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We connect the frustrating reality of perimenopause sleep changes with the underlying biology, then explain why progesterone is often the first hormone to drop even when cycles still look regular. We walk through oral micronised progesterone, what the evidence says about sleep and night sweats, and how to approach testing, tracking, and safer decision-making.
• the common pattern of going to bed exhausted but waking unrefreshed
• why night waking and early morning wake-ups can have a physiological cause
• progesterone as a neurosteroid that supports GABA and sleep stability
• how allopregnanolone acts on the GABA-A receptor to deepen sleep
• why anovulatory cycles can create progesterone deficiency from mid-30s
• oral micronised progesterone versus synthetic progestins and why it matters
• nightly versus cyclical dosing and how practitioners choose between them
• what the 2023 Canadian trial showed and the nuance around its primary outcome
• practical steps including symptom tracking and when a DUTCH test can help
• consult questions that support informed consent and safer prescribing
The information shared in this podcast does not substitute working with your primary health care provider; it is general in nature and not considered personalised advice.
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