OM DENNE EPISODE
Dr Noriyuki Kasahara speaks with ecancertv at AACR2016 about his cancer-targeting retroviral therapies which illicit host immune responses.
Historically, oncolytic viruses have struggled to compete with host immunity to reach their target and the immunosuppresive tumour environment. But by using a retroviral factor, Dr Kasahara's lab reports selective targeting of cancer cells with a gene primer that in turn responds to a non-toxic pro-drug to kill the 'infected' tumour cells.
Dr Kasahara reports significant extension to patient survival compared to current chemotherapy treatments, with no systemic toxicity and high-tumour specificity.
Trials are ongoing.
Historically, oncolytic viruses have struggled to compete with host immunity to reach their target and the immunosuppresive tumour environment. But by using a retroviral factor, Dr Kasahara's lab reports selective targeting of cancer cells with a gene primer that in turn responds to a non-toxic pro-drug to kill the 'infected' tumour cells.
Dr Kasahara reports significant extension to patient survival compared to current chemotherapy treatments, with no systemic toxicity and high-tumour specificity.
Trials are ongoing.
Engelsk
USA
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ANDRE EPISODE I DENNE PODCAST
Dr Rafaella Sordella speaks with ecancertv at AACR 2016 about cell plasticity affecting its susceptibility to therapies.
With specific regard to non-genetic mechanisms of resistance in cancer cells, Dr Sordella explains the flexible cell state, how some cells persist and respond to therapies, and …
Dr Robert Gillies talks to ecancertv at AACR 2016 about novel imaging techniques in tumour habitats.
Considering the stalling durable response rate of many targeted-therapy patients due to tumour evolution, Dr Gillies discusses the value of multiple imaging techniques to determining tumour habitat…
Dr Philip Low speaks with ecancertv at AACR 2016 about a novel technique to selectively identify tumour cells in vivo.
With potentially toxic side effects to uncontrolled tumour lysis and hard-to-target heterogeneity, Dr Low describes a new method of using fluorescein dye to bridge tumours and T C…
Dr Xose Puente speaks with ecancertv at AACR2016 about his discoveries of mutations in non-coding regions driving tumourigensis in chronic lymphocytic leukaemia.
Using a library of genomic data from CLL patients, Dr Puente's lab were able to determine point mutations outside of the coding regions …
Dr Martine Piccart presents at AACR 2016 about the results of the MINDACT trial.
Using a new diagnostic assay, Mammaprint, to scan for a 70 gene signature, Dr Piccart reports significant predictive potential for determining breast cancer relapse risk.
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