepal, from China, et cetera, that can still yield burbering. So it's a bit like like coffee. You've got Arabica, you've got Robusta, et cetera. They've all got caffeine in them, you know, but this one's bitter, this one's a bit a bit sweeter, et cetera.
00:25:54
Speaker 1: You know.
00:25:54
Speaker 2: So there's those subtle differences that make the big difference. And all the research is on Burbersstata, right, they're not They're not on.
00:26:05
Speaker 1: The other ones. And and how would you know? How would someone know if they look on the laboring label again, if it should.
00:26:10
Speaker 2: Be on the label, should say if it's an Australian product, it should be on the label that.
00:26:15
Speaker 1: It is burberous aristarta can I just talk to you about quite question? Maybe you could explain why all the sudden has become popular and what the hell is it? Where's it come from? When do you take these things? With food? Without food? How do I know whether they should be having some fatty food like yogurt with it or something like that?
00:26:33
Speaker 2: Okay, so so on on on that one food or no food with with the advanced delivery systems, it doesn't matter, It doesn't matter. Yeah, you can take it whenever you want, right, And that's the beauty of them, right, because trying to remember, you know, take food and then take take it. You know, it's it's it's too hard for people.
00:26:54
Speaker 1: Okay, Well now what is carcert course, it's okay, where's it come from?
00:26:59
Speaker 2: Look, it's an interesting moleculars, it's what. It's in a class called polyp phenols. So it's a polyphonomic molecule. Whenever whenever you read any sort of research on any any inflammatory condition, they'll the conclusion will be almost the same, you know, across thousands of papers, and that is works in the test tube, doesn't work in humans. Wow, It's like why not? You know, And the reason being is that in the test tube. You can control the dose in the In the human you're you're left up to everybody's own devices. You know, someone will absorb one percent, this other goal will absorb point one, but it's always a low percentage, you know. So by increasing that percentage with a delivery system, you're getting you're getting the full benefits. Now querstin its main main function anti inflammatory, So it's in the same category as as Kirkman Amiga threes. You know, inflammation is multi multifaceted, so you can't get rid of inflammation just just with one substance. There's there's multiple that you have to have to take.
00:28:31
Speaker 1: And maybe you could explained that pony are the polyfannel piece, because lots of things are described as polyphannels. Olive ar, for example, there's lots of things blueberries. What are we talking about here, though? What is a polyphanel?
00:28:45
Speaker 2: Just generally speaking, a particular chemical structure that that is is that characterizes certain molecules, you know. So so yeah, Kirkman is retrol.
00:29:00
Speaker 1: As reservetrol does the same thing.
00:29:02
Speaker 2: They're all poly polyphenols, yeah, yeah, polyphenolics.
00:29:06
Speaker 1: Yeah, And now olive oil is one two, isn't it very low.
00:29:10
Speaker 2: Olive O is mainly made up of a substance called alayic acid. Yeah, something like seventy seventy percent of it's laic acid, so very high. But then it does you know, if it's the extra.
00:29:22
Speaker 1: Virgin depends on what their intensity is here.
00:29:26
Speaker 2: Yeah, that's right.
00:29:27
Speaker 1: What about blueberries? The skin very high, very high.
00:29:30
Speaker 2: Very high. Anything that you see that's in that red blue color range is high. Chances are very high that it's it's high in polyphenolics.
00:29:42
Speaker 1: And resveratrol is off the grapes skinners, is it right?
00:29:45
Speaker 2: That's one source, one source.
00:29:47
Speaker 1: Yeah, yeah, how do you find this stuff? You send people over so you's looking for all this stuff or we have it here locally.
00:29:52
Speaker 2: Yeah, look, there's there's there's roughly about two to three thousand ingredients that the TGA allows you to use. Okay, so the majority of those are herbal, but nonetheless it's it's a big number, you know. Is it? Is it possible to know everything? Not really, you know, but if you want to target a particular condition, you can. You can do quick research even with AI and say, you know what's good for senescence and cells for example, you know.
00:30:30
Speaker 1: Being the cells being dormant. Yeah, yeah, and how to get rid of siness and cells?
00:30:35
Speaker 2: Is that? So? What what substances would you know? Probably help? So yeah, AI will give you a list then you can say, okay, where do they come from?
00:30:46
Speaker 1: You know?
00:30:46
Speaker 2: So, so it's it's it's a bit of bit of research, you know, whether you're using AI or using PubMed or the research gate.
00:30:54
Speaker 1: Being published medical journals, yeah, supplications or research work.
00:30:59
Speaker 2: Yeah, it's a particular website that's run by the American the US Library.
00:31:06
Speaker 1: Yeah, and just for those people who might be listening apartment readings, published reports which usually done peer reviewed reports done at a scholarly level and perhaps even a peer in a journal and general and then you can work out whether or not it's a ranking journal or not, so whether or not you want to rely on that publication.
00:31:27
Speaker 2: That's that's right, Yeah, because there's there's a lot of journals that there is a ranking system. We typically look at journals at a five and above. Anything that's three and below it's not worth.
00:31:42
Speaker 1: Them because because generally speaking, the peer review process is fairly average in that because they do it for free, and so you're finding and what's interesting about that just for anyone who's listening. And I'd be interested to hear what you say about when you are using as a tool as opposed to the ultimate answer. But as a tool, it's worth saying to you in your instruction today, I just give me stuff that comes from ranked journals, as opposed to just going on there and have a look at an instagram. But I will do that sometimes it'll dish us from crap to you. Absolutely, so I always asked her to go. I asked it to look at published scholarly articles only you know which. The old Google scholar was always pretty good place to go to in the old days. But old day's only been a year ago, you can now. But now AI will help you. You've got to be careful to A tells you, because I will tell you what all the populist people who've got no idea on instagram sprooking that must kill your brain? Yes, yeah, I mean, what are some of the more popular things that you see that sort of aggravate your intellectual processes. I mean, what is around supplements for example? People should be careful perhaps.
00:33:02
Speaker 2: Or the life bozones is the big one, yeah.
00:33:05
Speaker 1: Life zonable delivery systems when it's not actually live zone.
00:33:08
Speaker 2: Yeah, and it's it's hard to validate. You know, there's companies out there that are worth, you know, five hundred million dollars US selling life pozons that are not life perzones.
00:33:22
Speaker 1: Yeah, I know some of those companies. I've seen them.
00:33:24
Speaker 2: Yeah, it's it's horrible.
00:33:27
Speaker 1: What about cerquit ten? What about its efficiency in delivery? And is a delivery system that you guys use for that? And I have noticed in capsules similar to what you're talking about some of the other other supplements. And is it something people should use only if they're taking statins or they should be using it generally.
00:33:46
Speaker 2: Yeah. Look, it's a substance that declines with age and as everything. The statins when they initially came out, they were combination products with coq ten.
00:33:59
Speaker 1: Are really there's inside.
00:34:00
Speaker 2: Yeah, it used to be used to be combo because they knew that the statins deplete your coke ten levels. Now it's it's not that the staaten uses up coke ten. It's more so the statin blocks the production of coke ten, and it blocks it in multiple paths, you know. So so it's it's pretty common that you're given statins to reduce your cholesterol, your bad cholesterol. But then ten years down the track you're dying from heart failure. Yeah, because you've depleted yourself of kke ten.
00:34:39
Speaker 1: You know. Wow, that's that's crazy.
00:34:42
Speaker 2: Yeah, it is, it is so so Yeah, if you're taking statin, definitely take coke ten.
00:34:49
Speaker 1: That's what about outside of your taking status just generally for general health. Unlets's say you're not you know, you're under forty or whatever.
00:34:56
Speaker 2: Well, it's it's it's sort of like like en the men. You know, you feel that energy burst and you can keep it going by by supplementation. It's just another another ingredient in the whole energy cascade.
00:35:16
Speaker 1: You know. Can you get it out of eating fruit or meat or.
00:35:21
Speaker 2: Naturally meat, Yeah, mainly from meat.
00:35:24
Speaker 1: From meat.
00:35:25
Speaker 2: I don't know how much you'd have to eat to get equivalent. It would have to be a lot, you know, and on a daily basis it would be a lot.
00:35:33
Speaker 1: Again, can I ask you? You might not want to answer this, but what do you take?
00:35:38
Speaker 2: What do I take?
00:35:39
Speaker 1: I mean, you're you're the dude like you're I mean, you're studying it, you're researching it, you're making it. You're passionate about it. We'll take a lot really so you live and breathe it.
00:35:52
Speaker 2: Yeah, yeah, yeah, absolutely.
00:35:54
Speaker 1: Give me an example of what you would.
00:35:56
Speaker 2: Well as a base. I take a Mega three what they call fatty acids. They're called a mega threes because there's a double bond at the number three position of this fatty acid. You know, they make up part of your cell membranes. So you know how earlier we said that the typical cell membranes made of phospholipids, phospholipids plus plus plus. You know, there's probably a thousand pluses, you know, and one of those is a mega threes. Phospholipids are quite rigid in in in their native state, so you need things like cholesterol Mega three, Mega six to give it fluidity. Yeah, So that's that's where a mega threes come in. They're they're they're in the in pretty much every cell membrane in your body. The problem we've got now is that where we've been needing so much Amiga sixers, it's a Mega six other fatty acids, but now that double bond, instead of being in the third position, it's in the sixth position. The significance of that is different reactions that go to play and the conversions that that happened. But Amiga six fats are pro inflammatory, Amiga three fats are anti inflammatory. Okay, So when you've got a cell and it's and it's viewing out inflammatory markers for whatever reason because someone punched you in the shoulder or whatever, those Amiga sixers are what create those inflammatory that process to happen. Okay, Amiga three will bring it back in line. Now, come down a bit, coming down now, because the Amiga sixers have recently, in the modern age, have become very popular. You know, your seed oils, you're cooking oils, et cetera. They're all Amiga six is compared to olive oil and all that sort of thing. Yeah yeah, all of the cheaper end of the oil scale. You know, your ratio has gone out of whack, right, So where it was one to one and that's the perfect ratio, it's now one Amiga three to six a Mega sixers or ten or twelve, you know, but it's way out of whack. So what's happening is is your cells in this continuous enti in this inflammatory process. You know, So by taking a Mega sixers, a Mega three. Sorry your trying to bring that balance back down again?
00:39:02
Speaker 1: And can you explain on the Amega three is? Where does because I'm confused? But E p A d h A finished that or has it got nothing to do with it?
00:39:12
Speaker 2: There are essential fatty acids and that chain length which you know, the double bond happens in the third position, so it's just a chain length, how big it is.
00:39:22
Speaker 1: But is that a way of taking is that a way of taking omega three or a mega three something separate to those those two things that all together E p.
00:39:30
Speaker 2: A d h A are a Mega three. Right, there's also d p A. There's there's a whole heap of them. But E p A d h A mainly comes from from fish oil, right and depending on what fish is it? Anchovy? Is the salmon? Is it? What grills it? Yeah? Real, the ratios are different, right?
00:39:54
Speaker 1: So that so if someone takes e b A g h A, that is a a Mega three supplement. Yes, reason for that is to balance out the potential intake of d h A and making just sure that maybe it hopefully gets to one to one ratio between the Mega sixers. Yeah, so what else do you take? Okay?
00:40:12
Speaker 2: So so mega threes D three, Kirkman and then risveratrol. So I take the Kirkman together with the risveratrol.
00:40:21
Speaker 1: In the same tablet or in the same Yeah.
00:40:24
Speaker 2: Yeah, my, My whole ideal world would be to make a tub of powder and take a scoop and.
00:40:31
Speaker 1: The everything's in there, everything's in there.
00:40:34
Speaker 2: Is it possible we should be able to come close?
00:40:37
Speaker 1: Like you just take a scooba powder and add water to or something.
00:40:40
Speaker 2: It's got your creatine and it it's got you know, it's got everything. Just add water.
00:40:45
Speaker 1: So what else do you take apart from the so so.
00:40:48
Speaker 2: Those they take berberine in the morning. Plus this other substance called oe A. It's short for oliol ethanola mine.
00:41:00
Speaker 1: So it helps you don't have to take olive all.
00:41:02
Speaker 2: Well, it comes from alayic acid, so it's a combination of alayic acid and ethanolamine. But it's it's a substance that that naturally occurs, occurs in your body and it affects it affects GLP one the naturally Yeah obviously not as not as hardcore as as a zeenpic and the other ones, but it's it's the body's natural approach to to GLP one. And what we also found is that, yeah, you hear about the gut microbiome, et cetera, there's a particular bacteria called Achamancia and and it influences that bacteria positively as well.
00:41:48
Speaker 1: You know, so it's sort of like a probiotic or something like that.
00:41:52
Speaker 2: I hate to say probiotic, but it's it's having a probiotic effect without being a probiotic.
00:41:59
Speaker 1: Yeah, So nutrition for the bacteria anyway, Yeah, a good bacteria.
00:42:03
Speaker 2: Yeah. Yeah.
00:42:04
Speaker 1: And on top of anything else, what are the things like vitamin C and.
00:42:09
Speaker 2: Take an iron working on putting together an iodine one as well, because iodine's completely overlooked.
00:42:19
Speaker 1: I feel it used to be in our salt all the time.
00:42:22
Speaker 2: It used to be, but you know, you had to stop taking salt because of your heart and yeah, making your arteries hard, et cetera. And the only place you can really get it from seafood, you know. So it's sort of like the omega three. You're not eating as much, you know, so you're not getting your omega three, you're not getting your iodine, et cetera.
00:42:41
Speaker 1: It's interesting and what is iod important for all.
00:42:44
Speaker 2: Your thyroid hormones. Yeah, so you're feeling tired, bit sluggish even after you've had a good night's sleep, et cetera. You know, chances are it's it's your balances there are out of whack.
00:42:57
Speaker 1: It's pretty complex all this stuff. Like I can see you even knew someone. You're a scientist and you know this stuff backwards and you're working on all the changes and right at the forefront of all this stuff. The average punter like me, it's a tough one to navigate. For us, it's impossible. Yeah, it is impossible. You've nearly got to be tactical, like you just got to go, oh shit out. Maybe I'll try this and just see what it does for me.
00:43:28
Speaker 2: I remember back in the eighties in at Uni and walked into my first lecture for biochemistry, and the professor said, oh, this is a good turn. Now there's three hundred of you, he said, By a second semester, there'll be one hundred and fifty of you. They said, by the end of second semester, there'll be ten.
00:43:49
Speaker 1: But people just drop out.
00:43:50
Speaker 2: They drop out because it's it's a damn difficult yeah subject and dry too, probably, And that was then back in the eighties, it's boomed in the last twenty is as a science. Yeah, I don't know how people do it.
00:44:06
Speaker 1: Because a lot of people bag this upplement industry, they say, and there's probably good reason for it in relation to some of the players generally speaking from what you're saying, George, supplements are important as long as you get the right ones and the right delivery system.
00:44:19
Speaker 2: Yeah, yeah, you can't. You can't need as much, and if you did, you'd be as big as a house.
00:44:25
Speaker 1: Especially as you get older. You just can't need as much.
00:44:27
Speaker 2: Yeah.
00:44:28
Speaker 1: I don't mean because you're going to get fat, You just don't have the same appetite. Your whole and your system becomes much less, much more inefficient in absorption anyway, just generally because you don't have as many things going on down there, things die off. Yeah, so you have to take supplements.
00:44:44
Speaker 2: Yeah, that's right, and it's only you know, like then Amends of this World that.
00:44:52
Speaker 1: Very recent research. Yeah, very very recent.
00:44:55
Speaker 2: So we still don't know what the outcome is going to be long term, but for the short term, like you said, you feel that hit of energy.
00:45:04
Speaker 1: Yeah, I do. I definitely do. I take a particular brand, but five hundred milligrams of what I take. I know you guys manufacture it. They come from you guys, but I honestly I've only been tall you for about maybe a month, and so I actually can turn you now. I have noticed a difference.
00:45:22
Speaker 2: Yeah, yeah, do the next thing. Stop taking it and.
00:45:25
Speaker 1: See, well I have done that. So I've done it on a week, take it for a week, and don't take it for a week.
00:45:29
Speaker 2: Yeah. You know.
00:45:30
Speaker 1: I try to maintain consistency in what happens otherwise in my life work, stress, you know, sleep exercisese other things. And I have noticed a difference on the weeks I take it compared to the weeks I don't take it. Yeah. Yeah, and therefore I now take it. Yeah, and I take it in the morning. I don't know if that's the right time, take it, Oh.
00:45:47
Speaker 2: Yeah that's the time.
00:45:48
Speaker 1: Yeah.
00:45:48
Speaker 2: Yeah. You don't want wanted to be energizing you while you're asleep.
00:45:52
Speaker 1: Well that's my issues. I wanted to make sure I sleep for me is very important, and I decided I don't want it. If this does work, I didn't want to be working at whilst I'm trying to get to sleep at night, So I take it in the morning and it tends to wear off, so to speak, by the time I go to bed at night. Do these things designed to have a half life?
00:46:11
Speaker 2: You know?
00:46:12
Speaker 1: I mean, do they sit in your system for a period or does that work?
00:46:16
Speaker 2: Yeah? You can design it to be immediate release or a sustained release or a long long release, you know, so so releasing just little bits every every hour sort of thing. What you're trying to do is when you're looking at the concentration of a substance in your blood plasma, you want to get away from from big peaks, spikes, spikes and then drops off.
00:46:45
Speaker 1: You don't have spikes and troughs.
00:46:46
Speaker 2: Yeah. You adapt the dose so that it becomes more of a little bit of a sort tooth, but not dramatic up and down.
00:46:54
Speaker 1: Yeah. So that's the volatility between the top and the bottom is much less. Yeah, and it's more or sort of evenly spread.
00:47:02
Speaker 2: Evenly spread. Yeah, But with repeated with repeated dosing, you know, you can't you can't do it with with one dose.
00:47:13
Speaker 1: Yeah, like give me in one tablet.
00:47:15
Speaker 2: Yeah.
00:47:15
Speaker 1: You need to take a capsule. Yeah, you need to take it every day, Yeah, every.
00:47:19
Speaker 2: Day or twice a day, you know, morning and night, you know, depends on what you're looking at. Something like Kirkerman where it's a very strong anti inflammatory. Yeah, that that that'll get absorbed within within a couple of hours and then over the next ten hours, you know, starts dropping dropping off. Now, if you're taking it for your inflame joints, you're getting that no pain and then pain slowly coming back, you know.
00:47:55
Speaker 1: And I tend to take that at night. Well take it both in the morning and right.
00:48:00
Speaker 2: Yeah, yeah, is what I'm saying, because you're going to get that peak as a dropping off, it's nighttime, you're back up again, right, you know, so you're not going to feel that waking up in the morning stiff and painful and whatever else, you.
00:48:15
Speaker 1: Know, which is commonplace as we age the hell.
00:48:20
Speaker 2: But if you take the right Kirkman, you're good.
00:48:23
Speaker 1: Well it's been fascinating George Cockiness and just repeat it. You're the founder, you're a chemist, but you're a founder of Farmaco Biotechnologies and doing great work made. But you know what's great about it, you're doing it here in Australia. Yeah, that's it's it's Australian based deep think deep thinking in relation to the supplement industry.
00:48:44
Speaker 2: Look, we've got we've got a great industry, a great regulator. The Unis are fantastic, top notch, and brand Australia is across the globe is really really good.
00:48:57
Speaker 1: It's funny, you know, I mentioned before I used to take them, I mean just brand, but I've now swept over to Future Labs and I'll say it now and and but prior to that me swapping over to the Milroe's Future Labs Supplements, I did know of another brand that actually had the quality of stuff that Momentous had the momentous being American brand, and it's been for me, it has been like a surprise and a delight to know that that's Australian based, because at the end of the day, when I'm putting inside me, I want to make sure it's it's the real deal and as most importantly, as prepared, probably not contaminated at least, and likely to have the effect that I'm expecting it to have. So and I know you guys involved with that organization Future Labs.
00:49:52
Speaker 2: Neil's Neil's a true visionary is great. It's once you feel that product and it's and it's doing different, different things for different people. You don't want to stop it. You know, you know that it's working.
00:50:13
Speaker 1: Do you make your own product?
00:50:15
Speaker 2: Do I?
00:50:16
Speaker 1: Not you, but your visitor.
00:50:17
Speaker 2: We're always experimenting. Yeah.
00:50:19
Speaker 1: Yeah, so you've got to make a lab table and yeah.
00:50:22
Speaker 2: We've got five labs, you know, so it's specializing in different things.
00:50:27
Speaker 1: I like the idea of that one scoop. Yeah, yeah, in the morning, one scoop at night, working and working on it. I might come in the lab and we might do it together. Collaboration. Really good to see George, Thanks much.
00:50:39
Speaker 2: That was great.
