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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.11.18.388843v1?rss=1
Authors: Van Oort, C. M., Ferrell, J. B., Remington, J. M., Wshah, S., Li, J.
Abstract:
Antibiotic resistance is a critical public health problem. Each year ${sim}2.8$ million resistant infections lead to more than 35,000 deaths in the U.S. alone. Anti-microbial peptides (AMPs) show promise in treating resistant infections. But, applications of known AMPs have encountered issues in development, production, and shelf-life. To drive the development of AMP-based treatments it is necessary to create design approaches with higher precision and selectivity towards resistant targets. In this paper we present AMPGAN v2, a generative adversarial network (GAN) based approach for rational AMP design. Like AMPGAN, AMPGAN v2 combines data driven priors and controlled generation. These elements allow for the generation of AMP candidates tailored for specific applications. AMPGAN v2 is able to generate AMP candidates that are novel and diverse, making it an efficient AMP design tool.
Copy rights belong to original authors. Visit the link for more info
http://biorxiv.org/cgi/content/short/2020.11.18.388843v1?rss=1
Authors: Van Oort, C. M., Ferrell, J. B., Remington, J. M., Wshah, S., Li, J.
Abstract:
Antibiotic resistance is a critical public health problem. Each year ${sim}2.8$ million resistant infections lead to more than 35,000 deaths in the U.S. alone. Anti-microbial peptides (AMPs) show promise in treating resistant infections. But, applications of known AMPs have encountered issues in development, production, and shelf-life. To drive the development of AMP-based treatments it is necessary to create design approaches with higher precision and selectivity towards resistant targets. In this paper we present AMPGAN v2, a generative adversarial network (GAN) based approach for rational AMP design. Like AMPGAN, AMPGAN v2 combines data driven priors and controlled generation. These elements allow for the generation of AMP candidates tailored for specific applications. AMPGAN v2 is able to generate AMP candidates that are novel and diverse, making it an efficient AMP design tool.
Copy rights belong to original authors. Visit the link for more info
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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.11.19.390005v1?rss=1
Authors: van Krugten, J., Danne, N., Peterman, E. J. G.
Abstract:
Sensing and reacting to the environment is essential for survival and procreation of most organisms. Caenorhabditis elegans senses soluble chem…
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.11.18.388561v1?rss=1
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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.11.18.389106v1?rss=1
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Abstract:
Adherent cells utilize local environmental cues to make decisions on their growth and movement. We have previously shown …
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.11.18.388066v1?rss=1
Authors: Longhan, X., Wang, Z., Huang, G., Liu, B., Zhou, Z., Liang, B., Liu, Y.
Abstract:
Lower limb assistive robots have a wide range of applications in medical rehabilitation, hiking, and the military. The…
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