ACERCA DE ESTE EPISODIO
In our film Forever Young, Ava receives an annual epigenetic treatment and leaves the clinic a year younger than she arrived. We wrote that as fiction. In June, Life Biosciences dosed the first human being with a partial epigenetic reprogramming therapy.
This is just one of many topics covered in our AMA with Dr. Thomas Lewis.
Dr. Thomas Lewis is a psychiatrist and neuroscientist, co-author of A General Theory of Love, and a co-star and producer of the film. You sent the questions. He answered.
Two notes on accuracy
The reprogramming trial discussed is a Phase 1 safety study run by Life Biosciences, which David Sinclair co-founded. The FDA cleared the application in January 2026, and the first participant was dosed on June 9. Clearance to begin a trial is not approval of a therapy.
On dementia genetics, Dr. Lewis describes research showing no genetic difference in people highly resistant to cognitive decline. That reflected the literature when he learned it. The largest study to date, published in January 2026 across 18,080 participants, found such people were 19 percent less likely to carry the APOE-e4 variant. His broader point holds. Genetics accounts for far less of dementia risk than was assumed a decade ago, though it is not absent.
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Sources
Nothing here is medical advice. Evidence suggests several of the interventions discussed may support healthspan, and each one should be discussed with your physician before you act on it.
Leone M, Barzilai N. An Updated Prioritization of Geroscience-Guided FDA-Approved Drugs Repurposed to Target Aging. Medical Research Archives. 2024;12(2).
Durant A, et al. Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers. Alzheimer’s & Dementia. 2026;22(1).
Newman SJ. Morbid: Debunking Modern Longevity Science. 2026.
Lewis T, Amini F, Lannon R. A General Theory of Love. Random House, 2000.
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