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The roundworm C. Elegans has proven to be a valuable organism for advancing understanding of fundamental molecular and cellular mechanisms of aging because of its short lifespan, ease of genetic manipulations, and fully documented cellular organization. During the past 10 years or so Scott Leiser's…
With the advent of new technological approaches and emerging discoveries has come a growing appreciation for the importance of astrocytes in neuroplasticity. In contrast to the chemical synapses between neurons, astrocytes are directly connected by gap junctions comprised of connexin proteins. In t…
Understanding how diet influences brain health is a very important area of research. During the past two decades there has been an exponential increase in research on the gut microbiome and its roles in health and disease. Diets high in fiber are not only improve gut health but may also be benefici…
The molecular machinery that translates the messenger RNAs into protein is located in ribosomes. Ribosomes are present within neurons in or near synapses, where they are particularly abundant in postsynaptic sites. Evidence suggests that local protein synthesis is required for the 'strengthening' (…
Protein nitrosylation a process by which redox reactions of nitric oxide (NO) and proteins result in covalent modification of the sulfur in the amino acid cysteine resulting in S-nitrosothiol (SNO). In this episode I talk with Scripps Research Professor Stuart Lipton about his research career highl…
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